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Medical Forum / General / Cardiology / April 2008Reduction in Blood Pressure With Statins
Results From the UCSD Statin Study, a Randomized Trial Beatrice A. Golomb, MD, PhD; Joel E. Dimsdale, MD; Halbert L. White, PhD; Janis B. Ritchie, BSN; Michael H. Criqui, MD, MPH Arch Intern Med. 2008;168(7):721-727. Background Some studies have suggested reductions in blood pressure (BP) with statin treatment, particularly in persons with hypertension. Randomized trial evidence is limited. Methods We performed a randomized, double-blind, placebo-controlled trial with equal allocation to simvastatin, 20 mg; pravastatin sodium,40 mg; or placebo for 6 months. Nine hundred seventy-three men and women without known cardiovascular disease or diabetes mellitus, with low- density lipoprotein cholesterol screening levels of 115 to 190mg/dL, had assessment of systolic and diastolic BP (SBP and DBP, respectively). Blood pressure values were compared for placebo vs statins by intention- to-treat (ITT) analysis. Additional analyses were performed that (1) were confined to subjects with neither high baseline BP (SBP >140 mm Hg or DBP >90mm Hg) nor receiving BP medications, to exclude groups in whom BP medications or medication changes may have influenced results, and (2) separately evaluated simvastatin and pravastatin (vs placebo). The time course of BP changes after statin initiation and the effect of stopping statins on BP were examined. Results Statins modestly but significantly reduced BP relative to placebo,by 2.2 mm Hg for SBP (P = .02) and 2.4mm Hg for DBP (P < .001) in ITT analysis.Blood pressure reductions ranged from 2.4 to 2.8 mm Hg for both SBP and DBP with both simvastatin and pravastatin, in those subjects with full follow-up, and without potential for influence by BP medications (ie, neither receiving nor meriting BP medications). Conclusions Reductions in SBP and DBP occurred with hydrophilic and lipophilic statins and extended to normotensive subjects. These modest effects may contribute to the reduced risk of stroke and cardiovascular events reported on statins. Trial Registration clinicaltrials.gov Identifier: NCT00330980 > Results From the UCSD Statin Study, a Randomized Trial > [quoted text clipped - 35 lines] > > Trial Registration clinicaltrials.gov Identifier: NCT00330980 1: Life Sci. 2008 Mar 8 [Epub ahead of print] Links Association between risk of myopathy and cholesterol-lowering effect: A comparison of all statins. Kobayashi M, Chisaki I, Narumi K, Hidaka K, Kagawa T, Itagaki S, Hirano T, Iseki K. Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-jo, Nishi-6-chome, Kita-ku, Sapporo 060-0812, Japan. In the present study, we examined the mechanisms underlying the cytotoxicity of pitavastatin, a new statin, and we compared the in vitro potencies of muscle cytotoxicity using a prototypic embryonal rhabdomyosarcoma cell line (RD cells), a typical side effect of statins and compared the cholesterol-lowering effects of statins using Hep G2 hepatoma cells. Pitavastatin reduced the number of viable cells and caused caspase-9 and -3/7 activation in a time- and concentration-dependent manner. The comparison of cytotoxities of statins showed that statins significantly reduced cell viability and markedly enhanced activity of caspase-3/7 in concentration-dependent manner. On the other hand, the effects of hydrophilic statins, pravastatin, rosuvastatin were very weak. The rank order of cytotoxicity was cerivastatin > simvastatin acid> fluvastatin > atorvastatin > lovastatin acid > pitavastatin >> rosuvastatin, pravastatin. Statin-induced cytotoxicity is associated with these partition coefficients. On the other hand, the cholesterol-lowering effect of statins did not correlate with these partition coefficients and cytotoxicity. Thus, it is necessary to consider the association between risk of myopathy and cholesterol-lowering effect of a statin for precise use of statins. PMID: 18402982 [PubMed - as supplied by publisher]  SignatureGarden in shade zone 5 S Jersey USA x-n0-archive: yes Thus, it is necessary to consider the association between > risk of myopathy and cholesterol-lowering effect of a statin for precise > use of statins. > PMID: 18402982 [PubMed - as supplied by