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Medical Forum / Diseases and Disorders / Prostate Cancer / January 2008

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Another statistic....

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USC Gamecock - 09 Jan 2008 03:27 GMT
Hi everyone.  Been awhile since I posted here.  As a reminder, here is
my bio/key stats:
Diagnosed with PCa - June 2005 (age 37)
Pre-surgery Gleason - 3+3=6
Post-surgery Gleason - 3+4=7
RRP (Dr. Alan Partin at John's Hopkins) - 8/12/2005
Sex (no drugs) within 8 weeks
Minor leakage with heavy physical endurance (continues, but not a big
issue)
PSA every 6 months since -- undetectable.  PRAISE GOD!

I come to you with a bit of burden this evening.  We learned today
that my brother (age 41 -- will be 42 in April) has this "monster" now
as well.  He has similar biopsy results as me and is considering all
options at this point.

If there is anyone that can still deny hereditary background to this
disease, try this one on for size..... Father (55 at diagnosis in 1991
-- still living), Paternal Uncle (80 at diagnosis -- now 86 an still
living well), Paternal Uncle (68 at diagnosis -- no longer living),
Brother (41 at diagnosis -- pondering alternatives).

Still praying for a cure and proactive way to stop this thing.  With
these statistics, the future seems pretty certain for my, now, 10 year
old son.  I think I'll start his PSA tests this year (only kidding --
but it doesn't seem as humorus as it once was).

Take care everyone....
Wes
USC Gamecock - 09 Jan 2008 03:30 GMT
Meant to also put my PSA count at diagnosis --- 0.7 (that's right,
POINT seven)
fred olsen - 09 Jan 2008 15:28 GMT
USC Gamecock schreef:
> Meant to also put my PSA count at diagnosis --- 0.7 (that's right,
> POINT seven)

Wes, do you mean you had a PSA count of 0.7 at the MOMENT you were
diagnosed with PCa?

I have PSA 0.6 and a small prostate with a hard lump, says my doctor so
have to go to the urologist tomorrow.

I am a little concerned......

Fred
I.P. Freely - 09 Jan 2008 17:14 GMT
> I have PSA 0.6 and a small prostate with a hard lump, says my doctor so
> have to go to the urologist tomorrow.
>
> I am a little concerned......

Good. If you  weren't, you might not bother following up. If a biopsy
(which is usually no more uncomfortable than a routine dental cleaning)
rules out cancer, you can relax. If the biopsy reveals cancer, you've
probably caught it very early and can be cured. It's a win/win scenario
unless you count little things like having a leaky, limp thing ... both
unlikely.

I.P.
safire - 09 Jan 2008 20:18 GMT
>> I have PSA 0.6 and a small prostate with a hard lump, says my doctor
>> so have to go to the urologist tomorrow.
[quoted text clipped - 9 lines]
>
> I.P.
This is extremely misleading advice from someone whose physicians
recommended rapid lead infusion (look it up). Read his posts: he's
always arguing with his doctors and tells you he's proud ignoring their
advice. The typical example of an obnoxious patient, that did some web
reading, can't place it in context but thinks he knows better than his
physician. Which probably explains why he has this leaky, limp thing and
many other problems, both  mental and physical.

If your biopsy - if you'll have one - reveals cancer it's not at all a
win/win scenario to "cure" it. Depending on your age, psa value, gleason
score and some other factors state of the art advice may very well not
to treat the cancer but watch its development, in your case while you
take tamsulosin. Small non-aggressive, non-life threatening cancers
don't need to be treated. See http://www.nccn.org/ and look for the
treatment guidelines for prostate cancer. You'll see that standard
practice is to apply "expectant management" (i.e.no treatment) for
T1-T2a low (2-6) Gleason Score cancers where PSA < 10 ng/ml.

A couple of months ago someone like you decided not to "cure" the cancer
like IP said you should. A Vietnam like month long bomb attack followed.
Just ignore IP, he's a frustrated grumpy old man.
c palmer - 09 Jan 2008 23:05 GMT
I.P. Freely wrote:
(snip)

If the biopsy reveals cancer, you've probably caught it very early and
can be cured. It's a win/win scenario unless you count little things
like having a leaky, limp thing ... both unlikely.
I.P.

