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Medical Forum / General / Cardiology / March 2006

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Cholesterol Drug Reverses Heart Disease

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listener - 13 Mar 2006 18:00 GMT
[Note: Original subject line - I did not make it up]

ATLANTA - People in a new study got their "bad cholesterol" to the lowest
levels ever seen and saw blockages in their blood vessels shrink by
taking a high dose of cholesterol drug, researchers reported Monday.

Doctors say it is the best evidence yet that heart disease actually can
be reversed, not just kept from getting worse.

Two-thirds of the 349 study participants had regression of heart artery
buildups when they took the maximum dose of Crestor, the strongest of the
cholesterol-lowering statin drugs on the market and one under fire by a
consumer group that contends it has more side effects than its
competitors.

It's too soon to tell whether this shrinkage of artery blockages will
result in fewer heart attacks, but doctors were excited by the
possibility.

"The holy grail has always been to try to reverse the disease," and this
shows a way to do that, said Dr. Steven Nissen, the Cleveland Clinic
cardiologist who led the research and reported results at the American
College of Cardiology meeting.

The study was paid for by AstraZeneca PLC, the maker of Crestor, a drug
that a consumer group has been lobbying to have pulled from the market.
Some reports have linked Crestor to higher rates of serious muscle
problems and kidney damage, especially among Asians.

The     Food and Drug Administration last year refused to order the drug
off the market but required a warning of the side effects on its label.

In the study, Crestor got people's LDL or "bad cholesterol" levels to
around 60 milligrams per deciliter of blood, down from roughly 130 at the
start of the experiment. HDL or "good cholesterol" levels rose modestly,
from 43 to 49.

"The body needs about 40 LDL, so we're getting pretty close to what the
body needs for general repair," said Dr. Christopher O'Connor, a Duke
University cardiologist who had no role in the study.

Study results were released Monday by the     Journal of the American
Medical Association, which will publish it in its April 5 edition.

### ==================================================================

What is the the relationship of plaque to the arterial wall that it
clings to? Does it degrade the wall? If so, isn't it possible that
"stable" plaque might be better off left as it is?  Wouldn't shrinking
areas of build-up make those weakened sections of arterial wall *more*
likely to rupture or can those areas heal up? Sorry for my ignorance
about this.

L.
Jim Chinnis - 13 Mar 2006 18:49 GMT
listener <listener@nospam.net> wrote in part:

>What is the the relationship of plaque to the arterial wall that it
>clings to? Does it degrade the wall? If so, isn't it possible that
>"stable" plaque might be better off left as it is?  Wouldn't shrinking
>areas of build-up make those weakened sections of arterial wall *more*
>likely to rupture or can those areas heal up? Sorry for my ignorance
>about this.

Plaque doesn't ahere to the inner surface of an artery. it isn't analogous
to crud in a pipe. It forms INSIDE the wall of the artery and causes the
inner layer (the "intima") to bulge into the open space (the "lumen").

As plaque builds up in a spot it distorts the intima (and media) more and
more. Scarring occurs, inflammation,  calcification, and stuff I don't
understand.

My guess is that shrinking plaque (atheromas) is mostly good because it
shrinks plaque that may be unstable. Of course, stable plaque can eventually
nearly close an artery, causing a clot and an MI or stroke anyway...

Not sure I can address your questions much beyond that.
--
Jim Chinnis   Warrenton, Virginia, USA
listener - 13 Mar 2006 19:02 GMT
> listener <listener@nospam.net> wrote in part:
>
[quoted text clipped - 8 lines]
> to crud in a pipe. It forms INSIDE the wall of the artery and causes the
> inner layer (the "intima") to bulge into the open space (the "lumen").

Ah. Yes, I thought the former.

> As plaque builds up in a spot it distorts the intima (and media) more and
> more. Scarring occurs, inflammation,  calcification, and stuff I don't
> understand.

So, if the plaque is "shrunk" what happens to the scarring and
calcification? I'm assuming inflammation lessens just from the
shrinking..?

> My guess is that shrinking plaque (atheromas) is mostly good because it
> shrinks plaque that may be unstable. Of course, stable plaque can eventually
> nearly close an artery, causing a clot and an MI or stroke anyway...

Yes. So if in fact a drug like crestor can reverse plaque build-up could
it also *prevent* the build-up in the first place, or atleast keep any
build up minimal?


> Not sure I can address your questions much beyond that.
> --
> Jim Chinnis   Warrenton, Virginia, USA

L.
Bill - 13 Mar 2006 20:00 GMT
>> listener <listener@nospam.net> wrote in part:
>>
[quoted text clipped - 21 lines]
> calcification? I'm assuming inflammation lessens just from the
> shrinking..?

People often talk of calcified plaque. So I assume if that goes, the calcium
goes with it.

Bill

>> My guess is that shrinking plaque (atheromas) is mostly good because it
>> shrinks plaque that may be unstable. Of course, stable plaque can
[quoted text clipped - 10 lines]
>
> L.
listener - 13 Mar 2006 22:09 GMT
"Bill" <xxx@yy.zz> wrote in news:xjjRf.4008$0k.2462
@newssvr31.news.prodigy.com:

>>> listener <listener@nospam.net> wrote in part:
>>>
[quoted text clipped - 26 lines]
>
> Bill

The study's author said today "I think you get rid of the lipid, and
what's now left is the fibrous material, which won't rupture," he
explained. "It's a stable scar ... there is nothing to cause morbidity or
mortality."

I'm sure we'll be hearing more news coming out of today's meeting of the
American College of Cardiology in Atlanta.

Another unanswered question is whether less plaque means fewer heart
attacks and strokes?

L.
Jason - 13 Mar 2006 22:12 GMT
> [Note: Original subject line - I did not make it up]
>
[quoted text clipped - 50 lines]
>
> L.

Please note these two sentences:
> The study was paid for by AstraZeneca PLC, the maker of Crestor, a drug
> that a consumer group has been lobbying to have pulled from the market.
> Some reports have linked Crestor to higher rates of serious muscle
> problems and kidney damage, especially among Asians.

The maker of Crestor (a statin medication) paid for the study.

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listener - 13 Mar 2006 22:10 GMT
jason@nospam.com (Jason) wrote in news:jason-1303061312460001@66-52-22-
22.lsan.pw-dia.impulse.net:

>> [Note: Original subject line - I did not make it up]
>>
[quoted text clipped - 58 lines]
>
> The maker of Crestor (a statin medication) paid for the study.

And?

L.
Jason - 14 Mar 2006 01:30 GMT
> jason@nospam.com (Jason) wrote in news:jason-1303061312460001@66-52-22-
> 22.lsan.pw-dia.impulse.net:
[quoted text clipped - 80 lines]
>
> L.

L.
I have a question for you. If the makers of a brand of cigarettes done a
study that showed that smoking cigarettes helped people that had lung
disease--would you have trust in the study?
I would have more trust in the study mentioned in the post if the study
had been done by a company or agency that was not linked to any company
that made statins. Statins companies have a built in bias (in favor of
statins) when they conduct studies. They "cherry pick" the people that
take part in their studies. For example, if a person that had any signs of
kidney or liver disease--they would not be choosen to take part in the
study.
Jason

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Tony Wesley - 14 Mar 2006 02:11 GMT
> I have a question for you. If the makers of a brand of cigarettes done a
> study that showed that smoking cigarettes helped people that had lung
> disease--would you have trust in the study?

You do have a point but your analogy is flawed.  There is a difference
between having a highly respected agency do the study albeit being paid
by the maker versus the manufacturer doing the stiudy.

> I would have more trust in the study mentioned in the post if the study
> had been done by a company or agency that was not linked to any company
> that made statins.

I agree, I would as well.  It's an imperfect world and research dollars
do not flow endlessly.

But do you have the mistrust of authors who are paid by the results of
the sales of their books?

