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Medical Forum / General / Cardiology / February 2005Red Yeast Rice Extract
Several years ago my Cholesterol reading was 290. My Dr. wanted to put me on Lipitor.. I said I would rather use RYR extract. He had no idea what that was but said give it a try and if it did not work he would pursue the Lipitor. After 6 mos. cholesterol was 164. Same lab same lipid profile. Regards, Ken Mevacor, the first statin, is red yeast rice. > Several years ago my Cholesterol reading was 290. > My Dr. wanted to put me on Lipitor.. I said I would rather use RYR [quoted text clipped - 5 lines] > > Regards, Ken > Mevacor, the first statin, is red yeast rice. it is`nt. Statins are synthtisized out from Apergillus terreus mould, RYR from Monascus strain. please read this, or the published Monograph by INPR, Inst.for Natural Products Research www.naturalproducts.org Difference of the compounds in Red Yeast Rice (CHOLESTIN/ MONACHOL) between Monacolins and Lovastatin Generally concerned, we must decide between Lacton-form and Hydoxy-acid-form in Red Yeast Rice, (because all Monacolins in RYR are eighter in Lacton-form and/or in Hydroxy-acid-form) a)Lactonform (C24H36O5) original and firstly named as als 6-alpha-Methylcompactin,Mevacor, Mevinacor, Mevlor, Mevinolin oder Monacolin K b)Hydroxysäure (C24H38O6) historic as Monacolinic K acid, Lovastatin acid, Lovastatin hydroxy acid and today as Mevinolinic acid or L 154819 described. chemical on interest is: 1 Molecul of the (open-ring) Lactonform (C24H36O5) + 1 Watermolecul (H2O) results the (closed-ring)Hyxdroxy-acid-form (C24H38O6), formerly and wrong as Monacolin K described, but correct as Mevinolinic acid (or as Lovastatin hydroxy acid or Lovastatin acid) to describe. In the Pharmacy Mevinacor contained the Lacton Lovastatin/Monacolin K about 20-35% and Mevinolinic-acid about 60-85%. (the more humidity of RYR the more different) The Lacton Lovastatin/Monacolin K on the other hand dissolved in Stomach-acid in Movinolinic-acid (20%) and further 10 % would be shared out as Lovastatin. thats pharmacologic interesting, because in the Human body the Lacton has another effect as Movinolinic-acid, this is significant. Mevinolinic-acid is direct pharmacologic effective, would faster admitted, but slowly from the Liver assimilated than the Lacton-form. REM. above described only the Red Yeast Rice known as formerly CHOLESTIN and not another products on the market, because some are a mix between Red Rice-food-color and chemical Lovastatin and include nephrotoxic compound Citrinin, see An analysis of nine proprietary Chinese red yeast rice dietary supplements: implications of variability in chemical profile and contents J Altern Complement Med 2001 Apr;7(2):133-9 (ISSN: 1075-5535) Heber D; Lembertas A; Lu QY; Bowerman S; Go VL UCLA Center for Human Nutrition, UCLA School of Medicine, Los Angeles, California 90095-1742, USA. dheber@mednet.ucla.edu. greetings MG Marengo, Link you refenced didn't come up. Can you recheck please. Are you saying that RYR extract is not th same as the statin drugs? I had trouble comprehending your post. Thanks, ken >> Mevacor, the first statin, is red yeast rice. > [quoted text clipped - 5 lines] > INPR, Inst.for Natural Products Research > www.naturalproducts.org > Marengo, Link you refenced didn't come up. > Can you recheck please. > > Are you saying that RYR extract is not th same as the statin drugs? > I had trouble comprehending your post. hello Ken, thats right, RYR is not the same as Statin Drugs. Statin Drugs contents Monacolin K only, RYR (with 4mg/g as promoted from CHOLESTIN supplier Pharmanex) contents only 1,6mg/g Monacolin K but/and 2,3mg/g Mevinolinic acid and some other compounds and Monacolin K is only oil-soluble, goes direct to the Liver,(consumed one time at evening) Mevinolinic acid is watersoluble, works gentle over Mouth,Stomach,Intestinal and partially through the Liver. thats the reason of lower (missing) side-effect with RYR (CHOLESTIN) greetings MG Re: RYR is not the same as Statin Drugs. Statin Drugs contain Monacolin K only. Red Yeast Rice is sold as just "Red Yeast Rice" also [in the USA] Contents is: Monascus purpureus. Monascus metabolic products are monacolin K and gamma-aminobutyric acid (GABA). RYR is a statin. Example: NOW Brand of RYR ~ 600mg capsules: http://store.yahoo.com/nowcatalog/3501.html Red Yeast Rice is a unique natural product native to China that's been used in Asian traditional medical systems since approximately 800 A.D. Produced by fermenting red yeast (Monascus purpureus) with white rice, Red Yeast Rice is commonly used in cooking applications to enhance the color and flavor of foods. Peking Duck is an example of the coloration and flavor imparted by Red Yeast Rice. NOW® Red Yeast Rice Extract is carefully produced to avoid the presence of citrinin, a sometimes toxic by-product of the fermentation process. Per PubMed: Monascus, a traditional Chinese fermentation fungus, is used as a natural dietary supplement. Its metabolic products monacolin K and gamma-aminobutyric acid (GABA) have each been proven to be a cholesterol-lowering drug and a hypotensive agent. Citrinin, another secondary metabolite, is toxic to humans, thus lowering the acceptability of red mold rice to the general public. Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids6 25794&dopt«stract > Re: RYR is not the same as Statin Drugs. Statin Drugs contain Monacolin > K only. [quoted text clipped - 3 lines] > monacolin K and gamma-aminobutyric acid (GABA). > RYR is a statin. hello Frankie, RYR it isn`nt a Statin: Monacolin K and some of its derivatives mentioned below evolve as a secondary metabolite in the growth of various fungus species (e.g. Aspergillus, Penicillium, Monascus, Pleurotus) 2,3,4,5). As inhibitors of Hydoxymethyl-Glutaryl-Coenzyme A-Reductase) they are of high pharmacological interest particularly regarding the cholestorol reducing factor (“Statine”) While statines like Monacolin K in its lactone form (Lovastatin, trade names Mevacor, Mevinacor, Mevlor) can be produced synthetically by the pharmaceutical industry as a clean substance, in herbal metabolism mixtures of both forms are formed in characteristic ratios with small amounts of additional bioynthetic precursors and enzymatic changed (esterified) and chemically dismantled (e.g. by water separation) derivates, whose pharmacological effect is not yet identified In lactone form Monacolin K (synonymous Mevinolin) is the b,d-dihydoxy-7-[1,2,6,7,8,8a-hexahydro-2,6-dimethyl-8-(2-methylbutyryloxy)-naphtalene-1-yl]-heptanoic acid d-lactone (Fig.1), which can be opened to hydroxy(mevinolinic acid form by basic hydrolysis (Fig.2)1 and:in fermented red Rioce Powder RYR is Monacolin K at 20-25% and hydroxy/mevinolinic acid at 60-70% some other compounds as: Monacolin K, Monacolin J, Monacolin L Monacolin M, Monacolin J Monacolin K Dehydromonacolin , Dihydromonacolin, Proteins, fat, 16 saturated,unsaturated fatty acids,Carbohydrates, starches, 22 amino acids .i.e. greetings MG Marengo, In simple terms please... If I take herbal RYR extract..do I need to worry about the effect it has on my liver as I would if I had taken lovastatin or some of the other statin DRUGS. Thank you, Ken >> Re: RYR is not the same as Statin Drugs. Statin Drugs contain Monacolin >> K only. [quoted text clipped - 33 lines] > greetings > MG hello Ken > In simple terms please... will try... > If I take herbal RYR extract..do I need to worry about the effect it has on > my liver as I would if I had taken lovastatin or some of the other statin > DRUGS. note please firstly: RYR is not a Herbal extract, RYR is a fermentation product with glutinus white Rice, after 10 days the grains are milled and filled in Capsules. thats it.normally. I don`t know your supplier for your RYR, but be careful. If your supplier can show you (deliver) his product also in grains, than its not a fake (mix from normal red rice foodcolor with Lovastatin) with sideeffects. see the Study from David Heber by UCLA greetings MG >Several years ago my Cholesterol reading was 290. >My Dr. wanted to put me on Lipitor.. I said I would rather use RYR extract. [quoted text clipped - 5 lines] > >Regards, Ken What dosage did you take? Brand? I take 20 mg Lipitor daily and would prefer a natural product. TIA DFB "When a legislature undertakes to proscribe the exercise of a citizen's constitutional rights it acts lawlessly and the citizen can take matters into his own hands and proceed on the basis that such a law is no law at all." - Justice William O. Douglas Just from experience I would suggest taking 600mg. 600mg is the lowest dosage capsule. If you attain the desired results, no need to increase. You must be warned though that although RYR is a natural substance, you still need to have your blood tests every 6 months, as RYR is a real statin. RYR can have [and does from personal experience] the same statin side effects. Also be aware that when changing from one statin to another, there is the possibility of the onset of side effects, even if you have not experienced side effects before. Just a heads-up.... Frankie > Just from experience I would suggest taking 600mg. > 600mg is the lowest dosage capsule. If you attain [quoted text clipped - 15 lines] > > Frankie I've been on 2400 mg/day (2 capsules in the a.m. and 2 in the p.m) of red yeast rice for over two years now and have never had any perceptible side effects. Combined with fish oil, I keep my cholesterol down to ~200. It's not the 160 I got from Lipitor but then I'd rather be able to walk up stairs without feeling like my legs are falling off. I had a terrible time on Lipitor and Zocor. CPK levels well over 600 (120 is normal). I order red yeast rice from www.swansonvitamins.com at ~$7 per one month supply. I used to use Cholestin but it's price got too high. I'd be willing to bet that there are millions of people who are having adverse side effects from the synthetic statins (Zocor, Lipitor, etc.) and don't even know it. All it takes is a simple additional blood test the next time you have a lipid profile done. Make sure they check your CPK level and discuss the results with your MD. |
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