On May 31, 7:02 pm, New...@bix.nex wrote:
> On Tue, 27 May 2008 20:04:53 -0400, Steven Bornfeld
>
[quoted text clipped - 13 lines]
>
> Because it doesn't exist.
That's it here: http://www.pfizerah.com/product_overview.asp?drug=PH&country=US&lang=EN&species=CN
Apparently, it seems to work for mice (according to the journal
article below).
Vaccine. 2005 May 2;23(24):3148-56.Click here to read Links
Evaluation of a monovalent companion animal periodontal disease
vaccine in an experimental mouse periodontitis model.
Hardham J, Reed M, Wong J, King K, Laurinat B, Sfintescu C, Evans RT.
Pfizer Inc., Veterinary Medicine Research and Development, 301
Henrietta Street, Kalamazoo, MI 49001, USA. john.m.hardham@pfizer.com
Periodontal disease in companion animals is clinically similar to
that of human periodontal disease. Despite the usage of veterinary
procedures and antibiotic therapy, the disease still remains as one of
the most highly prevalent disorders seen by veterinarians. The goal of
this study was to evaluate the immunogenic properties and vaccine
performance of a monovalent canine periodontal disease vaccine in the
mouse oral challenge model of periodontitis. Mice vaccinated
subcutaneously with inactivated, whole-cell bacterin preparations of
Porphyromonas gulae displayed both high titers of anti-P. gulae
specific antibodies and significantly reduced alveolar bone loss in
response to homologous, heterologous, and cross-species challenge.
Based on the results of these studies, a periodontal disease vaccine
may be a useful tool in preventing the progression of periodontitis in
animals.
Steven Bornfeld - 31 May 2008 23:30 GMT
> On May 31, 7:02 pm, New...@bix.nex wrote:
>> On Tue, 27 May 2008 20:04:53 -0400, Steven Bornfeld
[quoted text clipped - 37 lines]
> may be a useful tool in preventing the progression of periodontitis in
> animals.
The most surprising thing here is the "cross-species challenge". We
don't have a lot of monovalent vaccines out there that we expect to work
on multiple organisms.
Steve