Genetic and lifestyle influence on CVD risk factors

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demeyer_tim@yahoo.com - 27 Jul 2006 14:25 GMT

Hello,

I'm looking for a resource (review or other) which estimates how much
of the variation in measurements of CVD risk factors is genetically
determined, and which percentage could be accounted for by lifestyle.

Risk factors I'm especially interested in are the inflammation markers
such as oxLDL, IL6, C-reactive protein(, fibrinogen),...

All info is welcome!

Thanks a lot,
Tim

Reply to this Message

Andrew B. Chung, MD/PhD - 27 Jul 2006 14:31 GMT

demeyer_...@yahoo.com wrote:

> Hello,
>
[quoted text clipped - 4 lines]
> Risk factors I'm especially interested in are the inflammation markers
> such as oxLDL, IL6, C-reactive protein(, fibrinogen),...

The latter as CVD risk factors are entirely the result of visceral
adipose tissue.

> All info is welcome!
>
> Thanks a lot

You are welcome, Tim.

All thanks and praise belong to the LORD, Whom I love with all my
being.

Prayerfully in Christ's amazing love,

Andrew B. Chung
Cardiologist, Atlanta, Georgia, USA
http://HeartMDPhD.com/HolySpirit

Message for the wolves in sheepskin:

http://groups.google.com/group/sci.med.cardiology/msg/4f43855be1cfa795?

or
http://tinyurl.com/s3bud (awaiting the frantic foot-stomping antics of
the anti-christ)

Reply to this Message

Juhana Harju - 28 Jul 2006 05:53 GMT

: I'm looking for a resource (review or other) which estimates how much
: of the variation in measurements of CVD risk factors is genetically
: determined, and which percentage could be accounted for by lifestyle.

According to the World Health Organization WHO and Harvard researchers 80
percent of premature heart disease can be prevent by life style changes such
as nutrition, weight control, exercise and not smoking. That might tell
something about the role of genetics in relation to life style factors.

: Risk factors I'm especially interested in are the inflammation markers
: such as oxLDL, IL6, C-reactive protein(, fibrinogen),...

Here is a slide about the relative importance of different risk factors.
Below is also a reference.

http://www.lipidsonline.org/slides/slide01.cfm?q=whs&dpg=3

Signature

Juhana

Reply to this Message

Juhana Harju - 28 Jul 2006 14:00 GMT

:: I'm looking for a resource (review or other) which estimates how much
:: of the variation in measurements of CVD risk factors is genetically
[quoted text clipped - 5 lines]
: not smoking. That might tell something about the role of genetics in
: relation to life style factors.

References:

WHO, EB109/14, 109th Session 24 November 2001, Provisional agenda item 3.10.

http://www.who.int/gb/ebwha/pdf_files/EB109/eeb10914.pdf

Willett WC. The Mediterranean diet: science and practice. Public Health
Nutr. 2006 Feb;9(1A):105-10.

http://tinyurl.com/lozlp

:: Risk factors I'm especially interested in are the inflammation
:: markers such as oxLDL, IL6, C-reactive protein(, fibrinogen),...
[quoted text clipped - 3 lines]
:
: http://www.lipidsonline.org/slides/slide01.cfm?q=whs&dpg=3

Signature

Juhana

Reply to this Message

Andrew B. Chung, MD/PhD - 28 Jul 2006 14:41 GMT

> : I'm looking for a resource (review or other) which estimates how much
> : of the variation in measurements of CVD risk factors is genetically
[quoted text clipped - 4 lines]
> as nutrition, weight control, exercise and not smoking. That might tell
> something about the role of genetics in relation to life style factors.

Of these the one "life style" factor that is growing the most rapidly
into a bigger problem in this world is the excessive visceral
adiposity, which can only be addressed by eating less and becoming
hungrier.