> Statins companies have a built in bias (in favor of
> statins) when they conduct studies. They "cherry pick" the people that
> take part in their studies. For example, if a person that had any signs of
> kidney or liver disease--they would not be choosen to take part in the
> study.

Those devious statins companies, excluding people when the drug is
contraindicated!
Jason - 15 Mar 2006 00:36 GMT
> > I have a question for you. If the makers of a brand of cigarettes done a
> > study that showed that smoking cigarettes helped people that had lung
[quoted text clipped - 22 lines]
> Those devious statins companies, excluding people when the drug is
> contraindicated!

You make some excellent points. Statins have helped lots of people.
However, they have also caused many people to develop kidney problems. As
you may know, doctors do prescribe statins to people that have kidney
problems. I read a book written by a doctor that is a kidney specialist
and actually teaches at a Johns Hopkins University School of Medicine. He
prescribes statins for his patients.
We both know those people that already have kidney problems may develop
even more medical problems as a result of taking statins. Studies like the
one mentioned above will cause even more doctors to prescibe statins to
patients--even if they have liver and kidney problems. Do you agree or
disagree?
Jason

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Tony Wesley - 15 Mar 2006 03:26 GMT
> We both know those people that already have kidney problems may develop
> even more medical problems as a result of taking statins.

Yes

> Studies like the
> one mentioned above will cause even more doctors to prescibe statins to
> patients--even if they have liver and kidney problems. Do you agree or
> disagree?

I'll disagree.  If you and I are aware of the AE of statins, hopefully
medical professionals are as well.
Jason - 16 Mar 2006 00:16 GMT
> > We both know those people that already have kidney problems may develop
> > even more medical problems as a result of taking statins.
[quoted text clipped - 8 lines]
> I'll disagree.  If you and I are aware of the AE of statins, hopefully
> medical professionals are as well.

Some are aware of the problems and some are not aware of the problems.
I know of at least two local family practice doctors that prescribed
statins to patients without first having a blood tests related to kidney
fuction and liver function (eg creatine levels).

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hawki63 - 16 Mar 2006 18:51 GMT
> > > We both know those people that already have kidney problems may develop
> > > even more medical problems as a result of taking statins.
[quoted text clipped - 13 lines]
> statins to patients without first having a blood tests related to kidney
> fuction and liver function (eg creatine levels).

so you live in an area where stupid doctors practice...so WHAT????

BTW....the test is for CREATININE.....totally different than CREATINE

you need to copy more accurately from your "books" Jason...since you
apparently have little medical knowledge
Jason - 16 Mar 2006 23:36 GMT
> > > > We both know those people that already have kidney problems may
> develop
[quoted text clipped - 22 lines]
> you need to copy more accurately from your "books" Jason...since you
> apparently have little medical knowledge

sorry about that--I should have checked the spelling--I have had lots of
problems with spelling as a result of statin related memory problems--
You would not believe how many times I have lost my car keys or had a hard
time remembering where I parked the car. The only good thing is the
exercise I have gotten as a result of walking around parking lots in
search of my car.

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Bill - 17 Mar 2006 02:27 GMT
>> > > > We both know those people that already have kidney problems may
>> develop
[quoted text clipped - 30 lines]
> exercise I have gotten as a result of walking around parking lots in
> search of my car.

You are using the argument that if event B followed event A then A caused B.
That is not necessarily so. Also, I believe you were on a high dose of red
yeast rice so you could also say that caused the problem.

In any case, it would be wise to not assume you know the cause of the problem
but rather have it checked out. Could be something different.

Do you have one of those cars with an alarm systems and a device that will
beep to help you find the car? If so, do you know the trick to increase its
range?

Bill
Jason - 17 Mar 2006 19:31 GMT
> >> > > > We both know those people that already have kidney problems may
> >> develop
[quoted text clipped - 43 lines]
>
> Bill

Bill,
Yes, I have one of those cars but the feature only words (at least on my
car) when you are within about 20 yards of the car. Regarding the
statins--I was taking Red Yeast Rice and the statin pills at the same
time. However, the dosage level for the statin was only (Provachol 20
mg--one pill per day). I was only taking one Red Yeast Rice capsule per
day. Many people take 40 mg statin pills or even 80 mg statin pills--they
are taking a much higher dose of statins than I was taking. Even when I
cut back to one half of a pill (10 mg) per day and no Red Yeast Rice
capsules--I continued to have high creatinine levels.
Jason

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Bill - 18 Mar 2006 04:40 GMT
>> >> > In article <1142389572.578960.112680@j33g2000cwa.googlegroups.com>,
>> >> > "Tony
[quoted text clipped - 58 lines]
> Yes, I have one of those cars but the feature only words (at least on my
> car) when you are within about 20 yards of the car.

Try putting the transmitter up under your chin while pressing the button. You
may get slightly better range because your body acts as an antenna. Try to
look in the general direction your car might be.

> Regarding the
> statins--I was taking Red Yeast Rice and the statin pills at the same
[quoted text clipped - 4 lines]
> cut back to one half of a pill (10 mg) per day and no Red Yeast Rice
> capsules--I continued to have high creatinine levels.

This makes it less likely that statins of the past are now causing what ever
problems you now have. But to the degree they do, the red yeast rice is also
as likely a suspect. In fact the two in combination may have made things
worse.

Bill

> Jason
Jason - 19 Mar 2006 00:03 GMT
> >> >> > In article <1142389572.578960.112680@j33g2000cwa.googlegroups.com>,
> >> >> > "Tony
[quoted text clipped - 78 lines]
>
> Bill

Bill,
Which is a higher dose of statins
one 20 mg Lovastatin (Mecacor) pill plus one Red Yeast Rice Capsule

or

One 80 mg Lovastatin pill

I should note that "a daily dose of red yeast rice contains about 5 mg of
lovastastin." source Dr. Cohen's statin book (page 103).

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Bill - 19 Mar 2006 03:01 GMT
>> >> > In article <CAhSf.54489$H71.9194@newssvr13.news.prodigy.com>,
>> >> > "hawki63"
[quoted text clipped - 102 lines]
> I should note that "a daily dose of red yeast rice contains about 5 mg of
> lovastastin." source Dr. Cohen's statin book (page 103).

I'll let you figure that out. But I thought you were taking the RYR in raw
form.

Bill
Jason - 19 Mar 2006 04:53 GMT
> >> >> > In article <CAhSf.54489$H71.9194@newssvr13.news.prodigy.com>,
> >> >> > "hawki63"
[quoted text clipped - 107 lines]
>
> Bill

Bill,
I don't know what was inside the RYR capsules that I purchased at the
local health food store. It's possible that it was the raw form. I doubt
that most people that take 80 mg statin pills realize that those pills are
more likely to cause side effects than the 20 mg statin pills.
Jason

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Bill - 19 Mar 2006 05:22 GMT
>> >> >> > In article <CAhSf.54489$H71.9194@newssvr13.news.prodigy.com>,
>> >> >> > "hawki63"
[quoted text clipped - 132 lines]
> more likely to cause side effects than the 20 mg statin pills.
> Jason

I think you are wrong there. Most people would realize that a higher dose of a
drug is more likely to have side effects.

But nevertheless you took a higher does of statins than was prescribed. For
most people they start you off at a low dose and see what happens. They do
blood tests and see what your reaction is. If you have no problems, but your
lipids are off, they may increase the dose.

