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Medical Forum / General / Dentistry / February 2005Bacteriophage
Anyone want to engage in a scientific discussion about bacteriophages? They are relatively unknown in this country due to the strong pharmaceutical lobby. I call that Big Pharma Lobby. But phages are used clinically in certain regions of Eastern Europe and the Ukraine. Joel > Anyone want to engage in a scientific discussion about bacteriophages? > [quoted text clipped - 5 lines] > > Joel I probably don't know enough to contribute much, but I would be interested in seeing the big picture regarding their clinical use. >> Anyone want to engage in a scientific discussion about bacteriophages? >> [quoted text clipped - 8 lines] >I probably don't know enough to contribute much, but I would be >interested in seeing the big picture regarding their clinical use. ** REPLY http://www.evergreen.edu/phage/eliava/grants.htm Eliava Grants Home Phage Therapy Addendum 2000 Alfred's Story Companies Polish Research Therapy News PhageBiotics Foundation Projects Ways to Give Tbilisi Eliava Institute Grants Contact Other Tbilisi People Evergreen Research Evergreen Phage Meetings General Meeting Calendar Evergreen Meeting Details Genomics Contact Info Links PostDocs Classic Papers Current Phage Books International Grants involving Phage and the Eliava Institute: -Information on the International Science and Technology Centers (ISTC) program -Science and Technology Centers in the Ukraine (STCU) program -Civilian Research and Defense Fund (CRDF) program These programs were set up to help scientists once supported by the Soviet military make a productive transition to the civilian sector; they are associated with the State Department and also involve Europe and Japan. They have become very supportive of phage work - 2 State Department representatives actually came to the last Evergreen Phage meeting to encourage involvement in their programs. Projects under way: Molecular Mechanisms of Bacteriophage Evolution and Host-to-Virus Transcription Transition During Bacteriophage Infection in Pathogenic Bacteria. PI - Tato Gabisonia; US Dept. of Health and Human Services, Rockville; US Partner: Konstantin Severinov, Rutgers; BTEP ISTC Grant G587 Analysis of Phage Specific Potentially Lethal Genes and Investigation of Antibacterial Activity of" Killer" Proteins. PIs - Mzia Kutateladze & Rezo Adamia. US partners: Jan Drake (National Institute of Environmental Health Sciences), Elizabeth Kutter, Charles Stewart; BTEP ISTC Grant G595 A new strategy for control of potato bacterial diseases based on application of specific phages. PI, Marina Tediashvili; partner: 3M; CRDF Grant N 527 Bacteriophage - a new approach for combating of the nosocomial respiratory infection caused by Ps. aeruginosa. PI - Nino Chanishvili, Co-ordinator - Paul Barrow, UK, INTAS-Georgia (joint funding from EC and Georgia) (completed) An epidemiological study of outbreaks of B. anthraxis in Georgia. PI- Sergo Rigvava, Co-ordinator Richard Sharp, CAMR, UK; INTAS Open Call Regional Experimental Center for Applied and Microbiology Research (RECAMBR). PI- Nino Chanishvili -- CRDF - Regional Experimental Support Centers Program Student Project 2001: Nino Chanishvili CRDF G 589 *Approved; still negotiating final research plan: [This step often takes over a year.] * Bacteriophages for the Treatment of Infectious Diseases Caused by Antibiotic-Resistant Bacterial Strains of Staphylococcus Aureus and Pseudomonas Aeruginosa. PI: Nana Balarjishvili. NATO partners: Henry Krisch (Toulouse); Elizabeth Kutter (Evergreen) ISTC Grant G510 * Sustained/Controlled-Release Drug Devices Containing Bacteriophages Based on New Biodegradable Poly (ester amide)s. Amiran Meipariani and Zemphira Alavidze [Supporting institute: Georgian Technical University / Research Center for Medical Polymers and Biomaterials, Tbilisi, Georgia - Ramaz Katsarava] -- ISTC Grant G589 * Monitoring and preventing the after-effects of natural hazards and water-borne epidemics through application of phage-based techniques. PI: Nino Chanishvili. [Supporting institutes: National Center for Diseases Control, Tbilisi, Georgia; Geophysics Institute, Tbilisi, Georgia. US collaborator: