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Medical Forum / Diseases and Disorders / Cancer / May 2008

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Vitamin K2 reduces the risk of prostate cancer

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Juhana Harju - 09 Apr 2008 06:48 GMT
Vitamin K2 seems to reduce the risk of prostate cancer according to this
study. In Western diets the best vitamin K2 sources are some cheeses,
yogurt, chicken, and turkey. The Japanese soy food /natto/ is much higher in
vitamin K2 but it has different kind of vitamin K2 (menaquinone-7) and it is
not clear if it would also have the similar effect, but I guess it would.

----------------------------------------------------------------------

Nimptsch K, Rohrmann S, Linseisen J.

Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg
cohort of the European Prospective Investigation into Cancer and Nutrition
(EPIC-Heidelberg).

American Journal of Clinical Nutrition, Vol. 87, No. 4, 985-992, April 2008.

Background: Anticarcinogenic activities of vitamin K have been observed in
various cancer cell lines, including prostate cancer cells. Epidemiologic
studies linking dietary intake of vitamin K with the development of prostate
cancer have not yet been conducted.

Objective: We evaluated the association between dietary intake of
phylloquinone (vitamin K1) and menaquinones (vitamin K2) and total and
advanced prostate cancer in the Heidelberg cohort of the European
Prospective Investigation into Cancer and Nutrition.

Design: At baseline, habitual dietary intake was assessed by means of a
food-frequency questionnaire. Dietary intake of phylloquinone and
menaquinones (MK-4-14) was estimated by using previously published
HPLC-based food-content data. Multivariate-adjusted relative risks of total
and advanced prostate cancer in relation to intakes of phylloquinone and
menaquinones were calculated in 11 319 men by means of Cox proportional
hazards regression.

Results: During a mean follow-up time of 8.6 y, 268 incident cases of
prostate cancer, including 113 advanced cases, were identified. We observed
a nonsignificant inverse association between total prostate cancer and total
menaquinone intake [multivariate relative risk (highest compared with lowest
quartile): 0.65; 95% CI: 0.39, 1.06]. The association was stronger for
advanced prostate cancer (0.37; 0.16, 0.88; P for trend = 0.03).
Menaquinones from dairy products had a stronger inverse association with
advanced prostate cancer than did menaquinones from meat. Phylloquinone
intake was unrelated to prostate cancer incidence (1.02; 0.70, 1.48).

Conclusions: Our results suggest an inverse association between the intake
of menaquinones, but not that of phylloquinone, and prostate cancer. Further
studies of dietary vitamin K and prostate cancer are warranted.

http://www.ajcn.org/cgi/content/abstract/87/4/985

[Not in PubMed yet.]

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Juhana Harju - 09 Apr 2008 17:21 GMT
> Vitamin K2 seems to reduce the risk of prostate cancer according to
> this study. In Western diets the best vitamin K2 sources are some
[quoted text clipped - 47 lines]
>
> [Not in PubMed yet.]

Vitamin K researcher, Professor Ceer Vermeer states in the news article of
NutraIngredients that vitamin K2 has a anti-tumor effect:

"'The anti-tumor effect of K2 vitamins has been suggested in several other
(mainly Japanese) papers; in most cases these papers were based on smaller
numbers, however. Also, in Japan it is usual to provide very high doses of
the short-chain menaquinone-4 (45 mg/day or higher)', said Dr. Vermeer.

'The elegance of the Nimptsch paper is that the effect is found at
nutritional doses of vitamin K', he added."

http://tinyurl.com/5zk9gs

Thanks to Matti Narkia's bookmarking I found this abstract which explains
that vitamin K2 induces a slow apoptosis (death) of cancer cells. That
should be the mechanism by which vitamin K2 is associated with reduced
prostate cancer risk.

http://tinyurl.com/69oa2d

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Taka - 10 Apr 2008 01:50 GMT
> > Vitamin K2 seems to reduce the risk of prostate cancer according to
> > this study. In Western diets the best vitamin K2 sources are some
[quoted text clipped - 72 lines]
>
> Ravintoblogini:http://ruohikolla.blogspot.com/

Now tell me what is better for killing cancer cells - VitK2 or
Omega-3s?  Both seem to work via the same mechanism, i.e. oxidative
stress leading to apoptosis which is preventable by VitE.  Japanese
have higher intakes of both and have therefore lower cancer rates and
are less obese (more apoptosis going on in their bodies).  But the
world longest living people are not from Japan but from Brazil and
France ... (the 113 old Japanese just died before reaching 120).