Prayerfully in Christ's amazing love,

Andrew B. Chung
Cardiologist, Atlanta, Georgia, USA
http://HeartMDPhD.com/HolySpirit

Message for the wolves in sheepskin who serve the anti-christ:
http://groups.google.com/group/sci.med.cardiology/msg/4f43855be1cfa795?

or
http://tinyurl.com/j9bpd (awaiting the frantic foot-stomping antics of
the anti-christ)

Message for my brethren who know the way, the truth, and the life:
http://groups.google.com/group/sci.med.cardiology/msg/7bff7f0b57577900?

or
http://tinyurl.com/fdn5l (expecting the anti-christ to have a coronary
here)

Message for the anti-christ, who serves satan:
LORD GOD Almighty is the Source of all intelligence, which clearly HE
has dialed down in your case.

Reply to this Message

Matti Narkia - 28 Jul 2006 14:22 GMT

>Hello,
>
>I'm looking for a resource (review or other) which estimates how much
>of the variation in measurements of CVD risk factors is genetically
>determined, and which percentage could be accounted for by lifestyle.

There is a potentially important subarea in lifestyle, which has been
largely ignored: the effect of fetal and childhood nutrition to the
risk of chronic diseases, mainly CVD, in adulthood. David Barker has
researched this a lot. Before he was mostly ignored, but recent data
has given some credibility to his research. He has published a lot,
here a smaple of references related to his research:

Barker DJ.
Adult consequences of fetal growth restriction.
Clin Obstet Gynecol. 2006 Jun;49(2):270-83.
PMID: 16721106 [PubMed - in process]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=16721106>

de Rooij SR, Painter RC, Roseboom TJ, Phillips DI, Osmond C, Barker
DJ, Tanck MW, Michels RP, Bossuyt PM, Bleker OP.
Glucose tolerance at age 58 and the decline of glucose tolerance in
comparison with age 50 in people prenatally exposed to the Dutch
famine.
Diabetologia. 2006 Apr;49(4):637-43. Epub 2006 Feb 10.
PMID: 16470406 [PubMed - in process]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=16470406>

Barker DJ, Osmond C, Forsen TJ, Kajantie E, Eriksson JG.
Trajectories of growth among children who have coronary events as
adults.
N Engl J Med. 2005 Oct 27;353(17):1802-9.
PMID: 16251536 [PubMed - indexed for MEDLINE]
<http://content.nejm.org/cgi/content/full/353/17/1802>

Barker DJ, Bagby SP.
Developmental antecedents of cardiovascular disease: a historical
perspective.
J Am Soc Nephrol. 2005 Sep;16(9):2537-44. Epub 2005 Jul 27. Review.
PMID: 16049070 [PubMed - indexed for MEDLINE]
<http://jasn.asnjournals.org/cgi/content/abstract/16/9/2537>

Sachdev HS, Fall CH, Osmond C, Lakshmy R, Dey Biswas SK, Leary SD,
Reddy KS, Barker DJ, Bhargava SK.
Anthropometric indicators of body composition in young adults:
relation to size at birth and serial measurements of body mass index
in childhood in the New Delhi birth cohort.
Am J Clin Nutr. 2005 Aug;82(2):456-66.
PMID: 16087993 [PubMed - indexed for MEDLINE]
<http://www.ajcn.org/cgi/content/abstract/82/2/456>

Syddall HE, Sayer AA, Simmonds SJ, Osmond C, Cox V, Dennison EM,
Barker DJ, Cooper C.
Birth weight, infant weight gain, and cause-specific mortality: the
Hertfordshire Cohort Study.
Am J Epidemiol. 2005 Jun 1;161(11):1074-80.
PMID: 15901628 [PubMed - indexed for MEDLINE]
<http://aje.oxfordjournals.org/cgi/content/abstract/161/11/1074>

Kajantie E, Osmond C, Barker DJ, Forsen T, Phillips DI, Eriksson JG.
Size at birth as a predictor of mortality in adulthood: a follow-up of
350 000 person-years.
Int J Epidemiol. 2005 Jun;34(3):655-63. Epub 2005 Mar 11.
PMID: 15764690 [PubMed - indexed for MEDLINE]
<http://ije.oxfordjournals.org/cgi/content/abstract/34/3/655>

Painter RC, Roseboom TJ, Bossuyt PM, Osmond C, Barker DJ, Bleker OP.
Adult mortality at age 57 after prenatal exposure to the Dutch famine.
Eur J Epidemiol. 2005;20(8):673-6.
PMID: 16151880 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=16151880>

