Medical Forum / General / Cardiology / March 2006
Cholesterol Drug Reverses Heart Disease
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listener - 13 Mar 2006 18:00 GMT [Note: Original subject line - I did not make it up]
ATLANTA - People in a new study got their "bad cholesterol" to the lowest levels ever seen and saw blockages in their blood vessels shrink by taking a high dose of cholesterol drug, researchers reported Monday.
Doctors say it is the best evidence yet that heart disease actually can be reversed, not just kept from getting worse.
Two-thirds of the 349 study participants had regression of heart artery buildups when they took the maximum dose of Crestor, the strongest of the cholesterol-lowering statin drugs on the market and one under fire by a consumer group that contends it has more side effects than its competitors.
It's too soon to tell whether this shrinkage of artery blockages will result in fewer heart attacks, but doctors were excited by the possibility.
"The holy grail has always been to try to reverse the disease," and this shows a way to do that, said Dr. Steven Nissen, the Cleveland Clinic cardiologist who led the research and reported results at the American College of Cardiology meeting.
The study was paid for by AstraZeneca PLC, the maker of Crestor, a drug that a consumer group has been lobbying to have pulled from the market. Some reports have linked Crestor to higher rates of serious muscle problems and kidney damage, especially among Asians.
The Food and Drug Administration last year refused to order the drug off the market but required a warning of the side effects on its label.
In the study, Crestor got people's LDL or "bad cholesterol" levels to around 60 milligrams per deciliter of blood, down from roughly 130 at the start of the experiment. HDL or "good cholesterol" levels rose modestly, from 43 to 49.
"The body needs about 40 LDL, so we're getting pretty close to what the body needs for general repair," said Dr. Christopher O'Connor, a Duke University cardiologist who had no role in the study.
Study results were released Monday by the Journal of the American Medical Association, which will publish it in its April 5 edition.
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What is the the relationship of plaque to the arterial wall that it clings to? Does it degrade the wall? If so, isn't it possible that "stable" plaque might be better off left as it is? Wouldn't shrinking areas of build-up make those weakened sections of arterial wall *more* likely to rupture or can those areas heal up? Sorry for my ignorance about this.
L.
Jim Chinnis - 13 Mar 2006 18:49 GMT listener <listener@nospam.net> wrote in part:
>What is the the relationship of plaque to the arterial wall that it >clings to? Does it degrade the wall? If so, isn't it possible that >"stable" plaque might be better off left as it is? Wouldn't shrinking >areas of build-up make those weakened sections of arterial wall *more* >likely to rupture or can those areas heal up? Sorry for my ignorance >about this. Plaque doesn't ahere to the inner surface of an artery. it isn't analogous to crud in a pipe. It forms INSIDE the wall of the artery and causes the inner layer (the "intima") to bulge into the open space (the "lumen").
As plaque builds up in a spot it distorts the intima (and media) more and more. Scarring occurs, inflammation, calcification, and stuff I don't understand.
My guess is that shrinking plaque (atheromas) is mostly good because it shrinks plaque that may be unstable. Of course, stable plaque can eventually nearly close an artery, causing a clot and an MI or stroke anyway...
Not sure I can address your questions much beyond that. -- Jim Chinnis Warrenton, Virginia, USA
listener - 13 Mar 2006 19:02 GMT > listener <listener@nospam.net> wrote in part: > [quoted text clipped - 8 lines] > to crud in a pipe. It forms INSIDE the wall of the artery and causes the > inner layer (the "intima") to bulge into the open space (the "lumen"). Ah. Yes, I thought the former.
> As plaque builds up in a spot it distorts the intima (and media) more and > more. Scarring occurs, inflammation, calcification, and stuff I don't > understand. So, if the plaque is "shrunk" what happens to the scarring and calcification? I'm assuming inflammation lessens just from the shrinking..?
> My guess is that shrinking plaque (atheromas) is mostly good because it > shrinks plaque that may be unstable. Of course, stable plaque can eventually > nearly close an artery, causing a clot and an MI or stroke anyway... Yes. So if in fact a drug like crestor can reverse plaque build-up could it also *prevent* the build-up in the first place, or atleast keep any build up minimal?
> Not sure I can address your questions much beyond that. > -- > Jim Chinnis Warrenton, Virginia, USA L.
Bill - 13 Mar 2006 20:00 GMT >> listener <listener@nospam.net> wrote in part: >> [quoted text clipped - 21 lines] > calcification? I'm assuming inflammation lessens just from the > shrinking..? People often talk of calcified plaque. So I assume if that goes, the calcium goes with it.
Bill
>> My guess is that shrinking plaque (atheromas) is mostly good because it >> shrinks plaque that may be unstable. Of course, stable plaque can [quoted text clipped - 10 lines] > > L. listener - 13 Mar 2006 22:09 GMT "Bill" <xxx@yy.zz> wrote in news:xjjRf.4008$0k.2462 @newssvr31.news.prodigy.com:
>>> listener <listener@nospam.net> wrote in part: >>> [quoted text clipped - 26 lines] > > Bill The study's author said today "I think you get rid of the lipid, and what's now left is the fibrous material, which won't rupture," he explained. "It's a stable scar ... there is nothing to cause morbidity or mortality."
I'm sure we'll be hearing more news coming out of today's meeting of the American College of Cardiology in Atlanta.
Another unanswered question is whether less plaque means fewer heart attacks and strokes?
L.
Jason - 13 Mar 2006 22:12 GMT > [Note: Original subject line - I did not make it up] > [quoted text clipped - 50 lines] > > L. Please note these two sentences:
> The study was paid for by AstraZeneca PLC, the maker of Crestor, a drug > that a consumer group has been lobbying to have pulled from the market. > Some reports have linked Crestor to higher rates of serious muscle > problems and kidney damage, especially among Asians. The maker of Crestor (a statin medication) paid for the study.
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listener - 13 Mar 2006 22:10 GMT jason@nospam.com (Jason) wrote in news:jason-1303061312460001@66-52-22- 22.lsan.pw-dia.impulse.net:
>> [Note: Original subject line - I did not make it up] >> [quoted text clipped - 58 lines] > > The maker of Crestor (a statin medication) paid for the study. And?
L.
Jason - 14 Mar 2006 01:30 GMT > jason@nospam.com (Jason) wrote in news:jason-1303061312460001@66-52-22- > 22.lsan.pw-dia.impulse.net: [quoted text clipped - 80 lines] > > L. L. I have a question for you. If the makers of a brand of cigarettes done a study that showed that smoking cigarettes helped people that had lung disease--would you have trust in the study? I would have more trust in the study mentioned in the post if the study had been done by a company or agency that was not linked to any company that made statins. Statins companies have a built in bias (in favor of statins) when they conduct studies. They "cherry pick" the people that take part in their studies. For example, if a person that had any signs of kidney or liver disease--they would not be choosen to take part in the study. Jason
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Tony Wesley - 14 Mar 2006 02:11 GMT > I have a question for you. If the makers of a brand of cigarettes done a > study that showed that smoking cigarettes helped people that had lung > disease--would you have trust in the study? You do have a point but your analogy is flawed. There is a difference between having a highly respected agency do the study albeit being paid by the maker versus the manufacturer doing the stiudy.
> I would have more trust in the study mentioned in the post if the study > had been done by a company or agency that was not linked to any company > that made statins. I agree, I would as well. It's an imperfect world and research dollars do not flow endlessly.
But do you have the mistrust of authors who are paid by the results of the sales of their books?
