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Medical Forum / General / Cardiology / February 2007problem with generic nifedipine
BP was nicely under control, 130-75, using Adalat nifedipine 90mg. Switched to generic, Mylan labs 90mg and BP soared to 145-95, tested for a week. Placed a pill of each in water. After two hours the Adalat brand had softened and began to breakdown. The Myan pill lost it's cosmetic coating but was hard and and same size. Is anyone aware of this problem? Can the generic pill be cut in half safely to speed absorbtion? Tom > BP was nicely under control, 130-75, using Adalat nifedipine 90mg. > Switched to generic, Mylan labs 90mg and BP soared to 145-95, tested [quoted text clipped - 3 lines] > this problem? Can the generic pill be cut in half safely to speed > absorbtion? Call your doctor. Your blood pressure could be high for other reasons. In addition, your doctor may know if this is a common occurance. Alternatively, you take an Adalat pill, if you have any left and call your doc if the blood pressure doesn't go down. If your blood pressure goes back down, I would take all the Mylan pills to the pharmacist, tell her what happened and ask either they be replaced with Adalat or you get your money back. And I would go fda.gov, click on Report a Problem with a product, and file an Adverse Event report. Also, ask you doc about this at the next visit if your BP stays down. The stomach pH is low, about 1. This is very acidic. The Mylan labs pills might dissolve in your stomach faster. Jeff > Tom > > BP was nicely under control, 130-75, using Adalat nifedipine 90mg. > > Switched to generic, Mylan labs 90mg and BP soared to 145-95, tested [quoted text clipped - 22 lines] > > > Tom Good advice Jeff ! I was thinking about possible counterfeit drugs. Bill  SignatureS Jersey USA Zone 5 Shade http://www.ocutech.com/ High tech Vison aid This article is posted under fair use rules in accordance with Title 17 U.S.C. Section 107, and is strictly for the educational and informative purposes. This material is distributed without profit. >> > BP was nicely under control, 130-75, using Adalat nifedipine 90mg. >> > Switched to generic, Mylan labs 90mg and BP soared to 145-95, tested [quoted text clipped - 29 lines] > > Good advice Jeff ! I was thinking about possible counterfeit drugs. Good thinking. The OP should look on the web site for mylan and see if the pills have the right markings: http://www.mylanpharms.com/product/productDetails.aspx?pid=105&query=1 If the pills don't have the proper markings, they're the wrong pills. Could be that the pharmacist pulled the wrong bottle of pills, the pills were packed wrong at the factory, or the pills are conterfeit.If they have the right markings, particularly if the markings look a little different, they could still be counterfeit. I am not sure why, the Adalat CC has a core or center that is rapid release and a slow release coating. I would have thought the core would be slow release, but the coating would be rapid release (so that the blood levels get to their values fast, and the slow release keeps them there). Anyway, if this is the case, breaking a pill in half may cause a rapid increase in blood levels and dangeriously low blood pressure. Jeff Jeff > Bill > >> <theodor...@lycos.com> wrote in message > >>news:1172665416.595457.186810@m58g2000cwm.googlegroups.com... [quoted text clipped - 66 lines] > > - Show quoted text - I checked the pill markings and o.k., the VA was the source, they switched from Adalat to the generic. Since the VA no longer uses Adalat I am working with Doc on another approach. (switched back to Adalat this am, one hour after taking bp 134-82) Thanks everyone for your suggestions. Tom <...> > I checked the pill markings and o.k., the VA was the source, they > switched from Adalat to the generic. Since the VA > no longer uses Adalat I am working with Doc on another approach. > (switched back to Adalat this am, one hour after taking > bp 134-82) Thanks everyone for your suggestions. I would call your doc and the VA pharmacist and tell them what happened. If this happened to you, how many vets did this happen to who don't check their blood pressure regularly? Also, go to fda.gov and report this. Also, call your local Walmart and see how much the drug is. It may be cheep enough (like under $10) that you won't care about the money. Jeff > Tom > <theodor...@lycos.com> wrote in message > [quoted text clipped - 21 lines] > > - Show quoted text - I emailed Mylan Labs early this am and a young lady called and I reviewed the tests. She said the product was made by Pfizer and the chemical structure was differnat then the Adalat product saying theirs was same as Procardia. I've alerted the various veterans sites re: checking and rechecking their BP if they too had their meds. changed. Tom |
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