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Medical Forum / General / Cardiology / August 2004

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Testosterone, Independent Risk Factor for Heart Disease

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Alfredo E. - 24 Aug 2004 16:56 GMT
Please, find enclosed some interesting paragraphs of the latest Life
Extension Magazine editorial, regarding testosterone and heart
disease:

Testosterone, Independent Risk Factor for Heart Disease.
The surprising finding from this new study is that blood pressure,
cholesterol, diabetes, smoking, and body mass index may not be the
major predictors of degree of coronary artery blockage. Instead, the
three independent risk factors that predicted the severity of coronary
artery occlusion were age, high-density lipoprotein (HDL), and free
testosterone. In this instance, "independent risk factor" means that
if you did everything else recommended to protect your heart, you
would still be at greater risk for serious coronary artery blockage if
you had low testosterone and low HDL.
In this study, aged men with low free testosterone and low HDL showed
more severe coronary blockage, leading the doctors to conclude:
"These findings, together with the findings of previous studies from
other laboratories, raise the possibility that in men selected for
coronary arteriography, age, HDL, and free testosterone may be
stronger predictors of degree of coronary artery disease than are
blood pressure, cholesterol, diabetes, smoking, and body mass index
(BMI)."1
The unexpected finding in this study was that low free testosterone is
also an independent predictor of the degree of coronary artery disease
in men

Millions of Needless Heart Attacks
It is remarkable how ignorant physicians remain about the lifesaving
benefits of testosterone replacement therapy. An overwhelming volume
of data shows that higher levels of testosterone protect against
disorders as diverse as Alzheimer's dementia, type II diabetes,
abdominal obesity, osteoporosis, muscle wasting, depression, cognitive
decline, loss of libido, inability to achieve erection,
inflammatory-related syndromes, and a range of cardiovascular diseases
Of particular interest is the ability of testosterone and other
hormone replacement therapies to lower cholesterol levels.27-29
Doctors are prescribing side-effect-prone statin drugs, when for many
patients, testosterone enhancement would reduce cholesterol and
possibly C-reactive protein.(?) The failure of doctors to recognize
the critical importance of aging men maintaining youthful testosterone
levels has resulted in millions of needless heart attacks.
Do not wait for your doctor to discover the incredible value of
testosterone replacement therapy. You may not live that long! Please
check your blood for free testosterone, PSA, and other hormones such
as estradiol, and then follow our protocols to re-establish your
levels to those of a healthy 21-year-old. Most people are pleasantly
surprised to find how much better they feel when these critical
hormones are restored.
fresh~horses@despammed.com - 24 Aug 2004 17:58 GMT
> Please, find enclosed some interesting paragraphs of the latest Life
> Extension Magazine editorial, regarding testosterone and heart
> disease:

This issue further complicated by the fact that STATINS lower
testosterone. Lowered testosterone. Erectile dysfunction. Increased
aggression... .

Zee

> Testosterone, Independent Risk Factor for Heart Disease.
> The surprising finding from this new study is that blood pressure,
[quoted text clipped - 40 lines]
> surprised to find how much better they feel when these critical
> hormones are restored.
liaM - 25 Aug 2004 12:07 GMT
>>Please, find enclosed some interesting paragraphs of the latest Life
>>Extension Magazine editorial, regarding testosterone and heart
[quoted text clipped - 3 lines]
> testosterone. Lowered testosterone. Erectile dysfunction. Increased
> aggression... .  

perhaps not.  increased depression, instead !

> Zee
fresh~horses - 25 Aug 2004 23:53 GMT
> >>Please, find enclosed some interesting paragraphs of the latest Life
> >>Extension Magazine editorial, regarding testosterone and heart
[quoted text clipped - 5 lines]
>
> perhaps not.  increased depression, instead !

Salut Liam

Depression can manifest as aggression and anger. Flip sides of the
same coin, if you will.

See:

STATINS AND NON-CARDIAC ENDPOINTS  
Authors:

GOLOMB BA

Author Address: BGOLOMB@UCSD.EDU, UCSD SCHOOL OF MEDICINE, 9500 GILMAN
DRIVE, 0995, LA JOLLA, CA 92093-0995

Source: Crisp Data Base National Institutes of Health

Abstract:

DESCRIPTION (adapted from investigator's abstract): A relation of
lowered cholesterol to increased aggressive behaviors (including
suicide) and impaired cognition has been variably demonstrated and
remains to be established or excluded with confidence. HMG-CoA
reductase inhibitors ("statins") are the most widely used agents and
their effects are of special interest. Purpose: To examine the effect
of statins on aggressive responding, cognition, and serotonin in
individuals with moderate LDL and no identified cardiovascular disease
(CVD). Hypothesis: Statin therapy will increase aggressive responding
on the PSAP (Point Subtraction Aggression paradigm, a standardized
aggression measure that correlates with both violent behavior and
serotonin); will reduce measures of cognition (including psychomotor
speed and attention); and will change serotonin (gauged by whole blood
serotonin), which may be a mediator of effects on behavior and perhaps
cognition. Secondarily, it is hypothesized that simvastatin
(lipophilic) will exert more potent effects on cognition (and perhaps
aggression) than pravastatin (hydrophilic); that serotonin (5HT)
changes will related to changes in aggressive responding and perhaps
cognition; and that a "susceptible subset" may be defined by baseline
characteristics including biochemistry, mood, personality, and
extremes of cardiovascular reactivity.

