WARNING:  The following is probably going to be a long, fact-filled post,
all about me, and probably not of much interest to any other than perhaps
the person who can answer my quandary.

The question is:  Is it likely that a dose of Lupron can spike cholesterol
and related numbers?

Background:  During 2000, I was diagnosed with PCa.  About that time, I was
also diagnosed with hypertension and my blood work (cholesterol, etc.)
numbers were high.  My weight was about 311 (36 BMI).

I immediately started walking and kept up this regimen to date.  Currently,
I walk 2.5 to 3.4 miles a day, 3 or 4 days a week.  I also began
hypertension and cholesterol meds and continue those to date.  My weight
increased over time.  It was 347 (41 BMI) in January 2009.  My blood
pressure was 140/82 and blood numbers were improved to and remained for
years about:  Cholesterol = 180; HDL = 33; LDL = 105; Triglycerides 338 --  
all too high or too low.

I started lifting weights when I retired January 10, 2009.  By March, my
weight ballooned to 358 (42.4 BMI) and I remembered muscle vs fat weight and
finally accepted that push aways were more important than push ups.  So, I
watched my diet.  But, my numbers were better: During April my BP was
116/65, Cholesterol = 145; LDL = 65; and Triglycerides = 236.  HDL did not
change.

Since January, I have had an impressive improvement in muscle strength:
biceps + 117%; pectoral fly + 275%; leg press + 228%; seated row + 118%;
shoulder press +175% (and since April) leg extension + 156%; rear deltoid
reverse fly + 153%; and leg curl + 112.  My 37-year back ache is gone.
While I thought I was doing well at my age in helping my kids with moving,
mulching, digging, etc., I am now doing much, much better.  I cannot tell
you how much adding a weight regimen to my life has helped.  I know, I
know...  I've been told this all my life!

But!!

On June 4, I had my uro appointment and got my 4-month Lupron shot.  The
next day, I had my blood pulled for PSA and blood numbers.  Yesterday, I
found that while my weight is down 25 pounds and BP is steady and great.
But my Cholesterol is 161 (up 16); LDL = 76 (okay, but up 11); and
triglycerides = 258 (up 22).  HDL is unchanged and too low at 33.  BTW, my T
was down, too, from 67 to 62 (on Lupron since 2003 and Casodex since 2006).

So what the hell happened?

Did my lupron shot 20 hours before lower my T?  Could it have had a spiking
effect on the rest of my numbers?  No change in diet since April and still
losing weight.