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Medical Forum / Diseases and Disorders / Cancer / March 2008Cancer/Dormant chronic disease & Immune Response?
Hello, I am bit unclear on how host immune defence(not immunotherapies) can delay & treat cancer and other dormant/latent diseases: Can host immune defence mechanism delay, treat & cure cancer and other chronic/latent diseases, eg; TB? If yes, how it works and progress, if a patient remains untreated by modern interventions? Best wishes. on 3/23/08 12:16 AM Kumar said the following: > Hello, > [quoted text clipped - 6 lines] > > Best wishes. the immune system can slow down cancer spread along with chemo. The problem with cancer is uncontrolled cell division (using lots of glucose). So the best approach is to try to turn off the cancer pathway. That is what epigenetics is all about. > on 3/23/08 12:16 AM Kumar said the following: > [quoted text clipped - 13 lines] > glucose). So the best approach is to try to turn off the cancer > pathway. That is what epigenetics is all about. Pls tell me more about turning off cancer pathway. If nutrients or blood supply to cancer cells is restricted or stopped, can it control cancer? Other way, Whether immune cells kill or can kill cancer cells, if immunity is strong? on 3/23/08 8:48 AM Kumar said the following: >> on 3/23/08 12:16 AM Kumar said the following: >> [quoted text clipped - 14 lines] > cancer? Other way, Whether immune cells kill or can kill cancer cells, > if immunity is strong? Well, the problem is other cells need nutrients too. And the immune system can't always identify wayward native cells. That is why people are rarely cured of cancer (i.e. uncontrolled cell division) Simply use google to search on 'epigenetics': http://www.google.com/search?source=ig&hl=en&rlz=&q=epigenetics&btnG=Google+Search This holds out the best hope for reprogramming the cancer cells, much like fixing bugs in software. > on 3/23/08 8:48 AM Kumar said the following: > [quoted text clipped - 20 lines] > system can't always identify wayward native cells. That is why people > are rarely cured of cancer (i.e. uncontrolled cell division) Whether following quote can be relevnt to how host defence works on cancer and other infections in dormacy: "Iron Loading and Disease Surveillance Eugene D. Weinberg Indiana University, Bloomington, Indiana, USA -------------------------------------------------------------------------------- Iron is an oxidant as well as a nutrient for invading microbial and neoplastic cells. Excessive iron in specific tissues and cells (iron loading) promotes development of infection, neoplasia, cardiomyopathy, arthropathy, and various endocrine and possibly neurodegenerative disorders. To contain and detoxify the metal, hosts have evolved an iron withholding defense system, but the system can be compromised by numerous factors. An array of behavioral, medical, and immunologic methods are in place or in development to strengthen iron withholding. Routine screening for iron loading could provide valuable information in epidemiologic, diagnostic, prophylactic, and therapeutic studies of emerging infectious diseases. http://www.cdc.gov/Ncidod/EID/vol5no3/weinberg.htm " Broadly, there may three states, primary, dormant and active in chronic dormant typediseases as cancer, TB etc. I think, there may be two types of progression in each state representing fight for survival betwwen host defence and disease agents. As such one should be direction towards cure/ treatment(host defence mediated) and other direction towards progression of disease(disease agent mediated. Whoever is stronger can wil ultimately. As such, I was willing to better understand, possible direction towards cure/treatment by host defence in all three states. Btw, When host defence recognizes cancer cells & start working? > Simply use google to search on 'epigenetics': > > http://www.google.com/search?source=ig&hl=en&rlz=&q=epigenetics&btnG=... > > This holds out the best hope for reprogramming the cancer cells, much > like fixing bugs in software.- Hide quoted text - Thanks, I shall check. > - Show quoted text - > Well, the problem is other cells need nutrients too. And the immune > system can't always identify wayward native cells. That is why people are > rarely cured of cancer (i.e. uncontrolled cell division) I wish people who purport to have at least some knowledge would be careful with posting erroneous statements....... "People are rarely cured of cancer..."? Over 95% of skin cancers are cured. The commonest 20 other cancers in adults account for over 90% of all adult cancers. The five year survival rate is 65% overall, and most of those people are cured. So people are OFTEN cured of cancer, not 'rarely" on 3/24/08 3:18 PM Steph said the following: >> Well, the problem is other cells need nutrients too. And the immune >> system can't always identify wayward native cells. That is why people are [quoted text clipped - 8 lines] > people are cured. > So people are OFTEN cured of cancer, not 'rarely" I guess I should have said 'Metastatic Cancer' and 'cancer free for the long term'. I wasn't thinking skin since that is so easy to detect and treat. Internal organs are a different scenario, but point well taken. Peace. > on 3/24/08 3:18 PM Steph said the following: >>> Well, the problem is other cells need nutrients too. And the immune [quoted text clipped - 14 lines] > treat. Internal organs are a different scenario, but point well taken. > Peace. Which is why skin cancers are left out of the stats. The 65% figure is for the other adult cancers. Metastatic cancer is almost always incurable, except in rare cancers like testicular germ cell tumours. The fact is however, the 5 year survival rate overall for the common cancers is at least as good as the five year survival rate for many other diseases like myocardial infarction and COPD. > > Well, the problem is other cells need nutrients too. And the immune > > system can't always identify wayward native cells. That is why people are [quoted text clipped - 8 lines] > people are cured. > So people are OFTEN cured of cancer, not 'rarely" Is it curing by reversing cancer cells to normal cells OR just killing them? On Mar 25, 1:18 am, "Steph" <st...@vancouvers.island> wrote: > "Dan" <dannom...@nospamstuff.org> wrote in message > [quoted text clipped - 13 lines] > people are cured. > So people are OFTEN cured of cancer, not 'rarely" >Is it curing by reversing cancer cells to normal cells OR just killing <them? Almost always cure is achieved by killing the cancer cells while damaging the healthy cells to a point less than killing them, and allowing repair and recovery > On Mar 25, 1:18 am, "Steph" <st...@vancouvers.island> wrote: > [quoted text clipped - 24 lines] > > - Show quoted text - Is it direct killing cancer cells by toxic doses and their removal OR also reversing them to commit sucide alike normal cells? on 3/25/08 10:35 AM Kumar said the following: >> On Mar 25, 1:18 am, "Steph" <st...@vancouvers.island> wrote: >> [quoted text clipped - 21 lines] > Is it direct killing cancer cells by toxic doses and their removal OR > also reversing them to commit sucide alike normal cells? Are you talking about epigenetic therapy? If so, the latter. > on 3/25/08 10:35 AM Kumar said the following: > [quoted text clipped - 30 lines] > > - Show quoted text - Have you looked up following link, indicating about possible immune response? http://www.cdc.gov/Ncidod/EID/vol5no3/weinberg.htm |
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