> Statins companies have a built in bias (in favor of > statins) when they conduct studies. They "cherry pick" the people that > take part in their studies. For example, if a person that had any signs of > kidney or liver disease--they would not be choosen to take part in the > study. Those devious statins companies, excluding people when the drug is contraindicated!
Jason - 15 Mar 2006 00:36 GMT > > I have a question for you. If the makers of a brand of cigarettes done a > > study that showed that smoking cigarettes helped people that had lung [quoted text clipped - 22 lines] > Those devious statins companies, excluding people when the drug is > contraindicated! You make some excellent points. Statins have helped lots of people. However, they have also caused many people to develop kidney problems. As you may know, doctors do prescribe statins to people that have kidney problems. I read a book written by a doctor that is a kidney specialist and actually teaches at a Johns Hopkins University School of Medicine. He prescribes statins for his patients. We both know those people that already have kidney problems may develop even more medical problems as a result of taking statins. Studies like the one mentioned above will cause even more doctors to prescibe statins to patients--even if they have liver and kidney problems. Do you agree or disagree? Jason
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Tony Wesley - 15 Mar 2006 03:26 GMT > We both know those people that already have kidney problems may develop > even more medical problems as a result of taking statins. Yes
> Studies like the > one mentioned above will cause even more doctors to prescibe statins to > patients--even if they have liver and kidney problems. Do you agree or > disagree? I'll disagree. If you and I are aware of the AE of statins, hopefully medical professionals are as well.
Jason - 16 Mar 2006 00:16 GMT > > We both know those people that already have kidney problems may develop > > even more medical problems as a result of taking statins. [quoted text clipped - 8 lines] > I'll disagree. If you and I are aware of the AE of statins, hopefully > medical professionals are as well. Some are aware of the problems and some are not aware of the problems. I know of at least two local family practice doctors that prescribed statins to patients without first having a blood tests related to kidney fuction and liver function (eg creatine levels).
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hawki63 - 16 Mar 2006 18:51 GMT > > > We both know those people that already have kidney problems may develop > > > even more medical problems as a result of taking statins. [quoted text clipped - 13 lines] > statins to patients without first having a blood tests related to kidney > fuction and liver function (eg creatine levels). so you live in an area where stupid doctors practice...so WHAT????
BTW....the test is for CREATININE.....totally different than CREATINE
you need to copy more accurately from your "books" Jason...since you apparently have little medical knowledge
Jason - 16 Mar 2006 23:36 GMT > > > > We both know those people that already have kidney problems may > develop [quoted text clipped - 22 lines] > you need to copy more accurately from your "books" Jason...since you > apparently have little medical knowledge sorry about that--I should have checked the spelling--I have had lots of problems with spelling as a result of statin related memory problems-- You would not believe how many times I have lost my car keys or had a hard time remembering where I parked the car. The only good thing is the exercise I have gotten as a result of walking around parking lots in search of my car.
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Bill - 17 Mar 2006 02:27 GMT >> > > > We both know those people that already have kidney problems may >> develop [quoted text clipped - 30 lines] > exercise I have gotten as a result of walking around parking lots in > search of my car. You are using the argument that if event B followed event A then A caused B. That is not necessarily so. Also, I believe you were on a high dose of red yeast rice so you could also say that caused the problem.
In any case, it would be wise to not assume you know the cause of the problem but rather have it checked out. Could be something different.
Do you have one of those cars with an alarm systems and a device that will beep to help you find the car? If so, do you know the trick to increase its range?
Bill
Jason - 17 Mar 2006 19:31 GMT > >> > > > We both know those people that already have kidney problems may > >> develop [quoted text clipped - 43 lines] > > Bill Bill, Yes, I have one of those cars but the feature only words (at least on my car) when you are within about 20 yards of the car. Regarding the statins--I was taking Red Yeast Rice and the statin pills at the same time. However, the dosage level for the statin was only (Provachol 20 mg--one pill per day). I was only taking one Red Yeast Rice capsule per day. Many people take 40 mg statin pills or even 80 mg statin pills--they are taking a much higher dose of statins than I was taking. Even when I cut back to one half of a pill (10 mg) per day and no Red Yeast Rice capsules--I continued to have high creatinine levels. Jason
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Bill - 18 Mar 2006 04:40 GMT >> >> > In article <1142389572.578960.112680@j33g2000cwa.googlegroups.com>, >> >> > "Tony [quoted text clipped - 58 lines] > Yes, I have one of those cars but the feature only words (at least on my > car) when you are within about 20 yards of the car. Try putting the transmitter up under your chin while pressing the button. You may get slightly better range because your body acts as an antenna. Try to look in the general direction your car might be.
> Regarding the > statins--I was taking Red Yeast Rice and the statin pills at the same [quoted text clipped - 4 lines] > cut back to one half of a pill (10 mg) per day and no Red Yeast Rice > capsules--I continued to have high creatinine levels. This makes it less likely that statins of the past are now causing what ever problems you now have. But to the degree they do, the red yeast rice is also as likely a suspect. In fact the two in combination may have made things worse.
Bill
> Jason Jason - 19 Mar 2006 00:03 GMT > >> >> > In article <1142389572.578960.112680@j33g2000cwa.googlegroups.com>, > >> >> > "Tony [quoted text clipped - 78 lines] > > Bill Bill, Which is a higher dose of statins one 20 mg Lovastatin (Mecacor) pill plus one Red Yeast Rice Capsule
or
One 80 mg Lovastatin pill
I should note that "a daily dose of red yeast rice contains about 5 mg of lovastastin." source Dr. Cohen's statin book (page 103).
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Bill - 19 Mar 2006 03:01 GMT >> >> > In article <CAhSf.54489$H71.9194@newssvr13.news.prodigy.com>, >> >> > "hawki63" [quoted text clipped - 102 lines] > I should note that "a daily dose of red yeast rice contains about 5 mg of > lovastastin." source Dr. Cohen's statin book (page 103). I'll let you figure that out. But I thought you were taking the RYR in raw form.
Bill
Jason - 19 Mar 2006 04:53 GMT > >> >> > In article <CAhSf.54489$H71.9194@newssvr13.news.prodigy.com>, > >> >> > "hawki63" [quoted text clipped - 107 lines] > > Bill Bill, I don't know what was inside the RYR capsules that I purchased at the local health food store. It's possible that it was the raw form. I doubt that most people that take 80 mg statin pills realize that those pills are more likely to cause side effects than the 20 mg statin pills. Jason
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Bill - 19 Mar 2006 05:22 GMT >> >> >> > In article <CAhSf.54489$H71.9194@newssvr13.news.prodigy.com>, >> >> >> > "hawki63" [quoted text clipped - 132 lines] > more likely to cause side effects than the 20 mg statin pills. > Jason I think you are wrong there. Most people would realize that a higher dose of a drug is more likely to have side effects.
But nevertheless you took a higher does of statins than was prescribed. For most people they start you off at a low dose and see what happens. They do blood tests and see what your reaction is. If you have no problems, but your lipids are off, they may increase the dose.
Bill
Jason - 19 Mar 2006 05:52 GMT > >> >> >> > In article <CAhSf.54489$H71.9194@newssvr13.news.prodigy.com>, > >> >> >> > "hawki63" [quoted text clipped - 142 lines] > > Bill Bill, You are discussing how good doctors do it. Some doctors start out their patients on high dose statins. I am thankful that my doctor started me off of the 20 mg dose instead of the 80 mg dose. Imagine the damage that may have been done if I had combined ryr capsules with 80 mg statin pills. Dr. Cohen discusses the bad doctors in his book. Jason
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hawki63 - 19 Mar 2006 09:06 GMT > > >> >> >> "Jason" <jason@nospam.com> wrote in message news:jason-1603061436140001@66-52-22-80.lsan.pw-dia.impulse.net...