University of North Carolina/Carolina Environmental Program, Partner: US Department of Health & Human Services, Rockville, MD, BTEP ISTC Grant G608 **Waiting for granting board decisions: ** Different Medicinal Forms of Bacteriophages for Treatment and Prevention of Bacterial Infections Induced by the Genera of Staphylococcus and Streptococcus - Inga Georgadze; Collaborator: University of Maryland / School of Medicine / Department of Epidemiology and Preventive Medicine, Baltimore -- ISTC G824 ** Prolonged Acting, High Effective, Antimastitis Preparation Composed Of Bacteriophages, Hyaluronidase And Biodegradable Polymer. PI: Tato Gabisonia; [Supporting institute: Georgian Technical University / Research Center for Medical Polymers and Biomaterials, Tbilisi, Georgia - Ramaz Katsarava]; US collaborator: Elizabeth Kutter -- STCU ** Study of interaction between antibiotics and bacteriophages in vitro taking into account the resistance of strains isolated from patients during the treatment of suppurative infections. PI: Zemphira Alavidze. [Collaboration: Dr. Guram Gvasalia, Regional Hospital] -- STCU ** Medicinal-Prophylactic Phage Preparation Against Bacterial Complications Induced by Proteus and Pseudomonas, in Extreme Conditions. PIs: Liana Gachechiladze and Inga Georgadze; US collaborator: Elizabeth Kutter - CRDF Scientists from the Eliava Institute are also collaborators on other international grants where the PIs are from other Georgian institutions; CR: Eliava Institute lead collaborator Bacteriophages Containing Drug Sustained/Controlled Release Type Polymeric Composites - New Effective Preparations for the Treatment of Infected Wounds and Cavities. Georgian Technical University / Research Center for Medical Polymers and Biomaterials, Tbilisi, Georgia - Ramaz Katsarava. Eliava Institute collaborators: Zemphira Alavidze and Amiran Meipariani. US collaborator: Glenn Morris, University of Maryland. ISTC Grant G446 [The Katsarava group has also been awarded a CRDF grant for development of a Regional Research Center for work with biopolymers and an additional ISTC grant is in the work plan-negotiation stages; these are clearly both also relevant to the goal of commercially making Phage Bioderm, which incorporates phages obtained from the Eliava Institute.] The Biological Dispersion Phenomenon and the Energetic of Microplankton: A Search for the Regularities and the Relationship to Environmental Fluctuations. CR Marina Tediashvili, Co-ordinator Professor Richard Kemp University of Wales, UK, INTAS Grant N 1390 Prevention of food spoilage by suppression of phenoloxidase perioxidase and growth of pathogenic micro-flora by use of natural inhibitors of plant origin. CR Marina Tediashvili, Co-ordinator , Jose Neptuno Rodrigues Lopes, University of Mursia, Spain- INTAS FOOD-2000 Evaluation of coastal pollution status and bio-indicators for the Black Sea (BIOBS). CR, Marina Tediashvili, Co-ordinator James Wilson, Center for the Environment Trinity College, Dublin, Ireland INTAS-Polluted Environments Bacteriophage against a number of medication resistant conditionally - pathogenic bacteria as an alternative to antibiotics. Biochimpharm Joint Stock Company (Golidjashvili Aleksandr Otarovich); Eliava Co-PI:Liana Gachechiladze. NATO collaborators: Humboldt University School of Medicine Charite, the Institute of Virology, Berlin; Elizabeth Kutter, Evergreen State College *ISTC Grant G534 Tuberculosis Bacteriophage: Development of Obtainment and Application Methods. Sergey Vashakidze Institute of Tuberculosis and Pulmonology, Tbilisi, Georgia; US collaborators: Merlin Technologies, Inc., Boston, MA; Public Health Research Institute, New York ** ISTC Grant G591 return to top For more information contact Dr. Elizabeth Kutter at phagebiotics@attbi.com. web counter tracks new visitors Last Updated: February 02, 2005 Site Manager: Gautam Dutta The Evergreen State College 2700 Evergreen Parkway NW Olympia, WA 98505 (360) 867-6000 > Anyone want to engage in a scientific discussion about bacteriophages? > [quoted text clipped - 5 lines] > > Joel I wonder what their use would be in Jaw Om or similar jaw diseases. I assume these are viruses which are able to selectively attack certain