Bill
Jason - 19 Mar 2006 05:52 GMT
> >> >> >> > In article <CAhSf.54489$H71.9194@newssvr13.news.prodigy.com>,
> >> >> >> > "hawki63"
[quoted text clipped - 142 lines]
>
> Bill

Bill,
You are discussing how good doctors do it. Some doctors start out their
patients on high dose statins. I am thankful that my doctor started me off
of the 20 mg dose instead of the 80 mg dose. Imagine the damage that may
have been done if I had combined ryr capsules with 80 mg statin pills. Dr.
Cohen discusses the bad doctors in his book.
Jason

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hawki63 - 19 Mar 2006 09:06 GMT
> > >> >> >> "Jason" <jason@nospam.com> wrote in message

news:jason-1603061436140001@66-52-22-80.lsan.pw-dia.impulse.net...
> > >> >> >> > In article <CAhSf.54489$H71.9194@newssvr13.news.prodigy.com>,
> > >> >> >> > "hawki63"
> > >> >> >> >
> > >> >> >> >> "Jason" <jason@nospam.com> wrote in message

news:jason-1503061517510001@66-52-22-98.lsan.pw-dia.impulse.net...
> > >> >> >> >> > In article
> > >> >> >> >> > <1142389572.578960.112680@j33g2000cwa.googlegroups.com>,
[quoted text clipped - 145 lines]
> You are discussing how good doctors do it. Some doctors start out their
> patients on high dose statins.

Jason...

until and WHEN you start prescribing..please STOP making generalizations
like the above...

"some" doctors start their patients on high dose statins?

and you know this ...BECAUSE you read it in a book??

Jason...ALL meds like statins,,blood pressure..diabetics etc are started at
a LOW dose..and gradually increased...

Again..perhaps you live in..or know personally prescribers are not following
the "standard of care"

hopefully they have good malpractice..cuz they likely will need it..

I am thankful that my doctor started me off
> of the 20 mg dose instead of the 80 mg dose. Imagine the damage that may
> have been done if I had combined ryr capsules with 80 mg statin pills. Dr.
> Cohen discusses the bad doctors in his book.
> Jason
Bill - 19 Mar 2006 09:28 GMT
>> >> >> > In article <5goSf.21852$tb3.8043@newssvr24.news.prodigy.net>,
>> >> >> > "Bill"
[quoted text clipped - 180 lines]
> Cohen discusses the bad doctors in his book.
> Jason

You are avoiding the issue. If you had any problems, you bear some
resposibility because you took more than the prescribed amount of statins.

Who knows how much or how they interacted?

Bill
hawki63 - 19 Mar 2006 17:47 GMT
> >> >> >> "Jason" <jason@nospam.com> wrote in message

news:jason-1703061031000001@66-52-22-66.lsan.pw-dia.impulse.net...
> >> >> >> > In article <5goSf.21852$tb3.8043@newssvr24.news.prodigy.net>,
> >> >> >> > "Bill"
> >> >> >> > <xxx@yy.zz> wrote:
> >> >> >> >
> >> >> >> >> "Jason" <jason@nospam.com> wrote in message

news:jason-1603061436140001@66-52-22-80.lsan.pw-dia.impulse.net...
> >> >> >> >> > In article <CAhSf.54489$H71.9194@newssvr13.news.prodigy.com>,
> >> >> >> >> > "hawki63"
> >> >> >> >> >
> >> >> >> >> >> "Jason" <jason@nospam.com> wrote in message

news:jason-1503061517510001@66-52-22-98.lsan.pw-dia.impulse.net...
> >> >> >> >> >> > In article
> >> >> >> >> >> > <1142389572.578960.112680@j33g2000cwa.googlegroups.com>,
[quoted text clipped - 180 lines]
>
> Bill
hawki63 - 19 Mar 2006 18:01 GMT
> >> >> >> "Jason" <jason@nospam.com> wrote in message

news:jason-1703061031000001@66-52-22-66.lsan.pw-dia.impulse.net...
> >> >> >> > In article <5goSf.21852$tb3.8043@newssvr24.news.prodigy.net>,
> >> >> >> > "Bill"
> >> >> >> > <xxx@yy.zz> wrote:
> >> >> >> >
> >> >> >> >> "Jason" <jason@nospam.com> wrote in message

news:jason-1603061436140001@66-52-22-80.lsan.pw-dia.impulse.net...
> >> >> >> >> > In article <CAhSf.54489$H71.9194@newssvr13.news.prodigy.com>,
> >> >> >> >> > "hawki63"
> >> >> >> >> >
> >> >> >> >> >> "Jason" <jason@nospam.com> wrote in message

news:jason-1503061517510001@66-52-22-98.lsan.pw-dia.impulse.net...
> >> >> >> >> >> > In article
> >> >> >> >> >> > <1142389572.578960.112680@j33g2000cwa.googlegroups.com>,
[quoted text clipped - 180 lines]
>
> Bill

Bill....Jason continues to seek out evidence that it is the
"bad doctors"...usually cited in some "book" he read that are the cause of
all evil  things that happen in medicine..including rare side effects..or
even events that may or may not have any bearing upon the meds given...

asking Jason to take responsibility...will only lead him to find another
book that backs up his lunancy..in practice we call the Jasons of the world
he 'worried well"...cuz regardless of the evidence..they continue to seek
out facts that confirm their preconceived notions...

just for fun...I did google on Jason from way back..about 18 months
ago..maybe even his first post..he had posted his lab results...which he
felt revealed the root of all of his problems..and that he blamed on
"statins"...firstly his potassium was 3.4...which is low..tho he insisted in
multiple postss that he KNEW he had hyperkalemia (??)...and that he cured
himself of that  by taking sodium bicarb and diuretics....many many of us
attempted to point out to him that a/ it was highly unlikely,,if not
impossible...to start with a potassium below normal and advance quiickly to
hyperkalemia...simply by using a salt substitute...it takes literally
pumping in potassium IV to raise the K that quickly..and again....no
reputablee health care provider would do that..

also ...he listed his kidney function tests a.s BUN of 7 (very very low
normal).. andd creatinine of 1.5....so he jumped to the conclusion that the
statins had caused him "kidney damage"...tho Robert and a phyician continued
to assure him that aa BUN of 7 is totally incompatible with kidney
dysfunction....in fact..tho a creatinine of 1.5 is on the high side of
normal...is it NOT evidence of "kidney damage"....one thing never mentioned
is "lab error"...when two function tests don't correlate..that should always
be considered..and both tests repeated...actually his next creatinine was
.9/........of course he credited that with his stopping of statins..

my impression of Jason is of a lonely..pathetic 54 year old man...sincerely
in need of some psych help..and someone needs to throw out all those books
he reads incessantly..and whose parts he picks apart to provide evidence to
"prove whatever point " he wants to..
hawki63 - 19 Mar 2006 19:39 GMT
top posted

I just read my angry reply...and feel a need to explain

we are having a "crisis" here...as my hubby had a routine colonoscopy 2
weeks ago..eleven polyps found and removed...one was malignant

so he faces major surgery this tues...so far all the scans etc do NOT reveal
any spread...Thank God

I guess it is hard to listen to whining at a time like this...

please send positive vibes on tues

thanks

> > >> >> > In article <EiLSf.21987$tb3.1651@newssvr24.news.prodigy.net>,
> "Bill"
[quoted text clipped - 18 lines]
> news:jason-1503061517510001@66-52-22-98.lsan.pw-dia.impulse.net...
> > >> >> >> >> >> > In article

<1142389572.578960.112680@j33g2000cwa.googlegroups.com>,
> > >> >> >> >> >> > "Tony
> > >> >> >> >> >> > Wesley" <tonywesley@gmail.com> wrote:
[quoted text clipped - 244 lines]
> he reads incessantly..and whose parts he picks apart to provide evidence to
> "prove whatever point " he wants to..
Tony Wesley - 19 Mar 2006 21:15 GMT
> top posted
>
[quoted text clipped - 5 lines]
> so he faces major surgery this tues...so far all the scans etc do NOT reveal
> any spread...Thank God

Best of wishes to you and your husband.  You'll need all of your
strength, to be the calm one when he's upset and nervous.  I hope and
pray that all goes well.

