Bone regeneration article

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Roy Brown - 22 Oct 2005 19:01 GMT

Made it to the front page of today's Globe and Mail. You should be able to view
it for a few days before they start charging for it. Link:
http://www.theglobeandmail.com/servlet/story/RTGAM.20051022.wxchin1022/BNStory/s
pecialScienceandHealth/
or
http://tinyurl.com/9kpay

Quote from article:
"Using a protein that can seduce adult stem cells into becoming bone tissue,
Cameron Clokie, head of oral and maxillofacial surgery at the University of
Toronto, has pioneered a technique to reset the jaw's skeletal clock - coaxing
bones to grow as they do in a newborn baby."

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Roy
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Mark & Steven Bornfeld - 22 Oct 2005 19:34 GMT

> Made it to the front page of today's Globe and Mail. You should be able to view
> it for a few days before they start charging for it. Link:
[quoted text clipped - 7 lines]
> Toronto, has pioneered a technique to reset the jaw's skeletal clock - coaxing
> bones to grow as they do in a newborn baby."

Someone posted a link over at sci.medicine a couple of hours ago.
I got the creeps when they claimed they were using adult stem cells.

Steve

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Mark & Steven Bornfeld DDS
http://www.dentaltwins.com
Brooklyn, NY
718-258-5001

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Sue - 22 Oct 2005 19:49 GMT

> > Made it to the front page of today's Globe and Mail. You should be able to view
> > it for a few days before they start charging for it. Link:
[quoted text clipped - 16 lines]
> Mark & Steven Bornfeld DDS
> http://www.dentaltwins.com

"Someone posted a link over at sci.medicine a couple of hours ago.
I got the creeps when they claimed they were using adult stem cells."

Reply.

Dr. Steve,

Why? Most people (who are religious) are disturbed by the use of
embryonic stem cells.
In this case, rather than using embryonic tissue, Pleuro or multipotent
adult stem cells can achieve new bone growth.

So why does this give you the creeps?

Thanks,
-Sue

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Steven Bornfeld - 22 Oct 2005 21:45 GMT

>>>Made it to the front page of today's Globe and Mail. You should be able to view
>>>it for a few days before they start charging for it. Link:
[quoted text clipped - 33 lines]
> Thanks,
> -Sue

I would like to see the research. Most bony regeneration involves
promotion of osteoblastic activity. The article posted from the lay
press implied de-differentiation. As described, this would seem to
carry some risks. Besides, stem cells don't act as
osteoblasts--osteoblasts act as osteoblasts. What is the point of
utilizing stem cells?

http://www.theglobeandmail.com/servlet/story/RTGAM.20051022.wxchin1022/BNStory/s
pecialScienceandHealth/

Steve

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Roy Brown - 23 Oct 2005 07:41 GMT

Google BMP and Clokie.
Seems to be lots of references.......

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Roy
rem NADA to reply

| >>>Made it to the front page of today's Globe and Mail. You should be able to view
| >>>it for a few days before they start charging for it. Link:
[quoted text clipped - 41 lines]
| osteoblasts--osteoblasts act as osteoblasts. What is the point of
| utilizing stem cells?

http://www.theglobeandmail.com/servlet/story/RTGAM.20051022.wxchin1022/BNStory/s
pecialScienceandHealth/

| Steve

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Sue - 23 Oct 2005 21:21 GMT

> Google BMP and Clokie.
> Seems to be lots of references.......
[quoted text clipped - 62 lines]
> | "nospam" to reply\par
> | }

Dr. Steve,

If you are a member of medscape here is great article that adresses
some of your concerns!:

http://www.medscape.com/viewarticle/446739_print

I am not familiar with BMP for use in jaw regeneration, but I know that
recombinent human BMP-2 (InFUSE) bone graft is being successfully used
in spinal fusion surgery for those suffering from dengenerative disc
disease. This eliminates the need for autograft (harvesting bone chips
from the pelvis) as is required in traditional surgery.

The referenced article addresses the osteoinductive properties of BMP-2
and BMP-7 (mainly). These effect mesenchymal stem cells. It also
addresses the research of various delivery methods, surgical appraoches
(as per spinal applications), as well as potential complications. The
main complications included heterotropic bone formation and antibody
formation. (article references extensive in-vitro, animal and human
clinical trials)

This article was printed in 2003 so perhaps it is a bit outdated. At
the time of print, evidence of SIGNIFICANT antibody formation had NOT
been observed in patients (yet) (BMP-2 seemed safer than BMP-7 in this
regard).

