That's great!  That step was on the critical path to a HT cure.  And the
problem seems simpler than they expected.  Good news.

Interesting indeed. First of all, I am unclear whether this discovery
has anything to do w/ HT w/ LHRH agonists like Lupron since the study
apparently dealt only w/ antiandrogens like Casodex. Secondly, it is
counter to the development of hormone-refractory PCa as described by
Walsh. In his book he says that there are hormone-sensitive and
hormone insensitive cells from the get-go and that, since the hormone
insensitive ones are not affected by HT, they eventually predominate
and the PCa as a whole becomes hormone insensitive or refractory. This
study lends credence to the popularly held belief that the cells
mutate from sensitive to insensitive. If that is true, aside from the
direct implications of the study, it suggests that early HT might be a
good idea - catch it before it mutates.

Bill Denton
RP 2/12/02
Memphis