> I guess it is hard to listen to whining at a time like this...

It is.  I too, have googled Jason's posts on occasion.  I understand
your feelings.

> please send positive vibes on tues

Tuesday?  Okay... positive vibes on the way, building to a peak on
Tuesday.
Robert - 19 Mar 2006 22:40 GMT
> > top posted
> >
[quoted text clipped - 5 lines]
> > so he faces major surgery this tues...so far all the scans etc do NOT reveal
> > any spread...Thank God

Sorry to hear it. My prayers are with you and your husband.
hawki63 - 20 Mar 2006 08:00 GMT
> > > top posted
> > >
[quoted text clipped - 8 lines]
>
> Sorry to hear it. My prayers are with you and your husband.

thanks Robert
hawki63 - 20 Mar 2006 07:59 GMT
> > top posted
> >
[quoted text clipped - 19 lines]
> Tuesday?  Okay... positive vibes on the way, building to a peak on
> Tuesday.

thanks...appreciate it..yes tues...first case...have to be there at 5am...

will check back
listener - 19 Mar 2006 22:37 GMT
"hawki63" <hawki63@sbcglobal.net> wrote in news:FzhTf.2829$tN3.597
@newssvr27.news.prodigy.net:

> top posted
>
[quoted text clipped - 11 lines]
>
> thanks

My thoughts and prayers are with you and your husband.

Positive vibes all the way...

L.
Hawki63@sbcglobal.net - 21 Mar 2006 00:43 GMT
thanks so much...

> "hawki63" <hawki63@sbcglobal.net> wrote in news:FzhTf.2829$tN3.597
> @newssvr27.news.prodigy.net:
[quoted text clipped - 21 lines]
>
> L.
Bill - 20 Mar 2006 00:58 GMT
> top posted
>
[quoted text clipped - 11 lines]
>
> thanks

I'll be thinking about both of you. Why did they need to go back in? To double
check on the malignant area? It looks like the colonoscopy did its job - to
find little problems before they become big ones. Let's hope so anyway.

Thinking of you both.

Bill

>> > >> >> > In article <EiLSf.21987$tb3.1651@newssvr24.news.prodigy.net>,
>> "Bill"
[quoted text clipped - 300 lines]
> to
>> "prove whatever point " he wants to..
hawki63 - 20 Mar 2006 08:03 GMT
> > top posted
> >
[quoted text clipped - 14 lines]
> I'll be thinking about both of you. Why did they need to go back in? To double
> check on the malignant area?

the "margins were not clear" ...ie maybe a cancer cell or two escaped and is
setting up houseskeeping somewhere else...

It looks like the colonoscopy did its job - to
> find little problems before they become big ones. Let's hope so anyway.

very very true.....anyone who waits til they have "symptoms" of colon
cancer...ie bleeding etc...are crazy...routine colos ..and early
detection..are analgous to mammos and pap smears

> Thinking of you both.
>
> Bill

thanks Bill...

> >> > >> >> "Jason" <jason@nospam.com> wrote in message

news:jason-1803061503440001@66-52-22-65.lsan.pw-dia.impulse.net...
> >> > >> >> > In article <EiLSf.21987$tb3.1651@newssvr24.news.prodigy.net>,
> >> "Bill"
[quoted text clipped - 300 lines]
> > to
> >> "prove whatever point " he wants to..
Jason - 20 Mar 2006 01:16 GMT
> >> >> >> > In article <5goSf.21852$tb3.8043@newssvr24.news.prodigy.net>,
> >> >> >> > "Bill"
[quoted text clipped - 4 lines]
> >> >> >> >> >
> >> >> >> >> >> "Jason" <jason@nospam.com> wrote in message

news:jason-1503061517510001@66-52-22-98.lsan.pw-dia.impulse.net...
> >> >> >> >> >> > In article
> >> >> >> >> >> > <1142389572.578960.112680@j33g2000cwa.googlegroups.com>,
[quoted text clipped - 180 lines]
>
> Bill

Bill,
Excellent point. I admit that should not have done it. At the time, I did
not know that ryr contained a statin. Once I found out, I stopped taking
ryr capsules. I no longer take statins or ryr capsules. I continue to have
some sort of kidney problem--My serum creatine is normal (1.0 MG/DL) but
the urine creatinine is 17. 6 MG/DL  (very low). The Urine Hemoglobin
screen was Positive and the Reference range is Negative. I will be
discussing these most recent test results with my doctor on Friday. What's
your guess? All other things were within normal limits. (Note Serum BUN
was 11 MG/DL (low side of normal limits).
Jason  
Jason

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Bill - 20 Mar 2006 03:57 GMT
>> >> >> > In article <EiLSf.21987$tb3.1651@newssvr24.news.prodigy.net>,
>> >> >> > "Bill"
[quoted text clipped - 227 lines]
> Jason
> Jason

Far beyond me to guess. Could be multiple things.

Bill
hawki63 - 17 Mar 2006 05:57 GMT
> > > > > We both know those people that already have kidney problems may
> > develop
[quoted text clipped - 29 lines]
> exercise I have gotten as a result of walking around parking lots in
> search of my car.

sorry Jason...please do not use your 3 months of statins on every "problem"
you perceive

you are excellent at making excuses.....
Tony Wesley - 15 Mar 2006 03:29 GMT
> You make some excellent points. Statins have helped lots of people.
> However, they have also caused many people to develop kidney problems.

On the other hand:

Statins prevent kidney problems in heart patients

Reported by Susan Aldridge, PhD, medical journalist

A new clinical trial suggest that cholesterol-lowering statins protect
heart patients from worsening kidney function.
We already know that high cholesterol can lead to kidney disease and
this can complicate heart problems. So it's interesting to learn that
lowering cholesterol can protect the kidneys from deterioration.

Researchers in Greece are reporting upon the Greek atorvastatin and
coronary heart disease evaluation (GREACE) study which covers 1,600
participants with heart disease who had normal kidney function at the
start of the study. Half of them were treated with atorvastatin while
the rest were assigned to low fat diet, exercise and weight loss.

At the end of three years, those on the statin had better kidney
function than those who were not.  [snip]

http://www.healthandage.com/default.cfm?curr_navi=01&curr_content=01&spr=en&fram
edef=1&curr_paramlist=healthandage;5995;1;haa_online_from;2;1;3;-;dsp_tooldetail

James216440@yahoo.com - 14 Mar 2006 02:26 GMT
> > jason@nospam.com (Jason) wrote in news:jason-1303061312460001@66-52-22-
> > 22.lsan.pw-dia.impulse.net:
[quoted text clipped - 98 lines]
> We respect those subscribers that ask for advice or provide advice.
> We do NOT respect the subscribers that enjoy criticizing people.

Jason,

I hardly think you are being realistic in your negative assumption
about AstroZenica.  This is the very FIRST time any study has actually
claimed to prove regression of plaque.  Past studies with statins and
other drugs either failed to find any measurable regression in plaques
or the regressions found were statistically insignificant.  Thus this
claim for Crestor is a break through claim and as such is going to draw
attention big time.  If AstroZenica overclaimed at this stage they
could find themselves with about as much credibility as a certain S.
Korean scientist who made fabulous cloning claims that turned out to be
lies.  To overclaim at this point could backlash and kill the drug for
them.  So I think you can be very comfortable that the claims made are
indeed accurate and will be reproduced.

The rub is if you go look at the actual numbers reported for regression
they are mighty, mighty small.  And I have not yet been able to get any
data on type of plaque which regressed.  Regressing a well calcified
plaque is someplace between insignificant and negative re likely health
outcomes.  So, is a real, but very small reduction in plaque going to
result in significant health benefits?  And how long will any benefit
last?  The answers to both questions might be breakthrough.  Or they
might be a great disappointment.  It does not look like we will have
real data on health on this issue for years to come.
Jason - 15 Mar 2006 00:31 GMT
> > > jason@nospam.com (Jason) wrote in news:jason-1303061312460001@66-52-22-
> > > 22.lsan.pw-dia.impulse.net:
[quoted text clipped - 123 lines]
> might be a great disappointment.  It does not look like we will have
> real data on health on this issue for years to come.

