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Medical Forum / General / Cardiology / November 2004Cholesterol Drugs May Not Reduce Risk of Dementia
NEW YORK (Reuters Health) - New study findings suggest that the cholesterol-lowering drugs know as "statins" do not appear to lower the risk of dementia or Alzheimer's disease, except possibly in cases of early-onset Alzheimer's disease. This runs counter to recent reports indicating that these drugs do, in fact, reduce the risk of dementia and Alzheimer's disease. The authors of the current study, reported in the November 9th issue of the medical journal Neurology, believe the discrepancy may have to do with how the data were analyzed. Dr. Gail Li, from the University of Washington in Seattle, and colleagues assessed the outcomes of 2,356 elderly subjects without dementia who were in a health maintenance organization. The subjects were enrolled in the study between 1994 and 1996 and were evaluated every two years until the end of 2002. During follow-up, 312 subjects were diagnosed with all-cause dementia and 168 with probable Alzheimer's disease. As noted, statin use did not have a significant effect on the risk of dementia or Alzheimer's disease. Moreover, there was no evidence that higher or lower doses of statin affected the development of dementia. However, statin use was linked with a lower risk of "probable" Alzheimer's disease in subjects younger than 80 years who also had a least one copy of APOE E4, a gene mutation associated with increased risk of Alzheimer's disease. But this relationship was not strong. "Our results argue against the general premise that statins used for prevention of coronary heart disease will result in prevention of dementia or Alzheimer's disease, except perhaps in subgroups at high risk for early-onset Alzheimer's disease or in persons starting statins at a younger age and taking them for longer periods of time," Li's team concludes. SOURCE: Neurology, November 9, 2004. Read Dr Graveline's book, "Lipitor - Thief of Memory and the Misguided War on Cholesterol". Statins definitely cause cognitive problems, such as: transient global anmesia, short term and long term memory loss and everything inbetween. These side effects sometimes disappear once statins are discontinued, but there are many cases where the damage is permanent. > Read Dr Graveline's book, "Lipitor - Thief of Memory and the Misguided > War on Cholesterol". Statins definitely cause cognitive problems, such > as: transient global anmesia, short term and long term memory loss and > everything inbetween. These side effects sometimes disappear once > statins are discontinued, but there are many cases where the damage is > permanent. I hear from people daily who's physicians don't recognize this as side effect of statins and are attributing to and treating for ALS, MS, and other things. It is difficult to explain to those who have not experienced this how it robs you of ability to even make it clear to others there is something wrong. If you do manage to articulate something, you are told it's owing to some other cause, even age--at 50!?. It also seems to vary, being better if you take yourself off the drug, but not disappearing, and then returning when you go back on. And it is incidious. It encompases all aspects of your life. Those who have transient global amnesia are aware iimmediately, but those who have short term nd executive function memory loss are not. People who suffer the latter are usually unable to get their physicians to understand, and they are told they are suffering nothing more than old age, but not having any experience with this, they don't know how to judge it, and begin avoiding, and coping, and covering up. Sometimes the saving grace is becoming so forgetful one forgets to take the drug for days on end, and improvement starts, and one is again able to discern and say: yes, this must be that drug. Zee birm47@gmail.com wrote in news:1101516943.904658.97070 @f14g2000cwb.googlegroups.com: > Read Dr Graveline's book, "Lipitor - Thief of Memory and the Misguided > War on Cholesterol". Statins definitely cause cognitive problems, such > as: transient global anmesia, short term and long term memory loss and > everything inbetween. These side effects sometimes disappear once > statins are discontinued, but there are many cases where the damage is > permanent. Can you provide some links to legitimate studies that support your conclusion, please. Thanks. L. One study mentioned in Dr Graveline's book: Medscape from WebMD 'Memory Loss' [create FREE login/password to read articles] Statin-Associated Memory Loss: Analysis of 60 Case Reports and Review of the Literature from Pharmacotherapy Posted 07/25/2003 http://www.medscape.com/viewarticle/458867_1 > One study mentioned in Dr Graveline's book: > [quoted text clipped - 7 lines] > > http://www.medscape.com/viewarticle/458867_1 Here is the conclusion from the article "Conclusion: Current literature is conflicting with regard to the effects of statins on memory loss. Experimental studies support links between cholesterol intake and amyloid synthesis; observational studies indicate that patients receiving statins have a reduced risk of dementia. However, available prospective studies show no cognitive or antiamyloid benefits for any statin. In addition, case reports raise the possibility that statins, in rare cases, may be associated with cognitive impairment, though causality is not certain." Note the words, "possibility", "rare", and "causality is not certain" Combined with the rest of the conclusion, I read this as saying the evidence is a mixed bag. Bill >> One study mentioned in Dr Graveline's book: >> [quoted text clipped - 24 lines] > > Bill Bill, You should know by now....they (birm47, zee, et al) sell the sizzle, not the