> > >> >> >> > In article <CAhSf.54489$H71.9194@newssvr13.news.prodigy.com>, > > >> >> >> > "hawki63" > > >> >> >> > > > >> >> >> >> "Jason" <jason@nospam.com> wrote in message news:jason-1503061517510001@66-52-22-98.lsan.pw-dia.impulse.net...
> > >> >> >> >> > In article > > >> >> >> >> > <1142389572.578960.112680@j33g2000cwa.googlegroups.com>, [quoted text clipped - 145 lines] > You are discussing how good doctors do it. Some doctors start out their > patients on high dose statins. Jason...
until and WHEN you start prescribing..please STOP making generalizations like the above...
"some" doctors start their patients on high dose statins?
and you know this ...BECAUSE you read it in a book??
Jason...ALL meds like statins,,blood pressure..diabetics etc are started at a LOW dose..and gradually increased...
Again..perhaps you live in..or know personally prescribers are not following the "standard of care"
hopefully they have good malpractice..cuz they likely will need it..
I am thankful that my doctor started me off
> of the 20 mg dose instead of the 80 mg dose. Imagine the damage that may > have been done if I had combined ryr capsules with 80 mg statin pills. Dr. > Cohen discusses the bad doctors in his book. > Jason Bill - 19 Mar 2006 09:28 GMT >> >> >> > In article <5goSf.21852$tb3.8043@newssvr24.news.prodigy.net>, >> >> >> > "Bill" [quoted text clipped - 180 lines] > Cohen discusses the bad doctors in his book. > Jason You are avoiding the issue. If you had any problems, you bear some resposibility because you took more than the prescribed amount of statins.
Who knows how much or how they interacted?
Bill
hawki63 - 19 Mar 2006 17:47 GMT > >> >> >> "Jason" <jason@nospam.com> wrote in message news:jason-1703061031000001@66-52-22-66.lsan.pw-dia.impulse.net...
> >> >> >> > In article <5goSf.21852$tb3.8043@newssvr24.news.prodigy.net>, > >> >> >> > "Bill" > >> >> >> > <xxx@yy.zz> wrote: > >> >> >> > > >> >> >> >> "Jason" <jason@nospam.com> wrote in message news:jason-1603061436140001@66-52-22-80.lsan.pw-dia.impulse.net...
> >> >> >> >> > In article <CAhSf.54489$H71.9194@newssvr13.news.prodigy.com>, > >> >> >> >> > "hawki63" > >> >> >> >> > > >> >> >> >> >> "Jason" <jason@nospam.com> wrote in message news:jason-1503061517510001@66-52-22-98.lsan.pw-dia.impulse.net...
> >> >> >> >> >> > In article > >> >> >> >> >> > <1142389572.578960.112680@j33g2000cwa.googlegroups.com>, [quoted text clipped - 180 lines] > > Bill hawki63 - 19 Mar 2006 18:01 GMT > >> >> >> "Jason" <jason@nospam.com> wrote in message news:jason-1703061031000001@66-52-22-66.lsan.pw-dia.impulse.net...
> >> >> >> > In article <5goSf.21852$tb3.8043@newssvr24.news.prodigy.net>, > >> >> >> > "Bill" > >> >> >> > <xxx@yy.zz> wrote: > >> >> >> > > >> >> >> >> "Jason" <jason@nospam.com> wrote in message news:jason-1603061436140001@66-52-22-80.lsan.pw-dia.impulse.net...
> >> >> >> >> > In article <CAhSf.54489$H71.9194@newssvr13.news.prodigy.com>, > >> >> >> >> > "hawki63" > >> >> >> >> > > >> >> >> >> >> "Jason" <jason@nospam.com> wrote in message news:jason-1503061517510001@66-52-22-98.lsan.pw-dia.impulse.net...
> >> >> >> >> >> > In article > >> >> >> >> >> > <1142389572.578960.112680@j33g2000cwa.googlegroups.com>, [quoted text clipped - 180 lines] > > Bill Bill....Jason continues to seek out evidence that it is the "bad doctors"...usually cited in some "book" he read that are the cause of all evil things that happen in medicine..including rare side effects..or even events that may or may not have any bearing upon the meds given...
asking Jason to take responsibility...will only lead him to find another book that backs up his lunancy..in practice we call the Jasons of the world he 'worried well"...cuz regardless of the evidence..they continue to seek out facts that confirm their preconceived notions...
just for fun...I did google on Jason from way back..about 18 months ago..maybe even his first post..he had posted his lab results...which he felt revealed the root of all of his problems..and that he blamed on "statins"...firstly his potassium was 3.4...which is low..tho he insisted in multiple postss that he KNEW he had hyperkalemia (??)...and that he cured himself of that by taking sodium bicarb and diuretics....many many of us attempted to point out to him that a/ it was highly unlikely,,if not impossible...to start with a potassium below normal and advance quiickly to hyperkalemia...simply by using a salt substitute...it takes literally pumping in potassium IV to raise the K that quickly..and again....no reputablee health care provider would do that..
also ...he listed his kidney function tests a.s BUN of 7 (very very low normal).. andd creatinine of 1.5....so he jumped to the conclusion that the statins had caused him "kidney damage"...tho Robert and a phyician continued to assure him that aa BUN of 7 is totally incompatible with kidney dysfunction....in fact..tho a creatinine of 1.5 is on the high side of normal...is it NOT evidence of "kidney damage"....one thing never mentioned is "lab error"...when two function tests don't correlate..that should always be considered..and both tests repeated...actually his next creatinine was .9/........of course he credited that with his stopping of statins..
my impression of Jason is of a lonely..pathetic 54 year old man...sincerely in need of some psych help..and someone needs to throw out all those books he reads incessantly..and whose parts he picks apart to provide evidence to "prove whatever point " he wants to..
hawki63 - 19 Mar 2006 19:39 GMT top posted
I just read my angry reply...and feel a need to explain
we are having a "crisis" here...as my hubby had a routine colonoscopy 2 weeks ago..eleven polyps found and removed...one was malignant
so he faces major surgery this tues...so far all the scans etc do NOT reveal any spread...Thank God
I guess it is hard to listen to whining at a time like this...
please send positive vibes on tues
thanks
> > >> >> > In article <EiLSf.21987$tb3.1651@newssvr24.news.prodigy.net>, > "Bill" [quoted text clipped - 18 lines] > news:jason-1503061517510001@66-52-22-98.lsan.pw-dia.impulse.net... > > >> >> >> >> >> > In article <1142389572.578960.112680@j33g2000cwa.googlegroups.com>,
> > >> >> >> >> >> > "Tony > > >> >> >> >> >> > Wesley" <tonywesley@gmail.com> wrote: [quoted text clipped - 244 lines] > he reads incessantly..and whose parts he picks apart to provide evidence to > "prove whatever point " he wants to.. Tony Wesley - 19 Mar 2006 21:15 GMT > top posted > [quoted text clipped - 5 lines] > so he faces major surgery this tues...so far all the scans etc do NOT reveal > any spread...Thank God Best of wishes to you and your husband. You'll need all of your strength, to be the calm one when he's upset and nervous. I hope and pray that all goes well.