However heterotropic bone formation was demonstrated in one clinical
trial that used a postereo lumbar interbody fusion (PLIF) with rhBMP-2.
This clinical trial was stopped. Luckily none of the pts experienced
spinal stenosis from this complication. (Many different surgical and
delivery approaches are described, but I cannot intelligiently
articulate the differences between these, sorry).

Smaller amounts of rhBMP seem to be safe, as autoregulation (negative
feedback mechanisms) appear to prevent overzealous bone formation.

This paper does not address the use of BMP for "growing a new jaw," but
it does give a very nice and extensive background re: the development
of rhBMP for spinal applications.

-Sue

PS If you cannot access the article I can send or reprint (but that may
be illegal?)

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Steven Bornfeld - 23 Oct 2005 21:48 GMT

> Dr. Steve,
>
[quoted text clipped - 40 lines]
> PS If you cannot access the article I can send or reprint (but that may
> be illegal?)

Thanks--I'll have a look when I have a chance.

Steve

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Sue - 23 Oct 2005 22:54 GMT

It is 17 pages long. I did not read the whole thing myself. I only
read the abstract, intro, potential complications, and conclusions.. &
sorry about all my typos. uggh.

Maybe BMP for dental applications has a longer road ahead... I do not
know how close they are.

Sue

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W_B - 24 Oct 2005 17:44 GMT

>> "Using a protein that can seduce adult stem cells into becoming bone tissue,
>> Cameron Clokie, head of oral and maxillofacial surgery at the University of
[quoted text clipped - 5 lines]
>
>Steve

The glass is half full.
--

W_B
Take out the G'RBAGE
wubbabubbazG@RBAGEyahoo.com

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Sue - 25 Oct 2005 16:18 GMT

LOL. Healthy skepticism. :-)

-Sue

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Sue - 22 Oct 2005 19:41 GMT

> Made it to the front page of today's Globe and Mail. You should be able to view
> it for a few days before they start charging for it. Link:
[quoted text clipped - 11 lines]
> Roy
> rem NADA to reply

Roy,
This is exciting for me. This is bone morphogenic protein (BMP).
Medtronic Mpls and Medtronic Sofmor Danek were involved in research
that brought this to market for use in spinal surgery.

Thanks for posting this. It is nice to see that BMP may be used in
other applications.

-Sue

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Sue - 22 Oct 2005 19:56 GMT

Actually scratch Pluripotent!!

...I mean Multipotent.

I do believe that they are speaking about multipotent adult stem cells,
but I will have to check it out.

Later,
-Sue

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Sue - 24 Oct 2005 16:12 GMT

Actually... posting the abstract summarizes the article more succinctly
and accurately than my earlier posts.

(Os Here it is just FYI for anyone who is interested)

Bone Morphogenetic Proteins and Spinal Fusion

David H. Walker, M.D., Neill M. Wright, M.D.
Neurosurg Focus 13(6), 2002. © 2002 American Association of
Neurological Surgeons

Posted 02/04/2003
Abstract and Introduction

Abstract
Bone morphogenetic proteins (BMPs) have increasingly become a focus of
research in the laboratory, with animal models, and in human clinical
trials for the treatment of spinal disorders. Basic science research
has elucidated the putative mechanism of action of BMPs, and the
efficacy of BMPs in inducing bone formation has been evaluated in
multiple animal models of anterior and posterior spinal fusion. Not
only has BMP been shown to improve the quality and amount of bone
formation when used as a supplement to autograft, it has also been
shown to promote superior fusion in the absence of autograft, even in
high-risk fusion models involving the use of nicotine or nonsteroidal
antiinflammatory agents. Both completed and ongoing clinical trials
have demonstrated the efficacy of recombinant BMP, leading to the first
BMP product being approved for clinical use earlier this year.

Animal models and clinical trials have also been used to evaluate the
safety of BMPs. Although few complications have been reported, BMPs can
induce heterotopic bone formation, especially when placed adjacent to
exposed neural elements. Potentially more serious, antibody formation
has been seen in up to 38% of patients in some clinical trials. No
clinical sequelae have been reported despite the development of
antibodies against BMP, a naturally occurring human protein implicated
in processes other than osteoinduction.

The future directions of biological manipulation of the osteoinduction
process include further understanding of the interactions of the BMP
subtypes, the interactions of BMP with its receptors, and exploring
other molecules capable of osteoinduction.

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