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Medical Forum / Diseases and Disorders / Prostate Cancer / February 2004

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Bill Denton - 11 Feb 2004 00:32 GMT
OK guys, I need some voices of reason, wisdom, experience, and psychic
ability. Here's the deal:
10/01 First ever PSA - 30  -  30 days on Cipro  -  PSA 33
12/01 Biopsy - PCa w/ G.S. 2+3
1/02  Bone scan, X-rays, MRI clear  
2/02  RP - G.S. 3+4, R seminal vesicle involvement, clear nodes, T3b
3/03  PSA nadir .07
6/03  PSA .17
8/03  PSA .2
1/04  PSA .37
2/04  Bone scan and ProstaScint - both clear (other than broken
ribs-?!?)

I'm seeing my uro tomorrow and I think he is going to want biopsy the
prostate bed but neither Walsh nor I see any reason to undergo that.
The question is whether I am metastatic not whether there is PCa in
the bed - that will be assumed. I think I should see a radiation
oncologist and if he thinks I should have RT then that's what I'll do;
if he thinks I need a biopsy then I'll do that first. But think about
it - in the absence of evidence of metastatis, how many of you would
you forego RT (your one chance of cure) and go to HT just because the
biopsy did not hit any PCa in the bed? So what good is the biopsy?Or
does the rad-onc need it to target the RT? I would think they would
hit the entire bed just in case.

Bill Denton
RP 2/12/02
Memphis
olfart - 11 Feb 2004 01:26 GMT
> OK guys, I need some voices of reason, wisdom, experience, and psychic
> ability. Here's the deal:
[quoted text clipped - 24 lines]
> RP 2/12/02
> Memphis

Hi Bill;
I'm relatively new at this, but I think consulting the Rad Onc is a good
idea. I don't believe that the biopsy is required in order to do RT on the
bed. In my case I will be getting 5 weeks of IMRT on the areas surrounding
the Prostate before I get a Theraseed implant. My Rad Onc has already shown
me how he will map the area around the Prostate for the radiation and it's
all done with scans, x-rays and the computer - no biopsy necessary. The fact
that you had RP and I won't may change how the RT is done - but I don't see
how. Hang in there for some more experienced advise from the group - and
good luck.
Age - 68
8/12/02 - PSA 3.7
10/13/03 - PSA 4.69
11/11/03 - PSA 4.8
11/18/03 - Biopsy - 10 cores
one core-25% of core-Gleason 4+4=8
all other cores benign tissue
12/10/03 - Consult - Oncologist
12/16/03 - Consult - Radiation Oncologist
Treatment Plan -
HT - started 12/17/03 - Eulixen & Lupron
Radiation - IMRT to begin 3/14/04 - for 5 weeks
Theraseed implant after Radiation completed
MH - 11 Feb 2004 02:28 GMT
Hi, Bill....

I agree with you.... I'd want to see a rad onc and pursue radiation of the
prostate bed right away.  *IF* the PSA doesn't come down afterwards, then
hit it with HT.  This seems to be the path most people have followed in such
cases.  Others with more experience here will be able to share more details,
I'm sure.

Hang in there!  And lean on us if you need a place to vent!

MikeH

> OK guys, I need some voices of reason, wisdom, experience, and psychic
> ability. Here's the deal:
[quoted text clipped - 24 lines]
> RP 2/12/02
> Memphis
Steve Kramer - 11 Feb 2004 12:14 GMT
I am not a doctor, but, for the life of me, I cannot imagine where a doctor
would probe in a biopsy if the suspect mass too tinier than what the
computer can see in a Prostascint Scan.

Signature

Prostate Cancer Survivor (so far), not a doctor
PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000
PSA  .1  .1  .1  .3  .4  .8
EBRT 05-07/2002 @ 47
PSA  .3 .2  .2  .2 .3
Erection 05/12/2003 @ 48
HTbegins 07/21/2003 @ 48
PSA  .1
Lupron 7/03, 8/03, 12/03

> OK guys, I need some voices of reason, wisdom, experience, and psychic
> ability. Here's the deal:
[quoted text clipped - 24 lines]
> RP 2/12/02
> Memphis
Alan Meyer - 12 Feb 2004 04:58 GMT
> I am not a doctor, but, for the life of me, I cannot imagine where a doctor
> would probe in a biopsy if the suspect mass too tinier than what the
> computer can see in a Prostascint Scan.

I'm not a doctor either, but I have to agree with Steve.
What will they biopsy?  Will it be 1 millimeter from the prostate
capsule?  5 millimeters?  10 millimeters?  In which direction?

My radiation covered the area 10 millimeters around the prostate
bed.  That's a decent volume of tissue - of all different kinds.  If
there were tumor extensions into any of it, they would have gotten
zapped.  If they had done a biopsy of a point, say, 3 millimeters up,
2 to the right, and 4 back from the top of the prostate capsule and
found no cancer, how much of that region would they ignore in
the radiation?  And how would they do it given that radiation covers
a lot more than just pinpoints?

I'm probably just ignorant, but if I were the patient, I'd like to hear
an explanation of what the biopsy will do before I went for it.

  Alan
Dave P - 11 Feb 2004 19:21 GMT
Hi Bill,

This is my story.

I was at .3  and it was 3 months after my RP. - 6 weeks after my RP I was at
<0.1

Many Doctors and some of the leading specialist in the US thought the cancer
spread from the bed since it returned so quickly. Some suggested going on HT
and Sloan Kettering told me they have never seen a case where radiation
worked when the psa came back so quickly and it would be best to go on HT. I
called them one day to tell them that my psa dropped to <0.01 after
radiation. They never returned my call.

