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Medical Forum / General / Cardiology / October 2007Cholesterol levels in small LDL particles predict the risk of coronary
Has anyone had their small LDL measured? Bill ........................................ : Eur Heart J. 2007 Oct 17; [Epub ahead of print] Cholesterol levels in small LDL particles predict the risk of coronary heart disease in the EPIC-Norfolk prospective population study. Arsenault BJ, Lemieux I, Després JP, Wareham NJ, Luben R, Kastelein JJ, Khaw KT, Boekholdt SM. Department of Cardiology, Québec Heart Institute, Hôpital Laval Research Centre, Pavilion Marguerite-D'Youville, 4th Floor, 2725, chemin Sainte-Foy, Québec, QC, Canada G1V 4G5. Aims To evaluate the association of low-density lipoprotein cholesterol (LDL-C) levels in small and large LDL particles with risk of incident coronary heart disease (CHD). Methods and results We performed a prospective case-control study nested in the EPIC-Norfolk cohort. Cases were apparently healthy men and women aged 45-79 years who developed fatal or non-fatal CHD (n = 1035), and who were matched by age, gender, and enrollment time to 1920 controls who remained free of CHD. Electrophoretic characteristics of LDL particles were measured using 2-16% polyacrylamide gradient gel electrophoresis. Concentrations of LDL-C(<255 A) were higher in cases than controls in men (1.34 +/- 0.88 vs. 1.15 +/- 0.80 mmol/L, P < 0.001) as well as in women (1.12 +/- 0.84 vs. 0.94 +/- 0.74 mmol/L, P < 0.001). The unadjusted odds ratio (OR) for future CHD in men of the top tertile of LDL-C(<255 A) was 1.68 (95% CI, 1.33-2.13; P < 0.001) whereas in women the unadjusted OR was 1.53 (95% CI, 1.13-2.07; P < 0.001). However, after further adjustments for confounding variables, the association between LDL-C(<255 A) and CHD was no longer significant in men and in women. Conclusion Cholesterol concentrations in different LDL subclasses show different relationships with CHD risk in this European cohort. PMID: 17947216 [PubMed - as supplied by publisher]  SignatureS Jersey USA Zone 5 Shade This article is posted under fair use rules in accordance with Title 17 U.S.C. Section 107, and is strictly for the educational and informative purposes. This material is distributed without profit. http://www.ocutech.com/ High tech Vison aid > Has anyone had their small LDL measured? > [quoted text clipped - 32 lines] > relationships with CHD risk in this European cohort. > PMID: 17947216 [PubMed - as supplied by publisher] Small LDL particles have a quite strong inverse correlation with triglycerides. Assessing LDL particle size does not give any information that has practical value in addition to triglyserides, IMHO. SignatureJuhana http://ruohikolla.blogspot.com/ "Juhana Harju" <nope@mail.fi> wrote in part: >Small LDL particles have a quite strong inverse correlation with >triglycerides. The correlation is not inverse. -- Jim Chinnis Warrenton, Virginia, USA > "Juhana Harju" <nope@mail.fi> wrote in part: > >> Small LDL particles have a quite strong inverse correlation with >> triglycerides. > > The correlation is not inverse. Are you just picky about the term or do you disagree? SignatureJuhana http://ruohikolla.blogspot.com/ > "Juhana Harju" <nope@mail.fi> wrote in part: > >> Small LDL particles have a quite strong inverse correlation with >> triglycerides. > > The correlation is not inverse. My mistake, sorry. SignatureJuhana http://ruohikolla.blogspot.com/ > > "Juhana Harju" <nope@mail.fi> wrote in part: > > [quoted text clipped - 4 lines] > > My mistake, sorry. Can I assume that triglycerides made lower will lower the small LDL. If so should not the impetus be placed on lower triglycerides. Statins would be an aberration and lower carbs the way to go. Yet the masses get the lipitor push and nothing about HFCS. Bill confused but money rules. SignatureS Jersey USA Zone 5 Shade This article is posted under fair use rules in accordance with Title 17 U.S.C. Section 107, and is strictly for the educational and informative purposes. This material is distributed without profit. http://www.ocutech.com/ High tech Vison aid > In article <5o9kegFluor...