James,
You make some excellent points. Statins have helped lots of people.
However, they have also caused many people to develop kidney problems. As
you may know, doctors do prescribe statins to people that have kidney
problems. I read a book written by a doctor that is a kidney specialist
and actually teaches at a Johns Hopkins University School of Medicine. He
prescribes statins for his patients.
We both know those people that already have kidney problems may develop
even more medical problems as a result of taking statins. Studies like the
one mentioned above will cause even more doctors to prescribe statins to
patients--even if they have liver and kidney problems. Do you agree or
disagree?
Those high doses needed to cause the the regression that you mentioned in
your post will cause lots of people to have side effects. As you may know,
if a person takes a low dose of a statin--they are less likely to have
side effects than if they took a high dose of that same statin.  
Jason

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Hawki63@sbcglobal.net - 15 Mar 2006 01:21 GMT
>> > > jason@nospam.com (Jason) wrote in
>> > > news:jason-1303061312460001@66-52-22-
[quoted text clipped - 166 lines]
> if a person takes a low dose of a statin--they are less likely to have
> side effects than if they took a high dose of that same statin.

actually that is not necessarily the case...if someone is going to have a
side effect..the lowest dose..for the shortest period..can cause the side
effect

Jason..

quit practicising medicine without a license

> Jason
Sharon Hope - 15 Mar 2006 04:27 GMT
>>> > > jason@nospam.com (Jason) wrote in
>>> > > news:jason-1303061312460001@66-52-22-
[quoted text clipped - 185 lines]
>
> quit practicising medicine without a license

Sure, but Dr. Cohen's book discusses evidence that statin adverse effects,
in particular, are dose related.

He also makes the point that the starting "lowest" dose approved is actually
a mid-point, and far too high a dose for much of the population.  Thus, 10
mg/day of Lipitor is too high for many, and it definitely was for my
husband.

Now the Crestor study, which according to the Editorial did not look for nor
list any adverse effects (can't find what you refuse to see), the mega doses
will begin.

>> Jason
Jason - 16 Mar 2006 00:22 GMT
> >> > > jason@nospam.com (Jason) wrote in
> >> > > news:jason-1303061312460001@66-52-22-
[quoted text clipped - 174 lines]
>
> quit practicising medicine without a license

Hello,
If you disagree with me, you need to read this book. The author of the
book explains why a low dose (of a statin) is less likely to cause side
effects than a high dose of the same statin.

WHAT YOU MUST KNOW ABOUT STATIN DRUGS AND THEIR NATURAL ALTERNATIVES
by Jay S. Cohen, M.D.

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Bill - 14 Mar 2006 02:49 GMT
>> jason@nospam.com (Jason) wrote in news:jason-1303061312460001@66-52-22-
>> 22.lsan.pw-dia.impulse.net:
[quoted text clipped - 85 lines]
> study that showed that smoking cigarettes helped people that had lung
> disease--would you have trust in the study?

That's a non-sequitor. The results of smoking on the lung are know to be
negative wheras the bulk of the evidence shows the effects of statins on the
heart are positive.

> I would have more trust in the study mentioned in the post if the study
> had been done by a company or agency that was not linked to any company
[quoted text clipped - 4 lines]
> study.
> Jason

I don't know what "any sign" means. What exactly is the criteria? But yes they
leave people with all sorts of illnesses out. And if you have liver disease
(and maybe kidney disease) you should probably should not be on a statin.

Bill
Jason - 15 Mar 2006 00:25 GMT
> >> jason@nospam.com (Jason) wrote in news:jason-1303061312460001@66-52-22-
> >> 22.lsan.pw-dia.impulse.net:
[quoted text clipped - 104 lines]
>
> Bill

Bill,
You make some excellent points. Statins have helped lots of people.
However, they have also caused many people to develop kidney problems. As
you may know, doctors do prescribe statins to people that have kidney
problems. I read a book written by a doctor that is a kidney specialist
and actually teaches at a Johns Hopkins University School of Medicine. He
prescribes statins for his patients.
We both know those people that already have kidney problems may develop
even more medical problems as a result of taking statins. Studies like the
one mentioned above will cause even more doctors to prescribe statins to
patients--even if they have liver and kidney problems. Do you agree or
disagree?
Jason

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Bill - 15 Mar 2006 00:52 GMT
>> >> jason@nospam.com (Jason) wrote in news:jason-1303061312460001@66-52-22-
>> >> 22.lsan.pw-dia.impulse.net:
[quoted text clipped - 125 lines]
> disagree?
> Jason

Yes if the results are backed up by other studies, and that's a good thing.
One must know the type of problem and whether it is sensitive to a statin.
Kindney stones would not be, for example. In fact, I did not see any warnings
about kidney problems with Crestor. With liver problems, it depends on the
nature of the problem. They should only go ahead after weighing the
risk/benefits with the patient and do frequent blood tests if the do go ahead.

Bill
listener - 14 Mar 2006 02:50 GMT
jason@nospam.com (Jason) wrote in news:jason-1303061630180001@66-52-22-
17.lsan.pw-dia.impulse.net:

>> jason@nospam.com (Jason) wrote in news:jason-1303061312460001@66-52-22-
>> 22.lsan.pw-dia.impulse.net:
[quoted text clipped - 93 lines]
> study.
> Jason

I hope you can see from my replies above that I am not taking this new
study at face value. I also think equating cigarettes with statins is a
poor analogy. To suggest that the incidents of AE and death from smoking
is somehow comparable to AE and death from statins is just not
supportable. The terrible Baycol debacle a few years ago caused approx.
100 deaths. According to the CDC, 440,000 annual deaths each year are
smoking-associated.

I do not disagree that, to some extent, companies may have a built-in
bias but that does not mean that studies done by or funded by them are
necessarily corrupt or invalid. Plus, there have been sufficient,
*independent* studies done that do show some benefit to statin use.

Personally, I think a med that would actually reverse heart disease in
some way would be a remakable discovery. Don't you? I'm open to that
possiblity, you're apparently are not.

L.
Jason - 15 Mar 2006 00:24 GMT
> jason@nospam.com (Jason) wrote in news:jason-1303061630180001@66-52-22-
> 17.lsan.pw-dia.impulse.net:
[quoted text clipped - 132 lines]
>
> L.

L.,
You make some excellent points. Statins have helped lots of people.
However, they have also caused many people to develop kidney problems. As
you may know, doctors do prescribe statins to people that have kidney
problems. I read a book written by a doctor that is a kidney specialist
and actually teaches at a Johns Hopkins University School of Medicine. He
prescribes statins for his patients.
We both know those people that already have kidney problems may develop
even more medical problems as a result of taking statins. Studies like the
one mentioned above will cause even more doctors to prescibe statins to
patients--even if they have liver and kidney problems. Do you agree or
disagree?
Jason

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Hawki63@sbcglobal.net - 15 Mar 2006 01:18 GMT
>> jason@nospam.com (Jason) wrote in news:jason-1303061630180001@66-52-22-
>> 17.lsan.pw-dia.impulse.net:
[quoted text clipped - 136 lines]
> You make some excellent points. Statins have helped lots of people.
> However, they have also caused many people to develop kidney problems.

no Jason....not lots of people...some...very few actually

unless you have a scientific quote to back that up

As
> you may know, doctors do prescribe statins to people that have kidney
> problems. I read a book written by a doctor that is a kidney specialist
> and actually teaches at a Johns Hopkins University School of Medicine. He
> prescribes statins for his patients.

depends on WHAT you define as "kidney problems" doesn't it??

do you TRULY think a reputable nephrologist would "prescribe statins"..etc
to ANY of his patients to whom the risk might outweigh the benefit??

if you do...you must think this doc..and all others...don't know the meaning
ofmalpractice

> We both know those people that already have kidney problems may develop
> even more medical problems as a result of taking statins. Studies like the
> one mentioned above will cause even more doctors to prescibe statins to
> patients--even if they have liver and kidney problems. Do you agree or
> disagree?

again..totally disagree...what you ..and others refuse to accept is that the
GOOD doctors who care about their patients..not to mention don'tlike the
word malpractice...do NOT prescribe meds like statins without pre and
frequent kidney and liver studies...

your blunt comment of "liver and kidney problems" indicates that you
probably don't know the difference between ..say a bladder infection (is
that a kidney problem??) or diminished kidney function..measured  by
creatinines etc...

medical providers are NOT as stupid as your "books" lead you to believe...

so quit making assumptions based upon your limited exposure ...

