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Medical Forum / Diseases and Disorders / Diabetes / October 2005Diet / bloodletting / iron chelators / insulin
So I wonder if .. NOW .. a 'low iron diet' .. is .. suggested .. ? <<snip>> insulin resistance significantly decreased after diet, and a further reduction was observed after phlebotomies. Iron depletion by desferrioxamine increased by twofold the (125)I-insulin-specific binding, whereas iron addition reduced insulin binding <<snip>> Aliment Pharmacol Ther. 2005 Nov;22 Suppl 2:61-3. Links Iron and insulin resistance. Fargion S, Dongiovanni P, Guzzo A, Colombo S, Valenti L, Fracanzani AL. Dipartimento Medicina Interna, Ospedale Maggiore IRCCS, Universita di Milano, Milano, Italy. Background : Preliminary clinical and experimental results suggest that iron can modify hepatocytes' insulin sensitivity by interfering with insulin receptor and intracellular insulin signalling. Aim : To evaluate in vivo the influence of iron on insulin resistance and insulin release in patients with non-alcoholic fatty liver disease and in vitro the interaction between iron and insulin sensitivity by analysing the effect of iron manipulation on insulin receptor expression in hepatoblastoma HepG2 cell line. Results : Insulin resistance evaluated by homeostatis model assessment (HOMA)-insulin resistance significantly decreased after diet, and a further reduction was observed after phlebotomies. Iron depletion by desferrioxamine increased by twofold the (125)I-insulin-specific binding, whereas iron addition reduced insulin binding, similarly to cells exposed to high glucose concentration. Conclusion : Iron status affects insulin sensitivity by modulating the transcription and membrane expression/affinity of insulin receptor expression in hepatocytes and influencing insulin-dependent gene expression suggesting that increased insulin clearance and decreased insulin resistance may contribute to the positive effect of iron depletion in patients with non-alcoholic fatty liver disease. PMID: 16225476 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking "So I wonder if .. NOW .. a 'low iron diet' .. is .. suggested .. ?" Looks like it could be for these folk: "patients with non-alcoholic fatty liver disease." But it says nothing about having that specific disorder and doesn't support the iron causes all disease because people eat meat idea. "So I wonder if .. NOW .. a 'low iron diet' .. is .. suggested .. ?" Looks like it could be for these folk: "patients with non-alcoholic fatty liver disease." So that would be .. for .. millions .. ? According to this study .. yes .. millions .. Jeez .. ----------------------------------------------------- <<snip>> millions of people <<snip>> Nonalcoholic fatty liver disease and the metabolic syndrome. Curr Opin Lipidol. 2005 Aug; 16(4): 421-427 Marchesini G, Marzocchi R, Agostini F, Bugianesi E PURPOSE OF REVIEW: Clinical, epidemiological and biochemical data strongly support the concept that nonalcoholic fatty liver disease is the hepatic manifestation of the metabolic syndrome. Insulin resistance is the common factor connecting obesity, diabetes, hypertension and dyslipidemia with fatty liver and the progression of hepatic disease to steatohepatitis, fibrosis, cirrhosis and hepatocellular carcinoma. RECENT FINDINGS: The association of nonalcoholic fatty liver disease with the features of the metabolic syndrome has been confirmed in several epidemiological studies. The diagnostic and clinical significance of raised liver enzymes has been questioned; advanced hepatic disease may also be present in individuals with ultrasonographically detected steatosis and normal aminotransferase levels. The role of adipokines (leptin, adiponectin) and cytokines (tumor necrosis factor-alpha, interleukin-6, transforming growth factor-beta) in disease progression is probably pivotal, mediated by oxidative stress. The importance of iron accumulation in this process has not been confirmed. Treatments aimed at weight loss remain a primary option; among pharmacological interventions, insulin sensitizers (glitazones and metformin) have confirmed beneficial effects on both biochemical and histological data, but new treatments are on the horizon. SUMMARY: Nonalcoholic fatty liver disease prevalence in Western countries is high and there is a trend towards a further increase, with millions of people at risk of advanced liver disease. The epidemiological evidence, the lifestyle origin of the disease and the cost of pharmacotherapy make prevention a primary goal, and will contribute to making behavior therapy the background treatment. We need specific programs and carefully controlled, randomized studies to tackle simultaneously all the components of the metabolic syndrome. Read more <">http://www.hubmed.org/display.cgi?issn=09579672;uids=15990591> Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Let me be more .. precise .. B-I-L-L-I-O-N-S .. of .. people .. http://www.findarticles.com/p/articles/mi_m0FDN/is_4_7/ai_91155401 NAFLD is known to affect 10-39 percent of the general global population with an average incidence of 20 percent. (5,6) It is the most common cause of increased liver enzyme levels in adults in the United States. (7) NAFLD occurs commonly in diabetics and the obese: 50 percent of diabetics (ranging between 21 and 78 percent), 57-74 percent of obese persons, (5) and 90 percent of morbidly obese persons (over 200 percent of ideal body weight) (8) are affected. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Bringing the focus back to the underlying question, does iron cause fatty liver disease or is its level an effect of it? It doesn't help the ironcauses all disease because people eat meat idea. Many millions of people in countries where few or no animal products are eaten have the highest levels of diabetes and one presumes higher risk for this disorder. This is yet another nail in the coffin where only one counter example is required to toss an idea. |
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