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Medical Forum / Diseases and Disorders / Prostate Cancer / May 2008

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Nanotechnology And Prostate Cancer

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R L - 24 May 2008 03:53 GMT
I have been excited about the possibilities of this technology since I
first saw the program on 60 minutes, and the other day on the CBS series
on cancer research. I did a little search today on Google and found that
a team at Yale was given a grant to study nanoparticles in prostate
cancer in April of 2007.   I hope this is something they will put on the
super fast track.  
~Ralph
Danger Mouse - 24 May 2008 08:50 GMT
>I have been excited about the possibilities of this technology since I
>first saw the program on 60 minutes, and the other day on the CBS series
[quoted text clipped - 3 lines]
>super fast track.  
>~Ralph

Stuff I read says it will go to clinical trials in about 3 years, and then
probably either be approved or not depending on how that turns out.  According
to my buddy who googled it last night, they have vectors allow the
nanoparticles to to seek out prostate, bone, and colon cancer .  Hopefully they
will find more.

Yes, this is wildly exciting stuff.  I'm hopeful it gets approved and is in use
in a few years in case my cancer returns.  Just lost my prostate last Tuesday
via robot attack, and supposedly have a 3 to 1 shot that I'll never see that
particular sort of cancer again.  If I do see it again, or find some other sort
of cancer, I'd love to have this option.

DM
R L - 24 May 2008 22:18 GMT
Thanks for your response.  I was lucky with kidney cancer (removed
kidney and attached ureter) in 2003.  In July of 2004 the pathologist
discovered Gleason 9 prostate cancer following a transuretheral
procedure.  The Urologist had not checked me for prostate cancer...I had
radiation therapy and a year later my PSA went up rapidly.  Bone scans
and CT scans of abdomen and pelvis revealed nothing.  The radiologist
was sharp enough to say..."there is something suspicious in lower lobe
of lung."  CT scan showed  I had multiple nodules in my lungs.  A biopsy
revealed adenocarcinoma.  They did a psa stain on the tissue and it was
prostate cancer of the lung.   Lupron shots caused the nodules to
resolve and the PSA dropped to less than .01 for about a year. The PSA
began to rise last September and the nodules in my lungs reappeared.
Now they have added Casodex pills daily.  The nodules stopped growing,
but did not resolve.  Bone scans, CT scans, and MRI scans of the spine
showed no cancer, except that in my lungs.  Since December  my PSA has
started to slowly rise.....from 0.7 to 2.4 over a period of about  five
or six months.  It would be nice to have something better than chemo to
look forward to.
Steve Kramer - 24 May 2008 23:09 GMT
> It would be nice to have something better than chemo to
> look forward to.

I wish you did, too, Ralph.  But, you've done well with a G9.
Alan Meyer - 26 May 2008 04:03 GMT
> ...  It would be nice to have something better than chemo to
> look forward to.

Ralph,

There are a number of treatments that can help before chemo
is started.  Some that I know about include:

Various supplements:
  pomegranate extract
  vitamin C
  resveratrol and quercetin
(I know that sounds a little silly, but a friend of mine with advanced
PCa was given all of those by Dr. Charles "Snuffy" Myers, a well
known medical oncologist specializing in PCa.

"Second line" hormone therapy - including estradiol patches
and ketoconazole.

Revlamid.  This is a thalidomide derivative.  After Myers put
my friend on this for one month, his hormone refractory cancer
showed a PSA drop from 14 to 8.  It has gradually come back
and Myers is going to try another revlamid treatment for him.

And chemotherapy itself.  The "average" benefit from chemo
doesn't sound great, but it's misleading.  One problem with the
existing numbers is that, in the past, chemo has not been given
until symptoms developed, very, very late in the game.  Some
docs now believe it can be much more effective if used earlier.
Also, the response to chemo varies considerably.  Some men
tolerate it well and some don't.  Some get a great deal of
benefit from it and some don't.  The averages are not a good
predictor of how any particular patient will do.

I hope you have access to a good medical oncologist who
is committed to battling with all of the tools available.  You
might still have more years ahead than you would otherwise
think and, who knows, you might benefit from one of the
new treatments that are now in development - perhaps in
a clinical trial.

I wish you the best of luck.

   Alan
Alex - 25 May 2008 04:08 GMT
>>I have been excited about the possibilities of this technology since I
>>first saw the program on 60 minutes, and the other day on the CBS series
[quoted text clipped - 23 lines]
>
> DM

One concern is if the tiny nano particles could migrate. New research
suggests nanontubes could act like asbestos if inhaled.
See http://www.sciencedaily.com/releases/2008/05/080520144004.htm.  A
concern about nanoparticles injected into the prostate is whether they might
migrate through the bloodstream to other parts of the body, notably the
lungs. (Even much larger items, such as the radioactive seeds injected into
the prostate for brachiotherapy, are known to wander far from "home.")

Alex
 
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