If you see the way the needle is fixed into the port, I doubt that it's
possible, at least, even if I was completely paranoiac during my cancer
treatment, this is not something which came across my mind. The main
potential complication of the port is thrombosis, this is what you have to
watch carefully if your hand or neck get strangely warm or swollen.

Regine

Are you saying that actually happened? If so, I'll try to research it
when I have a moment.
J

...

Yes this can certainly happen. Extravasation and tissuing are essentially
the same thing....the chemo drug gets into the tissues and can cause a toxic
local reaction sometimes resulting in a necrotic ulcer which can be a bugger
to heal.
Having said that I wouldn't get into a panic about it. If the site is still
ok after a few weeks then chances are no great damage has been done. I've
seen a few instances of chemo going where it shouldn't and there were no
major problems as I recall.
Doctors and nurses usually are imagining the worst possible scenario when
this happens, hence the tense reaction. Wait and see is my advice. After the
initial event there is little that can be done anyway.
MIKE

If she was getting the usual first-line combination of melphalan and
prednisone she could develop (delayed) tissue necrosis at the site of
extravasation, although melphalan is generally not considered a
vesicant.  Local treatment: Infiltrate the site with hyaluronidase.
Apply heat and compression.