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Medical Forum / General / Cardiology / October 2005Hypertension , strange pattern .
I find my hypertension very unstable after I became T2 diabetic . My diabetes is very much on the control with Metformin - twice daily . Recently I was advised 1500 grams of calcium after bone density scan . I find my BP is normal in the mornings and slowly builds up during afternoon and after my dinner it reduces back to near normal levels . What is this strange phenomenon due to ? Any help and suggestions are welcome . Kam > I find my hypertension very unstable after I became T2 diabetic . My > diabetes is very much on the control with Metformin - twice daily . [quoted text clipped - 6 lines] > > Kam Kam, I suggest that you copy and post your message in this newsgroup: misc.health.diabetes I also suggest that you read this book since it explains in detail how the kidneys work. "Coping With Kidney Disease--A 12 Step Program to Help You Avoid Dialysis" by Mackenzie Walser, M.D. (kidney specialist) Those people at the diabetes newsgroup might be able to tell you about other books that could help you. Jason  SignatureNEWSGROUP SUBSCRIBERS MOTTO We respect those subscribers that ask for advice or provide advice. We do NOT respect the subscribers that enjoy criticizing people. > I find my hypertension very unstable after I became T2 diabetic . My > diabetes is very much on the control with Metformin - twice daily . [quoted text clipped - 6 lines] > > Kam What are your diet and activity like? Do you eat or supplement for adequate magnesium and potassium? How long have you been taking metformin? Susan > What are your diet and activity like? Do you eat or supplement for > adequate magnesium and potassium? How long have you been taking metformin? > > Susan I am on metformin for the last 3 yrs . I take one centrium silver a day . I am a vegeterian but do eat eggs , cheese and dairy products . I take long walks regularly . I hope this helps . Kam > > What are your diet and activity like? Do you eat or supplement for > > adequate magnesium and potassium? How long have you been taking metformin? [quoted text clipped - 6 lines] > > Kam Kam, Salt has major effect on blood pressure. Try becoming a total vegetarian for a week--no eggs, cheese or dairy products. Eat lots of almonds (for protein) or buy protein powder that has a very low sodium (salt) content such as Mixed Berry Rice Protein. After you do that, measure your blood pressure during the last two days of the week to see if the experiment was a success or failure. You should also visit a health food store and buy a bottle of Mineral Capsules. You should also ask these questions to your doctor. Jason SignatureNEWSGROUP SUBSCRIBERS MOTTO We respect those subscribers that ask for advice or provide advice. We do NOT respect the subscribers that enjoy criticizing people. >>>What are your diet and activity like? Do you eat or supplement for >>>adequate magnesium and potassium? How long have you been taking metformin? [quoted text clipped - 18 lines] > You should also ask these questions to your doctor. > Jason Vegetarianism is a horrible choice for a diabtic. Skip the rice crap and eat more eggs to control bg. Susan > Kam, > Salt has major effect on blood pressure. Try becoming a total vegetarian [quoted text clipped - 7 lines] > You should also ask these questions to your doctor. > Jason My sodium levels are lower than normal and potassium levels are little higher than normal . Kam x-no-archiv: yes >>What are your diet and activity like? Do you eat or supplement for >>adequate magnesium and potassium? How long have you been taking metformin? [quoted text clipped - 6 lines] > > Kam You haven't provided enough information here. I would say, though that your questions may elicit better informed ideas from alt.support.diabetes than here. What do you eat for meals each day? How much of it is carbohydrate, how much is fat, how much is protein? MOST importantly, what are your post prandial (one hour, especially) glucose numbers like when you test? Do your higher post meal numbers correlate with worse hypertension? Do eggs (you could have arachidonic acid sensitivity, leading to higher bp)? How much magnesium and potassium is in your diet? Susan > I find my hypertension very unstable after I became T2 diabetic . My > diabetes is very much on the control with Metformin - twice daily . [quoted text clipped - 6 lines] > > Kam Salt sensitivity is increased in diabetes which can be one possibility. Nephrol Dial Transplant. 2005 Oct;20(10):2113-9. Epub 2005 May 3. Related Articles, Books, LinkOut Salt-sensitive blood pressure--an intermediate phenotype predisposing to diabetic nephropathy? Strojek K, Nicod J, Ferrari P, Grzeszczak W, Gorska J, Dick B, Frey F, Ritz E. Department of Internal Diseases, Diabetology and Nephrology, Silesian Medical Academy, 3-go Maja 13/15, Zabrze 41-800, Poland. kstrojek@slam.katowice.pl BACKGROUND: Family studies point to important genetic determinants of diabetic nephropathy (DN). Blood pressure (BP) is higher in offspring of patients with type 2 diabetes and DN, but the pathomechanisms involved have not been elucidated. METHODS: We examined the salt sensitivity of BP after 5 days equilibration on a low (20 mmol/day) vs high salt diet (220 mmol/day) in three matched groups of 15 subjects each: (i) control individuals; (ii) offspring of type 2 diabetic parents without DN (DN-); and (iii) offspring of type 2 diabetic parents with DN (DN+). Ambulatory BP and hormones involved in sodium homeostasis [plasma renin activity (PRA), aldosterone and atrial natriuretic peptide (ANP)] as well as the tetrahydrocortisol + 5-allotetrahydrocortisol/tetrahydrocortisone (THF + 5alphaTHF)/THE) ratio in the urine as an index of 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) activity were analysed. RESULTS: In offspring of DN+ patients on a high salt diet, systolic and diastolic BP was 137/82+/-10/8 mmHg vs 125/77+/-12/8 mmHg in offspring of DN- patients (P<0.01 for systolic BP). The salt-induced difference in mean BP between high and low salt diet was 5.2+/-3.3 mmHg in offspring of DN+ patients vs 0.7+/-4.7 mmHg in offspring of DN- patients (P<0.002). The proportion of 'salt-sensitive' individuals was 67% in offspring of DN+ patients vs 20% in offspring of DN- patients (P<0.05). In all groups, a high salt diet caused a comparable decrease of PRA and p-aldosterone accompanied by an increase in ANP. The urinary (THF + 5alphaTHF)/THE ratio was 1.23+/-0.36 in salt-sensitive individuals and 0.99+/-0.33 (P<0.03) in salt-resistant subjects, consistent with increased activity of 11betaHSD2. CONCLUSIONS: BP is more salt sensitive in offspring of type 2 diabetic patients with diabetic nephropathy. The salt sensitivity of BP may be an intermediate phenotype in individuals with a high risk of future diabetic nephropathy. PMID: 15870224 [PubMed - in process] How long ago did you discover this? Are you using only one med for controlling HBP? You may want to talk to a doc about using 2 med for BP control. |
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