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Medical Forum / Diseases and Disorders / Prostate Cancer / January 2008

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CNTO 328 & Mitoxantrone For Advanced Prostate Cancer

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Paul - 24 Jan 2008 15:50 GMT
Has anyone undergone this treatment or know anything about it? My Dad
is considering joining this study.

Signature

PSA @ 45 yrs. = 4.7 02/06/2007
Biopsy 03/16/2007 G7(3+4),T1c
RLRP 06/12/2007 G7(3+4),T2cN0M0 Neg margins
PSA 07/16/2007 = <0.1
PSA 09/12/2007 = <0.1
PSA 12/18/2007 = <0.1

Unquestionably Confused - 24 Jan 2008 18:07 GMT
> Has anyone undergone this treatment or know anything about it? My Dad
> is considering joining this study.

>PSA @ 45 yrs. = 4.7 02/06/2007
>Biopsy 03/16/2007 G7(3+4),T1c
>RLRP 06/12/2007 G7(3+4),T2cN0M0 Neg margins
>PSA 07/16/2007 = <0.1
>PSA 09/12/2007 = <0.1
>PSA 12/18/2007 = <0.1

I know nothing about the study or treatment but, being a seven year
survivor with a less glowing post op path report, I am compelled to ask
WHY your father would consider follow-up chemo earmarked for ADVANCED PCa.

Am I missing something here?  Why roll the dice for additional side
effects of chemo in addition to the SE's he's already dealing with
(hopefully, these are minimal) from the RLRP?
Paul - 25 Jan 2008 02:17 GMT
>> Has anyone undergone this treatment or know anything about it? My Dad
>> is considering joining this study.
[quoted text clipped - 13 lines]
>effects of chemo in addition to the SE's he's already dealing with
>(hopefully, these are minimal) from the RLRP?

Sorry for the confusion, the stats you are reading in my sig is
unfortunately (or should I say fortunately at this point)  *my* tale
of the tape.

My Dad was diagnosed with PCa 12 years ago at age 61 with a Gleason
Score of 8. He was a man who had never taken care of himself
healthwise and had to get a double bypass, just to be able to get the
seeds that were pretty much his only option at that time.

The brachytherapy bought him another eleven years after which it had
gotten into his bones. He has been receiving Taxotare every three
weeks for a little over a year. His Dr. is now suggesting this because
his response to the Taxotare is not what it was and there's a spot on
his liver now as well....

Signature

PSA @ 45 yrs. = 4.7 02/06/2007
Biopsy 03/16/2007 G7(3+4),T1c
RLRP 06/12/2007 G7(3+4),T2cN0M0 Neg margins
PSA 07/16/2007 = <0.1
PSA 09/12/2007 = <0.1
PSA 12/18/2007 = <0.1

Alan Meyer - 24 Jan 2008 23:11 GMT
> Has anyone undergone this treatment or know anything about it? My Dad
> is considering joining this study.
[quoted text clipped - 6 lines]
> PSA 09/12/2007 = <0.1
> PSA 12/18/2007 = <0.1

I search clinicaltrials.gov for:

  cnto 328 AND mitoxantrone AND prostate cancer

There was one hit, with the clinical trials ID = NCT00385827.

It looks to me like your Dad doesn't qualify for the trial.  It's for
men with advanced, metastatic cancer - clearly not your Dad's
situation.

Has someone recommended this to him?  Or have I got the
wrong trial?

   Alan
Paul - 25 Jan 2008 02:22 GMT
>> Has anyone undergone this treatment or know anything about it? My Dad
>> is considering joining this study.
[quoted text clipped - 21 lines]
>
>    Alan

Alan,

I'll cut and paste my response to UC below. Unfortunately my Dad's
about as advanced as one can be in this battle :(  He takes great
solace in the fact that his misfortune had me screening at 40 and
hopefully I caught mine early enough at 45.

"Sorry for the confusion, the stats you are reading in my sig is
unfortunately (or should I say fortunately at this point)  *my* tale
of the tape.

My Dad was diagnosed with PCa 12 years ago at age 61 with a Gleason
Score of 8. He was a man who had never taken care of himself
healthwise and had to get a double bypass, just to be able to get the
seeds that were pretty much his only option at that time.

The brachytherapy bought him another eleven years after which it had
gotten into his bones. He has been receiving Taxotare every three
weeks for a little over a year. His Dr. is now suggesting this because
his response to the Taxotare is not what it was and there's a spot on
his liver now as well...."

Signature

PSA @ 45 yrs. = 4.7 02/06/2007
Biopsy 03/16/2007 G7(3+4),T1c
RLRP 06/12/2007 G7(3+4),T2cN0M0 Neg margins
PSA 07/16/2007 = <0.1
PSA 09/12/2007 = <0.1
PSA 12/18/2007 = <0.1


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