"a thimble full of knowledge...a basketful of mouth"

> Jason
Sharon Hope - 15 Mar 2006 06:39 GMT
Hawki,

Suggest you send the same lecture to the UPI Senior Editor, who wrote this
article, using the kind of term you have outlawed, "KIDNEY DAMAGE"
(actually, quoting from Consumer Reports, who used that term you have
outlawed, "KIDNEY DAMAGE", so you had better also send them your lecture
aimed at Jason at the end of this message):

http://www.upi.com/ConsumerHealthDaily/view.php?StoryID=20060314-114327-7082r

Consumer Health
HealthWrap: The heart-disease dilemma
By DAN OLMSTED
UPI Senior Editor

Indisputably good news has emerged from the cardiologists' convention this
week in Atlanta: A study shows the anti-cholesterol drug Crestor reversed
the effects of atherosclerosis in patients with evidence of coronary artery
disease.

<Snip>

We hate to rain on this parade -- and, in fact, we hope the study points the
way to a new era of heart-healing medication -- but it's important to
remember one sobering fact: Pharmaceuticals have side effects. And
sometimes, the more effective they are, the more potent those effects.

<Snip>

In January the independent Consumer Reports listed 12 drugs "having known or
suspected serious risks that were undetected or underestimated when the FDA
approved them." While appropriate in some cases, the magazine said, the
risks are sufficiently serious that until more is known, "these drugs should
be prescribed only when other options have failed, be avoided by people
whose medical conditions make them especially vulnerable to harmful
reactions, and used only with careful monitoring for adverse reactions."

One of the 12 was Crestor, which Consumer Reports said may cause "muscle
breakdown, kidney damage. (Other statins may have similar risks, but current
evidence appears stronger for Crestor, especially at high doses and in
Asian-Americans.)"

<Snip - READ THE FULL ARTICLE AT THE LINK PROVIDED>

>>> jason@nospam.com (Jason) wrote in news:jason-1303061630180001@66-52-22-
>>> 17.lsan.pw-dia.impulse.net:
[quoted text clipped - 191 lines]
>
>> Jason
Bill - 15 Mar 2006 07:57 GMT
> Hawki,
>
[quoted text clipped - 3 lines]
> outlawed, "KIDNEY DAMAGE", so you had better also send them your lecture
> aimed at Jason at the end of this message):

You do it again. You quote a reliable source but distort the quote. It says
"May Cause Kidney Damage" not that it does. You claim that Hawki outlawed the
use of the words "Kidney Damage" she did not and you provided nothing to back
up that claim.

Bill

> http://www.upi.com/ConsumerHealthDaily/view.php?StoryID=20060314-114327-7082r
>
[quoted text clipped - 214 lines]
>>
>>> Jason
Jason - 16 Mar 2006 00:11 GMT
> >> jason@nospam.com (Jason) wrote in news:jason-1303061630180001@66-52-22-
> >> 17.lsan.pw-dia.impulse.net:
[quoted text clipped - 176 lines]
>
> "a thimble full of knowledge...a basketful of mouth"

You made some great points. If you want to read the book--the title is

"Coping With Kidney Disease" by Mackenzie Walker, M.D. (kidney specialist)
He teaches at Johns Hopkins University School of Medicine.

He has treated patients that have various types of kidney disease that
have very high chol. levels. In those situations--statins are about the
only way of bringing down those chol. levels. If the patients develop
problems, he precribes other types of statins or discontinues statins. I
did not mean to imply that the doctor does not care about the health of
his patients.

It's my guess that lots of doctors prescribe statins to people that have
liver and kidney problems. Do you agree or disagree?

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hawki63 - 16 Mar 2006 05:35 GMT
> > >> jason@nospam.com (Jason) wrote in news:jason-1303061630180001@66-52-22-
> > >> 17.lsan.pw-dia.impulse.net:
[quoted text clipped - 146 lines]
> > > and actually teaches at a Johns Hopkins University School of Medicine. He
> > > prescribes statins for his patients.

Jason...you read way too many books that you cannot understand given your
limited medical knowledge

re: statins and kidney disease  (from my prescribing reference).....

"myopathy/rhabdomyolsis...RARE instances of above with acute renal failure
have been reported"  so..yes...statins have a risk of rhabdo...which is
rare...

further on  "dosage in patients with renal insufficiency...no modification
of dosage for patients with MILD to MODERATE renal insufficiency.....with
severe pre existing impairment,,not on dialysis...should be started at
5mg..and not exceed 10mg...plus obviously renal function must be monitored"

what that means Jason..is that renal patients have a very high risk of CV
disease...so NOT giving them statins may make their prognosis
worse....risk/benefit ratio...

BTW...there is NO evidence that the rare cases of rhabdo occurred in
patients with pre existing renal insufficiency..

NOR is renal insufficiency considered a contraindication..

so Jason...tho rhabdo CAN cause acute renal failure...it can with the same
rareness in those with normal as abnormal renal function.... ALLL meds given
to those with measurable renal impairment are given at much lower doses..but
to say that "statins cause kidney problems"..thus the fact that a
nephrologist is using it for his patient population indicates that you have
not a clue as to what actually constitutes risk/benefit ratio

in the same source..under contraindications "crestor is contraindicated in
patients with "active liver disease"....PLUS even those who begin treatment
with NORMAL liver function are monitored at regular intervals...KNOWING that
this class of drugs can affect the liver...again risk/benefit ratio...if you
know of a drug that has NO risks..yet has benefits...you deserve a Nobel
prize...

why just the other night on that new "miracles" show...a guy who received
ONE course of penicillin ended up blind !!(the miracle concerned stem cells
and transplants that restored his sight after 22 years of blindness

WHAT?? penicillin can cause blindness?? well.....gollee..better pull it all
off the shelves where it cannot cure infections in the 99/999999% of the
population that don't become blind

> > depends on WHAT you define as "kidney problems" doesn't it??
> >
[quoted text clipped - 6 lines]
> > > We both know those people that already have kidney problems may develop
> > > even more medical problems as a result of taking statins.

again...you are wrong...or your definition of kidney problems is wayyyy
skewed......

Studies like the
> > > one mentioned above will cause even more doctors to prescibe statins to
> > > patients--even if they have liver and kidney problems. Do you agree or
[quoted text clipped - 30 lines]
> It's my guess that lots of doctors prescribe statins to people that have
> liver and kidney problems. Do you agree or disagree?
Tony Wesley - 16 Mar 2006 06:32 GMT
> why just the other night on that new "miracles" show...a guy who received
> ONE course of penicillin ended up blind !!(the miracle concerned stem cells
[quoted text clipped - 3 lines]
> off the shelves where it cannot cure infections in the 99/999999% of the
> population that don't become blind

I didn't know it could cause blindness.  I did have a minor AE from
penicillin when I was a kid, my arm swelled up. The doctor said I was
allergic to penicillin and I had to be very carefull not to take it
again.  As I recall, he explained that after one allegric reaction, the
body's sensitivity increases greatly and a second dose could kill me.

