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Medical Forum / General / Cardiology / December 2004

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Cholesterol very reactive to diet, advice sought

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Chuck - 03 Dec 2004 20:34 GMT
Hi all,

I am new to this group, but have used many others. Here is my
question...

I am 51 years old. My recent blood test showed a total cholesterol of
221. Some other recent tests have been 210 or so. But I have also had
tests, in the last 10 years, with a result of <180. I have found that
my cholesterol result is very reactive to relatively small changes in
my diet. If I go from eating very healthy to eating pretty healthy my
total cholesterol goes from 175 to 215 or so. A big jump, it seems to
me. I am not talking about major swings in my diet, like going from
vegan to BigMac freak. I mean relaxing my eating standards a bit, and
having a few more small cookies or some extra meat on my lunch
sandwich.

Does this ring a bell with anyone? Any particular advice about this
condition?

Now I should be honest and say that it is possible my diet
deteriorates more than I am admitting, when my result goes up, but
I'll consider that possibility second.

TIA,
Chuck Connell
GaryG - 03 Dec 2004 20:51 GMT
> Hi all,
>
[quoted text clipped - 21 lines]
> TIA,
> Chuck Connell

Are you sure it's related to diet?  Those tests can vary quite a bit from
test to test, depending on how long you fasted, etc. so the variation you're
seeing may not be directly related to your diet.

Many people find that their cholesterol levels are resistant to changes in
diet and exercise...this just means that you drew the short straw in the
genetic lottery, and your liver is efficient at producing cholesterol.  I'm
51 too, work out regularly, and watch what I eat (at 6', 174, I'm not
overweight).  But, if I didn't take my daily dose of niacin, my total
cholesterol would be around 240 (with a low level of the good HDL).

However, if you know your levels go up when you eat crap, and go down when
you don't...well, don't eat crap!  FWIW, cookies and other baked products
often contain "trans-fats" which have been implicated in heart disease -
they're a "substance abuse issue" for me, so I limit my exposure to them as
much as possible (not easy this time of year!).

Signature

GG
http://www.WeightWare.com
Your Weight and Health Diary

Chuck Connell - 03 Dec 2004 20:58 GMT
Thanks Gary,

I am fairly sure the change is related to diet, because it has happened
quite a few times over many years. I always do the test first thing in the
AM, after fasting for 12 hours.

Chuck
Frankie - 04 Dec 2004 05:52 GMT
Chuck,

What are your individual levels?
LDL
HDL
VLDL
Triglycerides
Total Cholesterol - 221

Frankie
Barry - 04 Dec 2004 06:32 GMT
> Hi all,
>
[quoted text clipped - 21 lines]
> TIA,
> Chuck Connell

Hello Chuck,
                    I am afraid I can only sympathize with you rather than
provide any answers. I maintain a pretty strict diet, and exercise within my
limited capabilities ( chronic cardiac failure), and am not overweight.
Obviously I don't smoke, and only consume alcohol infrequently in small amounts.
Because of widespread atherosclerosis (involving renal and carotid arteries, and
others, I presume) it is important for me to lower my LDL and Triglycerides
(which were in the moderately high range) and raise my HDL which just scaped
into the normal (desirable) range. We use the mmol/L measurement scale here
(Australia) and it is difficult for me to translate the numbers into the
American measurements. I cannot take Statins or Fibrates having had serious
side-effects from both. After 12 months of serious diet attitude, and exercise
(limited as above), I only manged to bring my Total Cholesterol down a couple of
points, and was left in the moderately high level. Same with the Triglycerides,
and I did not improve my HDL. The Consultant was very reluctant about niacin for
me. I now take a plant sterols supplement which seems to have helped a bit, but
essentially I am where I was two years ago. Plant sterols apparently only retard
the absorption of cholesterol from the gut ,unlike statins which interfere with
the bio-synthesis of cholesterol in the liver. Most of the cholesterol in our
bodies is produced by the body, diet normally only playing a small part. You
compound the  problem by adding dietary cholesterol to the naturally produced
amount, but diet can only do so much when the genes are switched on to produce
an essential substance. We all know people who eat great quantities of saturated
fats, don't exercise etc and have low and very desirable levels of LDL.Clearly
genetic "disposition"is of great importance, but what is it about the gene (s)
that decides the production level - or maybe the body is responding to a need ?
In the case of Familial Hyperlipidaemia the role of genes is more certain, and I
assume a mutated gene or genes are involved. But I am not sure about this,and if
anybody knows if mutated gene(s) have been found that is (are) passed on from
generation to generation I would be interested. Does anyone know the action and
side effects of Ezetimibe, as this has been mentioned to me, but after my
problems with statins (including heart failure) I am hesitant about taking
medication. I have been told that Ezetimibe only retards absorption from the
gut, so I presume it is only relevant to consumption of cholesterol not
production. If anyone knows I would be grateful to learn. There are many
mysteries, at least to me, about this essential substance, and whether in fact
it does the damage claimed.
Chuck, my advice (unqualified) would be to maintain a strict diet, and your
exercise. Keep your weight right, and remember that walnuts, almonds and oat
bran can help to raise your HDL. As you have probably guessed, I place a greater
importance on the genetic aspects of the "problem". Good Luck.
Regards, Barry
Frankie - 05 Dec 2004 03:30 GMT
G'day Mate,

Below are two easy conversion charts from "Healing Hearts Foundation":

Conversion: US and International Lipids Measures for Cholesterol
Cholesterol: Based on a factor of .0259 Rounded off to the nearest
hundredth
http://heart.kumu.org/cholcomp.html

Conversion: US and International Lipids Measures for Triglycerides
Triglycerides: Based on a factor of .01129 Rounded off to the nearest
hundredth
http://heart.kumu.org/triglcomp.html

Re:  Ezetimibe (Zetia)
Source: http://www.fda.gov/cder/foi/label/2002/21445lbl.pdf

Ezetimibe reduces total-C, LDL-C, Apo B, and TG, and increases HDL-C in
patients with hypercholesterolemia.
Ezetimibe reduces blood cholesterol by inhibiting the absorption of
cholesterol by the small intestine.
Ezetimibe had no clinically meaningful effect on the plasma
concentrations of the fatsoluble vitamins A, D, and E
and did not impair adrenocortical steroid hormone production.

The cholesterol content of the liver is derived predominantly from
three sources. The liver can synthesize
cholesterol, take up cholesterol from the blood from circulating
lipoproteins, or take up cholesterol absorbed by
the small intestine. Intestinal cholesterol is derived primarily from
cholesterol secreted in the bile and from
dietary cholesterol.

Ezetimibe has a mechanism of action that differs from those of other
classes of cholesterol-reducing
compounds (HMG-CoA reductase inhibitors, bile acid sequestrants
[resins], fibric acid derivatives, and plant
stanols).

Ezetimibe does not inhibit cholesterol synthesis in the liver, or
increase bile acid excretion. Instead,
ezetimibe localizes and appears to act at the brush border of the small
intestine and inhibits the absorption of
cholesterol, leading to a decrease in the delivery of intestinal
cholesterol to the liver. This causes a reduction of
hepatic cholesterol stores and an increase in clearance of cholesterol
from the blood; this distinct mechanism is
complementary to that of HMG-CoA reductase inhibitors.

Frankie
Barry - 05 Dec 2004 05:12 GMT
Thankyou Frankie - your information is much appreciated.
Regards, Barry

> G'day Mate,
>
[quoted text clipped - 46 lines]
>
> Frankie
us_visa@yahoo.com - 31 Dec 2004 22:10 GMT
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a ton of weight.

Hope this helps you also :)
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