Anyone (else) run into the problem of sleepiness when adding lisinopril
(10 mg) to HCTZ (25 mg, for one month)? I took the first pill in mid
afternoon and when I got sleepy, decided to "take a nap". I did wake up
twice, but by the next morning had slept 11+ hours (6+ is normal). Other
differences I noticed were clumsiness, plugged ears and a runny nose. (I
do have an Onrom 711 and while my sbp had dropped about 15 points, it was
in normal range.)
Called the MD's office and he was sceptical that lisinoprol could cause
those symptoms. He offered the options of continuing for a week or being
switched to Diovan. (My next scheduled appointment is in 4 weeks.) Since
the main reason I find to take Diovan is that it is less likely to produce
the cough side effect, I opted to continue, but I've reduced the dosage to
approx. 2/3 pill and the HCTZ to 1/2. After two more days, still have the
side-effects and the sbp is back up in 140-155 range.
I'm now understanding why people drop bp treatment. I'm female, 70,
otherwise in good health and ISH seems to be par for the course. I'm
physically active (ok, not as active in the winter) and with the HCTZ
alone, I was not pleased with my reduced exercise tolerance. Imo, there
must be a point of diminishing returns in reducing bp to the ideal range
in some patients. Otoh, I do appreciate that treating high bp must be a
frustrating experince for MDs; similar to treating excess weight.
Dionysus - 20 Jan 2006 18:48 GMT
> Anyone (else) run into the problem of sleepiness when adding lisinopril
> (10 mg) to HCTZ (25 mg, for one month)? I took the first pill in mid
[quoted text clipped - 19 lines]
> in some patients. Otoh, I do appreciate that treating high bp must be a
> frustrating experince for MDs; similar to treating excess weight.
Started Lisinopril a year ago. After about a month developed Peripheral
Neuropathy.
Doctor said Lisinopril could not cause this but web research showed this to
be a possible side effect. Had extensive testing for cause of Peripheral
Neuropathy at Johns Hopkins. Tests did not reveal a cause. I quit taking
the Lisinipril and now control my BP with diet and exercise.
Peabody - 20 Jan 2006 23:01 GMT
Ann says...
> I'm now understanding why people drop bp treatment. I'm
> female, 70, otherwise in good health and ISH seems to be
[quoted text clipped - 5 lines]
> that treating high bp must be a frustrating experince
> for MDs; similar to treating excess weight.
It's an interesting question as to whether, for a 70
year-old woman, blood pressure in the 140-155 range is
likely to cause any problems, or whether reducing it through
drugs is likely to favorably affect morbidity or mortality.
This question remains unsettled with regard to cholesterol,
and the same may be true for blood pressure.
In my experience, doctors these days are completely focused
on the frigging test numbers, and completely uninterested in
the effects on your quality of life of the drugs they give
you to achieve those numbers.
I don't know about the Lisinopril. I tried it for a few
months with no problems, but it had virtually no effect on
my BP.
Derek F - 20 Jan 2006 23:28 GMT
> Anyone (else) run into the problem of sleepiness when adding lisinopril
> (10 mg) to HCTZ (25 mg, for one month)? I took the first pill in mid
[quoted text clipped - 19 lines]
> in some patients. Otoh, I do appreciate that treating high bp must be a
> frustrating experince for MDs; similar to treating excess weight.
I developed a widespread itch, rash and blotches after being prescribed
lisinopril. My GP did not believe it was brought on by the drug. I went to a
dermatologist and his diagnosis was instant, "Drug induced, stop taking
lisiniprol and it will be gone in three weeks"
Derek.
Don Kirkman - 21 Jan 2006 00:30 GMT
It seems to me I heard somewhere that Ann wrote in article
<pan.2006.01.20.18.08.44.246177@epix.net>:
>Anyone (else) run into the problem of sleepiness when adding lisinopril
>(10 mg) to HCTZ (25 mg, for one month)? I took the first pill in mid
[quoted text clipped - 3 lines]
>do have an Onrom 711 and while my sbp had dropped about 15 points, it was
>in normal range.)
I've been on Lisinopril 20mg for several years (probably around five,
but I've forgotten when I started), but never in combination with
HCTZ--my other prescription meds are Lipitor 80mg (7+ years) and
atenolol 12.5mg (about 5 years). No problems with any of the three,
liver tests are clean, and I remain physically active (age 77).
I know a negative report may not help much, but it may help you focus
your search for the trigger.
Good luck.

Signature
Don Kirkman
Ann - 22 Jan 2006 09:16 GMT
Thanks to all for the replies; they were helpful.
Good news/bad news. After two more days of being zonked, I was less
sleepy and bp was into preferred range. But, the plugged ears became
tinnitus. Also, some mild itchiness similar to signs of a food allergy.
Last dose, I did cut out the HCTZ entirely. According to one
manufacturer's dosage instructions for a combo pill, that's what should be
done in the first place for 70+ers, That is, discontinue HCTZ for 2-3
days, then try the patient on lisinitrol alone ... then go to the combo if
there are no problems.
I had a family member who got into a situation where she was taking two
diuretics, potassium, an ACE/HCTZ como, verapamil, and toprol + misc heart
meds and misc misc meds. One day when I went to see her at meds time
(assisted living facility), was surprised to see that two asthma inhalers
had been added. She never had allergies and claratin had already been
prescibed. Now I realize that it was likely to combat side effects of
other meds. (Yes, she did have only a single primary care MD.) She did
"live" to be 90, but at quite a price. But seeing that scenario did
clarify for me what my choices would be.
Thanks again ...
Grant - 28 Jan 2006 07:46 GMT
I've been on Lisinopril 20mg for several years in combination with Atenolol
and Norvasc. Never had a problem related to these drugs.
George
> Anyone (else) run into the problem of sleepiness when adding lisinopril
> (10 mg) to HCTZ (25 mg, for one month)? I took the first pill in mid
[quoted text clipped - 19 lines]
> in some patients. Otoh, I do appreciate that treating high bp must be a
> frustrating experince for MDs; similar to treating excess weight.
Andrew B. Chung, MD/PhD - 28 Jan 2006 11:16 GMT
> I've been on Lisinopril 20mg for several years in combination with Atenolol
> and Norvasc. Never had a problem related to these drugs.
Many don't.
Will be available to "glow" and chat about this and other things like
cardiology, diabetes, cooking and nutrition that interest those
following this thread here during the next on-line chat (02/02/06) from
6 to 7 pm EST:
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For those who are put off by the signature, my advance apologies for
how the LORD has reshaped me:
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Prayerfully in Christ's love,
Andrew
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