bacteria. >I wonder what their use would be in Jaw Om or similar >jaw diseases. I assume these are viruses which are able >to selectively attack certain bacteria. YES! What are jaw Om diseases? Joel > >I wonder what their use would be in Jaw Om or similar > >jaw diseases. I assume these are viruses which are able [quoted text clipped - 5 lines] > > Joel Jaw Osteomyeltis. However someone pointed out that frequntly bacterial infections create biofilms which seem to protect them from these phages >> What are jaw Om diseases? >> [quoted text clipped - 3 lines] >bacterial infections create biofilms which seem to protect them from >these phages Very unusual, I hope you are not referring to NICO. Joel Here is some NIH material Definition Return to top Osteomyelitis is an acute or chronic bone infection, usually caused by bacteria. Causes, incidence, and risk factors Return to top The infection that causes osteomyelitis often is in another part of the body and spreads to the bone via the blood. Affected bone may have been predisposed to infection because of recent trauma. In children, the long bones are usually affected. In adults, the vertebrae and the pelvis are most commonly affected. Bone infection can be caused by bacteria or by fungus. When the bone is infected, pus is produced within the bone, which may result in an abscess. The abscess then deprives the bone of its blood supply. Chronic osteomyelitis results when bone tissue dies as a result of the lost blood supply. Chronic infection can persist intermittently for years. Risk factors are recent trauma, diabetes, hemodialysis, and intravenous drug abuse. People who have had their spleen removed are also at higher risk for osteomyelitis. The incidence of osteomyelitis is 2 in 10,000 people. Symptoms Return to top Pain in the bone Local swelling, redness, and warmth Fever Nausea General discomfort, uneasiness, or ill feeling (malaise) Drainage of pus through the skin (in chronic osteomyelitis) Additional symptoms that may be associated with this disease: Excessive sweating Chills Low back pain Swelling of the ankles, feet, and legs Signs and tests Return to top A physical examination shows bone tenderness and possibly swelling and redness. A bone scan indicates infected bone. A CBC shows elevated white blood cell count. The ESR is elevated. Blood cultures may help identify the causative organism. An MRI and a needle aspiration of the area around infected bones for culture may be done. A bone lesion biopsy and culture may be positive for the organism. A skin lesion with a sinus tract (the lesion "tunnels" under the tissues) may yield drainage of pus for culture. This disease may alter the results of the following tests: Joint x-ray Hand x-ray Extremity x-ray Bone x-ray ALP (alkaline phosphatase) isoenzyme ALP Treatment Return to top The objective of treatment is to eliminate the infection and prevent the development of chronic infection. Intravenous antibiotics are started early and may later be changed depending on culture results. Some new antibiotics can be very effective when given orally. In chronic infection, surgical removal of dead bone tissue is usually necessary. The open space left by the removed bone tissue may be filled with bone graft or by packing material to promote the growth of new bone tissue. Antibiotic therapy is continued for at least 3 weeks after surgery. As i said before I have chronic Om diagnosed by biopsy. The "trauma" probably being excessive Hg leakage from a filling near that location (or the fashionable term these days being Hg reabsorption). It kills the bone blood supply allowing bacteria to get in. I don't have any nerve pain and I don't want to get into a debate about whether OM/ON causes nerve pain, although you might want to look at this: Jawbone cavities and trigeminal and atypical facial neuralgias. Ratner EJ, Person P, Kleinman DJ, Shklar G, Socransky SS. Oral Surg Oral Med Oral Pathol 1979 Jul;48(1):3-20 http://www.ncbi.nlm.nih.gov/entrez/PubMed&list_uids=287984&dopt=Abstract The possible role of dental and oral disease in the etiology of idiopathic trigeminal and atypical facial neuralgias has been examined. Among thirty-eight patients with idiopathic trigeminal neuralgia and twenty-three