From: safire@tele-net.com (safire) penned:

This is extremely misleading advice from someone whose physicians
recommended rapid lead infusion (look it up). Read his posts: he's
always arguing with his doctors and tells you he's proud ignoring their
advice. The typical example of an obnoxious patient, that did some web
reading, can't place it in context but thinks he knows better than his
physician. Which probably explains why he has this leaky, limp thing and
many other problems, both mental and physical.
If your biopsy - if you'll have one - reveals cancer it's not at all a
win/win scenario to "cure" it. Depending on your age, psa value, gleason
score and some other factors state of the art advice may very well not
to treat the cancer but watch its development, in your case while you
take tamsulosin. Small non-aggressive, non-life threatening cancers
don't need to be treated. See http://www.nccn.org/ and look for the
treatment guidelines for prostate cancer. You'll see that standard
practice is to apply "expectant management" (i.e.no treatment) for
T1-T2a low (2-6) Gleason Score cancers where PSA < 10 ng/ml.
A couple of months ago someone like you decided not to "cure" the cancer
like IP said you should. A Vietnam like month long bomb attack followed.
Just ignore IP, he's a frustrated grumpy old man.  

---------------------------------------------------

=> don't you find it interesting that someone is quoting scripture and
verse while damning a poster for giving their opinion and then ends it
with, "The typical example of an obnoxious patient, that did some web
reading, can't place it in context but thinks he knows better than his
physician. Which probably explains why he has this leaky, limp thing and
many other problems, both mental and physical."?????

i'll stay for facts.  here's the facts.  

safire stated, "Small non-aggressive, non-life threatening cancers don't
need to be treated. See http://www.nccn.org/ and look for the treatment
guidelines for prostate cancer."

safire is quoting the guidelines for one organization.  how many
different non profit cancer organizations have guidelines different that
what this organization states?  that's a fact - look it up.  see the
difference.

it is a fact that safire is making a prejudical (look up the word -
prejudice) statement about someone who has never met, hasn't talk to,
does not know the poster's background in this field, nor his medical
expertise.  

now, this group is about support, not anti-support.   if you are going
to disagree with what another poster says,  you have the right to do so,
but please remember this............. are you really helping the person
who has been dx'ed with pca and came to this newsgroup looking for help
only to fight a group of people squabbling about who thinks they know
more about prostate cancer or treatments.

but to focus back and  address the facts of this post,  if you go to
http://www.nccn.org/ and go to their disclosure information,  here's
some of what they said....

they admit that some of the people have active relationships with
interested parties such as pharmaceutical companies, medical device
companies, insurance companies, patient advocacy groups and government
agencies.

and they state further that a panel may decide to exclude a panel member
from discussions in areas where s/he may have a perceived conflict of
interest, but that doesn't mean that it will exclude a panel member.

while the concept may be a good one, it is one of many thoughts on what
guidelines should be.

below is part of the NCCN Disclosure of Organizational Relationships for
your reading pleasure......

~ curtis

------

    NCCN Disclosure of Organizational Relationships

The development of NCCN information is based upon the independent
evaluation of available scientific evidence integrated with the expert
judgment of leading clinicians. The NCCN is dedicated to the provision
of sound, evidenced-based, authoritative recommendations that serve the
best interests of patients with cancer.
A complete description (Winn, 2003) of the process for the development
of the NCCN Clinical Practice Guidelines in Oncology™ is available for
review.

Notwithstanding the above, it is critical to all who use the NCCN
Clinical Practice Guidelines in Oncology™, the NCCN/ACS Treatment
Guidelines for Patients, The NCCN Drugs and Biologics Compendium™,
Task Force Reports and other information products to understand any
potential sources of bias introduced into the development of NCCN
information that is trusted by physicians, patients and other interested
parties.
NCCN Guideline Panel Members contribute their time and expertise on a
pro bono basis. Volunteer contributions from our 750 Panel Members
account for more than 10 thousand hours per year. However, the NCCN
recognizes that as leading experts and faculty members of prestigious
academic cancer centers, most Guideline Panel Members are involved in
clinical research and may have other active relationships with
interested parties such as pharmaceutical companies, medical device
companies, insurance companies, patient advocacy groups and government
agencies. It is important that these relationships be disclosed and
readily available to the end user of the information to incorporate into
that person's decision-making process.

The major components of such disclosure are financial support to
individual panel members by entities outside the NCCN and financial
support to the NCCN itself.