Anyway, I did the research and I opted for IMRT. My psa is now <0.01

I would see a Rad Oncologist.

I have read that it is best to get the salvage radiation done when your PSA
is below .6 for best results. I went in at .3  Research states the lower the
better. My dose was 68,400 gy. My uro stated that 68-72 was the range that
would be effective - the more the better. My Rad Onc stated that he would
only give my 68,400. Research states that anything above 64 gy is
appropriate for Salvage Radiation. I would of opted for 72+ if it was my
decision. I trusted the Doc and took the 68gy. My Uro wanted me to take HT
before radiation. I had the HT pills and was scheduled to get the shot.
Amazingly I never followed through with the HT and just got the radiation. I
was so pissed off and dejected at the time and being a health nut I decided
to fight this disease on my own terms. My Rad Onc wasn't all that enthused
about HT either with salvage radiation anyway. He stated that their wasn't
enough research on it and if the cancer was in the IMRT zone then there
would be a 95% chance of a cure/success. If my Rad Onc wanted me to do the
HT I definetly would have.

I had a positive margin. PSA was 4.8 before RP and my gleason was 3+4, 47
yrs old.

It was my last ditch attempt before HT. I give thanks to God for it working
and pray daily that it remains at <0.01  I believe that the radiation got
all of the cancer and if there is anything remaining my immune system will
get the rest or at least hold it at bay. I am working daily on strenghening
my immune system

You never know whats going to happen, it may seem like your down and out
when in reality your one treatment away from winning -so keep the faith. You
can beat this thing.

I will pray for you. It can work. Nobody on earth knows at this time if it
has spread. Your Rad Onc Dr will explain everything.

Wishing you the best.

Dave P

> OK guys, I need some voices of reason, wisdom, experience, and psychic
> ability. Here's the deal:
[quoted text clipped - 24 lines]
> RP 2/12/02
> Memphis
Alan Meyer - 12 Feb 2004 04:59 GMT
> Hi Bill,
>
> This is my story. ...

Dave,

Thanks for posting that.  It gives a lot of useful detail about
possibilities and techniques in salvage radiation.

  Alan
Bill Denton - 12 Feb 2004 16:46 GMT
Thank you, Dave; I think most of us have figured out that w/ this
disease you sometimes just have to go for the chance you have of cure
and be damned w/ the statistics. How long has it been since your RT?

Oh, before my uro could mention the B word I just told him that I
wanted to see a rad-onc and get his opinion on RT. He agreed but he
thinks it is useless because my PSA was detectable w/i a year.

Now get this - I had a .1 and then .2 but then insisted on another lab
using the ultrasensitive test and it came back w/ 2 successive .07s
before a .18 and up to .37 from there. So I observed that although it
was detectable at .1 - .2 w/i 9 mos., it subsequently was
"undetectable" at .07, and that it was 15 mos. before confirmed
detectability. He said no, the .07 IS detectable so you have always
been detectable after the first .1. In other words, 3 men get PSAs,
one the standard test that comes back <.1, the second gets the
ultrasensitive that comes back .07, and the third gets the super
sensitive one that comes back .003. According to my uro, the second
and third guys are at greater statistical risk of metastasis because
they have "detectable" PSA while the first does not. That's even
though the first may actually have gotten .09 had he had a more
sensitive test. Is that ridiculous or what? Am I not correct that when
the Partin II tables were done, the best they had was the standard
test so <.1 is the cutoff the tables use for "detectability?" So, if
you are going to use those tables, don't you have to assume that
anything below .1 is "undetectable?"

Bill Denton
RP 2/12/02    (Note that today is my 2-year anniversary.)
Memphis
Dave P - 12 Feb 2004 19:33 GMT
Bill,

Below is a research study on Salvage Radiation.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgicmd=Retrieve&db=PubMed&list_uids=14
532786&dopt=Abstract


My last IMRT treatment was May 21, 2003. My next PSA is in April.

My Rad Onc stated that it would be useless to perform a biopsy. Like finding
a needle in a haystack the size of Utah. The prostatinct procedure was also
out of the question since it really doesn't detect PCa at 0.3 levels. I
believe the Dr thought I was toast and he really didn't want to go ahead
with the Radiation and was definetly not optimistic. As a matter of fact
they were going to cancel the treatments due to a mri scan that showed I had
a swollen lymph node in my groin. They called me a few hours later and told
me it was a large blood vessel that looked like a lymph node.

The people on this group kept my hope alive and provided better info and
honest answers than any Dr ever did.

It is worth a shot to investigate radiation.

Wishing you the best.

Dave P

> Thank you, Dave; I think most of us have figured out that w/ this
> disease you sometimes just have to go for the chance you have of cure
[quoted text clipped - 26 lines]
> RP 2/12/02    (Note that today is my 2-year anniversary.)
> Memphis
Steve Kramer - 12 Feb 2004 22:22 GMT
Congratulation, Bill.  2 years and counting.  Let us hope it represents a
very small percentage of the rest of your life.

Signature

Prostate Cancer Survivor (so far), not a doctor
PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000
PSA  .1  .1  .1  .3  .4  .8
EBRT 05-07/2002 @ 47
PSA  .3 .2  .2  .2 .3
Erection 05/12/2003 @ 48
HTbegins 07/21/2003 @ 48
PSA  .1
Lupron 7/03, 8/03, 12/03

> Thank you, Dave; I think most of us have figured out that w/ this
> disease you sometimes just have to go for the chance you have of cure
[quoted text clipped - 26 lines]
> RP 2/12/02    (Note that today is my 2-year anniversary.)
> Memphis
 
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