Dairy and calcium consumption and inverse association with colong cancer

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Susan - 27 Mar 2006 19:49 GMT

http://www.medscape.com/viewarticle/528420?sssdmh=dm1.186557&src=nldne

" * Milk was the dairy product most associated with a reduced risk
for colorectal cancer. Subjects who consumed more than 1.5 glasses of
milk per day had a 33% lower risk for colorectal cancer vs participants
who drank less than 2 glasses per week. The benefit of milk appeared
regardless of milk fat content. The authors note that cheese and yogurt
may not have improved colorectal cancer risk on their own because these
foods accounted for a much smaller fraction of dietary calcium
consumption compared with milk.

Pearls for Practice

* A pooled analysis of prospective trials demonstrated that
consumption of both dairy products and calcium consumption had an
inverse relationship on the risk for colorectal cancer. The benefits of
milk consumption were limited to cancer of the distal colon and rectum.
* The current study found that dietary consumption of both calcium
and dairy products reduces the overall incidence of colorectal cancer in
men, with no significantly different effects on specific colonic sites
of cancer. Milk was the most effective dairy product in reducing the
risk for colorectal cancer, and there was little added preventive
benefit above a daily intake of 1400 mg of dietary calcium per day."

Note, fat content did not alter risk.

Susan

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Jim Chinnis - 27 Mar 2006 21:04 GMT

Susan <nevermind@nomail.com> wrote in part:

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>Susan

Unfortunately, some of us have prostates:

Br J Nutr. 2006 Mar;95(3):539-45.

Dairy products, calcium and phosphorus intake, and the risk of prostate
cancer: results of the French prospective SU.VI.MAX (Supplementation en
Vitamines et Mineraux Antioxydants) study.

Kesse E, Bertrais S, Astorg P, Jaouen A, Arnault N, Galan P, Hercberg S.

Inserm U557 (UMR Inserm/Inra/Cnam), ISTNA-CNAM, 5 rue Vertbois, F-75003
Paris, France.

Although dairy products have been found to be associated with an elevated
risk of prostate cancer, studies investigating the potential effect of Ca
are limited, and findings are inconsistent. The objective of the present
study was to test the relationship between the risk of prostate cancer and
consumption of dairy products and Ca. The analysis included 2776 men from
the French SU.VI.MAX (Supplementation en Vitamines et Mineraux Antioxydants)
prospective study, among whom sixty-nine developed prostate cancer during
the follow-up period (median: 7.7 years). Food consumption was assessed at
inclusion from repeated 24 h records and nutrient intake was calculated
using a food composition table. A higher risk of prostate cancer was
observed among subjects with higher dairy product (relative risk (RR; 95 %
CI), 4th quartile v. 1st: 1.35 (1.02, 1.78), P=0.04) and Ca intake (RR (95 %
CI), 4th quartile v. 1st: 2.43 (1.05, 5.62), P=0.04). Nevertheless, we
identified a harmful effect of yoghurt consumption upon the risk of prostate
cancer (RR (95 % CI), increment 125 g/d: 1.61 (1.07, 2.43), P=0.02)
independently of the Ca content. Our data support the hypothesis that dairy
products have a harmful effect with respect to the risk of prostate cancer,
largely related to Ca content. The higher risk of prostate cancer with
linear increasing yoghurt consumption seems to be independent of Ca and may
be related to some other component.
--
Jim Chinnis Warrenton, Virginia, USA

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Susan - 27 Mar 2006 21:08 GMT

> Unfortunately, some of us have prostates:
>
[quoted text clipped - 29 lines]
> linear increasing yoghurt consumption seems to be independent of Ca and may
> be related to some other component.

Isn't this correlation, not causation? Hyperinsulinemia is closely
associated with both types of cancer, and dairy is usually a large part
of the diet that reduces it.

Susan

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Jim Chinnis - 27 Mar 2006 21:16 GMT

Susan <nevermind@nomail.com> wrote in part:

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>Isn't this correlation, not causation?

Of course.

>Hyperinsulinemia is closely
>associated with both types of cancer, and dairy is usually a large part
>of the diet that reduces it.

Nutritional science is a dirty, murky affair, isn't it?
--
Jim Chinnis Warrenton, Virginia, USA

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Susan - 27 Mar 2006 21:20 GMT

> Nutritional science is a dirty, murky affair, isn't it?
> --

Yep yep yep.

Susan

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trumpetfish@comcast.net - 28 Mar 2006 22:55 GMT

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> Susan

So now enter the life saving Mediterranean diet. Wait it's the olive
oil, no I think it's the red wine, it must be the fruits and veggies,
blah blah blah blah blah.........But the one thing missing in the
Mediterranean dinner menu, is a tall cold glass of wholesome MILK...!!

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