As to Guidelines Panel Members, the NCCN requires at the beginning of
each panel meeting, a disclosure of any potential conflicts of interest,
including, but not limited to, research support, service on advisory
boards or speakers bureaus, consultancies, and equity holdings. A panel
may decide to exclude a panel member from discussions in areas where
s/he may have a perceived conflict of interest. Aggregate panel
disclosures are published with each guideline.

knowledge is power - growing old is mandatory - growing wise is optional    
"Many more men die with prostate cancer than of it. Growing old is
invariably fatal. Prostate cancer is only sometimes so."
http://community.webtv.net/PALMER_ENT/doc
Slobodon - 10 Jan 2008 00:12 GMT
When you respond to this garbage, you become part of the problem. These
people would wither on the vine were it not for their enablers....

I.P. Freely wrote:
(snip)

If the biopsy reveals cancer, you've probably caught it very early and
can be cured. It's a win/win scenario unless you count little things
like having a leaky, limp thing ... both unlikely.
I.P.

From: safire@tele-net.com (safire) penned:

This is extremely misleading advice from someone whose physicians
recommended rapid lead infusion (look it up). Read his posts: he's
always arguing with his doctors and tells you he's proud ignoring their
advice. The typical example of an obnoxious patient, that did some web
reading, can't place it in context but thinks he knows better than his
physician. Which probably explains why he has this leaky, limp thing and
many other problems, both mental and physical.
If your biopsy - if you'll have one - reveals cancer it's not at all a
win/win scenario to "cure" it. Depending on your age, psa value, gleason
score and some other factors state of the art advice may very well not
to treat the cancer but watch its development, in your case while you
take tamsulosin. Small non-aggressive, non-life threatening cancers
don't need to be treated. See http://www.nccn.org/ and look for the
treatment guidelines for prostate cancer. You'll see that standard
practice is to apply "expectant management" (i.e.no treatment) for
T1-T2a low (2-6) Gleason Score cancers where PSA < 10 ng/ml.
A couple of months ago someone like you decided not to "cure" the cancer
like IP said you should. A Vietnam like month long bomb attack followed.
Just ignore IP, he's a frustrated grumpy old man.

---------------------------------------------------

=> don't you find it interesting that someone is quoting scripture and
verse while damning a poster for giving their opinion and then ends it
with, "The typical example of an obnoxious patient, that did some web
reading, can't place it in context but thinks he knows better than his
physician. Which probably explains why he has this leaky, limp thing and
many other problems, both mental and physical."?????

i'll stay for facts.  here's the facts.

safire stated, "Small non-aggressive, non-life threatening cancers don't
need to be treated. See http://www.nccn.org/ and look for the treatment
guidelines for prostate cancer."

safire is quoting the guidelines for one organization.  how many
different non profit cancer organizations have guidelines different that
what this organization states?  that's a fact - look it up.  see the
difference.

it is a fact that safire is making a prejudical (look up the word -
prejudice) statement about someone who has never met, hasn't talk to,
does not know the poster's background in this field, nor his medical
expertise.

now, this group is about support, not anti-support.   if you are going
to disagree with what another poster says,  you have the right to do so,
but please remember this............. are you really helping the person
who has been dx'ed with pca and came to this newsgroup looking for help
only to fight a group of people squabbling about who thinks they know
more about prostate cancer or treatments.

but to focus back and  address the facts of this post,  if you go to
http://www.nccn.org/ and go to their disclosure information,  here's
some of what they said....

they admit that some of the people have active relationships with
interested parties such as pharmaceutical companies, medical device
companies, insurance companies, patient advocacy groups and government
agencies.

and they state further that a panel may decide to exclude a panel member
from discussions in areas where s/he may have a perceived conflict of
interest, but that doesn't mean that it will exclude a panel member.

while the concept may be a good one, it is one of many thoughts on what
guidelines should be.

below is part of the NCCN Disclosure of Organizational Relationships for
your reading pleasure......

~ curtis

------

NCCN Disclosure of Organizational Relationships

The development of NCCN information is based upon the independent
evaluation of available scientific evidence integrated with the expert
judgment of leading clinicians. The NCCN is dedicated to the provision
of sound, evidenced-based, authoritative recommendations that serve the
best interests of patients with cancer.
A complete description (Winn, 2003) of the process for the development
of the NCCN Clinical Practice Guidelines in OncologyT is available for
review.

