> > Just ordered.
>
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> --
> Juhana
>>> Just ordered.
>>
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> Is there any reason to think that nattokinase is effective against CVD
> or otherwise safe?
I am not an expert on this issue but there are some studies showing that
nattokinase is a powerful fibrinolytic enzyme preventing thrombosis. The
problem with warfarin like blood thinning medications is that while they
prevent arterial clotting they induce arterial calfication at the same time
because they prevent the full carboxylation of matrix Cla protein. That does
not happen if you use nattokinase. So my personal opinion is that
nattokinase is probably a much safer fibrinolytic agent than warfarin.
Consuming nattokinase as the fermented food /natto/ is probably even better
as you get an ample amount of specific vitamin K2 (meaquinone-7) and soy
flavonoids at the same time.
Clin Hemorheol Microcirc. 2006;35(1-2):139-42.
Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell
aggregation and whole blood viscosity.
Pais E, Alexy T, Holsworth RE, Meiselman HJ.
Department of Physiology and Biophysics, Keck School of Medicine, University
of Southern California, Los Angeles, CA 90033, USA.
The vegetable cheese-like food, natto, is extremely popular in Japan with a
history extending back over 1000 years. A fibrinolytic enzyme, termed
nattokinase, can be extracted from natto; the enzyme is a subtilisin-like
serine protease composed of 275 amino acid residues and has a molecular
weight of 27.7 kDa. In vitro and in vivo studies have consistently
demonstrated the potent pro-fibrinolytic effect of the enzyme. However, no
studies to date have evaluated the effects of nattokinase on various
hemorheological parameters and thus we have begun to assess the effects of
the enzyme on RBC aggregation and blood viscosity. Blood samples were
incubated with nattokinase (final activities of 0, 15.6, 31.3, 62.5 and 125
units/ml) for 30 minutes at 37 degrees C. RBC aggregation was measured using
a Myrenne MA-1 aggregometer and blood viscosity assessed over 1-1000 s(-1)
with a computer controlled scanning capillary rheometer (Rheolog). Our in
vitro results showed a significant, dose-dependent decrease of RBC
aggregation and low-shear viscosity, with these beneficial effects evident
at concentrations similar to those achieved in previous in vivo animal
trials. Our preliminary data thus indicate positive in vitro hemorheological
effects of nattokinase, and suggest its potential value as a therapeutic
agent and the need for additional studies and clinical trials. PMID:
16899918
http://tinyurl.com/24qx6c

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Juhana
Juhana Harju - 18 Jun 2007 07:10 GMT
>>>> Just ordered.
>>>
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> calfication at the same time because they prevent the full
> carboxylation of matrix Cla protein.
Should be matrix Gla protein.
> That does not happen if you use
> nattokinase. So my personal opinion is that nattokinase is probably a
[quoted text clipped - 33 lines]
>
> http://tinyurl.com/24qx6c

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Juhana
MarilynMann - 18 Jun 2007 09:52 GMT
> >>> Just ordered.
>
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>
> - Show quoted text -
I think the key words here are "the need for additional studies and
clinical trials." See http://www.fvleiden.org/ask/70.html. Not
saying there aren't problems with warfarin.
Marilyn
Juhana Harju - 18 Jun 2007 10:19 GMT
> I think the key words here are "the need for additional studies and
> clinical trials."
Well, yes, of course.
> See http://www.fvleiden.org/ask/70.html. Not
> saying there aren't problems with warfarin.
While I think that there is much accurate information on that site I think
that it exaggerates the risks of nattokinase and is negligent about the
risks of warfarin. But this is just my personal opinion, I am not a
physician. (But I am not involved in natto business either. ;-) )

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