Kathleen Doheny, "Fish Oil Fights Smog's Effect on Heart", Forbes, May
26, 2005,
Link:
http://www.forbes.com/lifestyle/health/feeds/hscout/2005/05/26/hscout525935.html
Daily supplements of fatty acid-rich fish oil may counteract the
effects of air pollution on the heart, researchers report.
"The cardiac responses to air pollutants were dramatically reduced in
those on fatty acids," said Dr. Fernando Holguin, an assistant
professor of medicine at Emory University School of Medicine. He
presented the research this week at the American Thoracic Society's
annual meeting in San Diego.
Holguin's team tracked the cardiac health of 50 elderly people, all
nursing home residents averaging 70 years of age and living in
smog-plagued Mexico City.
Each resident received a one-gram oil capsule twice a day (once in the
morning and again in the evening) containing omega-3 fatty acids. Half
of the group received fish oil capsules and the other half soy oil
capsules.
The researchers took ongoing measurements of each participant's cardiac
function, focusing specifically on their heart rate variability.
Heart-rate variability refers to the heart rate alterations from beat
to beat.
"Exposure to the particles of air pollution reduces heart rate
variability, and taking the omega-3 fatty acids increased it," Holguin
explained. "Increased heart rate variability reduces heart disease
risk."
The fish oil was much better at keeping heart rate healthy than was the
soy oil, the Emory team found. "Those on soy oil had just marginal
protection," Holguin said, while "those on fish oil had a complete
abolishment of the effect of the [smog] particles on the heart."
Another expert, Dr. Zi-Jian Xu, a staff cardiologist at Santa
Monica-UCLA Medical Center and an assistant clinical professor of
medicine at the David Geffen School of Medicine, UCLA, said he is not
surprised by the results. "Fish oil has been found to reduce
cardiovascular events, mainly heart attack and stroke," he said. "It
has also been shown to modestly reduce the risk of another heart
attack. The theory is that omega-3 fatty acids can improve
cardiovascular health."
The new finding is also consistent with previous research, Xu added.
Holguin advises that people follow the advice of the American Heart
Association (AHA) with regards to their daily intake of omega-3 fatty
acids. The AHA currently recommends that individuals with documented
heart disease eat about one gram of omega-3 fatty acids a day,
preferably from fatty fish. Beyond that, supplements could be
considered "in consultation with the physician," the AHA recommends.
Those without documented heart disease are advised by the AHA to eat a
variety of fish, preferably fatty species such as salmon, mackerel and
sardines, at least twice a week and to include oils and foods rich in
alpha-linolenic acid (flaxseed, canola and soybean oils, flaxseed and
walnuts) in the diet.
More information To learn more about outdoor air pollution, visit the
American Lung Association.
montygram - 26 May 2005 19:35 GMT
Once again, there is no basic control They way to do this correctly
would be to measure the AA content via skin biopsies, then see what the
effects are. Fish oil counteractes arachidonic acid metabolization,
which is how this effect they demonstratte is produced. However, if a
person has little arachidonic acid in them to begin with, they don't
need the fish oil. Fish oil is very susceptible to lipid peroxidation,
in vivo or ex vivo, and studies of Eskimos on such diets revealed very
low life expectancies due to the free radical damge these fatty acids
do to human bodies. Get some Asians who eat loads of coconut product
and use no high omega 6 fatty acid foods and put them in the study and
then we'll see for sure. Until then, the only mechanism known that can
produce this effect is how fish oil blocks AA metabolization, but since
AA is so dangerous, why have it in your body in the first place? If
you read the entire scientific literature, you realize that AA cannot
be in a human body beyond trace amounts without doing serious damage.
Just today, sciencedaily.com had a report of higher AA levels in
depressed patients. You can do this epxeriment on yourself: eat a
huge amount of oily fish and stay away from sources of large amounts of
omega 6s, and see what happens to your body. Guess what? It's already
been done.
Biochemist Ray Peat noted:
"An oil researcher spent 100 days eating what he considered to be the
Eskimo diet, seal blubber and mackerel paste. He observed that his
blood lipid peroxides (measured as malondialdehyde, MDA)
reached a level 50 times higher than normal, and although MDA
is teratogenic, he said he wasn't worried about fathering
deformed children, because his sperm count had gone to zero."
Original source: Sinclair, H., Prog. Lipid Res. 25: 667-72,
"History of EFA & their prostanoids: some personal
reminiscences."
If you want your MDA levels 50 times higher than normal, go right
ahead, but there is only scientific evidence (and plenty of it) against
this situation. MDA levels are used as markers of cellular level
damage. Do a pubmed.com search for MDA and read through the studies to
see for yourself. There are over 10,000 studies to choose from there.