Medical Forum / Diseases and Disorders / Cancer / May 2008
Vitamin K2 reduces the risk of prostate cancer
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Juhana Harju - 09 Apr 2008 06:48 GMT Vitamin K2 seems to reduce the risk of prostate cancer according to this study. In Western diets the best vitamin K2 sources are some cheeses, yogurt, chicken, and turkey. The Japanese soy food /natto/ is much higher in vitamin K2 but it has different kind of vitamin K2 (menaquinone-7) and it is not clear if it would also have the similar effect, but I guess it would.
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Nimptsch K, Rohrmann S, Linseisen J.
Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg).
American Journal of Clinical Nutrition, Vol. 87, No. 4, 985-992, April 2008.
Background: Anticarcinogenic activities of vitamin K have been observed in various cancer cell lines, including prostate cancer cells. Epidemiologic studies linking dietary intake of vitamin K with the development of prostate cancer have not yet been conducted.
Objective: We evaluated the association between dietary intake of phylloquinone (vitamin K1) and menaquinones (vitamin K2) and total and advanced prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition.
Design: At baseline, habitual dietary intake was assessed by means of a food-frequency questionnaire. Dietary intake of phylloquinone and menaquinones (MK-4-14) was estimated by using previously published HPLC-based food-content data. Multivariate-adjusted relative risks of total and advanced prostate cancer in relation to intakes of phylloquinone and menaquinones were calculated in 11 319 men by means of Cox proportional hazards regression.
Results: During a mean follow-up time of 8.6 y, 268 incident cases of prostate cancer, including 113 advanced cases, were identified. We observed a nonsignificant inverse association between total prostate cancer and total menaquinone intake [multivariate relative risk (highest compared with lowest quartile): 0.65; 95% CI: 0.39, 1.06]. The association was stronger for advanced prostate cancer (0.37; 0.16, 0.88; P for trend = 0.03). Menaquinones from dairy products had a stronger inverse association with advanced prostate cancer than did menaquinones from meat. Phylloquinone intake was unrelated to prostate cancer incidence (1.02; 0.70, 1.48).
Conclusions: Our results suggest an inverse association between the intake of menaquinones, but not that of phylloquinone, and prostate cancer. Further studies of dietary vitamin K and prostate cancer are warranted.
http://www.ajcn.org/cgi/content/abstract/87/4/985
[Not in PubMed yet.]
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Juhana Harju - 09 Apr 2008 17:21 GMT > Vitamin K2 seems to reduce the risk of prostate cancer according to > this study. In Western diets the best vitamin K2 sources are some [quoted text clipped - 47 lines] > > [Not in PubMed yet.] Vitamin K researcher, Professor Ceer Vermeer states in the news article of NutraIngredients that vitamin K2 has a anti-tumor effect:
"'The anti-tumor effect of K2 vitamins has been suggested in several other (mainly Japanese) papers; in most cases these papers were based on smaller numbers, however. Also, in Japan it is usual to provide very high doses of the short-chain menaquinone-4 (45 mg/day or higher)', said Dr. Vermeer.
'The elegance of the Nimptsch paper is that the effect is found at nutritional doses of vitamin K', he added."
http://tinyurl.com/5zk9gs
Thanks to Matti Narkia's bookmarking I found this abstract which explains that vitamin K2 induces a slow apoptosis (death) of cancer cells. That should be the mechanism by which vitamin K2 is associated with reduced prostate cancer risk.
http://tinyurl.com/69oa2d
 Signature Juhana
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Taka - 10 Apr 2008 01:50 GMT > > Vitamin K2 seems to reduce the risk of prostate cancer according to > > this study. In Western diets the best vitamin K2 sources are some [quoted text clipped - 72 lines] > > Ravintoblogini:http://ruohikolla.blogspot.com/ Now tell me what is better for killing cancer cells - VitK2 or Omega-3s? Both seem to work via the same mechanism, i.e. oxidative stress leading to apoptosis which is preventable by VitE. Japanese have higher intakes of both and have therefore lower cancer rates and are less obese (more apoptosis going on in their bodies). But the world longest living people are not from Japan but from Brazil and France ... (the 113 old Japanese just died before reaching 120).
Taka
Dan - 10 Apr 2008 03:46 GMT on 4/9/08 7:50 PM Taka said the following:
>>> Vitamin K2 seems to reduce the risk of prostate cancer according to >>> this study. In Western diets the best vitamin K2 sources are some [quoted text clipped - 74 lines] > > Taka It is very hard to compare populations because of different life-styles. But some general points can be made for all that are mostly obvious: reduce mental stress, get good sleep, eat well from all the macro groups that gives you good energy, and practice good hygiene. If you can provide a living, move to the country side for fresher air. And get your 15-30 minutes sunlight (depending on skin hue) everyday!
