Here's a start ........... I do not know what other studies say .... I
'll look more later on today.

DISCLAIMER ~ these are lab experiments and may have nothing to do with
human beings.

And these are huge amounts of fluoride!

Joel

***

Basic Clin Pharmacol Toxicol. 2004 Oct;95(4):162-5. Related Articles,
Links  

 
The effect of tamoxifen and fluoride on bone mineral density,
biomechanical properties and blood lipids in ovariectomized rats.

Czerny B, Pawlik A, Juzyszyn Z, Mysliwiec Z.

Department of Pharmacokinetics and Therapeutic Drug Monitoring,
Pomeranian Medical University, Powstancow Wielkopolskich 72, PL-70-111
Szczecin, Poland.

The most important aspect of therapy with fluoride and tamoxifen
concerns its influence on bone tissue and lipid metabolism. The aim of
the study was to evaluate the effect of tamoxifen and natrium fluoride
(NaF) on bone metabolism, biochemical properties and blood lipids
levels in ovariectomized rats. The study was performed in Wistar rats
divided into 5 subgroups: ovariectomized controls, rats treated with
NaF 20 mg/kg/24 hr, rats treated with NaF 20 mg/kg/24 hr+tamoxifen 2
mg/kg/24 hr, rats treated with NaF 20 mg/kg/24 hr plus tamoxifen 4
mg/kg/24 hr, and sham-operated controls. In ovariectomized rats the
increase of total cholesterol, low-density lipoproteins cholesterol
(LDL-cholesterol) as well as the decrease of bone mineral content,
bone mineral density and biomechanical properties was observed. The
therapy with NaF increased the level of total cholesterol,
LDL-cholesterol, triglycerides, bone mineral density, bone mineral
content. In this group the decrease of bone strength and stiffness was
observed. The administration of tamoxifen reduced the changes in
plasma lipid levels, but did not improve the biomechanical properties
of bone tissue.

PMID: 15504151 [PubMed - in process