Taka
Dan - 10 Apr 2008 03:46 GMT
on 4/9/08 7:50 PM Taka said the following:
>>> Vitamin K2 seems to reduce the risk of prostate cancer according to
>>> this study. In Western diets the best vitamin K2 sources are some
[quoted text clipped - 74 lines]
>
> Taka

It is very hard to compare populations because of different life-styles.
 But some general points can be made for all that are mostly obvious:
reduce mental stress, get good sleep, eat well from all the macro groups
that gives you good energy, and practice good hygiene.  If you can
provide a living, move to the country side for fresher air.  And get
your 15-30 minutes sunlight (depending on skin hue) everyday!
Taka - 10 Apr 2008 06:11 GMT
> If you can
> provide a living, move to the country side for fresher air.  And get
> your 15-30 minutes sunlight (depending on skin hue) everyday!

That may be problematic since people tend moving into big cities
recently (at least in Japan).  When they are young for entertainment
and after they mature for the job/living.  So I think the evolution
will move in favor of the adapted city dwellers.  The sunshine and
physical activity can be compensated for in sports clubs/gyms and
sunbathing salons but those who wouldn't need it will save more time.
Also the adapted city dwellers of the future may not be the smartest
since they will invest more time into reproduction than education and
thinking generally.  The current social system well supports this and
the "stupid" people are better to control by the establishment.  Also
adaptation to the junk food such as refined carbohydrates and
vegetable oils will help them to propagate.

Taka
trigonometry1972@gmail.com | - 10 Apr 2008 08:46 GMT
> > If you can
> > provide a living, move to the country side for fresher air.  And get
[quoted text clipped - 14 lines]
>
> Taka

Having seen both the big cities and small towns of my region, I think
they all
pretty much look alike. And I think the denizens of each eat much
the same way overall. The more educated eat slightly better and
the poor considerably worse generally speaking.
It also seems to me education is also a social control that
blocks at least as much thinking as it creates.

For the generations prior to modern times with its application of
hygiene and germ theory,
the cities were in my opinion a likely place to die of infectious
disease at least more
so the in the countryside.

Give it a little time, with a population collapse in the human
population city
dwellers may again be back to the 1 to 20 ratio of previous eras.
Collapses of populations have happened before and so logically should
happen again.

Trig

'You can fool most of the people most of the time
and you fool some of the people some of the time
but you can't fool all of the people all of time.'
Dan - 10 Apr 2008 13:33 GMT
on 4/10/08 2:46 AM trigonometry1972@gmail.com | said the following:

>>> If you can
>>> provide a living, move to the country side for fresher air.  And get
[quoted text clipped - 39 lines]
> and you fool some of the people some of the time
> but you can't fool all of the people all of time.'

I made no comment on small towns.  I am talking about the individual.
Countryside air is more healthy than city air.
Taka - 13 Apr 2008 16:11 GMT
On Apr 10, 4:46 pm, "trigonometry1...@gmail.com |"
<trigonometry1...@gmail.com> wrote:
> Give it a little time, with a population collapse in the human
> population city
> dwellers may again be back to the 1 to 20 ratio of previous eras.
> Collapses of populations have happened before and so logically should
> happen again.

I don't think the cities are going to collapse anytime soon unless
e.g. big earthquake hits right under Tokyo (but even that would have
only a small localized effect) or there is a global war.  Not only
antibiotics but also vaccination protects people from the common
epidemics.  The pets like dogs are compulsory vaccinated too.  The
cattle and poultry can live in crowded conditions even thriving on
food they are not evolutionary adapted to consume such as grains in
the case of cows thanks to antibiotics and hormones.  The city
dwellers are in a sense in similar conditions.  Even the avian
influenza "epidemic" in farm birds is successfully being prevented by
vaccination e.g. in China.  With the rise of these new "technologies"
and things such as genetic engineering and the globalization which
prevents wars I think there is no longer the "city collapse cycle".
Things like the refined "synthetic" foods and vaccines create huge
business opportunity for the drug companies to sell drugs inhibiting
their long term ill effects such as autoimmunity and allergies.

Taka
trigonometry1972@gmail.com | - 24 Apr 2008 05:43 GMT
> On Apr 10, 4:46 pm, "trigonometry1...@gmail.com |"
>
[quoted text clipped - 23 lines]
>
> Taka

War is always coming and so is collapse. A virus or other pathogen
will
find a way. More people, more poorly fed people will in time
result in disorder, breakdown, lack of prevention, lack of
immunity and then it will take off, IMO.
Dan - 10 Apr 2008 13:31 GMT
on 4/10/08 12:11 AM Taka said the following:
>> If you can
>> provide a living, move to the country side for fresher air.  And get
[quoted text clipped - 14 lines]
>
> Taka

The industrial revolution is over in Western countries.  The Internet
allows you to live anywhere if you are knowledge worker.  And don't
follow the masses off the cliff.  -- Dan
noname - 12 Apr 2008 10:55 GMT
> on 4/10/08 12:11 AM Taka said the following:
> >> If you can
[quoted text clipped - 19 lines]
> allows you to live anywhere if you are knowledge worker.  And don't
> follow the masses off the cliff.  -- Dan