Taka - 10 Apr 2008 06:11 GMT > If you can > provide a living, move to the country side for fresher air. And get > your 15-30 minutes sunlight (depending on skin hue) everyday! That may be problematic since people tend moving into big cities recently (at least in Japan). When they are young for entertainment and after they mature for the job/living. So I think the evolution will move in favor of the adapted city dwellers. The sunshine and physical activity can be compensated for in sports clubs/gyms and sunbathing salons but those who wouldn't need it will save more time. Also the adapted city dwellers of the future may not be the smartest since they will invest more time into reproduction than education and thinking generally. The current social system well supports this and the "stupid" people are better to control by the establishment. Also adaptation to the junk food such as refined carbohydrates and vegetable oils will help them to propagate.
Taka
trigonometry1972@gmail.com | - 10 Apr 2008 08:46 GMT > > If you can > > provide a living, move to the country side for fresher air. And get [quoted text clipped - 14 lines] > > Taka Having seen both the big cities and small towns of my region, I think they all pretty much look alike. And I think the denizens of each eat much the same way overall. The more educated eat slightly better and the poor considerably worse generally speaking. It also seems to me education is also a social control that blocks at least as much thinking as it creates.
For the generations prior to modern times with its application of hygiene and germ theory, the cities were in my opinion a likely place to die of infectious disease at least more so the in the countryside.
Give it a little time, with a population collapse in the human population city dwellers may again be back to the 1 to 20 ratio of previous eras. Collapses of populations have happened before and so logically should happen again.
Trig
'You can fool most of the people most of the time and you fool some of the people some of the time but you can't fool all of the people all of time.'
Dan - 10 Apr 2008 13:33 GMT on 4/10/08 2:46 AM trigonometry1972@gmail.com | said the following:
>>> If you can >>> provide a living, move to the country side for fresher air. And get [quoted text clipped - 39 lines] > and you fool some of the people some of the time > but you can't fool all of the people all of time.' I made no comment on small towns. I am talking about the individual. Countryside air is more healthy than city air.
Taka - 13 Apr 2008 16:11 GMT On Apr 10, 4:46 pm, "trigonometry1...@gmail.com |" <trigonometry1...@gmail.com> wrote:
> Give it a little time, with a population collapse in the human > population city > dwellers may again be back to the 1 to 20 ratio of previous eras. > Collapses of populations have happened before and so logically should > happen again. I don't think the cities are going to collapse anytime soon unless e.g. big earthquake hits right under Tokyo (but even that would have only a small localized effect) or there is a global war. Not only antibiotics but also vaccination protects people from the common epidemics. The pets like dogs are compulsory vaccinated too. The cattle and poultry can live in crowded conditions even thriving on food they are not evolutionary adapted to consume such as grains in the case of cows thanks to antibiotics and hormones. The city dwellers are in a sense in similar conditions. Even the avian influenza "epidemic" in farm birds is successfully being prevented by vaccination e.g. in China. With the rise of these new "technologies" and things such as genetic engineering and the globalization which prevents wars I think there is no longer the "city collapse cycle". Things like the refined "synthetic" foods and vaccines create huge business opportunity for the drug companies to sell drugs inhibiting their long term ill effects such as autoimmunity and allergies.
Taka
trigonometry1972@gmail.com | - 24 Apr 2008 05:43 GMT > On Apr 10, 4:46 pm, "trigonometry1...@gmail.com |" > [quoted text clipped - 23 lines] > > Taka War is always coming and so is collapse. A virus or other pathogen will find a way. More people, more poorly fed people will in time result in disorder, breakdown, lack of prevention, lack of immunity and then it will take off, IMO.
Dan - 10 Apr 2008 13:31 GMT on 4/10/08 12:11 AM Taka said the following:
>> If you can >> provide a living, move to the country side for fresher air. And get [quoted text clipped - 14 lines] > > Taka The industrial revolution is over in Western countries. The Internet allows you to live anywhere if you are knowledge worker. And don't follow the masses off the cliff. -- Dan
noname - 12 Apr 2008 10:55 GMT > on 4/10/08 12:11 AM Taka said the following: > >> If you can [quoted text clipped - 19 lines] > allows you to live anywhere if you are knowledge worker. And don't > follow the masses off the cliff. -- Dan Twenty years ago everyone thought and hoped that the internet would allow every knowledge worker to telecommute, but it's just not happening. Only very few people have that luxury. In fact, major companies are cutting back on who they allow to telecommute - demanding face-to-face interaction and all-day monitoring. Maybe it will still happen some day, but we aren't there yet.
