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Medical Forum / Diseases and Disorders / Prostate Cancer / February 2004

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Antioxidants and Soy supplements during Radiation ?

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Kurt Pearson - 05 Feb 2004 03:34 GMT
Hello All,

What are your thoughts on continuing or discontinuing anti-oxidants and soy
supplements during radiation treatment?

I asked my Radiologist about this, and he said it was up to me as a personal
choice.  He said he doubted that one could take enough anti-oxidants to
protect any of the cancer cells from the radiation.

I am currently taking vitamins C and E, Selenium and Genistein Soy
supplements.

I am due to have seed implants in a few weeks, followed by EBRT.

Thanks,

           Kurt

PSA 20 07/05/2003 @ Age 46

Biopsy 07/18/2003 12 out 12 cores positive Gleason 3+4, T3

Bone Scan 07/22/2003 Negative

CT Scan 07/29/2003 Negative Spread

Lymph Nodes Dissection and Seminal Vesicles Biopsy 08/21/2003 Negative

Lupron started 08/29/2003

PSA 5.8 09/23/2003

PSA 5.2 12/24/2003

Brachytherapy I-125 Seed Implants Scheduled for 02/18/2004

5 weeks of EBRT Scheduled for 03/20/2004

Scheduled to be on Lupron for 2 years

Treatments by Kaiser Permanente Northern California
Steve Kramer - 05 Feb 2004 11:20 GMT
> What are your thoughts on continuing or discontinuing anti-oxidants and soy
> supplements during radiation treatment?
[quoted text clipped - 5 lines]
> I am currently taking vitamins C and E, Selenium and Genistein Soy
> supplements.

The better you can do for your natural tissue during radiation, the better
you will be with regard to side effects.  Walk a lot.  Drink a lot of water.
Get more sleep than you are used to.  And, I would take the antioxidants.
Antioxidants are good for you; bad for cancer.

Signature

Prostate Cancer Survivor (so far), not a doctor
PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000
PSA  .1  .1  .1  .3  .4  .8
EBRT 05-07/2002 @ 47
PSA  .3 .2  .2  .2 .3
Erection 05/12/2003 @ 48
HTbegins 07/21/2003 @ 48
PSA  .1
Lupron 7/03, 8/03, 12/03

> Hello All,
ron - 05 Feb 2004 16:10 GMT
Hi Kurt...Your question, do antioxidants help cancerous cells more or
less than normal cells during RT, has been around for a long time.
Since the question has been around for a while, this might mean that
it is a close call and probably doesn't matter too much one way or the
other.  Here is a recent abstract that reviews data on the subject.
Judging by the last sentence, it looks like the authors conclude that
antioxidants help...Best wishes and good health, Ron

Cancer Treat Rev. 2002 Apr;28(2):79-91

Pros and cons of antioxidant use during radiation therapy.

Prasad KN, Cole WC, Kumar B, Che Prasad K.

Center for Vitamin and Cancer Research, Department of Radiology,
Health Sciences Center, University of Colorado, Denver, CO 80262, USA.
kedar.prasad@uchsc.edu

Radiation therapy is one of the major treatment modalities in the
management of human cancer. While impressive progress like more
accurate dosimetry and more precise methods of radiation targeting to
tumor tissue has been made, the value of radiation therapy in tumor
control may have reached a plateau. At present, two opposing
hypotheses regarding the use of antioxidants during radiation therapy
have been proposed. One hypothesis states that supplementation with
high doses of multiple micronutrients including high dose dietary
antioxidants (vitamins C and E, and carotenoids) may improve the
efficacy of radiation therapy by increasing tumor response and
decreasing some of its toxicity on normal cells. The other hypothesis
suggests that antioxidants (dietary or endogenously made) should not
be used during radiation therapy, because they would protect cancer
cells against radiation damage. Each of these hypotheses is based on
different conceptual frameworks that are derived from results obtained
from specific experimental designs, and thus, each may be correct
within its parameters. The question arises whether any of these
concepts and experimental designs can be used during radiation therapy
to improve the management of human cancer by this modality. This
review has analyzed published data that are used in support of each
hypothesis, and has revealed that the current controversies can be
resolved, if the results obtained from one experimental design are not
extrapolated to the other. This review has also discussed the
scientific rationale for a micronutrient protocol that includes high
doses of dietary antioxidants (vitamin C, vitamin E succinate and
natural beta-carotene) which can be used adjunctively with radiation
therapy.

> Hello All,
>
[quoted text clipped - 37 lines]
>
> Treatments by Kaiser Permanente Northern California
Kurt Pearson - 08 Feb 2004 00:08 GMT
 Thanks Steve and Ron for reply... I have decided to keep taking the
antioxidants and soy supplements.
 Thanks, again.