> I guess it is hard to listen to whining at a time like this... It is. I too, have googled Jason's posts on occasion. I understand your feelings.
> please send positive vibes on tues Tuesday? Okay... positive vibes on the way, building to a peak on Tuesday.
Robert - 19 Mar 2006 22:40 GMT > > top posted > > [quoted text clipped - 5 lines] > > so he faces major surgery this tues...so far all the scans etc do NOT reveal > > any spread...Thank God Sorry to hear it. My prayers are with you and your husband.
hawki63 - 20 Mar 2006 08:00 GMT > > > top posted > > > [quoted text clipped - 8 lines] > > Sorry to hear it. My prayers are with you and your husband. thanks Robert
hawki63 - 20 Mar 2006 07:59 GMT > > top posted > > [quoted text clipped - 19 lines] > Tuesday? Okay... positive vibes on the way, building to a peak on > Tuesday. thanks...appreciate it..yes tues...first case...have to be there at 5am...
will check back
listener - 19 Mar 2006 22:37 GMT "hawki63" <hawki63@sbcglobal.net> wrote in news:FzhTf.2829$tN3.597 @newssvr27.news.prodigy.net:
> top posted > [quoted text clipped - 11 lines] > > thanks My thoughts and prayers are with you and your husband.
Positive vibes all the way...
L.
Hawki63@sbcglobal.net - 21 Mar 2006 00:43 GMT thanks so much...
> "hawki63" <hawki63@sbcglobal.net> wrote in news:FzhTf.2829$tN3.597 > @newssvr27.news.prodigy.net: [quoted text clipped - 21 lines] > > L. Bill - 20 Mar 2006 00:58 GMT > top posted > [quoted text clipped - 11 lines] > > thanks I'll be thinking about both of you. Why did they need to go back in? To double check on the malignant area? It looks like the colonoscopy did its job - to find little problems before they become big ones. Let's hope so anyway.
Thinking of you both.
Bill
>> > >> >> > In article <EiLSf.21987$tb3.1651@newssvr24.news.prodigy.net>, >> "Bill" [quoted text clipped - 300 lines] > to >> "prove whatever point " he wants to.. hawki63 - 20 Mar 2006 08:03 GMT > > top posted > > [quoted text clipped - 14 lines] > I'll be thinking about both of you. Why did they need to go back in? To double > check on the malignant area? the "margins were not clear" ...ie maybe a cancer cell or two escaped and is setting up houseskeeping somewhere else...
It looks like the colonoscopy did its job - to
> find little problems before they become big ones. Let's hope so anyway. very very true.....anyone who waits til they have "symptoms" of colon cancer...ie bleeding etc...are crazy...routine colos ..and early detection..are analgous to mammos and pap smears
> Thinking of you both. > > Bill thanks Bill...
> >> > >> >> "Jason" <jason@nospam.com> wrote in message news:jason-1803061503440001@66-52-22-65.lsan.pw-dia.impulse.net...
> >> > >> >> > In article <EiLSf.21987$tb3.1651@newssvr24.news.prodigy.net>, > >> "Bill" [quoted text clipped - 300 lines] > > to > >> "prove whatever point " he wants to.. Jason - 20 Mar 2006 01:16 GMT > >> >> >> > In article <5goSf.21852$tb3.8043@newssvr24.news.prodigy.net>, > >> >> >> > "Bill" [quoted text clipped - 4 lines] > >> >> >> >> > > >> >> >> >> >> "Jason" <jason@nospam.com> wrote in message news:jason-1503061517510001@66-52-22-98.lsan.pw-dia.impulse.net...
> >> >> >> >> >> > In article > >> >> >> >> >> > <1142389572.578960.112680@j33g2000cwa.googlegroups.com>, [quoted text clipped - 180 lines] > > Bill Bill, Excellent point. I admit that should not have done it. At the time, I did not know that ryr contained a statin. Once I found out, I stopped taking ryr capsules. I no longer take statins or ryr capsules. I continue to have some sort of kidney problem--My serum creatine is normal (1.0 MG/DL) but the urine creatinine is 17. 6 MG/DL (very low). The Urine Hemoglobin screen was Positive and the Reference range is Negative. I will be discussing these most recent test results with my doctor on Friday. What's your guess? All other things were within normal limits. (Note Serum BUN was 11 MG/DL (low side of normal limits). Jason Jason
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Bill - 20 Mar 2006 03:57 GMT >> >> >> > In article <EiLSf.21987$tb3.1651@newssvr24.news.prodigy.net>, >> >> >> > "Bill" [quoted text clipped - 227 lines] > Jason > Jason Far beyond me to guess. Could be multiple things.
Bill
hawki63 - 17 Mar 2006 05:57 GMT > > > > > We both know those people that already have kidney problems may > > develop [quoted text clipped - 29 lines] > exercise I have gotten as a result of walking around parking lots in > search of my car. sorry Jason...please do not use your 3 months of statins on every "problem" you perceive
you are excellent at making excuses.....
Tony Wesley - 15 Mar 2006 03:29 GMT > You make some excellent points. Statins have helped lots of people. > However, they have also caused many people to develop kidney problems. On the other hand:
Statins prevent kidney problems in heart patients
Reported by Susan Aldridge, PhD, medical journalist
A new clinical trial suggest that cholesterol-lowering statins protect heart patients from worsening kidney function. We already know that high cholesterol can lead to kidney disease and this can complicate heart problems. So it's interesting to learn that lowering cholesterol can protect the kidneys from deterioration.
Researchers in Greece are reporting upon the Greek atorvastatin and coronary heart disease evaluation (GREACE) study which covers 1,600 participants with heart disease who had normal kidney function at the start of the study. Half of them were treated with atorvastatin while the rest were assigned to low fat diet, exercise and weight loss.
At the end of three years, those on the statin had better kidney function than those who were not. [snip]
http://www.healthandage.com/default.cfm?curr_navi=01&curr_content=01&spr=en&fram edef=1&curr_paramlist=healthandage;5995;1;haa_online_from;2;1;3;-;dsp_tooldetail
James216440@yahoo.com - 14 Mar 2006 02:26 GMT > > jason@nospam.com (Jason) wrote in news:jason-1303061312460001@66-52-22- > > 22.lsan.pw-dia.impulse.net: [quoted text clipped - 98 lines] > We respect those subscribers that ask for advice or provide advice. > We do NOT respect the subscribers that enjoy criticizing people. Jason,
I hardly think you are being realistic in your negative assumption about AstroZenica. This is the very FIRST time any study has actually claimed to prove regression of plaque. Past studies with statins and other drugs either failed to find any measurable regression in plaques or the regressions found were statistically insignificant. Thus this claim for Crestor is a break through claim and as such is going to draw attention big time. If AstroZenica overclaimed at this stage they could find themselves with about as much credibility as a certain S. Korean scientist who made fabulous cloning claims that turned out to be lies. To overclaim at this point could backlash and kill the drug for them. So I think you can be very comfortable that the claims made are indeed accurate and will be reproduced.
The rub is if you go look at the actual numbers reported for regression they are mighty, mighty small. And I have not yet been able to get any data on type of plaque which regressed. Regressing a well calcified plaque is someplace between insignificant and negative re likely health outcomes. So, is a real, but very small reduction in plaque going to result in significant health benefits? And how long will any benefit last? The answers to both questions might be breakthrough. Or they might be a great disappointment. It does not look like we will have real data on health on this issue for years to come.