publisher] Of course they lower blood pressure, they suppress adrenal function, which explains a LOT about the awful, declining quality of life so many statin users report. Susan > x-n0-archive: yes > [quoted text clipped - 5 lines] > > Susan and for all those statin takers who do not have increased blood pressure........how about a little hypotension. great for the brain to be hypoperfused. Susan <nevermind@nomail.com> wrote in news:66i065F2k0t23U1 @mid.individual.net: > x-n0-archive: yes > [quoted text clipped - 8 lines] > > Susan I must have missed where the highly respected Dr. Golomb said that. > I must have missed where the highly respected Dr. Golomb said that. I must've missed where you've ever posted other than to shill for statins. NIH is studying adrenal suppression by statins right now. Susan >x-no-archive: yes > [quoted text clipped - 5 lines] > >Susan Beta blockers lower blood pressure by suppresing adrenal response, so if the study turns out that statins do this also then would substantiate the OP's premise. Zob > Beta blockers lower blood pressure by suppresing adrenal response, so > if the study turns out that statins do this also then would > substantiate the OP's premise. > > Zob The mechanism is different with statins; all of our adrenal steroids, including sex hormones, are made from LDL. The body raises LDL as part of the endocrine feedback loop to try and maintain normal endocrine function. Lower LDL to below endogenous levels and you deprive the body of the material required to produce adrenal steroids. Susan Susan <nevermind@nomail.com> wrote in news:66ksv8F2kd14oU1 @mid.individual.net: > I must've missed where you've ever posted other than to shill for statins. > > NIH is studying adrenal suppression by statins right now. > > Susan This is just too funny! Are you saying Dr. Golomb is a paid shill? She would be offended, for sure. All I did was report on the results of her study, without comment. This is the same study that has been ongoing for years and many of you anti-statinites couldn't wait for results to appear - thinking they would, of course, all be negative. You are a hopeless bunch. > This is just too funny! Are you saying Dr. Golomb is a paid shill? She > would be offended, for sure. All I did was report on the results of her [quoted text clipped - 3 lines] > > You are a hopeless bunch. I'm saying you post only to shill statins, IME. And lots of "respected" doctors shill for drug companies. Those are the ones the drug companies most like to pay off, er... hire. Turns out that the docs don't even have to write the papers, the drug companies (Vioxx anyone?) hire ghost writers to spare the docs any real effort. Susan Susan <nevermind@nomail.com> wrote in news:66nam3F2kieb5U1 @mid.individual.net: > x-no-archive: yes > [quoted text clipped - 16 lines] > > Susan Forget about me in this post. I made no comment on the article I posted. But if you seriously think that Dr. Golomb is a shill for drug companies you are more delusional that I already suspected. Better yet, why don't you give her a call and ask her. https://www.statineffects.com/info/contact.htm Bill <b2forewagner@snip.net> wrote in news:b2forewagner- D344E3.16350114042008@sn-indi.vsrv-sjc.supernews.net: >> Results From the UCSD Statin Study, a Randomized Trial >> [quoted text clipped - 41 lines] > Association between risk of myopathy and cholesterol-lowering effect: A > comparison of all statins. Yes, better to deflect than admit you might be wrong. > Results From the UCSD Statin Study, a Randomized Trial > [quoted text clipped - 35 lines] > > Trial Registration �clinicaltrials.gov Identifier: NCT00330980 This is a lot of bull. I wonder what cholesterol pill manufacturer paid off the authors of this article. BS. If any dummy believes this they are stupid. Gee that last paragraph ::::: These modest > effects may contribute to the reduced risk of stroke and cardiovascular > events reported on statins. GEE DO THEY THIN THE BLOOD TOO RUDUCING THE RISKS OF STROKES. BLAH BLAH lipanzmarija7@aol.com wrote in news:b3bd6483-cc10-46d0-a1bc-ff96d2f1ad70 @k37g2000hsf.googlegroups.com: >> Results From the UCSD Statin Study, a Randomized Trial >> [quoted text clipped - 48 lines] >> events reported on statins. GEE DO THEY THIN THE BLOOD TOO RUDUCING THE RI > SKS OF STROKES. BLAH BLAH This came out of the University of California San Diego Statin Effects Study, which Dr. Golomb runs and has been ongoing for a few years now. Why don't you give them a call and tell them how stupid you think they are. (858) 558-4950 x 206. > lipanzmari...