.................................
Take a peak at  

http://www.thebards.net/music/lyrics/Always_Look_Bright_Side_Life.shtml

Sounds like you been involved with your medical folks.  Good.

William(Bill)

It is so hard to guess where symptoms come from, its always helpful to
have a name to what is going on, that in itself will releive anxiety.

Having children is a major event, and can bring fear and excitement
and maifest itself in many ways.  I am not a doctor, but I am old <G>
and have many experiences with things that 'look like' panic attacks.

Have you been examined by a <good> allergist, I know many things can
trigger episodes with rapid heart, and can wear a body down.

best wishes to you and yours,
Aquery

Don

You are not going to find a pill to fix your life.

Consider you may need to talk to someone other than the good folks here
about whatever it is that is making you anxious. It may not be anything
originating with your heart. And relax: being a father isn't going to
be so hard. You sound like a very caring and thoughtful young man. Best
of luck. Zee

Wall Street Journal

September 28, 2004

FDA to Probe Antidepressant Risks for Adults

After Planning Warning for Kids, Agency to Re-Examine Evidence
Suggesting No Danger of Suicide

By ANNA WILDE MATHEWS

After determining that antidepressants can pose a risk to young people,
the Food and Drug Administration is turning its attention to the drugs'
effects in adults.

The FDA says it will do a study of risks to adults in light of the
evidence of a tie between the widely prescribed drugs and suicidal
tendencies in children and adolescents.

That finding -- after an exhaustive re-examination of clinical-trial
data on young people -- led the agency to say it will require a strong
label warning about antidepressants' risks for young people. Now FDA
officials will comb through the existing data on adult clinical trials
in the same detailed fashion.

"We learned from that," says Janet Woodcock, a deputy commissioner of
the FDA. "It's a different way of analyzing the data." British
regulators also are studying adult data for evidence of suicide risk.

The FDA has examined the issue in adults before, and found no increased
risk of suicide.

It's unclear why some drugs could increase suicidal tendencies only in
a small subset of young people, and not in adults. One theory is that
younger people may have less control over their impulses, or less
ability to cope with or understand an unexpected drug effect. "One
hypothesis is that in some patients, [these drugs] have a disinhibiting
effect," says Wayne Goodman, chairman of the FDA panel that examined
the issue in young people. "Children are already a bit disinhibited"
because their brains aren't fully developed.

Many doctors believe "there is something different in depression in
children and adolescents versus adults," says John Mann, a professor of
psychiatry at Columbia University.

Doctors say it's well-established that children and adults don't always
respond to medications in the same way. For example, the
antidepressants in wide use today -- mostly selective serotonin
reuptake inhibitors, or SSRIs -- are effective in adults, but most
haven't been proven to work in young people. Similarly, older
antidepressants known as tricyclics, which aren't widely used, are
considered effective for adults but not children. Moreover,
tranquilizing medicines such as Ambien and Valium are far more likely
to cause side effects such as hallucination and agitation in children
than adults.

WEIGHING DIFFERENCES

Why risk of suicidal behavior with antidepressants may be different in
adults than young people

· Young people may have less impulse control, or less ability to cope
with an unexpected drug effect.

· Depression in adolescents may be fundamentally different from
depression in adults.

· Developmental differences between the pediatric and adult brains
may play a role.

SSRIs, including Prozac, Paxil and Zoloft, act to increase the amount
of serotonin, a chemical in the brain that affects mood. Children's
serotonin systems are more active than those in older people, says Dr.
Mann, though it isn't clear why or whether this would make the SSRIs
ineffective or create side effects. "There may be other developmental
differences" between adult and pediatric brains, he says.

The FDA has much more information available to study about adults and
antidepressants than it had about young people. It has a database of
234 randomized trials for 20 drugs that it plans to use in its new
study, Dr. Woodcock says. For pediatric patients, the FDA analyzed 23
pediatric drug-industry trials, and one result from a National
Institutes of Health study.

Dr. Woodcock says the agency had gone through the adult database, in an
analysis that still is being finalized, for trends based on the number
of actual suicides.

As it did with the pediatric clinical trials, the agency will examine
closely the adult data in an effort to find and characterize individual
incidents that could indicate suicidal tendencies. The agency is trying
to decide on its exact approach, such as whether the data should be
sent to outside researchers to examine.

Concern among regulators and the public over the possible downsides of
antidepressants emerged in 1990, when Martin Teicher, chief of a
laboratory at McLean Hospital in Massachusetts, wrote a paper
describing six patients who experienced "intense, violent suicidal
thoughts" after taking Eli Lilly & Co.'s Prozac.