Barker DJ.
The developmental origins of insulin resistance.
Horm Res. 2005;64 Suppl 3:2-7. Epub 2006 Jan 20. Review.
PMID: 16439838 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=16439838>

Barker DJ, Hanson MA.
Altered regional blood flow in the fetus: the origins of
cardiovascular disease?
Acta Paediatr. 2004 Dec;93(12):1559-60.
PMID: 15841760 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=15841760>

Barker DJ.
The developmental origins of chronic adult disease.
Acta Paediatr Suppl. 2004 Dec;93(446):26-33. Review.
PMID: 15702667 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=15702667>

Barker DJ.
The developmental origins of adult disease.
J Am Coll Nutr. 2004 Dec;23(6 Suppl):588S-595S. Review.
PMID: 15640511 [PubMed - indexed for MEDLINE]
<http://www.jacn.org/cgi/content/abstract/23/suppl_6/588S>

Kajantie E, Rautanen A, Kere J, Andersson S, Yliharsila H, Osmond C,
Barker DJ, Forsen T, Eriksson J.
The effects of the ACE gene insertion/deletion polymorphism on glucose
tolerance and insulin secretion in elderly people are modified by
birth weight.
J Clin Endocrinol Metab. 2004 Nov;89(11):5738-41.
PMID: 15531537 [PubMed - indexed for MEDLINE]
<http://jcem.endojournals.org/cgi/content/full/89/11/5738>

Day IN, Chen XH, Gaunt TR, King TH, Voropanov A, Ye S, Rodriguez S,
Syddall HE, Sayer AA, Dennison EM, Tabassum F, Barker DJ, Cooper C,
Phillips DI.
Late life metabolic syndrome, early growth, and common polymorphism in
the growth hormone and placental lactogen gene cluster.
J Clin Endocrinol Metab. 2004 Nov;89(11):5569-76.
PMID: 15531513 [PubMed - indexed for MEDLINE]
<http://jcem.endojournals.org/cgi/content/full/89/11/5569>

Barker DJ.
The developmental origins of well-being.
Philos Trans R Soc Lond B Biol Sci. 2004 Sep 29;359(1449):1359-66.
Review.
PMID: 15347527 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=15347527>

Sayer AA, Syddall HE, Dennison EM, Gilbody HJ, Duggleby SL, Cooper C,
Barker DJ, Phillips DI.
Birth weight, weight at 1 y of age, and body composition in older men:
findings from the Hertfordshire Cohort Study.
Am J Clin Nutr. 2004 Jul;80(1):199-203.
PMID: 15213049 [PubMed - indexed for MEDLINE]
<http://www.ajcn.org/cgi/content/full/80/1/199>

Eriksson JG, Yliharsila H, Forsen T, Osmond C, Barker DJ.
Exercise protects against glucose intolerance in individuals with a
small body size at birth.
Prev Med. 2004 Jul;39(1):164-7.
PMID: 15207998 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=15207998>

Bhargava SK, Sachdev HS, Fall CH, Osmond C, Lakshmy R, Barker DJ,
Biswas SK, Ramji S, Prabhakaran D, Reddy KS.
Relation of serial changes in childhood body-mass index to impaired
glucose tolerance in young adulthood.
N Engl J Med. 2004 Feb 26;350(9):865-75.
PMID: 14985484 [PubMed - indexed for MEDLINE]
<http://content.nejm.org/cgi/content/full/350/9/865>

Kajantie E, Eriksson J, Osmond C, Wood PJ, Forsen T, Barker DJ,
Phillips DI.
Size at birth, the metabolic syndrome and 24-h salivary cortisol
profile.
Clin Endocrinol (Oxf). 2004 Feb;60(2):201-7.
PMID: 14725681 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=14725681>

Forsen TJ, Eriksson JG, Osmond C, Barker DJ.
The infant growth of boys who later develop coronary heart disease.
Ann Med. 2004;36(5):389-92.
PMID: 15478313 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=15478313>

Forsen T, Osmond C, Eriksson JG, Barker DJ.
Growth of girls who later develop coronary heart disease.
Heart. 2004 Jan;90(1):20-4.
PMID: 14676233 [PubMed - indexed for MEDLINE]
<http://heart.bmjjournals.com/cgi/content/full/90/1/20>

