Effect of heavy drinking on atherosclerosis?

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Peabody - 15 May 2008 15:32 GMT

I need to find an authoritative reference outlining the effect of
heavy regular (not binge drinking as such) alcohol consumption on
plaque buildup - if in fact there is any such relationship.

Thanks for any suggestions.

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Uncle Frederik - 15 May 2008 16:16 GMT

Peabody has brought this to us :

> Thanks for any suggestions.

Google?

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Susan - 15 May 2008 16:37 GMT

> I need to find an authoritative reference outlining the effect of
> heavy regular (not binge drinking as such) alcohol consumption on
> plaque buildup - if in fact there is any such relationship.
>
> Thanks for any suggestions.

I'm not going to do your search for you, but I do know that heavy
regular drinking causes high cortisol, which carries with it all the
damage that steroid abuse does, including diabetes and CVD.

Susan

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Andrew B. Chung, MD/PhD - 15 May 2008 21:02 GMT

> I need to find an authoritative reference outlining the effect of
> heavy regular (not binge drinking as such) alcohol consumption on
> plaque buildup - if in fact there is any such relationship.

http://archinte.ama-assn.org/cgi/content/full/160/17/2605

"Finally, among men initially consuming 1 drink per day or more (n=4483), those who increased intake had a 63% increased risk of CVD compared with men with no changes."

Hope the above reference is helpful.

Prayerfully in the infinite power and might of the Holy Spirit,

Andrew <><
--
Andrew B. Chung, MD/PhD
Lawful steward of http://EmoryCardiology.com
A latter-day disciple of the KING of kings and LORD of lords.
http://HeartMDPhD.com/HolySpirit/DiscipleNow

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J666 - 15 May 2008 21:37 GMT

On Thu, 15 May 2008 15:02:37 -0500, Andrew B. Chung, MD/PhD wrote

> http://archinte.ama-assn.org/cgi/content/full/160/17/2605
>
[quoted text clipped - 7 lines]
>
> Andrew

So if follow the 2PD Blah Blan and just drink 2 pounds of Vodka or gin a day,
then you will avoid heart disease and will be healthy and blessed.

See http://heartmdphd.com/LaChaim

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Peabody - 15 May 2008 22:02 GMT

Andrew B. Chung, MD/PhD says...

>> I need to find an authoritative reference outlining the
>> effect of heavy regular (not binge drinking as such) alcohol
>> consumption on plaque buildup - if in fact there is any such
>> relationship.

> http://archinte.ama-assn.org/cgi/content/full/160/17/260 5

Thanks for the reference, Andrew.

However, on careful reading, I find pretty much the same thing I
found on my original search. There doesn't really appear to be a
strong correlation between heavy alcohol consumption and
atherosclerosis per se, although there is with respect to
myopathy and strokes.

I found this link:

http://www.aim-digest.com/gateway/pages/general/articles/J-shaped
%20curve.htm

which contains this:

> The authors conducted a meta-analysis of 156 papers on 15
> alcohol-related conditions, including a total of 116,706 cases.
[quoted text clipped - 4 lines]
> esophagus, 3.8 of the larynx, 1.2 of the colon, 1.4 of the
> rectum, 1.8 of the liver, and 2.4 of the breast.

> For non-neoplastic conditions, corresponding RR estimates for
> 100 g/day were 4.2 for essential hypertension, 1.1 for coronary
[quoted text clipped - 4 lines]
> coronary heart disease, ischemic stroke, and gastro-duodenal
> ulcer.

Notice the "mere" 1.1 relative risk ratio for CHD.

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Andrew B. Chung, MD/PhD - 16 May 2008 02:54 GMT

> Andrew, in the Holy Spirit, boldly wrote:
>
[quoted text clipped - 6 lines]
>
> Thanks for the reference, Andrew.

Laus Deo :-)

> However, on careful reading, I find pretty much the same thing I
> found on my original search. There doesn't really appear to be a
[quoted text clipped - 28 lines]
>
> Notice the "mere" 1.1 relative risk ratio for CHD.

The earlier cited study is more persuasive because they documented a
dose response.

Be hungry... be healthy... be hungrier... be healthier...

Prayerfully in the infinite power and might of the Holy Spirit,

Andrew <><
--
http://tinyurl.com/45eyrl

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