Cancer, aspirin and statins...

Thread view:

Enable EMail Alerts

Start New Thread

Thread rating:

James Michael Howard - 18 May 2005 17:34 GMT

It is my hypothesis (1994) that testosterone increases breast cancer, and other
caner, rates ("Testosterone may cause breast cancer," International Journal of
Cancer 2005; 115: 497 and Annals of Internal Medicine 2005; 142: 471-2).

Statins reduce cellular production of testosterone up to 52% (Fertil Steril.
2004 Oct;82 Suppl 3:1193-7). Aspirin, which also reduces cancer with prolonged
use also reduces testosterone. I suggest this supports my hypothesis that
testosterone is involved in the initiation of breast cancer.

James Michael Howard
Fayetteville, Arkansas

Reply to this Message

Steph - 19 May 2005 02:09 GMT

> It is my hypothesis (1994) that testosterone increases breast cancer, and
> other
> caner, rates ("Testosterone may cause breast cancer," International
> Journal of
> Cancer 2005; 115: 497 and Annals of Internal Medicine 2005; 142: 471-2).

If it were that simple, breast cancer would be common in men......

> Statins reduce cellular production of testosterone up to 52% (Fertil
> Steril.
[quoted text clipped - 5 lines]
> James Michael Howard
> Fayetteville, Arkansas

Reply to this Message

James Michael Howard - 19 May 2005 11:53 GMT

>> It is my hypothesis (1994) that testosterone increases breast cancer, and
>> other
[quoted text clipped - 13 lines]
>> James Michael Howard
>> Fayetteville, Arkansas

You forgot Ockham's razor. First, start with the simpeist explanation. Next,
you have to understand that women have two hormones at work, estradiol and
testosterone affected their breasts. Men have one hormone at work. Also, you
need to know that a number of reports have supported my hypothesis regarding the
importance of testosterone in breast cancer in women. One says that
testosterone may be more important than estradiol: "testosterone might be more
strongly associated with [breast cancer] risk than estradiol" (Journal of the
National Cancer Institute 2002; 94: 606-616). "The estimated relative [breast
cancer] risks between upper and lower tertiles were 2.07 (95% confidence
interval [CI] 0.97-4.41) for estrone in postmenopausal women, 2.01 (95% CI
0.96-4.21) for testosterone in premenopausal women, and 2.40 (95% CI 1.11-5.21)
for testosterone in postmenopausal women, after adjusting for age at first live
birth, waist-to-hip ratio, total calorie intake, a history of fibroadenoma, a
family history of breast cancer and SHBG." (International Journal of Cancer
2003; 105: 92-7). ...and here is, I think, the latest: "CONCLUSIONS: Our
results support the hypothesis that elevated blood concentrations of androgens
are associated with an increased risk of breast cancer in premenopausal women."
(J Natl Cancer Inst. 2005 May 18;97(10):755-65).

Reply to this Message

Steph - 19 May 2005 16:25 GMT

>>> It is my hypothesis (1994) that testosterone increases breast cancer,
>>> and
[quoted text clipped - 46 lines]
> women."
> (J Natl Cancer Inst. 2005 May 18;97(10):755-65).

And I think you need to get a grip.
The complex interaction between oestrogen and testosterone undoubtedly has a
profound influence on both benign and malignant breast tissue.
But your statements that "testosterone increases breast cancer" or
"Testosterone may cause breast cancer," are simplistic nonsense - the test
being the simple one I stated

Reply to this Message