@aol.com wrote in news:b3bd6483-cc10-46d0-a1bc-ff96d2f1ad70 > @k37g2000hsf.googlegroups.com: [quoted text clipped - 72 lines] > > - Show quoted text - I WOULDN'T WASTE THE TIME OF DAY CALLING THOSE CROOKS. PLUS THE FDA CDC AND DEPT OF HLTH & HUMAN SERVICES COULD GO YOU KNOW WHERE. Conclusions Reductions in SBP and DBP occurred with hydrophilic and lipophilic statins and extended to normotensive subjects. These modest effects may contribute to the reduced risk of stroke and cardiovascular events reported on statins. Trial Registration clinicaltrials.gov Identifier: NCT00330980 I STILL SAY THIS ABOVE PARAGRAPH IS A LOT OF BULL. I AGREE WITH SUSAN'S COMMENTS. THE CAUSE OF PLAQUE AND ARTERIAL DISEASE IS CHRONIC LAY LOWING INFLAMATION WHICH IN TURN CAUSES DAMAGE TO ARTERY WALLS. THEN NATURALLY IF YOU HAVE A ROUGH DAMAGED PIPE GARBAGE WILL STICK TO IT. THIS BIG DEAL ON KEEPING CHOLESTEROL SO EXTREMELY LOW IS SICK. ONE NEEDS CHOLESTEROL FOR VARIOUS THINGS ESP LIKE MAKING ANTI BODIES ETC. TOO LOW IS NO GOOD EITHER. AND THE PEOPLE THAT EXPERIENCED SERIOUS NERVE DAMAGE AND MUSCLE DAMAGE FROM CERTAIN STATINS. IT ALL IN THE MONEY. WHAT HAPPENED TO THAT GREAT PERI-OPERATIVE BETA BLOCKER STUDY A FEW YRS. AGO. SILENCE. I KNOW OF A LOVED ONE THAT WAS SERIOUSLY INJURED BEING IN THAT STUDY LIKE INFARCTION- BRADYCARDYIA- ACUTE KIDNEY FAILURE- FIBRILATION- GANGRENE- ENCEPHALAPATHY - COLLAPSED LUNG AND LATER DIED. IT WAS DENIED THE PATIENT WAS IN THE STUDY AND THE WIFE WAS NEVER TOLD OF THOSE HORRIBLE THINGS THAT HAPPENED. WIFE HAPPENED TO SEE ON ONE OF THE DIAGNOSIS SHEETS COLLAPSED LUNG THEN STARTED CHECKING. IT WAS DISCOVERED THE PATIENT WAS IN IT PLUS THEY WERE A LOW RISK AND THE STUDY WAS FOR INTERMEDIATE & HIGH RISK FOR CARDIAC PROBLEMS DURING THE SURGERY. THEN IT WAS SAID THEY WERE IN THE CONTROL ARM OF THE STUDY - BUT THE WIFE HAS A COPYOF THE THIRTY FOLLOW UP ASSESSMENT SHEET - IS PATIENT STILL ON BETA BLOCKERS -IF SO WHAT DOSE ETC. SIGNED BY THE STUDY CO- ORDINATOR. THEY REFUSE TO GIVE THE WIFE HER HUSBAND'S PERI- OPERATIVE FLOW REPORT PLUS WIFE FOUND OUT THE STUDY REPORT WAS DONE THROUGH ANOTHER SOURCE. IT'S ALL IN THE MONEY -BETA BLOCKERS ARE CHEAP CHEAP AND DANGEROUS. A LOT OF PEOPLE ARE ALLERGIC TO THEM TOO. THIS WHOLE AMERICAN MED. SYSTEM IS CORRUPT. lipanzmarija7@aol.com wrote in news:b719d021-12e9-4635-b716-be8d1e66e7c2 @k13g2000hse.googlegroups.com: >> This came out of the University of California San Diego Statin Effects >> Study, which Dr. Golomb runs and has been ongoing for a few years now. [quoted text clipped - 38 lines] > CHEAP CHEAP AND DANGEROUS. A LOT OF PEOPLE ARE ALLERGIC TO THEM TOO. > THIS WHOLE AMERICAN MED. SYSTEM IS CORRUPT. Yes, you're right. Don't call. > lipanzmari...@aol.com wrote in news:b719d021-12e9-4635-b716-be8d1e66e7c2 > @k13g2000hse.googlegroups.com: > Yes, you're right. Don't call.- Hide quoted text - > > - Show quoted text - My suspicion is that this is the only study from dr. golomb's group that could find publication...... eml <mmlevy46@hotmail.com> wrote in news:f4d87650-8b96-4764-ac12- 9985af358c30@c65g2000hsa.googlegroups.com: >> lipanzmari...@aol.com wrote in news:b719d021-12e9-4635-b716-be8d1e66e7c2 >> @k13g2000hse.googlegroups.com: [quoted text clipped - 5 lines] > My suspicion is that this is the only study from dr. golomb's group > that could find publication...... Why don't you put your suspicion where your mouth is - call her and ask. I'm sure she would enlighen you. See ya... >>lipanzmari...@aol.com wrote in news:b719d021-12e9-4635-b716-be8d1e66e7c2 >>@k13g2000hse.googlegroups.com: [quoted text clipped - 5 lines] > My suspicion is that this is the only study from dr. golomb's group > that could find publication...... It's very possible that, at least in the short term, the adrenal suppression by statins will lower blood pressure, but adrenal suppression over the long haul comes with a LOT of serious problems and collateral damage. Susan |
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