Eriksson JG, Forsen TJ, Osmond C, Barker DJ.
Pathways of infant and childhood growth that lead to type 2 diabetes.
Diabetes Care. 2003 Nov;26(11):3006-10.
PMID: 14578231 [PubMed - indexed for MEDLINE]
<http://care.diabetesjournals.org/cgi/content/full/26/11/3006>

Roseboom TJ, Van Der Meulen JH, Ravelli AC, Osmond C, Barker DJ,
Bleker OP.
Perceived health of adults after prenatal exposure to the Dutch
famine.
Paediatr Perinat Epidemiol. 2003 Oct;17(4):391-7.
PMID: 14629322 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=14629322>

Barker DJ, Lackland DT.
Prenatal influences on stroke mortality in England and Wales.
Stroke. 2003 Jul;34(7):1598-602. Epub 2003 Jun 19.
PMID: 12817108 [PubMed - indexed for MEDLINE]
<http://stroke.ahajournals.org/cgi/content/full/34/7/1598>

Yliharsila H, Eriksson JG, Forsen T, Kajantie E, Osmond C, Barker DJ.
Self-perpetuating effects of birth size on blood pressure levels in
elderly people.
Hypertension. 2003 Mar;41(3):446-50. Epub 2003 Feb 17.
PMID: 12623941 [PubMed - indexed for MEDLINE]
<http://hyper.ahajournals.org/cgi/content/full/41/3/446>

Kajantie E, Fall CH, Seppala M, Koistinen R, Dunkel L, Yliharsila H,
Osmond C, Andersson S, Barker DJ, Forsen T, Holt RI, Phillips DI,
Eriksson J.
Serum insulin-like growth factor (IGF)-I and IGF-binding protein-1 in
elderly people: relationships with cardiovascular risk factors, body
composition, size at birth, and childhood growth.
J Clin Endocrinol Metab. 2003 Mar;88(3):1059-65.
PMID: 12629086 [PubMed - indexed for MEDLINE]
<http://jcem.endojournals.org/cgi/content/full/88/3/1059>

Eriksson JG, Forsen T, Tuomilehto J, Osmond C, Barker DJ.
Early adiposity rebound in childhood and risk of Type 2 diabetes in
adult life.
Diabetologia. 2003 Feb;46(2):190-4. Epub 2003 Jan 8.
PMID: 12627317 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=12627317>

Barker DJ.
Coronary heart disease: a disorder of growth.
Horm Res. 2003;59 Suppl 1:35-41. Review.
PMID: 12566719 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=12566719>

Barker DJ, Eriksson JG, Forsen T, Osmond C. Fetal origins of adult
disease: strength of effects and biological basis.
Int J Epidemiol. 2002 Dec;31(6):1235-9.
PMID: 12540728 [PubMed - indexed for MEDLINE]
<http://ije.oxfordjournals.org/cgi/content/full/31/6/1235>

Kajantie E, Phillips DI, Andersson S, Barker DJ, Dunkel L, Forsen T,
Osmond C, Tuominen J, Wood PJ, Eriksson J.
Size at birth, gestational age and cortisol secretion in adult life:
foetal programming of both hyper- and hypocortisolism?
Clin Endocrinol (Oxf). 2002 Nov;57(5):635-41.
PMID: 12390338 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=12390338>

Robinson SM, Barker DJ.
Coronary heart disease: a disorder of growth.
Proc Nutr Soc. 2002 Nov;61(4):537-42. Review.
PMID: 12691183 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=12691183>
<http://www.ingentaconnect.com/content/cabi/pns/2002/00000061/00000004/art00016?t
oken=005516bd9da88e3f6a4b6e4e395e4e6b63314f39412f415d4855255f2c492b6c7b5a515ec9c
e579dd3fe7>
(Koko artikkelikin on ilmainen)

Barker DJ, Forsen T, Eriksson JG, Osmond C.
Growth and living conditions in childhood and hypertension in adult
life: a longitudinal study.
J Hypertens. 2002 Oct;20(10):1951-6.
PMID: 12359972 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=12359972>