RATING BEHAVIOR

The FDA had outside experts come up with classifications to sort
potentially suicide-related events that occurred in antidepressant
trials with young people. Here are some of the categories, along with
actual examples:

Suicide attempt: A girl lit herself on fire. A 15-year-old impulsively
slit her wrists following a fight with her mother; the wounds were
superficial and weren't stitched.

Preparatory actions toward imminent suicidal behavior: A 16-year-old
tried to hang herself and was prevented by her family. An 11-year-old
held a knife to his wrist and threatened to harm himself.

Self-injurious behavior with no suicidal intent: A girl cut herself but
denied that she was suicidal and said it gave her a "good, weird"
feeling.

Suicidal thoughts: A patient had thoughts for three days of killing
himself, but didn't take any action.

Source: Kelly Posner of Columbia University, the principal
investigator

The finding in young people "makes the association in adults seem more
credible," Dr. Teicher says today. But in 1991, an FDA advisory
committee -- after examining the Teicher paper as well as evidence from
Eli Lilly -- concluded there was "no credible evidence" that Prozac
caused suicides.

Why medications that are supposed to alleviate depression could, in
rare cases, actually have the opposite effect remains a mystery. Dr.
Teicher wrote a summary that included several theories. One was that
the drugs could give patients more energy before lifting their
depression, enabling them to act on a suicidal impulse. Another was
that the drugs could somehow worsen depression in a small subset of
patients. A third theory was that the antidepressants could cause a
state of agitation and restlessness.

The questions about the adult risk of Prozac and similar drugs never
completely disappeared, in part because of litigation against the
medicines' makers brought by people charging that they or their
relatives were hurt by the drugs. David Healy, a professor at the
University of Wales in the United Kingdom and a controversial critic of
the drugs, argued in a paper in 2003 that, analyzed in a certain way,
clinical-trial results could show a greater risk of suicidal acts tied
to antidepressants.

Drug makers have questioned Dr. Healy's methodology and said repeated
studies of their clinical trials show no evidence to back his point.
Lilly's analysis of Prozac clinical-trial results found no
statistically significant connection between the drug and suicide.
Rather, it showed a correlation between use of the drug and fewer
suicidal thoughts, when compared with placebo pills. Separately, a 1995
paper in the Journal of European Neuropsychopharmacology reported
"significantly fewer" new suicidal thoughts, and fewer suicides, among
patients taking Paxil compared with those on placebos.

"Each time it has been looked at, there is no suggestion of an
association" with suicidal tendencies in adults, with relation to
SSRIs, says Alan Metz, North American medical director for
GlaxoSmithKline PLC, Paxil's maker.

Further support for that camp came from researchers who authored an
April 2003 report in the American Journal of Psychiatry based on their
analysis of FDA clinical-trial data. They found there was no
statistical difference in the suicide rate between patients taking
antidepressants and those taking placebo pills.

Still, the FDA's findings about young people and antidepressants puts a
new spotlight on the old questions. The agency's analysis of a series
of pediatric clinical trials -- endorsed by its committee of outside
advisers -- found that in perhaps 2% to 3% of the time, the
antidepressants appeared to raise the risk of suicidal thoughts or
actions. None of the patients actually committed suicide.

Write to Anna Wilde Mathews at anna.mathews@wsj.com1
URL for this article:

http://online.wsj.com/article/0,,SB109632629148029432,00.html
Copyright 2004 Dow Jones & Company, Inc. All Rights Reserved

Don, I post through Google, so it can take hours for your post to show
up there, but I see on my server you asked why it only happens in the
afternoon.

I had the blessing to meet doctors that did not 'cookie cut' me when
trying to find out what was wrong, 25 years ago, not knowing does
cause anxiety.

In the beginning when my heart went funny it was said I panicked, but
it did not feel like panic, but years later it was found out I had
Reactive Hypoglycemia, I also had to keep a log of things I did all
day, reading a newspaper would cause rapid heartbeat and  sick feeling
for instance.

I owned a beauty shop, became sensitive to all personal care products,
its actually a big problem.

There are doctors out there that know alot how daily chemical
exposures affect the heart.

Of course I cannot say this is what is your symptoms are from, but we
can't leave any stone unturned.

My hotmail addy is on the header should you want to talk more, I don't
know where you are, but I know there is a cardiologist in Dallas that
is very good, and a doctor in Virgina that has also help countless
people, many books and research available.

In my search for what the Long QT is, I find it is many meds that can
cause it, what are meds, "chemicals".

Best wishes and love those babies and hug your wife, even if she is a
bit tired and grouchy :)

Aquery

Have I confused you with another Don posting recently? Sorry. Some meds
can cause the symptoms you describe, including SSRI antidepressants
which it sounds like you are considering.

For the OP: googleBeta 2 allows you to post and see instantly.

http://groups-beta.google.com/group/sci.med.cardiology/browse_thread/thread/2220
5d0d707dc300#86313c9ad86620b6