 Kurt

 PSA 20 07/05/2003 @ Age 46
 Biopsy 07/18/2003 12 out 12 cores positive Gleason 3+4, T3
 Bone Scan 07/22/2003 Negative
 CT Scan 07/29/2003 Negative Spread
 Lymph Nodes Dissection and Seminal Vesicles Biopsy 08/21/2003 Negative
 Lupron started 08/29/2003
 PSA 5.8 09/23/2003
 PSA 5.2 12/24/2003
 Brachytherapy I-125 Seed Implants Scheduled for 02/18/2004
 5 weeks of EBRT Scheduled for /03/20/2004
 > Hi Kurt...Your question, do antioxidants help cancerous cells more or
 > less than normal cells during RT, has been around for a long time.
 > Since the question has been around for a while, this might mean that
 > it is a close call and probably doesn't matter too much one way or the
 > other.  Here is a recent abstract that reviews data on the subject.
 > Judging by the last sentence, it looks like the authors conclude that
 > antioxidants help...Best wishes and good health, Ron
 >
 > Cancer Treat Rev. 2002 Apr;28(2):79-91
 >
 > Pros and cons of antioxidant use during radiation therapy.
 >
 > Prasad KN, Cole WC, Kumar B, Che Prasad K.
 >
 > Center for Vitamin and Cancer Research, Department of Radiology,
 > Health Sciences Center, University of Colorado, Denver, CO 80262, USA.
 > kedar.prasad@uchsc.edu
 >
 > Radiation therapy is one of the major treatment modalities in the
 > management of human cancer. While impressive progress like more
 > accurate dosimetry and more precise methods of radiation targeting to
 > tumor tissue has been made, the value of radiation therapy in tumor
 > control may have reached a plateau. At present, two opposing
 > hypotheses regarding the use of antioxidants during radiation therapy
 > have been proposed. One hypothesis states that supplementation with
 > high doses of multiple micronutrients including high dose dietary
 > antioxidants (vitamins C and E, and carotenoids) may improve the
 > efficacy of radiation therapy by increasing tumor response and
 > decreasing some of its toxicity on normal cells. The other hypothesis
 > suggests that antioxidants (dietary or endogenously made) should not
 > be used during radiation therapy, because they would protect cancer
 > cells against radiation damage. Each of these hypotheses is based on
 > different conceptual frameworks that are derived from results obtained
 > from specific experimental designs, and thus, each may be correct
 > within its parameters. The question arises whether any of these
 > concepts and experimental designs can be used during radiation therapy
 > to improve the management of human cancer by this modality. This
 > review has analyzed published data that are used in support of each
 > hypothesis, and has revealed that the current controversies can be
 > resolved, if the results obtained from one experimental design are not
 > extrapolated to the other. This review has also discussed the
 > scientific rationale for a micronutrient protocol that includes high
 > doses of dietary antioxidants (vitamin C, vitamin E succinate and
 > natural beta-carotene) which can be used adjunctively with radiation
 > therapy.
 >
 >
 >
 > "Kurt Pearson" <kpearson@surewest.net> wrote in message
news:<1023edkovi5f795@corp.supernews.com>...
 > > Hello All,
 > >
 > >
 > >
 > > What are your thoughts on continuing or discontinuing anti-oxidants
and soy
 > > supplements during radiation treatment?
 > >
 > > I asked my Radiologist about this, and he said it was up to me as a
personal
 > > choice.  He said he doubted that one could take enough anti-oxidants
to
 > > protect any of the cancer cells from the radiation.
 > >
 > > I am currently taking vitamins C and E, Selenium and Genistein Soy
 > > supplements.
 > >
 > > I am due to have seed implants in a few weeks, followed by EBRT.
 > >
 > >
 > >
 > >  Thanks,
 > >
 > >             Kurt
 > >
 > >
 > >
 > >
 > >
 > > PSA 20 07/05/2003 @ Age 46
 > >
 > > Biopsy 07/18/2003 12 out 12 cores positive Gleason 3+4, T3
 > >
 > > Bone Scan 07/22/2003 Negative
 > >
 > > CT Scan 07/29/2003 Negative Spread
 > >
 > > Lymph Nodes Dissection and Seminal Vesicles Biopsy 08/21/2003 Negative
 > >
 > > Lupron started 08/29/2003
 > >
 > > PSA 5.8 09/23/2003
 > >
 > > PSA 5.2 12/24/2003
 > >
 > > Brachytherapy I-125 Seed Implants Scheduled for 02/18/2004
 > >
 > > 5 weeks of EBRT Scheduled for 03/20/2004
 > >
 > > Scheduled to be on Lupron for 2 years
 > >
 > > Treatments by Kaiser Permanente Northern California
Jack - 13 Feb 2004 03:22 GMT
"Kurt Pearson asked "What are your thoughts on continuing or
discontinuing anti-oxidants and soy supplements during radiation
treatment?"

This is a subject that has interested me quite some time.  I have
followed a fairly healthy low-fat diet (almost vegetarian) for years.
As part of my education on PC, I was fortunate to have heard Dr.
Charles Myers speak here in Sarasota in Oct on the management of PC.
The thrust of his presentation was that many cancers, and particularly
PC, can be effectively managed by diet, exercise, nutritional
supplements, vitamins, stress reduction.  He is not a 'kook'. He
pointed out the very powerful cancer fighting attributes of
antioxidants such as Selenium, lycopene, Vitamins E and C. He also had
a lot of good things to say about soy.  However, his presentation made
it clear that when undergoing radiation therapy, these antioxidants
can actually end up protecting the cancer cells as well as healthy
cells.  I emailed his web site and was answered by his wife, Dr. Rose
Myers a Phd nutritionist, that I was to follow my radiation
oncologists direction to not take all the above during treatment.
   I highly recommend that anyone interested in this subject
carefully review these web sites:
http://www.prostateforum.com/
http://www.ecpcp.org/    
http://www.wcrf.org/report/index.lasso


Sailor Jack: Age 63, excellent health, diagnosed in Sept (PSA 4,
Gleason 3+4, T1b, volume 34cc) I elected IMRT (25 treatments Dec-Jan)
and will get seeds next week (Pu-103).
 
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