Jason - 15 Mar 2006 00:31 GMT > > > jason@nospam.com (Jason) wrote in news:jason-1303061312460001@66-52-22- > > > 22.lsan.pw-dia.impulse.net: [quoted text clipped - 123 lines] > might be a great disappointment. It does not look like we will have > real data on health on this issue for years to come. James, You make some excellent points. Statins have helped lots of people. However, they have also caused many people to develop kidney problems. As you may know, doctors do prescribe statins to people that have kidney problems. I read a book written by a doctor that is a kidney specialist and actually teaches at a Johns Hopkins University School of Medicine. He prescribes statins for his patients. We both know those people that already have kidney problems may develop even more medical problems as a result of taking statins. Studies like the one mentioned above will cause even more doctors to prescribe statins to patients--even if they have liver and kidney problems. Do you agree or disagree? Those high doses needed to cause the the regression that you mentioned in your post will cause lots of people to have side effects. As you may know, if a person takes a low dose of a statin--they are less likely to have side effects than if they took a high dose of that same statin. Jason
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Hawki63@sbcglobal.net - 15 Mar 2006 01:21 GMT >> > > jason@nospam.com (Jason) wrote in >> > > news:jason-1303061312460001@66-52-22- [quoted text clipped - 166 lines] > if a person takes a low dose of a statin--they are less likely to have > side effects than if they took a high dose of that same statin. actually that is not necessarily the case...if someone is going to have a side effect..the lowest dose..for the shortest period..can cause the side effect
Jason..
quit practicising medicine without a license
> Jason Sharon Hope - 15 Mar 2006 04:27 GMT >>> > > jason@nospam.com (Jason) wrote in >>> > > news:jason-1303061312460001@66-52-22- [quoted text clipped - 185 lines] > > quit practicising medicine without a license Sure, but Dr. Cohen's book discusses evidence that statin adverse effects, in particular, are dose related.
He also makes the point that the starting "lowest" dose approved is actually a mid-point, and far too high a dose for much of the population. Thus, 10 mg/day of Lipitor is too high for many, and it definitely was for my husband.
Now the Crestor study, which according to the Editorial did not look for nor list any adverse effects (can't find what you refuse to see), the mega doses will begin.
>> Jason Jason - 16 Mar 2006 00:22 GMT > >> > > jason@nospam.com (Jason) wrote in > >> > > news:jason-1303061312460001@66-52-22- [quoted text clipped - 174 lines] > > quit practicising medicine without a license Hello, If you disagree with me, you need to read this book. The author of the book explains why a low dose (of a statin) is less likely to cause side effects than a high dose of the same statin.
WHAT YOU MUST KNOW ABOUT STATIN DRUGS AND THEIR NATURAL ALTERNATIVES by Jay S. Cohen, M.D.
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Bill - 14 Mar 2006 02:49 GMT >> jason@nospam.com (Jason) wrote in news:jason-1303061312460001@66-52-22- >> 22.lsan.pw-dia.impulse.net: [quoted text clipped - 85 lines] > study that showed that smoking cigarettes helped people that had lung > disease--would you have trust in the study? That's a non-sequitor. The results of smoking on the lung are know to be negative wheras the bulk of the evidence shows the effects of statins on the heart are positive.
> I would have more trust in the study mentioned in the post if the study > had been done by a company or agency that was not linked to any company [quoted text clipped - 4 lines] > study. > Jason I don't know what "any sign" means. What exactly is the criteria? But yes they leave people with all sorts of illnesses out. And if you have liver disease (and maybe kidney disease) you should probably should not be on a statin.
Bill
Jason - 15 Mar 2006 00:25 GMT > >> jason@nospam.com (Jason) wrote in news:jason-1303061312460001@66-52-22- > >> 22.lsan.pw-dia.impulse.net: [quoted text clipped - 104 lines] > > Bill Bill, You make some excellent points. Statins have helped lots of people. However, they have also caused many people to develop kidney problems. As you may know, doctors do prescribe statins to people that have kidney problems. I read a book written by a doctor that is a kidney specialist and actually teaches at a Johns Hopkins University School of Medicine. He prescribes statins for his patients. We both know those people that already have kidney problems may develop even more medical problems as a result of taking statins. Studies like the one mentioned above will cause even more doctors to prescribe statins to patients--even if they have liver and kidney problems. Do you agree or disagree? Jason
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Bill - 15 Mar 2006 00:52 GMT >> >> jason@nospam.com (Jason) wrote in news:jason-1303061312460001@66-52-22- >> >> 22.lsan.pw-dia.impulse.net: [quoted text clipped - 125 lines] > disagree? > Jason Yes if the results are backed up by other studies, and that's a good thing. One must know the type of problem and whether it is sensitive to a statin. Kindney stones would not be, for example. In fact, I did not see any warnings about kidney problems with Crestor. With liver problems, it depends on the nature of the problem. They should only go ahead after weighing the risk/benefits with the patient and do frequent blood tests if the do go ahead.
Bill
listener - 14 Mar 2006 02:50 GMT jason@nospam.com (Jason) wrote in news:jason-1303061630180001@66-52-22- 17.lsan.pw-dia.impulse.net:
>> jason@nospam.com (Jason) wrote in news:jason-1303061312460001@66-52-22- >> 22.lsan.pw-dia.impulse.net: [quoted text clipped - 93 lines] > study. > Jason I hope you can see from my replies above that I am not taking this new study at face value. I also think equating cigarettes with statins is a poor analogy. To suggest that the incidents of AE and death from smoking is somehow comparable to AE and death from statins is just not supportable. The terrible Baycol debacle a few years ago caused approx. 100 deaths. According to the CDC, 440,000 annual deaths each year are smoking-associated.
I do not disagree that, to some extent, companies may have a built-in bias but that does not mean that studies done by or funded by them are necessarily corrupt or invalid. Plus, there have been sufficient, *independent* studies done that do show some benefit to statin use.
Personally, I think a med that would actually reverse heart disease in some way would be a remakable discovery. Don't you? I'm open to that possiblity, you're apparently are not.
L.
Jason - 15 Mar 2006 00:24 GMT > jason@nospam.com (Jason) wrote in news:jason-1303061630180001@66-52-22- > 17.lsan.pw-dia.impulse.net: [quoted text clipped - 132 lines] > > L. L., You make some excellent points. Statins have helped lots of people. However, they have also caused many people to develop kidney problems. As you may know, doctors do prescribe statins to people that have kidney problems. I read a book written by a doctor that is a kidney specialist and actually teaches at a Johns Hopkins University School of Medicine. He prescribes statins for his patients. We both know those people that already have kidney problems may develop even more medical problems as a result of taking statins. Studies like the one mentioned above will cause even more doctors to prescibe statins to patients--even if they have liver and kidney problems. Do you agree or disagree? Jason
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Hawki63@sbcglobal.net - 15 Mar 2006 01:18 GMT >> jason@nospam.com (Jason) wrote in news:jason-1303061630180001@66-52-22- >> 17.lsan.pw-dia.impulse.net: [quoted text clipped - 136 lines] > You make some excellent points. Statins have helped lots of people. > However, they have also caused many people to develop kidney problems. no Jason....not lots of people...some...very few actually
unless you have a scientific quote to back that up
As
> you may know, doctors do prescribe statins to people that have kidney > problems. I read a book written by a doctor that is a kidney specialist > and actually teaches at a Johns Hopkins University School of Medicine. He > prescribes statins for his patients. depends on WHAT you define as "kidney problems" doesn't it??
do you TRULY think a reputable nephrologist would "prescribe statins"..etc to ANY of his patients to whom the risk might outweigh the benefit??
if you do...you must think this doc..and all others...don't know the meaning ofmalpractice
> We both know those people that already have kidney problems may develop > even more medical problems as a result of taking statins. Studies like the > one mentioned above will cause even more doctors to prescibe statins to > patients--even if they have liver and kidney problems. Do you agree or > disagree? again..totally disagree...what you ..and others refuse to accept is that the GOOD doctors who care about their patients..not to mention don'tlike the word malpractice...do NOT prescribe meds like statins without pre and frequent kidney and liver studies...
your blunt comment of "liver and kidney problems" indicates that you probably don't know the difference between ..say a bladder infection (is that a kidney problem??) or diminished kidney function..measured by creatinines etc...
medical providers are NOT as stupid as your "books" lead you to believe...
so quit making assumptions based upon your limited exposure ...