Twenty years ago everyone thought and hoped that the internet would
allow every knowledge worker to telecommute, but it's just not
happening. Only very few people have that luxury. In fact, major
companies are cutting back on who they allow to telecommute -
demanding face-to-face interaction and all-day monitoring. Maybe it
will still happen some day, but we aren't there yet.
Taka - 12 Apr 2008 15:18 GMT
> Twenty years ago everyone thought and hoped that the internet would
> allow every knowledge worker to telecommute, but it's just not
> happening. Only very few people have that luxury. In fact, major
> companies are cutting back on who they allow to telecommute -
> demanding face-to-face interaction and all-day monitoring. Maybe it
> will still happen some day, but we aren't there yet.

I second that.  If you were a computer programmer or an online trader
you can work from your home "high in the country mountains" but for
most people their personal presence at the workplace in the city is
required.  So they are going to live close to their workplace inside
the city and breathe the metropolitan air.

Taka
dorsy1943 - 24 Apr 2008 13:45 GMT
> > > Vitamin K2 seems to reduce the risk of prostate cancer according to
> > > this study. In Western diets the best vitamin K2 sources are some
[quoted text clipped - 84 lines]
>
> - Show quoted text -

Taka, I'll tell you the truth, I would prize longevity but unless I
will  be able to lob tennis balls over a net and take salsa lessons, I
really do not aim for 120.  I do not do these things now, but if you
live that long it would be nice to try something new.   I would
consider myself lucky to live to an active independent 110.

Dolores
Marshall Price - 27 Apr 2008 02:02 GMT
>>> Vitamin K2 seems to reduce the risk of prostate cancer according to
>>> this study. In Western diets the best vitamin K2 sources are some
[quoted text clipped - 74 lines]
>
> Taka

I heard just recently on a show about government-sponsored health care
practices around the world that the Japanese have the longest life
expectancies.  It was "Frontline: Sick Around the World."

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Juhana Harju - 27 Apr 2008 06:29 GMT
> I heard just recently on a show about government-sponsored health care
> practices around the world that the Japanese have the longest life
> expectancies.  It was "Frontline: Sick Around the World."

What is remarkable is the fact that Japanese also have to longest _healthy_
life expectancy.

http://www.who.int/inf-pr-2000/en/pr2000-life.html

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Juhana Harju - 27 Apr 2008 06:42 GMT
>> I heard just recently on a show about government-sponsored health
>> care practices around the world that the Japanese have the longest
[quoted text clipped - 4 lines]
>
> http://www.who.int/inf-pr-2000/en/pr2000-life.html

More recent and detailed data can be obtained from here:

http://www.who.int/whosis/indicators/2007HALE0/en/

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Marshall Price - 27 Apr 2008 21:33 GMT
>>> I heard just recently on a show about government-sponsored health
>>> care practices around the world that the Japanese have the longest
[quoted text clipped - 7 lines]
>
> http://www.who.int/whosis/indicators/2007HALE0/en/

  What do you do with an .xls file?

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Marshall Price of Miami
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Juhana Harju - 28 Apr 2008 05:16 GMT
>>>> I heard just recently on a show about government-sponsored health
>>>> care practices around the world that the Japanese have the longest
[quoted text clipped - 9 lines]
>
>  What do you do with an .xls file?

That is a good question. I also had problems with that file. However, I did
find the link in the right upper corner useful (Data: Healthy life
expectancy (HALE) at birth (years)).

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RF - 11 May 2008 05:05 GMT
>>>> I heard just recently on a show about government-sponsored health
>>>> care practices around the world that the Japanese have the longest
[quoted text clipped - 9 lines]
>
>   What do you do with an .xls file?

Use Microsoft Excel to open and read it. If you
don't have that, try OpenOffice.org.
It has the equivalent of Word, Excel, etc
Marshall Price - 27 Apr 2008 21:29 GMT
>> I heard just recently on a show about government-sponsored health care
>> practices around the world that the Japanese have the longest life
[quoted text clipped - 4 lines]
>
> http://www.who.int/inf-pr-2000/en/pr2000-life.html

  I don't know why, but I didn't expect to see Australia ranking so
high.  It's such a mysterious country -- sort of a cross between Wales
and Brazil.  ;-)

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Marshall Price of Miami
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Juhana Harju - 28 Apr 2008 05:21 GMT
>>> I heard just recently on a show about government-sponsored health
>>> care practices around the world that the Japanese have the longest
[quoted text clipped - 8 lines]
> high.  It's such a mysterious country -- sort of a cross between Wales
> and Brazil.  ;-)

Perhaps it is healthy to keep the head downwards. ;-)

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