Medical Forum / General / Cardiology / December 2004
Cholesterol very reactive to diet, advice sought
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Chuck - 03 Dec 2004 20:34 GMT Hi all,
I am new to this group, but have used many others. Here is my question...
I am 51 years old. My recent blood test showed a total cholesterol of 221. Some other recent tests have been 210 or so. But I have also had tests, in the last 10 years, with a result of <180. I have found that my cholesterol result is very reactive to relatively small changes in my diet. If I go from eating very healthy to eating pretty healthy my total cholesterol goes from 175 to 215 or so. A big jump, it seems to me. I am not talking about major swings in my diet, like going from vegan to BigMac freak. I mean relaxing my eating standards a bit, and having a few more small cookies or some extra meat on my lunch sandwich.
Does this ring a bell with anyone? Any particular advice about this condition?
Now I should be honest and say that it is possible my diet deteriorates more than I am admitting, when my result goes up, but I'll consider that possibility second.
TIA, Chuck Connell
GaryG - 03 Dec 2004 20:51 GMT > Hi all, > [quoted text clipped - 21 lines] > TIA, > Chuck Connell Are you sure it's related to diet? Those tests can vary quite a bit from test to test, depending on how long you fasted, etc. so the variation you're seeing may not be directly related to your diet.
Many people find that their cholesterol levels are resistant to changes in diet and exercise...this just means that you drew the short straw in the genetic lottery, and your liver is efficient at producing cholesterol. I'm 51 too, work out regularly, and watch what I eat (at 6', 174, I'm not overweight). But, if I didn't take my daily dose of niacin, my total cholesterol would be around 240 (with a low level of the good HDL).
However, if you know your levels go up when you eat crap, and go down when you don't...well, don't eat crap! FWIW, cookies and other baked products often contain "trans-fats" which have been implicated in heart disease - they're a "substance abuse issue" for me, so I limit my exposure to them as much as possible (not easy this time of year!).
 Signature GG http://www.WeightWare.com Your Weight and Health Diary
Chuck Connell - 03 Dec 2004 20:58 GMT Thanks Gary,
I am fairly sure the change is related to diet, because it has happened quite a few times over many years. I always do the test first thing in the AM, after fasting for 12 hours.
Chuck
Frankie - 04 Dec 2004 05:52 GMT Chuck,
What are your individual levels? LDL HDL VLDL Triglycerides Total Cholesterol - 221
Frankie
Barry - 04 Dec 2004 06:32 GMT > Hi all, > [quoted text clipped - 21 lines] > TIA, > Chuck Connell Hello Chuck, I am afraid I can only sympathize with you rather than provide any answers. I maintain a pretty strict diet, and exercise within my limited capabilities ( chronic cardiac failure), and am not overweight. Obviously I don't smoke, and only consume alcohol infrequently in small amounts. Because of widespread atherosclerosis (involving renal and carotid arteries, and others, I presume) it is important for me to lower my LDL and Triglycerides (which were in the moderately high range) and raise my HDL which just scaped into the normal (desirable) range. We use the mmol/L measurement scale here (Australia) and it is difficult for me to translate the numbers into the American measurements. I cannot take Statins or Fibrates having had serious side-effects from both. After 12 months of serious diet attitude, and exercise (limited as above), I only manged to bring my Total Cholesterol down a couple of points, and was left in the moderately high level. Same with the Triglycerides, and I did not improve my HDL. The Consultant was very reluctant about niacin for me. I now take a plant sterols supplement which seems to have helped a bit, but essentially I am where I was two years ago. Plant sterols apparently only retard the absorption of cholesterol from the gut ,unlike statins which interfere with the bio-synthesis of cholesterol in the liver. Most of the cholesterol in our bodies is produced by the body, diet normally only playing a small part. You compound the problem by adding dietary cholesterol to the naturally produced amount, but diet can only do so much when the genes are switched on to produce an essential substance. We all know people who eat great quantities of saturated fats, don't exercise etc and have low and very desirable levels of LDL.Clearly genetic "disposition"is of great importance, but what is it about the gene (s) that decides the production level - or maybe the body is responding to a need ? In the case of Familial Hyperlipidaemia the role of genes is more certain, and I assume a mutated gene or genes are involved. But I am not sure about this,and if anybody knows if mutated gene(s) have been found that is (are) passed on from generation to generation I would be interested. Does anyone know the action and side effects of Ezetimibe, as this has been mentioned to me, but after my problems with statins (including heart failure) I am hesitant about taking medication. I have been told that Ezetimibe only retards absorption from the gut, so I presume it is only relevant to consumption of cholesterol not production. If anyone knows I would be grateful to learn. There are many mysteries, at least to me, about this essential substance, and whether in fact it does the damage claimed. Chuck, my advice (unqualified) would be to maintain a strict diet, and your exercise. Keep your weight right, and remember that walnuts, almonds and oat bran can help to raise your HDL. As you have probably guessed, I place a greater importance on the genetic aspects of the "problem". Good Luck. Regards, Barry
Frankie - 05 Dec 2004 03:30 GMT G'day Mate,
Below are two easy conversion charts from "Healing Hearts Foundation":
Conversion: US and International Lipids Measures for Cholesterol Cholesterol: Based on a factor of .0259 Rounded off to the nearest hundredth http://heart.kumu.org/cholcomp.html
Conversion: US and International Lipids Measures for Triglycerides Triglycerides: Based on a factor of .01129 Rounded off to the nearest hundredth http://heart.kumu.org/triglcomp.html
Re: Ezetimibe (Zetia) Source: http://www.fda.gov/cder/foi/label/2002/21445lbl.pdf
Ezetimibe reduces total-C, LDL-C, Apo B, and TG, and increases HDL-C in patients with hypercholesterolemia. Ezetimibe reduces blood cholesterol by inhibiting the absorption of cholesterol by the small intestine. Ezetimibe had no clinically meaningful effect on the plasma concentrations of the fatsoluble vitamins A, D, and E and did not impair adrenocortical steroid hormone production.
The cholesterol content of the liver is derived predominantly from three sources. The liver can synthesize cholesterol, take up cholesterol from the blood from circulating lipoproteins, or take up cholesterol absorbed by the small intestine. Intestinal cholesterol is derived primarily from cholesterol secreted in the bile and from dietary cholesterol.
Ezetimibe has a mechanism of action that differs from those of other classes of cholesterol-reducing compounds (HMG-CoA reductase inhibitors, bile acid sequestrants [resins], fibric acid derivatives, and plant stanols).
Ezetimibe does not inhibit cholesterol synthesis in the liver, or increase bile acid excretion. Instead, ezetimibe localizes and appears to act at the brush border of the small intestine and inhibits the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver. This causes a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the blood; this distinct mechanism is complementary to that of HMG-CoA reductase inhibitors.
Frankie
Barry - 05 Dec 2004 05:12 GMT Thankyou Frankie - your information is much appreciated. Regards, Barry
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