Notwithstanding the above, it is critical to all who use the NCCN
Clinical Practice Guidelines in OncologyT, the NCCN/ACS Treatment
Guidelines for Patients, The NCCN Drugs and Biologics CompendiumT,
Task Force Reports and other information products to understand any
potential sources of bias introduced into the development of NCCN
information that is trusted by physicians, patients and other interested
parties.
NCCN Guideline Panel Members contribute their time and expertise on a
pro bono basis. Volunteer contributions from our 750 Panel Members
account for more than 10 thousand hours per year. However, the NCCN
recognizes that as leading experts and faculty members of prestigious
academic cancer centers, most Guideline Panel Members are involved in
clinical research and may have other active relationships with
interested parties such as pharmaceutical companies, medical device
companies, insurance companies, patient advocacy groups and government
agencies. It is important that these relationships be disclosed and
readily available to the end user of the information to incorporate into
that person's decision-making process.

The major components of such disclosure are financial support to
individual panel members by entities outside the NCCN and financial
support to the NCCN itself.

As to Guidelines Panel Members, the NCCN requires at the beginning of
each panel meeting, a disclosure of any potential conflicts of interest,
including, but not limited to, research support, service on advisory
boards or speakers bureaus, consultancies, and equity holdings. A panel
may decide to exclude a panel member from discussions in areas where
s/he may have a perceived conflict of interest. Aggregate panel
disclosures are published with each guideline.

knowledge is power - growing old is mandatory - growing wise is optional
"Many more men die with prostate cancer than of it. Growing old is
invariably fatal. Prostate cancer is only sometimes so."
http://community.webtv.net/PALMER_ENT/doc
safire - 10 Jan 2008 12:35 GMT
> I.P. Freely wrote:
> (snip)
[quoted text clipped - 34 lines]
> physician. Which probably explains why he has this leaky, limp thing and
> many other problems, both mental and physical."?????

Read again: "can't place it in context".

YouPee admitted twice the past weeks that he ignored his doctor's
advice. That's his business. But suggesting to Fred that, if cancer is
found, he should have it cured is misleading advice because YouPee
doesn't know Fred's conditions, as he hasn't been tested yet. Just as
misleading as his statement that side effects of active treatment are
"unlikely". YouPee and his foot soldiers just won't accept that watchful
waiting or expectant management is, depending on the circumstances of
the patient, a prudent course of action, as is confirmed by all
responsible organizations.

> i'll stay for facts.  here's the facts.  
>
[quoted text clipped - 3 lines]
>
> safire is quoting the guidelines for one organization.  
Actually those of the NHS.

how many
> different non profit cancer organizations have guidelines different that
> what this organization states?

Give me one of those "many" representative organizations that claim all
cancers should always be "cured" as YouPee asserts.

 that's a fact - look it up.  see the
> difference.

Show me.

> it is a fact that safire is making a prejudical (look up the word -
> prejudice) statement about someone who has never met, hasn't talk to,
> does not know the poster's background in this field, nor his medical
> expertise.  

No I didn't, I gave the general guidelines. Read it again. Read
"depending...". Your "fact" is a lie. YouPee gave individual "advice".

> below is part of the NCCN Disclosure of Organizational Relationships for
> your reading pleasure......

What the hell are you implying? That NCCN is promoting watchful waiting
because some people have a financial interest in that alternative? Is
that why the typical urologist shares YouPee's prejudicial attitude?
Don't you think that's a bit silly? If not, please explain how NCCN
members are conflicted in this case.
> ~ curtis
>
[quoted text clipped - 46 lines]
> invariably fatal. Prostate cancer is only sometimes so."
> http://community.webtv.net/PALMER_ENT/doc
Alan Meyer - 09 Jan 2008 19:41 GMT
> PSA every 6 months since -- undetectable.  PRAISE GOD!

Excellent news Wes.

> ... Father (55 at diagnosis in 1991 -- still living) ...

That's one I particularly liked to see.

A strong family tendency towards PCa.  Diagnosed at a later
age than his sons.  Treated almost 17 years ago.
-- AND STILL ALIVE --

   Alan
Steve Kramer - 09 Jan 2008 23:30 GMT
> Hi everyone.  Been awhile since I posted here.

Almost exactly two years, Wes!!

> PSA every 6 months since -- undetectable.  PRAISE GOD!

Considering your age at the time, that is probably most correct response.

> If there is anyone that can still deny hereditary background to this
> disease, try this one on for size..... Father (55 at diagnosis in 1991
> -- still living), Paternal Uncle (80 at diagnosis -- now 86 an still
> living well), Paternal Uncle (68 at diagnosis -- no longer living),
> Brother (41 at diagnosis -- pondering alternatives).