"a thimble full of knowledge...a basketful of mouth"
> Jason Sharon Hope - 15 Mar 2006 06:39 GMT Hawki,
Suggest you send the same lecture to the UPI Senior Editor, who wrote this article, using the kind of term you have outlawed, "KIDNEY DAMAGE" (actually, quoting from Consumer Reports, who used that term you have outlawed, "KIDNEY DAMAGE", so you had better also send them your lecture aimed at Jason at the end of this message):
http://www.upi.com/ConsumerHealthDaily/view.php?StoryID=20060314-114327-7082r
Consumer Health HealthWrap: The heart-disease dilemma By DAN OLMSTED UPI Senior Editor
Indisputably good news has emerged from the cardiologists' convention this week in Atlanta: A study shows the anti-cholesterol drug Crestor reversed the effects of atherosclerosis in patients with evidence of coronary artery disease.
<Snip>
We hate to rain on this parade -- and, in fact, we hope the study points the way to a new era of heart-healing medication -- but it's important to remember one sobering fact: Pharmaceuticals have side effects. And sometimes, the more effective they are, the more potent those effects.
<Snip>
In January the independent Consumer Reports listed 12 drugs "having known or suspected serious risks that were undetected or underestimated when the FDA approved them." While appropriate in some cases, the magazine said, the risks are sufficiently serious that until more is known, "these drugs should be prescribed only when other options have failed, be avoided by people whose medical conditions make them especially vulnerable to harmful reactions, and used only with careful monitoring for adverse reactions."
One of the 12 was Crestor, which Consumer Reports said may cause "muscle breakdown, kidney damage. (Other statins may have similar risks, but current evidence appears stronger for Crestor, especially at high doses and in Asian-Americans.)"
<Snip - READ THE FULL ARTICLE AT THE LINK PROVIDED>
>>> jason@nospam.com (Jason) wrote in news:jason-1303061630180001@66-52-22- >>> 17.lsan.pw-dia.impulse.net: [quoted text clipped - 191 lines] > >> Jason Bill - 15 Mar 2006 07:57 GMT > Hawki, > [quoted text clipped - 3 lines] > outlawed, "KIDNEY DAMAGE", so you had better also send them your lecture > aimed at Jason at the end of this message): You do it again. You quote a reliable source but distort the quote. It says "May Cause Kidney Damage" not that it does. You claim that Hawki outlawed the use of the words "Kidney Damage" she did not and you provided nothing to back up that claim.
Bill
> http://www.upi.com/ConsumerHealthDaily/view.php?StoryID=20060314-114327-7082r > [quoted text clipped - 214 lines] >> >>> Jason Jason - 16 Mar 2006 00:11 GMT > >> jason@nospam.com (Jason) wrote in news:jason-1303061630180001@66-52-22- > >> 17.lsan.pw-dia.impulse.net: [quoted text clipped - 176 lines] > > "a thimble full of knowledge...a basketful of mouth" You made some great points. If you want to read the book--the title is
"Coping With Kidney Disease" by Mackenzie Walker, M.D. (kidney specialist) He teaches at Johns Hopkins University School of Medicine.
He has treated patients that have various types of kidney disease that have very high chol. levels. In those situations--statins are about the only way of bringing down those chol. levels. If the patients develop problems, he precribes other types of statins or discontinues statins. I did not mean to imply that the doctor does not care about the health of his patients.
It's my guess that lots of doctors prescribe statins to people that have liver and kidney problems. Do you agree or disagree?
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hawki63 - 16 Mar 2006 05:35 GMT > > >> jason@nospam.com (Jason) wrote in news:jason-1303061630180001@66-52-22- > > >> 17.lsan.pw-dia.impulse.net: [quoted text clipped - 146 lines] > > > and actually teaches at a Johns Hopkins University School of Medicine. He > > > prescribes statins for his patients. Jason...you read way too many books that you cannot understand given your limited medical knowledge
re: statins and kidney disease (from my prescribing reference).....
"myopathy/rhabdomyolsis...RARE instances of above with acute renal failure have been reported" so..yes...statins have a risk of rhabdo...which is rare...
further on "dosage in patients with renal insufficiency...no modification of dosage for patients with MILD to MODERATE renal insufficiency.....with severe pre existing impairment,,not on dialysis...should be started at 5mg..and not exceed 10mg...plus obviously renal function must be monitored"
what that means Jason..is that renal patients have a very high risk of CV disease...so NOT giving them statins may make their prognosis worse....risk/benefit ratio...
BTW...there is NO evidence that the rare cases of rhabdo occurred in patients with pre existing renal insufficiency..
NOR is renal insufficiency considered a contraindication..
so Jason...tho rhabdo CAN cause acute renal failure...it can with the same rareness in those with normal as abnormal renal function.... ALLL meds given to those with measurable renal impairment are given at much lower doses..but to say that "statins cause kidney problems"..thus the fact that a nephrologist is using it for his patient population indicates that you have not a clue as to what actually constitutes risk/benefit ratio
in the same source..under contraindications "crestor is contraindicated in patients with "active liver disease"....PLUS even those who begin treatment with NORMAL liver function are monitored at regular intervals...KNOWING that this class of drugs can affect the liver...again risk/benefit ratio...if you know of a drug that has NO risks..yet has benefits...you deserve a Nobel prize...
why just the other night on that new "miracles" show...a guy who received ONE course of penicillin ended up blind !!(the miracle concerned stem cells and transplants that restored his sight after 22 years of blindness
WHAT?? penicillin can cause blindness?? well.....gollee..better pull it all off the shelves where it cannot cure infections in the 99/999999% of the population that don't become blind
> > depends on WHAT you define as "kidney problems" doesn't it?? > > [quoted text clipped - 6 lines] > > > We both know those people that already have kidney problems may develop > > > even more medical problems as a result of taking statins. again...you are wrong...or your definition of kidney problems is wayyyy skewed......
Studies like the
> > > one mentioned above will cause even more doctors to prescibe statins to > > > patients--even if they have liver and kidney problems. Do you agree or [quoted text clipped - 30 lines] > It's my guess that lots of doctors prescribe statins to people that have > liver and kidney problems. Do you agree or disagree? Tony Wesley - 16 Mar 2006 06:32 GMT > why just the other night on that new "miracles" show...a guy who received > ONE course of penicillin ended up blind !!(the miracle concerned stem cells [quoted text clipped - 3 lines] > off the shelves where it cannot cure infections in the 99/999999% of the > population that don't become blind I didn't know it could cause blindness. I did have a minor AE from penicillin when I was a kid, my arm swelled up. The doctor said I was allergic to penicillin and I had to be very carefull not to take it again. As I recall, he explained that after one allegric reaction, the body's sensitivity increases greatly and a second dose could kill me.