patients with atypical facial neuralgia, there was in nearly all instances a close relationship between pain experienced and the existence of cavities in alveolar bone and jawbone of the patients. The cavities were at the sites of previous tooth extractions and, although at times more than 1 cm. in a given diameter, were usually not detectable by x-rays. A new method for their detection and localization was developed empirically, based on the observation that peripheral infiltration of local anesthetic into or very close to the bone cavity rapidly abolished trigger and pain perception by patients during persistence of the anesthetic action. Histopathologic examination of bone removed from cavities by curettage revealed, in both idiopathic trigeminal and atypical facial neuralgias, a similar pattern characterized by a highly vascular abnormal healing response of bone. Some lesions presented a mild chronic inflammatory (lymphocytic) infiltration. Preliminary microbiologic studies of material from the walls of the cavities showed the existence within them of a complex, mixed polymicrobial aerobic and anaerobic flora. Treatment consisted of vigorous curettage of the bone cavities, repeated if necessary, plus administration of antibiotics to induce healing and filling-in of the cavities by new bone. Responses of patients to the above treatment consisted of marked to complete pain remissions, the longest of which has been for 9 years. Complete healing leads to complete and persistent pain remissions. It was concluded that in both idiopathic trigeminal and atypical facial neuralgias, dental and oral pathoses may be major etiologic factors. I'd be very interested to hear your scientific respone to this article >As i said before I have chronic Om diagnosed by biopsy. The "trauma" >probably >being excessive Hg leakage from a filling near that location (or the >fashionable True, those 17 micrograms can cause some big damage. Where is this substantiated in the dental literature? Joel > >As i said before I have chronic Om diagnosed by biopsy. The "trauma" > >probably [quoted text clipped - 6 lines] > > Joel The idiociy of this argument is that no one on this list can state an upper limit on elemental (or methyl) Hg release from amalgam in practice. Your underlying premise is that all amalgam gives off a well distributed amount of Hg which is exactly 17 ug for each fillings, which is false. As for heavy metal exposure causing jaw bone problems that is well known, only you and other dentists seem to think that if Hg comes from amalgam it is safe. Why would I care what the dental literature says (not that I have searched for it), when the dental literature denied amalgam had a vapor pressure until 10 years ago. Even a monkey could comprehend that if excessive Hg can cause bone damage in an industrial setting , then unusal Hg leakage from amalgam could cause the same thing. Did you see the article I posted? You seem to know as much about OM as you do about amalgam and Hg >> True, those 17 micrograms can cause some big damage. >> >> Where is this substantiated in the dental literature? >> >> Joel I say remove one proton from every Hg molecule. -- W_B Take out the G'RBAGE wubbabubbazG@RBAGEyahoo.com >The idiociy of this argument is that no one on this >list can state an upper limit on elemental (or methyl) >Hg release from amalgam in practice. Your underlying premise is that >all amalgam gives off a well distributed amount of >Hg which is exactly 17 ug for each fillings, which is false. Jan told me it was exactly seventeen micrograms ...... > Even a monkey could comprehend >that if excessive Hg can cause bone damage in an >industrial setting , then unusal Hg lea Send bananas, FedEx. >>I wonder what their use would be in Jaw Om or similar >>jaw diseases. I assume these are viruses which are able [quoted text clipped - 5 lines] > >Joel Tired jaws after repeating a mantra ? -- W_B wubbabubbazG@RBAGEyahoo.com Take out the G'RBAGE >>>I wonder what their use would be in Jaw Om or similar >>>jaw diseases. I assume these are viruses which are able [quoted text clipped - 7 lines] >> >Tired jaws after repeating a mantra ? Jaw Om Shanti diseases? |
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