About a year ago, I was at a seminar where they discussed predictors of PCa.
Science has narrowed down the probabilities to heredity only if the relative
gets it before his 50s.  My grandfather probably died of it.  My father got
it at 42 and I got it at 46.  Your father and definitely you were probable
predictors for you brother and son; moreso than your uncles -- not that it
matters now, huh?

> I think I'll start his PSA tests this year (only kidding --
> but it doesn't seem as humorus as it once was).

My son is 29.  He begins next year.  Brings tears to these old eyes.

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  <.1  <.1  <.1  .27  .37  .75            PSAD 0.19 years
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32                       PSAD .056 years
Lupron 07/03 (1 mo) 8/03 and every 4 months there after
PSA  .07 .05 .06 .09 .08 .132 .145       PSAD 1.4 years
Casodex added daily 07/06
PSA <0.04, <0.05, <0.04, <0.04 10/11/07
Non Illegitimi Carborundum
I.P. Freely - 10 Jan 2008 00:16 GMT
> My son is 29.  He begins [PSA checks] next year.  

But won't he have the advantage of genetic testing for a PC gene,
especially one for aggressive PC?

I.P.
Steve Kramer - 10 Jan 2008 11:42 GMT
>> My son is 29.  He begins [PSA checks] next year.
>
> But won't he have the advantage of genetic testing for a PC gene,
> especially one for aggressive PC?

As a matter of fact, I think so.  There is a group of scientists working on
the PCa problem right here at the University of Cincinnati.  We have made
some quiet inquiries and we believe we, within the next five years, will
have my whole surviving family (brothers, step brother, son, and grandsons)
worked up on DNA.  They seem rather interested in it.

My father always wore his Marine fatigue cap while working.  He wore it most
of his life.  I am trying to get up the balls to talk to his second wife
(who I haven't talked to since he died) and get the DNA out of it.  I am 99%
sure she would not have thrown it away, but only 50% sure she didn't wash
it.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  <.1  <.1  <.1  .27  .37  .75            PSAD 0.19 years
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32                       PSAD .056 years
Lupron 07/03 (1 mo) 8/03 and every 4 months there after
PSA  .07 .05 .06 .09 .08 .132 .145       PSAD 1.4 years
Casodex added daily 07/06
PSA <0.04, <0.05, <0.04, <0.04 10/11/07
Non Illegitimi Carborundum

callalily - 10 Jan 2008 03:07 GMT
Dear Wes,

This is hot off the press.  Maybe the BRCA gene has something to do
with it.   Have you ever had genetic testing?

Some months ago, spouse asked me for suggestions on what to write on
his Dad's Father's Day card.  I suggested . . . "Thanks for the gift
that keeps on giving" or "Dad, you're great --  there is nothing you
ever had that you did not share with me".  Husb pitched in with some
similar ideas, but we ended up instead with the boring, "Dad: you're
Superman", Batman & Capt. America all rolled into one.  Imagine!
Superman has PC.  Well, he's of age.

[T's father is a nice guy, but missing some parental screws -- had PC
10 yrs ago, but never bothered to tell his son to get tested.  We had
no idea . . .]

L.
-------------------------------------------------------------------------------------------------------------

Men Unaware  Of Their Cancer Risk When Female Relatives Test Positive
For
BRCA  Mutation

(January 2, 2008) -- Men whose  mothers, sisters or daughters test
positive
for a cancer-causing gene mutation  also have an increased risk of
developing
the disease but are unaware of that  risk. Like their female
relatives,
fathers, sons or brothers can also harbor a  mutation in the BRCA 1 or
2 genes.

Male carriers of these mutations, more  commonly called the "breast
cancer genes,"
face a 14 percent lifetime risk of  developing prostate cancer as well
as a 6
percent lifetime risk of developing  breast cancer.
_full story_(http://www.sciencedaily.com/releases/
2007/12/071214094042.htm)
Califchief - 11 Jan 2008 06:00 GMT
Steve K wrote:

>> My son is 29.  He begins [PSA checks] next year.

And I.P answered:

> But won't he have the advantage of genetic testing for a PC gene,
> especially one for aggressive PC?

As soon as I was diagnosed with ankylosing spondylitis and
the doc stated I was carrying the HLA-B27 genetic marker,
my 4 sons (the youngest 8 years old) ran out and got tested.

___ Blue Wave/QWK v2.12
 
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