@mid.individual.net>, > [quoted text clipped - 23 lines] > > http://www.ocutech.com/ High tech Vison aid And not much about fish oil Am J Clin Nutr. 2007 Aug;86(2):324-33. Links Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men.Kelley DS, Siegel D, Vemuri M, Mackey BE. Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, University of California Davis, CA 95616-8683, USA. dkelley@whnrc.usda.gov BACKGROUND: The effects of docosahexaenoic acid (DHA) on the mean size and concentrations of VLDL, LDL, and HDL subclasses have not been previously studied. OBJECTIVE: We determined the effects of DHA supplementation on the concentrations of apoproteins; large, medium, and small VLDL, LDL, and HDL particles; and the mean diameters of these particles in fasting and postprandial plasma. DESIGN: Hypertriglyceridemic men aged 39-66 y (n = 34) participated in a double-blind, randomized, placebo-controlled parallel study. They received no supplements for the first 8 d and received either 7.5 g DHA oil/d (3 g DHA/d) or olive oil (placebo) for the last 90 d. Lipoprotein particle diameters and concentrations were measured by nuclear magnetic resonance spectroscopy. RESULTS: DHA supplementation for 45 d significantly (P < 0.05) decreased concentrations of fasting triacylglycerol (24%), large VLDL (92%), and intermediate-density lipoproteins (53%) and the mean diameter of VLDL particles (11.1 nm). It elevated concentrations of LDL cholesterol (12.6%), small VLDL particles (133%), and large LDL particles (120%) and the mean diameter of LDL particles (0.6 nm) in fasting plasma. Similar changes were observed for area under the curve for postprandial samples (0-6 h); however, the number of small dense LDL particles decreased significantly (21%), and the change in LDL cholesterol was not significant. Continued supplementation with DHA beyond 45 d caused no further changes; placebo treatment altered none of the responses tested. CONCLUSION: DHA supplementation may improve cardiovascular health by lowering concentrations of triacylglycerols and small, dense LDL particles. PMID: 17684201 [PubMed - indexed for MEDLINE . Thanks Vince > > > "Juhana Harju" <nope@mail.fi> wrote in part: > > > [quoted text clipped - 9 lines] > would be an aberration and lower carbs the way to go. Yet the masses > get the lipitor push and nothing about HFCS. It is not HFCS but the presence of harmful VAT that is the cause of increased LDL especially small dense LDL, low HDL and high triglycerides, which are all features of metabolic syndrome (MetS). Truth is simple. Be hungry... be healthy... be hungrier... be blessed: http://TheWellnessFoundation.com/PressRelease Prayerfully in the infinite power and might of the Holy Spirit, Andrew <>< -- Andrew B. Chung, MD/PhD Lawful steward of http://EmoryCardiology.com Bondservant to the KING of kings and LORD of lords. Our armchair internist opines: "It is not HFCS but the presence of harmful VAT that is the cause of increased LDL especially small dense LDL, low HDL and high triglycerides, which are all features of metabolic syndrome (MetS). Truth is simple." No. Evidence to the contrary happily reviewed if you can present it. The two pound diet,aka 2 pd etc., and attendant notions is trash science. And that is simply the truth. God bless. > The two pound diet,aka 2 pd etc., and attendant notions is trash > science. I could care less if it is scientific. It works. As if you had the first ounce of credibility to determine scientific examination. So, tell us, how is it being a Formula 1 driver? > > "Juhana Harju" <nope@mail.fi> wrote in part: > > [quoted text clipped - 4 lines] > > My mistake, sorry. Juhana you must be punished. Turn up the sauna another 10 degrees ! Envious Bill SignatureS Jersey USA Zone 5 Shade This article is posted under fair use rules in accordance with Title 17 U.S.C. Section 107, and is strictly for the educational and informative purposes. This material is distributed without profit. http://www.ocutech.com/ High tech Vison aid |
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