Hi Steve, I actually have something good to report for a change. You
may recall that the Lupron I was on was beginning to fail as my psa
began to climb and at a pretty scary rate. I was just getting ready to
go off the Lupron at that time, so did so anyhow. After a year or so
being off of it, maybe a year and a half??, I went back on it three
months ago, with the addition of Casodex.
Neither my oncologist nor the urologist believed that it was going to be
effective, that I was hormone refractory, but it was worth a try. My
psa then was 2.1 and now after three months on Lupron and Casodex it has
dropped to 0.4. That is the lowest it has been in a couple years now.
I am still looking closely at some trials, but sure feel a lot better
with the lowering of the psa rather than the constant upward trend.
Also on a good note, the SE's so far have not been nearly as much of a
problem as the last two times on ADT. Life is good.
> Hi Steve, I actually have something good to report for a change. You may
> recall that the Lupron I was on was beginning to fail as my psa began to
[quoted text clipped - 7 lines]
> then was 2.1 and now after three months on Lupron and Casodex it has
> dropped to 0.4. That is the lowest it has been in a couple years now.
That is so fantastic as to be almost unbelievable. I am extremely happy for
you.
> I am still looking closely at some trials, but sure feel a lot better with
> the lowering of the psa rather than the constant upward trend.
I cannot help but to think that trials would be most effective at .040. I
wish I could get myself to accept that notion while I am at .040.
> ... I went back on it three
> months ago, with the addition of Casodex.
If your doctor hasn't done it, he should get a testosterone reading.
I remember that Steve Kramer was on Lupron for years, but his
T rating was actually well above the "castrate" level. When his
PSA started to climb he added Casodex and brought it under
control again.
It's possible that Lupron just wasn't enough to hold his cancer
in check and he needed the Casodex to block the remaining T
from feeding his cancer cells.
In short, Steve was not necessarily hormone refractory. He
may just not have had an intense enough HT.
I think everyone on HT should be tested for this.
> Neither my oncologist nor the urologist believed that it was going to be
> effective, that I was hormone refractory, but it was worth a try. My
> psa then was 2.1 and now after three months on Lupron and Casodex it has
> dropped to 0.4. That is the lowest it has been in a couple years now.
That is excellent news.
> Also on a good note, the SE's so far have not been nearly as much of a
> problem as the last two times on ADT.
More excellent news.
> Life is good.
Ain't it the truth.
Best of luck.
Alan
Steve Kramer - 27 Feb 2008 09:18 GMT
> If your doctor hasn't done it, he should get a testosterone reading.
> I remember that Steve Kramer was on Lupron for years, but his
> T rating was actually well above the "castrate" level. When his
> PSA started to climb he added Casodex and brought it under
> control again.
Actually, I started ADT1 in July 2003 and due to a rise in PSA added Casodex
in 2006. It was not until 2007 that I had my T tested and it was 61. The
best explanation I have heard is that my T probably was knocked down
sufficiently and, after three years, started to rise; requiring the Casodex
to knock the PSA back down.
This, in no way, disputes Alan's recommendations regarding T testing.

Signature
PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA <.1 <.1 <.1 .27 .37 .75 PSAD 0.19 years
EBRT 05-07/2002 @ 47
PSA .34 .22 .15 .21 .32 PSAD .056 years
Lupron 07/03 (1 mo) 8/03 and every 4 months there after
PSA .07 .05 .06 .09 .08 .132 .145 PSAD 1.4 years
Casodex added daily 07/06
PSA <0.04, <0.05, <0.04, <0.04, <0.1 2/12/08
Non Illegitimi Carborundum
Bob C. - 27 Feb 2008 16:40 GMT
>> ... I went back on it three
>> months ago, with the addition of Casodex.
>
> If your doctor hasn't done it, he should get a testosterone reading.
Thanks Alan, makes sense. I have already canceled my lab work for this
week which was just for the usual cholesterol and such, and am going to
have a face to face with the doctor first to address several issues.
Then they can pull some extra blood and do several additional tests and
I'll add the request to have T checked as well. Thanks for the input.