Keywords:

serotonin

hydropathy

blood chemistry

antihypercholesterolemic agent

clinical trial

drug adverse effect

oxidoreductase inhibitor

human subject

HMG coA reductase

aggression

cognition

psychomotor function

human therapy evaluation

violence

clinical research

behavioral /social science research tag

Language: English

Publication Types:

Research

Supporting Agency: U.S. DEPT. OF HEALTH AND HUMAN SERVICES; PUBLIC
HEALTH SERVICE; NATIONAL INSTITUTES OF HEALTH, NATIONAL HEART, LUNG,
AND BLOOD INSTITUTE

Country or State: CALIFORNIA

Entry Month: June, 2003

Zip Code: 92093-0995

Year of Publication: 2002

Secondary Source ID: CRISP/2002/HL63055-04

Award Type: G

Document Number: CRISP/2002/HL63055-04



> > Zee
liaM - 26 Aug 2004 00:28 GMT
Yes.. Zee  ;)

When will you send me a picture of you !?  !!
fresh~horses@despammed.com - 26 Aug 2004 01:02 GMT
> Yes.. Zee  ;)
>
> When will you send me a picture of you !?  !!

Wha!?

Would how I look make a difference to your judgement of my analytical
and intellectual abilities? Hah!

Ask Andrew.

Zee
liaM - 26 Aug 2004 01:19 GMT
>>Yes.. Zee  ;)
>>
[quoted text clipped - 4 lines]
> Would how I look make a difference to your judgement of my analytical
> and intellectual abilities? Hah!

No, absolutely not.  It's just that I've grown fond of you !

> Ask Andrew.

for his picture ??!!  I'm uncertain whether I imagined seeing his
picture on his web site, but Zee, I have no trouble imagining
what he looks like..  holly molly, a chinese christian, it's easy !!

> Zee

liaM
great grandson and granson of chinese protestant pastors and westernized
doctors
fresh~horses@despammed.com - 27 Aug 2004 07:49 GMT
> >>Yes.. Zee  ;)
> >>
> >>When will you send me a picture of you !?  !!

I did. Zee
liaM - 27 Aug 2004 11:30 GMT
>>>>Yes.. Zee  ;)
>>>>
>>>>When will you send me a picture of you !?  !!
>
> I did. Zee

Thanks Zee.  I love intelligent women..

liaM
fresh~horses - 27 Aug 2004 16:33 GMT
> >>>>Yes.. Zee  ;)
> >>>>
[quoted text clipped - 5 lines]
>
> liaM

In spite of how men talk about wanting women with intelligence I
always found what I had had more currency. <s>

Zee
liaM - 27 Aug 2004 16:42 GMT
> In spite of how men talk about wanting women with intelligence I
> always found what I had had more currency. <s>
>
> Zee

ça fait mieux bander, n'est pas..  ;)

PS. no photo yet..   try

 cuddly@mindless.com
fresh~horses - 27 Aug 2004 23:33 GMT
> > In spite of how men talk about wanting women with intelligence I
> > always found what I had had more currency. <s>
> >
> > Zee
>
> ça fait mieux bander, n'est pas..  ;)

Non! I'm a good cook. A very good cook.

Zee

> PS. no photo yet..   try
>
>   cuddly@mindless.com
liaM - 28 Aug 2004 01:12 GMT
>>>In spite of how men talk about wanting women with intelligence I
>>>always found what I had had more currency. <s>
[quoted text clipped - 4 lines]
>
> Non! I'm a good cook. A very good cook.

I believe you are.. Zee.  A good cook and intelligent.

And good-looking like you wouldn't believe.  (Which brings me back to
the marrow of the bone of my contention )

Go ahead.. make a soup out of it !     ;)

liaM
Bill - 26 Aug 2004 05:18 GMT
> > >>Please, find enclosed some interesting paragraphs of the latest Life
> > >>Extension Magazine editorial, regarding testosterone and heart
[quoted text clipped - 106 lines]
>
> > > Zee

Does this just not say that they are looking at the question?

Bill
fresh~horses@despammed.com - 26 Aug 2004 08:03 GMT
Yes Bill. As does Muldoon et al in (but not only...) Neuropsychology of
Cardiovascular Disease, Waldstein. Zee

> > liaM <cuddly@mindless.com> wrote in message
> news:<cghrph$v8a$1@news-reader5.wanadoo.fr>...
[quoted text clipped - 113 lines]
>
> Bill
liaM - 24 Aug 2004 19:25 GMT
> You may not live that long! Please
> check your blood for free testosterone, PSA, and other hormones such
> as estradiol, and then follow our protocols to re-establish your
> levels to those of a healthy 21-year-old. Most people are pleasantly
> surprised to find how much better they feel when these critical
> hormones are restored.

20 mg pravastatin  daily for a year definetely lowered my sex drive..
Mirek Fidler - 24 Aug 2004 21:38 GMT
> would still be at greater risk for serious coronary artery blockage if
> you had low testosterone and low HDL.

Funny thing is that most things that are adviced to lower LDL are
responsible to lowering HDL and testosterone and vice versa :)))

Best thing you can do to raise your HDL and testosterone is to eat more
saturated fat - but that will raise your LDL too....

Mirek
 
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