Eriksson JG, Forsen T, Tuomilehto J, Osmond C, Barker DJ.
Early growth and coronary heart disease in later life: longitudinal
study.
BMJ. 2001 Apr 21;322(7292):949-53.
PMID: 11312225 [PubMed - indexed for MEDLINE]
<http://bmj.bmjjournals.com/cgi/content/full/322/7292/949>

Law CM, Egger P, Dada O, Delgado H, Kylberg E, Lavin P, Tang GH, von
Hertzen H, Shiell AW, Barker DJ.
Body size at birth and blood pressure among children in developing
countries.
Int J Epidemiol. 2001 Feb;30(1):52-7.
PMID: 11171856 [PubMed - indexed for MEDLINE]
<http://ije.oxfordjournals.org/cgi/content/full/30/1/52>

Roseboom TJ, van der Meulen JH, van Montfrans GA, Ravelli AC, Osmond
C, Barker DJ, Bleker OP.
Maternal nutrition during gestation and blood pressure in later life.
J Hypertens. 2001 Jan;19(1):29-34.
PMID: 11204301 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=11204301>

Godfrey KM, Barker DJ.
Fetal nutrition and adult disease.
Am J Clin Nutr. 2000 May;71(5 Suppl):1344S-52S. Review.
PMID: 10799412 [PubMed - indexed for MEDLINE]
<http://www.ajcn.org/cgi/content/full/71/5/1344S>

Ravelli AC, van Der Meulen JH, Osmond C, Barker DJ, Bleker OP.
Obesity at the age of 50 y in men and women exposed to famine
prenatally.
Am J Clin Nutr. 1999 Nov;70(5):811-6.
PMID: 10539740 [PubMed - indexed for MEDLINE]
<http://www.ajcn.org/cgi/content/full/70/5/811>

Barker DJ
Why heart disease mortality is low in France. Commentary: intrauterine
nutrition may be important.
BMJ. 1999 May 29;318(7196):1477-8.
PMID: 10419294 [PubMed - indexed for MEDLINE]
<http://bmj.bmjjournals.com/cgi/content/full/318/7196/1471#resp2>

Eriksson JG, Forsen T, Tuomilehto J, Winter PD, Osmond C, Barker DJ.
Catch-up growth in childhood and death from coronary heart disease:
longitudinal study.
BMJ. 1999 Feb 13;318(7181):427-31.
PMID: 9974455 [PubMed - indexed for MEDLINE]
<http://bmj.bmjjournals.com/cgi/content/full/318/7181/427>

Forsen T, Eriksson JG, Tuomilehto J, Teramo K, Osmond C, Barker DJ.
Mother's weight in pregnancy and coronary heart disease in a cohort of
Finnish men: follow up study.
BMJ. 1997 Oct 4;315(7112):837-40.
PMID: 9353502 [PubMed - indexed for MEDLINE]
<http://bmj.bmjjournals.com/cgi/content/full/315/7112/837>

Barker DJ.
Maternal nutrition, fetal nutrition, and disease in later life.
Nutrition. 1997 Sep;13(9):807-13. Review.
PMID: 9290095 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=9290095>

Stein CE, Fall CH, Kumaran K, Osmond C, Cox V, Barker DJ.
Fetal growth and coronary heart disease in south India.
Lancet. 1996 Nov 9;348(9037):1269-73.
PMID: 8909379 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=8909379>

Barker DJ, Osmond C, Rodin I, Fall CH, Winter PD.
Low weight gain in infancy and suicide in adult life.
BMJ. 1995 Nov 4;311(7014):1203.
PMID: 7488897 [PubMed - indexed for MEDLINE]
<http://bmj.bmjjournals.com/cgi/content/full/311/7014/1203

Barker DJ.
Fetal origins of coronary heart disease.
BMJ. 1995 Jul 15;311(6998):171-4. Review.
PMID: 7613432 [PubMed - indexed for MEDLINE]
<http://bmj.bmjjournals.com/cgi/content/full/311/6998/171>

Barker DJ, Martyn CN, Osmond C, Hales CN, Fall CH.
Growth in utero and serum cholesterol concentrations in adult life.
BMJ. 1993 Dec 11;307(6918):1524-7.
PMID: 8274921 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=8274921>

