Anticancer Res. 2001 Nov-Dec;21(6A):3773-6. Related Articles, Links

Antiviral, cytotoxic and apoptotic activities of picolinic acid on
human immunodeficiency virus-1 and human herpes simplex virus-2
infected cells.

Fernandez-Pol JA, Klos DJ, Hamilton PD.

Laboratory of Molecular Oncology, DVA Medical Center, St. Louis, MO
63106, USA. fernandezpol@earthlink.net

The antiviral, cytotoxic and apoptotic effects of picolinic acid
against human immunodeficiency virus-1 (HIV-1) and human herpes simplex
virus-2 (HSV-2) infected cells were evaluated in cultured cells using
in vitro assays. Picolinic acid was tested at several concentrations
(from 0.15 to 3 mM) against one input dilution of the viruses to
determine if the agent had any antiviral activity against HIV-1 or
HSV-2. The results showed that picolinic acid at 1.5 mM (185 ug/mL) and
3 mM (369 ug/mL) was active against HIV-1 and HSV-2-infected cells,
causing cytotoxicity which resulted in apoptosis and lack of viral
replication. In parallel control experiments with non-infected cells,
picolinic acid also caused cytotoxicity and apoptosis, which was more
prominent at 3 mM than at 1.5 mM. Thus, infected cells appear to be
slightly more sensitive to the cytotoxic and apoptotic effects of
picolinic acid. The overlapping of the antiviral profile with the
cytotoxic profile of picolinic acid indicates that, in vitro, the most
likely sequence of events is that picolinic acid initially causes
cytotoxicity which in turn results in apoptosis of cells infected with
HIV-1 or HSV-2 and thus reduces the amount of viral replication.

PMID: 11911246 [PubMed - indexed for MEDLINE]

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