I just googled and found this page:
Deaths from Penicillin allergy: 400 deaths annually among Americans (NIAID)
Source: http://www.wrongdiagnosis.com/p/penicillin_allergy/prognosis.htm
-----
Contrast that to Baycol:
The maker of Baycol (cerivastatin), a popular cholesterol-lowering drug used by about 700,000 Americans, voluntarily pulled the medicine off the market August 8 because of numerous deaths associated with its use.
Officials at the Food and Drug Administration said 31 people have died of complications of severe muscle breakdown [...]
Source: http://www.mercola.com/2001/aug/18/baycol.htm
hawki63 - 16 Mar 2006 18:54 GMT > > why just the other night on that new "miracles" show...a guy who received > > ONE course of penicillin ended up blind !!(the miracle concerned stem cells [quoted text clipped - 5 lines] > > I didn't know it could cause blindness. precisely my point...this poor soul experienced the side effect of ALL side effects...I also have never heard of Penicillin causing blindness
your quote also proved a point....400 deaths per year from penicillin allergic reactions...vs 31 from Baycol
which med would you yank...??
I did have a minor AE from
> penicillin when I was a kid, my arm swelled up. The doctor said I was > allergic to penicillin and I had to be very carefull not to take it [quoted text clipped - 21 lines] > > Source: http://www.mercola.com/2001/aug/18/baycol.htm Larry - 17 Mar 2006 00:03 GMT >>>>>jason@nospam.com (Jason) wrote in > [quoted text clipped - 425 lines] >>It's my guess that lots of doctors prescribe statins to people that have >>liver and kidney problems. Do you agree or disagree? Finally someone with some "balanced" sense has posted to this NG. He doesn't deny that there are adverse effects, but he make complete sense that the drugs must continue to be used. It is up to you ask to whether or not you want to take what is in reality a small risk.
Larry E.
hawki63 - 17 Mar 2006 01:24 GMT > >>>>>jason@nospam.com (Jason) wrote in > > [quoted text clipped - 432 lines] > > Larry E. Larry...
I hope you are referring to me...tho I am a "she" not a he...
As a health care professional...I am a nurse practitioner with 40 years experience in the medical field...I cannot let the Jasons of the world who "read books"...extrapolate as innaccurately as he does...time and again
Sharon Hope is an entirely different story....Sharon has had a personal and frustrating experience with her husband...
but her comments almost NEVER are totally innaccurate...
and I cannot condemn her for her anti statin stance...
the saying always is "doesn't matter how few experience a risk related to a med or treatment...if it is YOU or your loved one...then it IS a 100% risk"
again..hopefully your "compliment " was meant for me...
Sharon Hope - 17 Mar 2006 04:42 GMT >> >>>>>jason@nospam.com (Jason) wrote in >> > [quoted text clipped - 487 lines] > > again..hopefully your "compliment " was meant for me... Thanks, that means a lot coming from you.
It strikes me that there is no general denial about penicillin, so there is no outcry against "I'm allergic to penicillin" bracelets, and doctors routinely ask about penicillin and other drug allergies when taking a patient's history. (and my husband now always answers "Lipitor" even though the mechanism of the AEs is not like an allergen.)
That general acceptance of adverse effects, and thereby appropriate precautions, are what seems to be missing with statin drugs. Given that they are the most prescribed class of drugs in the world, and in the history of the world, the 'rare' adverse effects can appear in a significant count of people.
My dad has been allergic to penicillin for as long as I can remember, and I have never heard any 'blame the patient' comments about that, never. Yet the denial of the statin AEs (while everyone says all drugs have AEs and agrees in the abstract) seems to generate attacks on the patient and those seeking treatment, and those attempting to warn others of the unpublicized and unacknowledged dangers.
Not saying you have done this, Hawki, just a general observation.
Why do you think there is such a drastic difference in the general reaction to AEs from the two drugs?
hawki63 - 17 Mar 2006 06:04 GMT > >> >>>>>jason@nospam.com (Jason) wrote in > >> > [quoted text clipped - 513 lines] > Why do you think there is such a drastic difference in the general reaction > to AEs from the two drugs? very interesting question...to which I don't have an answer
perhaps it is too soon to extrapolate that as many folks taking statins will be wearing "allergy" bracelets in the future...
tho ...the adverse reaction to penicillin is truly of an allergic nature..ie...sets up the cascade that causes the rash..the difficulty breathing..and worst case scenerio...anaphylactic reaction and maybe death
so...even tho statin problems such as those you know of can be devestating...they are not allergic in the true sense of the word...
adverse and allergic are not the same animal
similar..but not the same
Jim Chinnis - 17 Mar 2006 06:13 GMT "hawki63" <hawki63@sbcglobal.net> wrote in part:
>> Why do you think there is such a drastic difference in the general >reaction [quoted text clipped - 15 lines] > >similar..but not the same Antibiotics are now being blamed for causing asthma years later when used in infancy. Some AEs are hard to discover, even after many years. I suspect that all drugs have such risks, at least to a few unlucky souls. -- Jim Chinnis Warrenton, Virginia, USA
Bill - 17 Mar 2006 09:58 GMT >>> >>>>>jason@nospam.com (Jason) wrote in >>> > [quoted text clipped - 499 lines] > Why do you think there is such a drastic difference in the general reaction > to AEs from the two drugs? I don't think there is. When a Dr. mentions the AEs of Lipitor, for example, he may note that there some muscle problems occasionally, but they are often small and typically reverse when the drug is discontinued. Rarely serious non-reversable problems develop. No one would have a negative reaction to that.
But if the person claiming the AE is not being truthful, for example claiming that it has been proven that Transient Global Amnesia occurs in greater than 2% of all Lipitor takers, then there may be a strong rebuttal - which has nothing to do with Lipitor, just with being factually accurate.
The more appropriate question is why are you so obviously hateful toward statins to the point of denying the benefits shown in trails and making up AEs which are more rumors than anything proven?
Bill
Larry - 17 Mar 2006 18:00 GMT snip
>>Finally someone with some "balanced" sense has posted to this NG. He >>doesn't deny that there are adverse effects, but he make complete sense [quoted text clipped - 22 lines] > > again..hopefully your "compliment " was meant for me... Frankly, this thread has become so convuluted that I can't pick out the exact quotes that caused me to issue the "compliment". I am looking for anything "balanced" and not one-sided or unfairly biased. As an example ... if someone posts that cigarette smoking causes lung-cancer, I really don't object to that because it's a well-proven fact that is substantiated by study after study and is well-accepted and well-known in the current medical community. This would not be a biased remark. But if someone posts saying that cell phone usage causes brain cancer ... that is a biased remark because it is NOT accepted (at least as of yet) as something that has been substantiated consistently by large studies over and over. In fact, there have been studies that conclude that they do and that they don't.
Same thing for statins, and same thing for most of Sharon's posts. I have said myself previously that I don't blame Sharon for her stance and I feel bad that her husband has suffered. But I disagree with you slightly ... when someone takes words out of context from studies to make it sound like those studies support their biased view (and by making it sound like that biased view is commonly accepted fact), or when someone misrepresents the larger body of evidence out there by making assertions and then only quoting the studies that suppor that view ... not only is this not balanced, it really is "inaccurate" ... and it is misleading.