Barker DJ, Gluckman PD, Godfrey KM, Harding JE, Owens JA, Robinson JS.
Fetal nutrition and cardiovascular disease in adult life.
Lancet. 1993 Apr 10;341(8850):938-41. Review.
PMID: 8096277 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=8096277>

Barker DJ, Meade TW, Fall CH, Lee A, Osmond C, Phipps K, Stirling Y.
Relation of fetal and infant growth to plasma fibrinogen and factor
VII concentrations in adult life.
BMJ. 1992 Jan 18;304(6820):148-52.
PMID: 1737158 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=1737158>

Barker DJ, Bull AR, Osmond C, Simmonds SJ.
Fetal and placental size and risk of hypertension in adult life.
BMJ. 1990 Aug 4;301(6746):259-62.
PMID: 2390618 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=2390618>

Barker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ.
Weight in infancy and death from ischaemic heart disease.
Lancet. 1989 Sep 9;2(8663):577-80.
PMID: 2570282 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=2570282>

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Matti Narkia

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Matti Narkia - 28 Jul 2006 14:27 GMT

>>Hello,
>>
[quoted text clipped - 7 lines]
>researched this a lot. Before he was mostly ignored, but recent data
>has given some credibility to his research.

Related web sites:

<http://www.barkertheory.com>

<http://www.zoominfo.com/Search/PersonDetail.aspx?PersonID=14935405>

Signature

Matti Narkia

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Matti Narkia - 29 Jul 2006 12:43 GMT

>>Hello,
>>
[quoted text clipped - 14 lines]
>PMID: 16721106 [PubMed - in process]
><http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=16721106>

Here some related references by UN Das:

Das UN.
Hypertension as a low-grade systemic inflammatory condition that has
its origins in the perinatal period.
J Assoc Physicians India. 2006 Feb;54:133-42. Review.
PMID: 16715619 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=16715619>

"... Low-grade systemic inflammation seen in hypertension seems to
have its origins in the perinatal period and availability of
adequate amounts of LCPUFAs during the critical periods of brain
growth prevents the development of hypertension. This indicates
that preventive strategies aimed at decreasing the incidence of
hypertension and its associated conditions such as
atherosclerosis, type 2 diabetes, coronary heart disease (CHD),
and cardiac failure in adulthood need to be instituted during the
perinatal period if they are to be effective."

Das UN.
Perinatal supplementation of long-chain polyunsaturated fatty acids,
immune response and adult diseases.
Med Sci Monit. 2004 May;10(5):HY19-25. Epub 2004 Apr 28.
PMID: 15114276 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=R
etrieve&dopt=abstractplus&list_uids=15114276>
<http://www.medscimonit.com/medscimonit/modules.php?name=GetPDF&pg=2&idm=4727>
(full text PDF)

Das UN.
Long-chain polyunsaturated fatty acids interact with nitric oxide,
superoxide anion, and transforming growth factor-beta to prevent human
essential hypertension.
Eur J Clin Nutr. 2004 Feb;58(2):195-203. Review.
PMID: 14749737 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=R
etrieve&dopt=abstractplus&list_uids=14749737>
<http://www.nature.com/ejcn/journal/v58/n2/full/1601766a.html>

"... LCPUFAs suppress angiotensin-converting enzyme (ACE)
activity, reduce angiotensin II formation, enhance eNO generation,
and suppress TGF-beta expression. Perinatal supplementation of
LCPUFAs decreases insulin resistance and prevents the development
of hypertension in adult life, whereas deficiency of LCPUFAs in
the perinatal period results in raised blood pressure later in
life. Patients with essential hypertension have low concentrations
of various LCPUFAs in their plasma phospholipid fraction. Based on
this, it is proposed that LCPUFAs serve as endogenous regulators
of ACE activity, O(2)(-*), eNO generation, and TGF-beta
expression. Further, LCPUFAs have actions similar to statins,
inhibit (especially omega-3 fatty acids) cyclooxygenase activity
and suppress the synthesis of proinflammatory cytokines, and
activate the parasympathetic nervous system, all actions that
reduce the risk of major vascular events. Hence, it is proposed
that availability of adequate amounts of LCPUFAs during the
critical periods of growth prevents the development of
hypertension in adulthood."

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