This is my second day with Ki67 but here goes anyway ....

Why not a diagnostic test for Ki67 within periodontal tissues?

Joel

Joel

Dr. Jai Maharaj   Jul 6 2004, 2:16 am     show options

Newsgroups: soc.culture.indian, alt.fan.jai-maharaj, sci.med,
sci.med.cardiology, misc.health.alternative, misc.health.diabetes,
alt.support.diabetes
Followup-To:
soc.culture.indian,alt.fan.jai-maharaj,sci.med,sci.med.cardiology,misc.health.alternative,misc.health.diabetes,alt.support.diabetes
From: use...@mantra.com (Dr. Jai Maharaj) - Find messages by this
author  
Date: Tue, 06 Jul 2004 09:16:31 GMT
Local: Tues, Jul 6 2004 2:16 am  
Subject: HEART MUSCLE CELLS REGENERATE AFTER A HEART ATTACK
Reply to Author | Forward | Print | Individual Message | Show original

NIH NEWS RELEASE

NATIONAL INSTITUTES OF HEALTH

National Heart, Lung, and Blood Institute  
http://www.nhlbi.nih.gov/index­.htm

EMBARGOED FOR RELEASE
Wednesday, June 6, 2001
5:00 p.m. EST  Contact:
NHLBI Communications Office (301) 496- 4236

Doug Dollemore, NIA (301) 496- 1752

Marjorie Roberts,
New York Medical College
(914) 594-4536

Scientists Find that Heart Muscle Cells Regenerate After
a Heart Attack

Challenging one of medicine's long-standing beliefs, a
team of scientists funded by the National Heart, Lung,
and Blood Institute (NHLBI) and the National Institute on
Aging (NIA) http://www.nih.gov/nia/  has found the
strongest evidence to date that human heart muscle cells
regenerate after a heart attack. In a paper published in
the June 7 issue of the New England Journal of Medicine,
scientists from New York Medical College in Valhalla, NY
report their success in finding large scale replication
of heart muscle cells in two regions of the heart, and in
identifying several other key indicators of cell
regeneration.

"It has long been assumed that when the heart is damaged
- such as after a heart attack - heart muscle cells do
not regenerate and the damage is permanent. This
assumption has been challenged in recent years by
evidence that heart muscle cells may in fact regenerate.
Now, this latest research provides the most dramatic and
clear-cut demonstration to date of heart cell
regeneration after cardiac injury," says Claude Lenfant,
M.D., director of the NHLBI, a component of the National
Institutes of Health (NIH).

"With this landmark study, we have a new understanding of
the heart that opens up the possibility of repairing
heart muscle damage after a heart attack," he adds.

"This finding, if confirmed, may begin to clarify how
hearts respond to the normal insults of aging through
previously undetected repair mechanisms," says David
Finkelstein, Ph.D., director of basic cardiovascular
research at the NIA.

Piero Anversa, M.D., professor of medicine and director
of the Cardiovascular Research Institute, and colleagues,
studied myocytes (heart muscle cells) from the hearts of
13 patients, 4 to 12 days after their heart attacks, and
from the hearts of 10 patients who did not have
cardiovascular disease. Samples were obtained from the
border zone near the site of the heart attack and from a
more distant site from the damaged tissue.

By viewing these areas of the heart with a high
resolution confocal microscope, Anversa and colleagues
were able to measure the expression of Ki67, a protein
found in the nucleus of dividing heart muscle cells. Ki67
is expressed during all phases of a cell's life cycle and
is a strong indicator of cell division.

The scientists also obtained images of mitotic division
and found other evidence of myoctye replication,
including the formation of the "mitotic spindle," and
"contractile ring," critical structural indicators of
cell division.

Important evidence of myocardial repair was demonstrated
by the mitotic index, a measurement of the degree of
myocyte division. In comparison with normal hearts, the
number of myoctyes multiplying in diseased hearts was 70
times higher in the border zone and 24 times higher in
the remote myocardium.

The next challenge, according to Anversa, is to find the
source of the dividing myoctyes. "Are these cells a sub-
population of known cells that retain the capacity to
divide, or are they multiplying cells that originate from
stem cells present in the heart?" he asks.

"There are preliminary indications that primitive cells
like stem cells exist in the human heart. Stem cells may
have the ability to develop into the various cardiac cell
types and form new healthy functioning myocardium. If we
can prove the existence of cardiac stem cells and make
these cells migrate to the region of tissue damage, we
could conceivably improve the repair of damaged heart
muscle and reduce heart failure," says Anversa.

Research on animal models supports this possibility. In
the April 4 issue of Nature, the Anversa team and a
colleague at the NIH reported that adult stem cells
isolated from mouse bone and injected into a damaged
mouse heart became functioning heart muscle by developing
into myocytes and coronary vessels. Moreover, the newly
formed tissue partially restored the heart's ability to
pump blood.

Although a cardiac stem cell has not yet been identified,
scientists have identified a neural stem cell in the
brain.

"Why not the heart?" asks Anversa.

To arrange an interview with an NHLBI scientist, contact
the NHLBI Communications Office at (301) 496 - 4236. To
interview Dr. Anversa, contact Marjorie Roberts, New York
Medical College, at (914) 594 - 4536. To interview Dr.
Finkelstein, contact the National Institute on Aging
Office of Communications and Public Liaison at (301) 496
- 1752.

http://www.nhlbi.nih.gov/new/p­ress/01-06-06.htm

Jai Maharaj
http://www.mantra.com/jai
Om Shanti

Hindu Holocaust Museum
http://www.mantra.com/holocaus­t

Hindu life, principles, spirituality and philosophy
http://www.hindu.org
http://www.hindunet.org

The truth about Islam and Muslims
http://www.flex.com/~jai/satya­mevajayate

The terrorist mission of Jesus stated in the Christian bible:

    "Think not that I am come to send peace on earth:
I came not so send peace, but a sword.
    "For I am come to set a man at variance against his
father, and the daughter against her mother, and the
daughter in law against her mother in law.
    "And a man's foes shall be they of his own
household.
- Matthew 10:34-36.

    o  Not for commercial use. Solely to be fairly used for the
educational purposes of research and open discussion. The contents of
this post may not have been authored by, and do not necessarily
represent
the opinion of the poster. The contents are protected by copyright law
and the exemption for fair use of copyrighted works.
    o  If you send private e-mail to me, it will likely not be read,
considered or answered if it does not contain your full legal name,
current e-mail and postal addresses, and live-voice telephone number.
    o  Posted for information and discussion. Views expressed by
others
are not necessarily those of the poster.


  Dr. Jai Maharaj   Jul 6 2004, 11:51 am     show options

Newsgroups: soc.culture.indian, alt.fan.jai-maharaj, sci.med,
sci.med.cardiology, misc.health.alternative, misc.health.diabetes,
alt.support.diabetes
Followup-To:
soc.culture.indian,alt.fan.jai-maharaj,sci.med,sci.med.cardiology,misc.health.alternative,misc.health.diabetes,alt.support.diabetes
From: use...@mantra.com (Dr. Jai Maharaj) - Find messages by this
author  
Date: Tue, 06 Jul 2004 18:51:55 GMT
Local: Tues, Jul 6 2004 11:51 am  
Subject: Re: HEART MUSCLE CELLS REGENERATE AFTER A HEART ATTACK
Reply to Author | Forward | Print | Individual Message | Show original

- Hide quoted text -
- Show quoted text -