I just googled and found this page:

Deaths from Penicillin allergy: 400 deaths annually among Americans
(NIAID)

Source:
http://www.wrongdiagnosis.com/p/penicillin_allergy/prognosis.htm

-----

Contrast that to Baycol:

The maker of Baycol (cerivastatin), a popular cholesterol-lowering drug
used by about 700,000 Americans, voluntarily pulled the medicine off
the market August 8 because of numerous deaths associated with its use.

Officials at the Food and Drug Administration said 31 people have died
of complications of severe muscle breakdown [...]

Source: http://www.mercola.com/2001/aug/18/baycol.htm
hawki63 - 16 Mar 2006 18:54 GMT
> > why just the other night on that new "miracles" show...a guy who received
> > ONE course of penicillin ended up blind !!(the miracle concerned stem cells
[quoted text clipped - 5 lines]
>
> I didn't know it could cause blindness.

precisely my point...this poor soul experienced the side effect of ALL side
effects...I also have never heard of Penicillin causing blindness

your quote also proved a point....400 deaths per year from penicillin
allergic reactions...vs 31 from Baycol

which med would you yank...??

 I did have a minor AE from
> penicillin when I was a kid, my arm swelled up. The doctor said I was
> allergic to penicillin and I had to be very carefull not to take it
[quoted text clipped - 21 lines]
>
> Source: http://www.mercola.com/2001/aug/18/baycol.htm
Larry - 17 Mar 2006 00:03 GMT
>>>>>jason@nospam.com (Jason) wrote in
>
[quoted text clipped - 425 lines]
>>It's my guess that lots of doctors prescribe statins to people that have
>>liver and kidney problems. Do you agree or disagree?

Finally someone with some "balanced" sense has posted to this NG. He
doesn't deny that there are adverse effects, but he make complete sense
that the drugs must continue to be used. It is up to you ask to whether
or not you want to take what is in reality a small risk.

Larry E.
hawki63 - 17 Mar 2006 01:24 GMT
> >>>>>jason@nospam.com (Jason) wrote in
> >
[quoted text clipped - 432 lines]
>
> Larry E.

Larry...

I hope you are referring to me...tho I am a "she" not a he...

As a health care professional...I am a nurse practitioner with 40 years
experience in the medical field...I cannot let the Jasons of the world who
"read books"...extrapolate as innaccurately as he does...time and again

Sharon Hope is an entirely different story....Sharon has had a personal and
frustrating experience with her husband...

but her comments almost NEVER are totally innaccurate...

and I cannot condemn her for her anti statin stance...

the saying always is "doesn't matter how few experience a risk related to a
med or treatment...if it is YOU or your loved one...then it IS a 100% risk"

again..hopefully your "compliment " was meant for me...
Sharon Hope - 17 Mar 2006 04:42 GMT
>> >>>>>jason@nospam.com (Jason) wrote in
>> >
[quoted text clipped - 487 lines]
>
> again..hopefully your "compliment " was meant for me...

Thanks, that means a lot coming from you.

It strikes me that there is no general denial about penicillin, so there is
no outcry against "I'm allergic to penicillin" bracelets, and doctors
routinely ask about penicillin and other drug allergies when taking a
patient's history.  (and my husband now always answers "Lipitor" even though
the mechanism of the AEs is not like an allergen.)

That general acceptance of adverse effects, and thereby appropriate
precautions, are what seems to be missing with statin drugs.  Given that
they are the most prescribed class of drugs in the world, and in the history
of the world, the 'rare' adverse effects can appear in a significant count
of people.

My dad has been allergic to penicillin for as long as I can remember, and I
have never heard any 'blame the patient' comments about that, never.  Yet
the denial of the statin AEs (while everyone says all drugs have AEs and
agrees in the abstract) seems to generate attacks on the patient and those
seeking treatment, and those attempting to warn others of the unpublicized
and unacknowledged dangers.

Not saying you have done this, Hawki, just a general observation.

Why do you think there is such a drastic difference in the general reaction
to AEs from the two drugs?
hawki63 - 17 Mar 2006 06:04 GMT
> >> >>>>>jason@nospam.com (Jason) wrote in
> >> >
[quoted text clipped - 513 lines]
> Why do you think there is such a drastic difference in the general reaction
> to AEs from the two drugs?

very interesting question...to which I don't have an answer

perhaps it is too soon to extrapolate that as many folks taking statins will
be wearing "allergy" bracelets in the future...

tho ...the adverse reaction to penicillin is truly of an allergic
nature..ie...sets up the cascade that causes the rash..the difficulty
breathing..and worst case scenerio...anaphylactic reaction and maybe death

so...even tho statin problems such as those you know of can be
devestating...they are not allergic in the true sense of the word...

adverse and allergic are not the same animal

similar..but not the same
Jim Chinnis - 17 Mar 2006 06:13 GMT
"hawki63" <hawki63@sbcglobal.net> wrote in part:

>> Why do you think there is such a drastic difference in the general
>reaction
[quoted text clipped - 15 lines]
>
>similar..but not the same

Antibiotics are now being blamed for causing asthma years later when used in
infancy. Some AEs are hard to discover, even after many years. I suspect
that all drugs have such risks, at least to a few unlucky souls.
--
Jim Chinnis   Warrenton, Virginia, USA
Bill - 17 Mar 2006 09:58 GMT
>>> >>>>>jason@nospam.com (Jason) wrote in
>>> >
[quoted text clipped - 499 lines]
> Why do you think there is such a drastic difference in the general reaction
> to AEs from the two drugs?

I don't think there is. When a Dr. mentions the AEs of Lipitor, for example,
he may note that there some muscle problems occasionally, but they are often
small and typically reverse when the drug is discontinued. Rarely serious
non-reversable problems develop.  No one would have a negative reaction to
that.

But if the person claiming the AE is not being truthful, for example claiming
that it has been proven that Transient Global Amnesia occurs in greater than
2% of all Lipitor takers, then there may be a strong rebuttal - which has
nothing to do with Lipitor, just with being factually accurate.

The more appropriate question is why are you so obviously hateful toward
statins to the point of denying the benefits shown in trails and making up AEs
which are more rumors than anything proven?

Bill
Larry - 17 Mar 2006 18:00 GMT
snip

>>Finally someone with some "balanced" sense has posted to this NG. He
>>doesn't deny that there are adverse effects, but he make complete sense
[quoted text clipped - 22 lines]
>
> again..hopefully your "compliment " was meant for me...

Frankly, this thread has become so convuluted that I can't pick out the
exact quotes that caused me to issue the "compliment". I am looking for
anything "balanced" and not one-sided or unfairly biased. As an example
... if someone posts that cigarette smoking causes lung-cancer, I really
don't object to that because it's a well-proven fact that is
substantiated by study after study and is well-accepted and well-known
in the current medical community. This would not be a biased remark. But
if someone posts saying that cell phone usage causes brain cancer ...
that is a biased remark because it is NOT accepted (at least as of yet)
as something that has been substantiated consistently by large studies
over and over. In fact, there have been studies that conclude that they
do and that they don't.

Same thing for statins, and same thing for most of Sharon's posts. I
have said myself previously that I don't blame Sharon for her stance and
I feel bad that her husband has suffered. But I disagree with you
slightly ... when someone takes words out of context from studies to
make it sound like those studies support their biased view (and by
making it sound like that biased view is commonly accepted fact), or
when someone misrepresents the larger body of evidence out there by
making assertions and then only quoting the studies that suppor that
view ... not only is this not balanced, it really is "inaccurate" ...
and it is misleading.