Taka - 12 Apr 2008 15:18 GMT > Twenty years ago everyone thought and hoped that the internet would > allow every knowledge worker to telecommute, but it's just not > happening. Only very few people have that luxury. In fact, major > companies are cutting back on who they allow to telecommute - > demanding face-to-face interaction and all-day monitoring. Maybe it > will still happen some day, but we aren't there yet. I second that. If you were a computer programmer or an online trader you can work from your home "high in the country mountains" but for most people their personal presence at the workplace in the city is required. So they are going to live close to their workplace inside the city and breathe the metropolitan air.
Taka
dorsy1943 - 24 Apr 2008 13:45 GMT > > > Vitamin K2 seems to reduce the risk of prostate cancer according to > > > this study. In Western diets the best vitamin K2 sources are some [quoted text clipped - 84 lines] > > - Show quoted text - Taka, I'll tell you the truth, I would prize longevity but unless I will be able to lob tennis balls over a net and take salsa lessons, I really do not aim for 120. I do not do these things now, but if you live that long it would be nice to try something new. I would consider myself lucky to live to an active independent 110.
Dolores
Marshall Price - 27 Apr 2008 02:02 GMT >>> Vitamin K2 seems to reduce the risk of prostate cancer according to >>> this study. In Western diets the best vitamin K2 sources are some [quoted text clipped - 74 lines] > > Taka I heard just recently on a show about government-sponsored health care practices around the world that the Japanese have the longest life expectancies. It was "Frontline: Sick Around the World."
 Signature Marshall Price of Miami Known to Yahoo as d021317c
Juhana Harju - 27 Apr 2008 06:29 GMT > I heard just recently on a show about government-sponsored health care > practices around the world that the Japanese have the longest life > expectancies. It was "Frontline: Sick Around the World." What is remarkable is the fact that Japanese also have to longest _healthy_ life expectancy.
http://www.who.int/inf-pr-2000/en/pr2000-life.html
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Juhana Harju - 27 Apr 2008 06:42 GMT >> I heard just recently on a show about government-sponsored health >> care practices around the world that the Japanese have the longest [quoted text clipped - 4 lines] > > http://www.who.int/inf-pr-2000/en/pr2000-life.html More recent and detailed data can be obtained from here:
http://www.who.int/whosis/indicators/2007HALE0/en/
 Signature Juhana
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Marshall Price - 27 Apr 2008 21:33 GMT >>> I heard just recently on a show about government-sponsored health >>> care practices around the world that the Japanese have the longest [quoted text clipped - 7 lines] > > http://www.who.int/whosis/indicators/2007HALE0/en/ What do you do with an .xls file?
 Signature Marshall Price of Miami Known to Yahoo as d021317c
Juhana Harju - 28 Apr 2008 05:16 GMT >>>> I heard just recently on a show about government-sponsored health >>>> care practices around the world that the Japanese have the longest [quoted text clipped - 9 lines] > > What do you do with an .xls file? That is a good question. I also had problems with that file. However, I did find the link in the right upper corner useful (Data: Healthy life expectancy (HALE) at birth (years)).
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RF - 11 May 2008 05:05 GMT >>>> I heard just recently on a show about government-sponsored health >>>> care practices around the world that the Japanese have the longest [quoted text clipped - 9 lines] > > What do you do with an .xls file? Use Microsoft Excel to open and read it. If you don't have that, try OpenOffice.org. It has the equivalent of Word, Excel, etc
Marshall Price - 27 Apr 2008 21:29 GMT >> I heard just recently on a show about government-sponsored health care >> practices around the world that the Japanese have the longest life [quoted text clipped - 4 lines] > > http://www.who.int/inf-pr-2000/en/pr2000-life.html I don't know why, but I didn't expect to see Australia ranking so high. It's such a mysterious country -- sort of a cross between Wales and Brazil. ;-)
 Signature Marshall Price of Miami Known to Yahoo as d021317c
Juhana Harju - 28 Apr 2008 05:21 GMT >>> I heard just recently on a show about government-sponsored health >>> care practices around the world that the Japanese have the longest [quoted text clipped - 8 lines] > high. It's such a mysterious country -- sort of a cross between Wales > and Brazil. ;-) Perhaps it is healthy to keep the head downwards. ;-)
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