steak. L. > birm47@gmail.com wrote in news:1101516943.904658.97070 > @f14g2000cwb.googlegroups.com: [quoted text clipped - 12 lines] > > L. Happy to oblige. Zee Bassuk SS, Wypij D, Berkman LF (2000), Cognitive impairment and mortality in the community-dwelling elderly. Am J Epidemiol 151(7):676-688. Frisoni GB, Fratiglioni L, Fastbom J et al. (1999), Mortality in nondemented subjects with cognitive impairment: the influence of health-related factors. Am J Epidemiol 150(10):1031-1044. Golomb BA, Kane T, Dimsdale JA (2004), Severe irritability associated with statin cholesterol-lowering drugs. QJM 97(4):229-235. Heart Protection Study Collaborative Group (2002), MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360(9326):7-22 [see comments]. King DS, Jones DW, Wofford MR et al. (2001), Cognitive impairment associated with atorvastatin. Presented at the American College of Clinical Pharmacy Spring Practice and Research Forum. Salt Lake City; April 22-25. King DS, Wilburn AJ, Wofford MR et al. (2003), Cognitive impairment associated with atorvastatin and simvastatin. Pharmacotherapy 23(12):1663-1667. Korten AE, Jorm AF, Jiao Z et al. (1999), Health, cognitive, and psychosocial factors as predictors of mortality in an elderly community sample. J Epidemiol Community Health 53(2):83-88. Muldoon MF, Barger SD, Ryan CM et al. (2000), Effects of lovastatin on cognitive function and psychological well-being. Am J Med 108(7):538-546. Muldoon MF, Ryan CM, Flory JD, Manuck SB (2002), Effects of simvastatin on cognitive functioning. Presented at the American Heart Association Scientific Sessions. Chicago; Nov. 17-20. Orsi A, Sherman O, Woldeselassie Z (2001), Simvastatin-associated memory loss. Pharmacotherapy 21(6):767-769. Smits CH, Deeg DJ, Kriegsman DM, Schmand B (1999), Cognitive functioning and health as determinants of mortality in an older population. Am J Epidemiol 150(9):978-986. Wagstaff LR, Mitton MW, Arvik BM, Doraiswamy PM (2003), Statin-associated memory loss: analysis of 60 case reports and review of the literature. Pharmacotherapy 23(7):871-880. >> birm47@gmail.com wrote in news:1101516943.904658.97070 >> @f14g2000cwb.googlegroups.com: [quoted text clipped - 65 lines] > Statin-associated memory loss: analysis of 60 case reports and review > of the literature. Pharmacotherapy 23(7):871-880. sh.t, did I step into another zee alias (birm47)! Oh well, now kfiled. (BTW, those aren't *links*) L. > >> birm47@gmail.com wrote in news:1101516943.904658.97070 > >> @f14g2000cwb.googlegroups.com: [quoted text clipped - 71 lines] > > L. Frank, the truth that I discern is that you do *not* have Zee (aka Outrider) killfilled :-) It is written in Ephesians 2: 10For we are God's workmanship, created in Christ Jesus to do good works, which God prepared in advance for us to do. All is a waste of time until you find the way to eternal life with the Creator of the universe. When you do, there is no waste of time because there will be an infinite amount of it. Walking about aimlessly thinking it is *your* time, *your* money, *your* lot, *your* labor, *your* profit, and *your* power that you are using is tantamount to self-worship. For Christ lights up the way through John 14: 6Jesus answered, "I am the way and the truth and the life. No one comes to the Father except through me..." This bring us back again to the following very simple decision tree for the untruthful folks such as yourself, Frank, who have chosen to walk in the "dark": (1) Accept Christ. Risk: Nothing. Benefits: Salvation, purposeful life, eternal life, unimaginable riches in God's eternal kingdom. (2) Reject Christ. Risk: Eternal separation from God. Eternal torment of your soul by satan. Benefits: Nothing. Again, one has to conclude that those (ie you, Carey, Steve, Bob, Zee, Hawki, Rolando, Don et al) who would reject Christ have not thought out their decision *logically*. Would suggest you cast a glance at Bob Pastorio as a special example of untruthfully eloquent self-worship (BTW, Bob remains in my prayers out of Christian love) who is being driven to madness by my ignoring him (http://makeashorterlink.com/?V29A236C9 and more recently http://makeashorterlink.com/?K50B237D9). All this power belongs to God who has judged Bob Pastorio with His Word (http://makeashorterlink.com/?G33F51E69). All praises to Him, Whom I love with all my heart, soul, mind, and strength :-) You will be in my prayers, dear Frank whom I love, in Christ's holy name. May you accept Christ as your personal Lord and Savior, someday, so that you too will escape satan's rule and torment of your soul after you die. Please do consider the following as your logic should dictate before it is too late: http://makeashorterlink.com/?I22222129 (Please note that God truly made this special link describing that He is the great "I am" and that His message is as simple as the number 2 which is a number between 1 to 9 and reminds us of His 2 commandments, the 2 arms of the cross, the 2nd part of the Trinity, the 2 finger sign of the Prince of Peace [who remains *V*ictorious over death and satan], and the 2PD Approach. Let it not ever be written that Christ did not make His presence known here on Usenet :-) Servant to the humblest person in the universe, Andrew -- Dr. Andrew B. Chung, MD/PhD Board-Certified Cardiologist http://www.heartmdphd.com/ ** Who is the humblest person in the universe? http://makeashorterlink.com/?L26062048 What is all this about? http://makeashorterlink.com/?R20632B48 Is this spam? http://makeashorterlink.com/?N69721867 > >> birm47@gmail.com wrote in news:1101516943.904658.97070 > >> @f14g2000cwb.googlegroups.com: [quoted text clipped - 71 lines] > > L. Listener said: "(BTW, those aren't *links*)" Perhaps we could hook you up to a feeding tube. Zee |
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