You are right ... if there are only a small % of people who experience
an adverse effect ... once it hits you or someone in your family, to you
... it is 100%. In fact, while my Dad has been on a statin for many
years and I honestly believe it has saved his life, my Mom tried them
and couldn't tolerate even the immediate short-term side effects. She
has since been placed on one that with the absolute lowest dosage ...
she seems to be tolerating. So for her, even though the drugs maybe
cause those side effects in a very small % of patients, she DID
experience them.

It is certainly appropriate to warn people OF THE RISK of adverse
effects ... absolutely! It is certainly worthwhile to relate your own
personal experience and try to help others avoid similar experiences by
making constructive suggestions. But it is not appropriate and
misleading to misrepresent the facts and try to pull the wool over
people's eyes.

What is appropriate? Let people know about your own experience, but also
let people know what the facts really are ... or at least choose
language that acknowledges that these are your personal experiences and
the experience of others ... but maybe not representative of ALL
experiences. All drugs have adverse effects ...we know that. But the
facts are that the adverse effects usually occur in a very small % of
the population. Let people know what those % are (vs. "STATINS CAUSE
______")and let them make their own informed decision. Advise patients
to question doctors when they prescribe meds. Advise patients to
question pharmacists about meds. Advise patients to research meds that
have been prescribed by researching their adverse effects on the
internet (by Sharon as well as more unbiased sources). Advise patients
to go for second opinions. etc, etc.

Larry E.
Jason - 17 Mar 2006 19:39 GMT
> >>>>>jason@nospam.com (Jason) wrote in
> >
[quoted text clipped - 432 lines]
>
> Larry E.

Larry,
I have done lots of research on statins and have came to the conclusion
that some people can take statins and have NO side effects but that other
people have all sorts of serious side effects when they take statins. My
main problem with statins is that many (perhaps most) doctors do not
discuss statin side effects with their patients. In addition, they should
also encourage their patients to try new diet plans and exercise plans
prior to prescribing statins. My doctor done NONE of those things. I have
learned from my research that many doctors are very much like my previous
doctor. They prescribe statins without first discussing side effects,
exercise plans or diet plans. Those doctors should also conduct kidney and
liver function blood tests (and examine the results) prior to prescribing
statins. I have a lot of respect for doctors that do these things.
However, most of them don't do these things.
Jason

Signature

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Larry - 17 Mar 2006 19:54 GMT
>>>>>>>jason@nospam.com (Jason) wrote in
>>>
[quoted text clipped - 448 lines]
> However, most of them don't do these things.
> Jason

Jason ...I can completely understand that point of view ... it makes
complete sense. But as I said in a previous post:

"If a doctor does this, there is a certain amount of ownness on you as
the patient to question it. I question nearly every recommendation that
my doctors give me asking if there are other options ... and whether
what they are recommending is really necessary. To a certain degree, you
must take responsibility as a patient for your own care. Even with
cancers, the right treatment option isn't always obvious and all oncs
can do is to help you better understand the options ... you must make
the final choice. Few patients realize how empowered they are and that
is one of the biggest issues we face. The physician should be viewed as
a consultant and since they are humans, they are not perfect.

Lastly, although I am not a physician ... I could see where there could
be situations where I would as a physician recommend that changing the
diet be tried first ... but there could very well be others where it
wouldn't be advisable and I might need to recommend that a patient
immediately be placed on a statin. So ... perhaps a 45 y/o man in
otherwise good health has angina and has an elevated cholesterol ... but
his stress test/thallium/possibly angiography show minimal or partial
occlusions. Makes sense here to try diet first. A 75 y/o man with 80%
occlusions who is diabetic with aggressive cardiac disease and who is
already not eating a lot of fatty foods ... whose occlusion % has
changed from 50% to 80% in the past year ... might be a situation where
I could see needing to go directly to a statin."

Larry E.
listener - 15 Mar 2006 03:45 GMT
jason@nospam.com (Jason) wrote in news:jason-1403061524310001@66-52-22-
67.lsan.pw-dia.impulse.net:

> L.,
> You make some excellent points. Statins have helped lots of people.
[quoted text clipped - 9 lines]
> disagree?
> Jason

I completely disagree.

L.
David Rind - 14 Mar 2006 02:58 GMT
> [Note: Original subject line - I did not make it up]
>
> ATLANTA - People in a new study got their "bad cholesterol" to the lowest
> levels ever seen and saw blockages in their blood vessels shrink by
> taking a high dose of cholesterol drug, researchers reported Monday.

The article is available free online at the JAMA website. Rather than
reading the article, though, I'd suggest reading the accompanying
editorial which points out a number of the problems with this study.

Signature

David Rind
drind@caregroup.harvard.edu

listener - 14 Mar 2006 03:26 GMT
David Rind <drind@caregroup.harvard.edu> wrote in news:dv57s9$h66$1
@reader2.panix.com:

>> [Note: Original subject line - I did not make it up]
>>
[quoted text clipped - 5 lines]
> reading the article, though, I'd suggest reading the accompanying
> editorial which points out a number of the problems with this study.

The ASTEROID Trial article:

http://jama.ama-assn.org/cgi/content/full/295.13.jpc60002v1

The editorial:

http://jama.ama-assn.org/cgi/content/full/295.13.jed60019v1

L.
Jim Chinnis - 14 Mar 2006 03:40 GMT
David Rind <drind@caregroup.harvard.edu> wrote in part:

>> [Note: Original subject line - I did not make it up]
>>
[quoted text clipped - 5 lines]
>reading the article, though, I'd suggest reading the accompanying
>editorial which points out a number of the problems with this study.

The editorial is excellent. Very good discussion of some of the broader
issues and research underway.
--
Jim Chinnis   Warrenton, Virginia, USA
Sharon Hope - 15 Mar 2006 07:05 GMT
Thanks David!

Comments and cautions are rolling in.  Per
http://www.upi.com/ConsumerHealthDaily/view.php?StoryID=20060314-114327-7082r
HealthWrap: The heart-disease dilemma
By DAN OLMSTED
UPI Senior Editor

Indisputably good news has emerged from the cardiologists' convention this
week in Atlanta: A study shows the anti-cholesterol drug Crestor reversed
the effects of atherosclerosis in patients with evidence of coronary artery
disease.

AstraZeneca's Crestor is a statin, a class of drug used to treat high
cholesterol. Evidence of their beneficial effects has been mounting. In
fact, rival pharmaceutical manufacturer Pfizer issued a statement Monday
downplaying the Crestor study.

"This is not the first time a statin has demonstrated plaque regression,"
Pfizer said in its statement. "The REVERSAL trial compared treatment with
Lipitor 80 mg to another lipid lowering agent over 18 months. In a subset of
high-plaque burden patients, Lipitor demonstrated a 5.9 percent ... total
plaque reduction with excellent toleration."

<ALL: Excerpts here for emphasis, READ the entire article at the link
provided)

But Graham went on to cite five other drugs he said are putting people at
risk: Meridia, Accutane, Serevent, Bextra -- and, yes, Crestor.

Nor was Graham the only one to sound an alarm. Public Citizen Health
Research Group, led by the redoubtable Dr. Sidney Wolfe, has tried to get it
recalled.

<snip>
One of the 12 was Crestor, which Consumer Reports said may cause "muscle
breakdown, kidney damage. (Other statins may have similar risks, but current
evidence appears stronger for Crestor, especially at high doses and in
Asian-Americans.)"

It is at the high dose that Crestor appears to reverse plaque.
Again, we're thrilled that anything appears to undo damage that can and does
kill many people. It's just important to remember that any decision to take
a drug requires a careful balancing of risks and benefits -- and,
ultimately, that is a decision only the patient can make.

<snip>

>> [Note: Original subject line - I did not make it up]
>>
[quoted text clipped - 5 lines]
> reading the article, though, I'd suggest reading the accompanying
> editorial which points out a number of the problems with this study.
 
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