"What are the two major autoregulation mechanism which controls the
local blood flow:  Metabolic and myogenic control.
Two phases can the local blood flow control : 1)Acute - rapid change
constriction/dilatation of arteriols, metarteriol et spincters
2)Long-term control provides a better control by increasing/decreasing
the physical size and number of blood vessels supplying the tissues.
http://www.studystack.com/studytable-24764 "

Hello,

The above quote indicate about Neovascularation & Vaso-obliteration and
decreased/increased local blood flow regulation and two major
autoregulation mechanism which controls the local blood flow;
Metabolic and myogenic control.

Under metabolic control, one is O2 level. However, I bit feel that
there may be such possibilty due to abnormal level of other nutriens in
blood enabling body system to control their supply to tissues
(homeostatis), avoid their toxicities and enable their excretion.
Espeacially those which can either be excreted if in excess via kidney,
digestive tract or via skin/nails and hair are to be thought.

As such, can metabolic control of local blood flow regulations be also
other nutrients level dependant?

If yes, how abnormal persitant high level of glucose(insulin also
though not a nutrient) be related to it?  

Best wishes.