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Medical Forum / Diseases and Disorders / Prostate Cancer / January 2008Chondroitin ?????
A few years ago I was taking Glucosamine/Chondroitin as a preventative for joint problems. I read somewhere that a prostate cancer expert Snuffy Myers?) said that there was evidence that Chondroitin caused the cancer to metastisise. I stopped taking it since I had seeds for PC. Now, my old (78) knees are acting up so I would like to resume taking the supplement. Do any of you have any recent information on Chondroitin vs prostate cancer? ---MIKE--- >>In the White Mountains of New Hampshire >> (44° 15' N - Elevation 1580') On January 15, Mike wrote: > A few years ago I was taking Glucosamine/Chondroitin as a preventative > for joint problems. That is its usual purpose, tx to osteoarthritis. > I read somewhere that a prostate cancer expert > Snuffy Myers?) said that there was evidence that Chondroitin caused the > cancer to metastisise. Sorry, but that won't do. What, exactly, did Snuffy say, and in what context? > I stopped taking it since I had seeds for PC. > Now, my old (78) knees are acting up so I would like to resume taking > the supplement. Do any of you have any recent information on > Chondroitin vs prostate cancer? No, sorry. Regards, Steve J > A few years ago I was taking Glucosamine/Chondroitin as a preventative > for joint problems. I read somewhere that a prostate cancer expert [quoted text clipped - 7 lines] > > >> (44° 15' N - Elevation 1580') Mike, I went to Pubmed (http://www.ncbi.nlm.nih.gov/pubmed) and tried the following search: prostate cancer metastasis chondroitin There were two hits, both highly technical studies in molecular biology that I couldn't understand. A simpler search on chondroitin and cancer got over 1000 hits. I'm thinking your best bet is to see a rheumatologist for advice on what to do. He's probably not going to know anything at all about chondroitin and cancer because it looks like the research is still very basic and theoretical and nowhere near being able to produce straightforward medical advice. However if you tell him that you have concerns about chondroitin he may be able to recommend some other treatments that will help that don't use it or any related compounds. It may be that a well designed program of exercise and stretching will do you a lot of good and not require any drugs. Good luck. Alan > A few years ago I was taking Glucosamine/Chondroitin as a preventative > for joint problems. I read somewhere that a prostate cancer expert [quoted text clipped - 7 lines] > > >> (44° 15' N - Elevation 1580') Hi Mike...Here is a link to the article by Dr. Myers (note the references at the bottom) that you are referring to. http://www.prostateforum.com/info-chondroitin.htm FWIW, I'm not aware of any more recent information...ron Do any of you have any recent information on Chondroitin vs prostate cancer? -------------------- High, Mike. Don't kow nothin' about chondroitin, but good to hear from you nonetheless. It's been quite awhile. Last I recall, the PSA was slowly rising. But that was a long time ago. How goes it? Speaking of knees, still haven't gotten up to New England. My wife is going through a couple of knee replacements. Maybe 2009. Hi Steve. My PSA has been slowly going up but since the doubling rate is long (about 3 years) my urologist is not concerned. He says something else will get me before the PC will (age 78, last PSA about 5.5). The only treatment would be hormones which would cause side effects that I don't need. The knee only bothers me going down stairs so I am trying the glucosimine/chondroitin. ---MIKE--- >>In the White Mountains of New Hampshire >> (44° 15' N - Elevation 1580') > The knee only bothers me going down stairs ... I'm sure you know the old adage, "the good go up, the bad go down". Put your bad leg down when going downstairs and follow it with the good one. It's bending the bad knee that hurts. Alan Hi Steve. My PSA has been slowly going up but since the doubling rate is long (about 3 years) my urologist is not concerned. He says something else will get me before the PC will (age 78, last PSA about 5.5). The only treatment would be hormones which would cause side effects that I don't need. The knee only bothers me going down stairs so I am trying the glucosimine/chondroitin. --- Yeah, that's a great rate for a 78-year-old man. In reading the Snuffy article, I believe he suggested Celebrex. I find this interesting because Canada Bob and Ken Schuster both take (or at least took) Celebrex FOR their cancer. Maybe you ought to look into that.  SignaturePSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA <.1 <.1 <.1 .27 .37 .75 PSAD 0.19 years EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 PSAD .056 years Lupron 07/03 (1 mo) 8/03 and every 4 months there after PSA .07 .05 .06 .09 .08 .132 .145 PSAD 1.4 years Casodex added daily 07/06 PSA <0.04, <0.05, <0.04, <0.04 10/11/07 Non Illegitimi Carborundum Steve wrote: > My wife is going through a couple of knee replacements. > Maybe 2009. Steve, please make sure she does all the pre-op exercises she should have received from her doctors. That will make recovery from surgery so much easier. ___ Blue Wave/QWK v2.12 Mike wrote: > The knee only bothers me going down stairs.... Mike, one adage I learned 7+ years ago is: DOWN WITH THE BAD UP WITH THE GOOD That means lead with the bad leg going downstairs and lead with the good leg going upstairs. This eliminates the need to bend the bad leg, and if you slip you'll hopefully fall in an upward motion rather than tumble down those stairs. ___ Blue Wave/QWK v2.12 Hello all! I read the information regarding chondroitin with some concern. I find that a daily dose of Glucosamine/Chondroitin along with MSM has made me forget that I have had the pain in the past. Now I am concerned and will investigate the PCa connection further. For those that are following this and use Chondroitin, are you going to stop using it? During my search for information on this I found positive information regarding Celebrex and it's positive role in stopping prostate cancer. Here is the link... http://www.sciencedaily.com/releases/2005/03/050309104538.htm I had stopped taking Celebrex because of some bad press a few years ago. I am now reconsidering starting it again. I will be talking to my Dr. about these ideas. I expect he will not comment on the Chondroitin because it is OTC. Does any one here have any information, feelings about stopping chondroitin and starting using Celebrex? Peter A few years ago I was taking Glucosamine/Chondroitin as a preventative for joint problems. I read somewhere that a prostate cancer expert Snuffy Myers?) said that there was evidence that Chondroitin caused the cancer to metastisise. I stopped taking it since I had seeds for PC. Now, my old (78) knees are acting up so I would like to resume taking the supplement. Do any of you have any recent information on Chondroitin vs prostate cancer? ---MIKE--- >>In the White Mountains of New Hampshire >> (44° 15' N - Elevation 1580') > Hello all! > I read the information regarding chondroitin with some concern. I find that [quoted text clipped - 16 lines] > > Peter" Hi Peter...When people compare NSAIDs, the first thing that often comes to mind is their relative ability to suppress COX-1 and COX-2 enzymes. You'd like to achieve maximal COX-2 suppression in order to block blood vessel creation (limit tumor growth hopefully more than other systems), while maintaining COX-1 for the gut. In one study, Lodine (etodolac) was compared with other NSAIDs in order to assess its effect on suppressing COX-1 and COX-2. This study showed that Lodine induced an 80% suppression of COX-2 (which was more effective than Celebrex) while only inhibiting 25% of the important COX-1. The problem becomes more difficult, however, because both Lodine and Celebrex have additional, but different, mechanisms by which they cause tumor cell apoptosis. So even though Lodine may preferable based on COX-2 suppression, further studies are needed to compare their relative overall effectiveness at destroyng cancer cells...ron > Hello all! > I read the information regarding chondroitin with some concern. I find > that a daily dose of Glucosamine/Chondroitin along with MSM has made me > forget that I have had the pain in the past. Now I am concerned and will > investigate the PCa connection further. For those that are following this > and use Chondroitin, are you going to stop using it? It's hard to know how effective this supplement is. However, there is some research that indicates that glucosamine is helpful to some people with arthritis, especially of the knee. I began taking this supplement a number of years ago to help manage some developing osteoarthritis in my knees. When I found out about this research, I stopped using pills with Chondroitin in them. For the last 3 or 4 years I have been taking 1500 mg of Glucosamine sulfate only. My arthritis has not gotten any worse since the change. But take that for what it's worth. There are many factors that affect arthritis. I keep my weight down and walk an hour a day, 7 days a week. That may be more important than the pills I take. > For those that are following > this and use Chondroitin, are you going to stop using it? Given Celebrex's heart threat, my gastrointestinal intolerance of NSAIDS including Cox-2 types, my knees (a little tender, but the pro team orthopod was outvoted by four other orthopods regarding cleanup surgery), and gluc/chond's favorable results with knee pain, I'm sticking with the gluc/chond until and unless its impact on PC becomes clearer. I.P. When I first heard of the PC connection, I gave the remaining bottle of pills to a friend that had been using an elaborate knee brace on one leg for skiing. After using the supplement he was able to get rid of the brace. I just started taking the supplement again and I will report back if my knee pain goes away. ---MIKE--- >>In the White Mountains of New Hampshire >> (44° 15' N - Elevation 1580') "For what's its worth" I have been taking a glu/chon +MSM mix (Nature Made "Triple Flex") that really has worked for me. A pain management Dr friend suggested it and it has removed my awareness of the joint issue. When I first heard of the PC connection, I gave the remaining bottle of pills to a friend that had been using an elaborate knee brace on one leg for skiing. After using the supplement he was able to get rid of the brace. I just started taking the supplement again and I will report back if my knee pain goes away. ---MIKE--- >>In the White Mountains of New Hampshire >> (44° 15' N - Elevation 1580') |
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