You are right ... if there are only a small % of people who experience an adverse effect ... once it hits you or someone in your family, to you ... it is 100%. In fact, while my Dad has been on a statin for many years and I honestly believe it has saved his life, my Mom tried them and couldn't tolerate even the immediate short-term side effects. She has since been placed on one that with the absolute lowest dosage ... she seems to be tolerating. So for her, even though the drugs maybe cause those side effects in a very small % of patients, she DID experience them.
It is certainly appropriate to warn people OF THE RISK of adverse effects ... absolutely! It is certainly worthwhile to relate your own personal experience and try to help others avoid similar experiences by making constructive suggestions. But it is not appropriate and misleading to misrepresent the facts and try to pull the wool over people's eyes.
What is appropriate? Let people know about your own experience, but also let people know what the facts really are ... or at least choose language that acknowledges that these are your personal experiences and the experience of others ... but maybe not representative of ALL experiences. All drugs have adverse effects ...we know that. But the facts are that the adverse effects usually occur in a very small % of the population. Let people know what those % are (vs. "STATINS CAUSE ______")and let them make their own informed decision. Advise patients to question doctors when they prescribe meds. Advise patients to question pharmacists about meds. Advise patients to research meds that have been prescribed by researching their adverse effects on the internet (by Sharon as well as more unbiased sources). Advise patients to go for second opinions. etc, etc.
Larry E.
Jason - 17 Mar 2006 19:39 GMT > >>>>>jason@nospam.com (Jason) wrote in > > [quoted text clipped - 432 lines] > > Larry E. Larry, I have done lots of research on statins and have came to the conclusion that some people can take statins and have NO side effects but that other people have all sorts of serious side effects when they take statins. My main problem with statins is that many (perhaps most) doctors do not discuss statin side effects with their patients. In addition, they should also encourage their patients to try new diet plans and exercise plans prior to prescribing statins. My doctor done NONE of those things. I have learned from my research that many doctors are very much like my previous doctor. They prescribe statins without first discussing side effects, exercise plans or diet plans. Those doctors should also conduct kidney and liver function blood tests (and examine the results) prior to prescribing statins. I have a lot of respect for doctors that do these things. However, most of them don't do these things. Jason
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Larry - 17 Mar 2006 19:54 GMT >>>>>>>jason@nospam.com (Jason) wrote in >>> [quoted text clipped - 448 lines] > However, most of them don't do these things. > Jason Jason ...I can completely understand that point of view ... it makes complete sense. But as I said in a previous post:
"If a doctor does this, there is a certain amount of ownness on you as the patient to question it. I question nearly every recommendation that my doctors give me asking if there are other options ... and whether what they are recommending is really necessary. To a certain degree, you must take responsibility as a patient for your own care. Even with cancers, the right treatment option isn't always obvious and all oncs can do is to help you better understand the options ... you must make the final choice. Few patients realize how empowered they are and that is one of the biggest issues we face. The physician should be viewed as a consultant and since they are humans, they are not perfect.
Lastly, although I am not a physician ... I could see where there could be situations where I would as a physician recommend that changing the diet be tried first ... but there could very well be others where it wouldn't be advisable and I might need to recommend that a patient immediately be placed on a statin. So ... perhaps a 45 y/o man in otherwise good health has angina and has an elevated cholesterol ... but his stress test/thallium/possibly angiography show minimal or partial occlusions. Makes sense here to try diet first. A 75 y/o man with 80% occlusions who is diabetic with aggressive cardiac disease and who is already not eating a lot of fatty foods ... whose occlusion % has changed from 50% to 80% in the past year ... might be a situation where I could see needing to go directly to a statin."
Larry E.
listener - 15 Mar 2006 03:45 GMT jason@nospam.com (Jason) wrote in news:jason-1403061524310001@66-52-22- 67.lsan.pw-dia.impulse.net:
> L., > You make some excellent points. Statins have helped lots of people. [quoted text clipped - 9 lines] > disagree? > Jason I completely disagree.
L.
David Rind - 14 Mar 2006 02:58 GMT > [Note: Original subject line - I did not make it up] > > ATLANTA - People in a new study got their "bad cholesterol" to the lowest > levels ever seen and saw blockages in their blood vessels shrink by > taking a high dose of cholesterol drug, researchers reported Monday. The article is available free online at the JAMA website. Rather than reading the article, though, I'd suggest reading the accompanying editorial which points out a number of the problems with this study.
 Signature David Rind drind@caregroup.harvard.edu
listener - 14 Mar 2006 03:26 GMT David Rind <drind@caregroup.harvard.edu> wrote in news:dv57s9$h66$1 @reader2.panix.com:
>> [Note: Original subject line - I did not make it up] >> [quoted text clipped - 5 lines] > reading the article, though, I'd suggest reading the accompanying > editorial which points out a number of the problems with this study. The ASTEROID Trial article:
http://jama.ama-assn.org/cgi/content/full/295.13.jpc60002v1
The editorial:
http://jama.ama-assn.org/cgi/content/full/295.13.jed60019v1
L.
Jim Chinnis - 14 Mar 2006 03:40 GMT David Rind <drind@caregroup.harvard.edu> wrote in part:
>> [Note: Original subject line - I did not make it up] >> [quoted text clipped - 5 lines] >reading the article, though, I'd suggest reading the accompanying >editorial which points out a number of the problems with this study. The editorial is excellent. Very good discussion of some of the broader issues and research underway. -- Jim Chinnis Warrenton, Virginia, USA
Sharon Hope - 15 Mar 2006 07:05 GMT Thanks David!
Comments and cautions are rolling in. Per http://www.upi.com/ConsumerHealthDaily/view.php?StoryID=20060314-114327-7082r HealthWrap: The heart-disease dilemma By DAN OLMSTED UPI Senior Editor
Indisputably good news has emerged from the cardiologists' convention this week in Atlanta: A study shows the anti-cholesterol drug Crestor reversed the effects of atherosclerosis in patients with evidence of coronary artery disease.
AstraZeneca's Crestor is a statin, a class of drug used to treat high cholesterol. Evidence of their beneficial effects has been mounting. In fact, rival pharmaceutical manufacturer Pfizer issued a statement Monday downplaying the Crestor study.
"This is not the first time a statin has demonstrated plaque regression," Pfizer said in its statement. "The REVERSAL trial compared treatment with Lipitor 80 mg to another lipid lowering agent over 18 months. In a subset of high-plaque burden patients, Lipitor demonstrated a 5.9 percent ... total plaque reduction with excellent toleration."
<ALL: Excerpts here for emphasis, READ the entire article at the link provided)
But Graham went on to cite five other drugs he said are putting people at risk: Meridia, Accutane, Serevent, Bextra -- and, yes, Crestor.
Nor was Graham the only one to sound an alarm. Public Citizen Health Research Group, led by the redoubtable Dr. Sidney Wolfe, has tried to get it recalled.
<snip> One of the 12 was Crestor, which Consumer Reports said may cause "muscle breakdown, kidney damage. (Other statins may have similar risks, but current evidence appears stronger for Crestor, especially at high doses and in Asian-Americans.)"
It is at the high dose that Crestor appears to reverse plaque. Again, we're thrilled that anything appears to undo damage that can and does kill many people. It's just important to remember that any decision to take a drug requires a careful balancing of risks and benefits -- and, ultimately, that is a decision only the patient can make.
<snip>
>> [Note: Original subject line - I did not make it up] >> [quoted text clipped - 5 lines] > reading the article, though, I'd suggest reading the accompanying > editorial which points out a number of the problems with this study.
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