Higher HDL - Cholesteryl ester transfer protein (CTEP), torcetrapib

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Pramesh Rutajit - 17 Sep 2006 16:21 GMT

The drug torcetrapib, a cholesteryl ester transfer protein related drug
appears to prevent the breakdown of HDL increasing it's level in the blood
resulting in reversal of cardiovascular disease.

Are there any natural sources for CETPs or any sources for torcetrapib?

HDL-raising drugs again in the news
http://www.theheart.org/article/627727.do

Pfizer Begins Manufacturing Torcetrapib
http://cholesterol.about.com/od/currentresearch/a/torcetrapib.htm

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Pramesh Rutajit - p2976221tongue@newsguy.com - remove tongue to reply.

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balatiru@gmail.com - 17 Sep 2006 17:15 GMT

I am doing fine. I am curious to know if Lpa a subcomponent of LDL-C
and can Lpa be anyway higher in count than you total LDC-C?

I reallly appereciate your quick response on this as I am concerned.

Thanks

> The drug torcetrapib, a cholesteryl ester transfer protein related drug
> appears to prevent the breakdown of HDL increasing it's level in the blood
[quoted text clipped - 11 lines]
>
> Pramesh Rutajit - p2976221tongue@newsguy.com - remove tongue to reply.

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Ignatz's Bricks - 18 Sep 2006 04:23 GMT

> Pramesh Rutajit wrotes:

>>Pfizer Begins Manufacturing Torcetrapib
>>http://cholesterol.about.com/od/currentresearch/a/torcetrapib.htm

Just noticed that the article is signed 14 months ago:
~Jennifer Moll 06/26/2005
Updated: June 27, 2005

I googled "torcetrapib" and didn't find much newer information, same on
www.fda.gov.

IB

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Pramesh Rutajit - 18 Sep 2006 15:32 GMT

>> Pramesh Rutajit wrotes:
>
[quoted text clipped - 9 lines]
>
> IB

I've looked on the net and MedLine quite a bit. What I was most interested
in was any nutritional supplements that might have CTEP inhibition. I was
hoping that someone might be able to point me in some direction.

Yes, I knew the article wasn't recent and while there are more recent ones,
they have no new information except that a new plant is being built to
manufacture torcetrapib.

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Kofi - 25 Sep 2006 10:38 GMT

> I've looked on the net and MedLine quite a bit. What I was most interested
> in was any nutritional supplements that might have CTEP inhibition. I was
> hoping that someone might be able to point me in some direction.

Acetyl-l-carnitine inhibits cholesteryl ester [PMID 14703509]. That's
all I got. It's conceivable taurine might also have an effect. Both
NAC and taurine deficiency can worse cholesterol profiles. You might
also cross reference "green tea" / EGCG / niacin / curcumin with
cholesteryl ester to see what turns up.

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