Medical Forum / Diseases and Disorders / Prostate Cancer / January 2008
Another statistic....
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USC Gamecock - 09 Jan 2008 03:27 GMT Hi everyone. Been awhile since I posted here. As a reminder, here is my bio/key stats: Diagnosed with PCa - June 2005 (age 37) Pre-surgery Gleason - 3+3=6 Post-surgery Gleason - 3+4=7 RRP (Dr. Alan Partin at John's Hopkins) - 8/12/2005 Sex (no drugs) within 8 weeks Minor leakage with heavy physical endurance (continues, but not a big issue) PSA every 6 months since -- undetectable. PRAISE GOD!
I come to you with a bit of burden this evening. We learned today that my brother (age 41 -- will be 42 in April) has this "monster" now as well. He has similar biopsy results as me and is considering all options at this point.
If there is anyone that can still deny hereditary background to this disease, try this one on for size..... Father (55 at diagnosis in 1991 -- still living), Paternal Uncle (80 at diagnosis -- now 86 an still living well), Paternal Uncle (68 at diagnosis -- no longer living), Brother (41 at diagnosis -- pondering alternatives).
Still praying for a cure and proactive way to stop this thing. With these statistics, the future seems pretty certain for my, now, 10 year old son. I think I'll start his PSA tests this year (only kidding -- but it doesn't seem as humorus as it once was).
Take care everyone.... Wes
USC Gamecock - 09 Jan 2008 03:30 GMT Meant to also put my PSA count at diagnosis --- 0.7 (that's right, POINT seven)
fred olsen - 09 Jan 2008 15:28 GMT USC Gamecock schreef:
> Meant to also put my PSA count at diagnosis --- 0.7 (that's right, > POINT seven) Wes, do you mean you had a PSA count of 0.7 at the MOMENT you were diagnosed with PCa?
I have PSA 0.6 and a small prostate with a hard lump, says my doctor so have to go to the urologist tomorrow.
I am a little concerned......
Fred
I.P. Freely - 09 Jan 2008 17:14 GMT > I have PSA 0.6 and a small prostate with a hard lump, says my doctor so > have to go to the urologist tomorrow. > > I am a little concerned...... Good. If you weren't, you might not bother following up. If a biopsy (which is usually no more uncomfortable than a routine dental cleaning) rules out cancer, you can relax. If the biopsy reveals cancer, you've probably caught it very early and can be cured. It's a win/win scenario unless you count little things like having a leaky, limp thing ... both unlikely.
I.P.
safire - 09 Jan 2008 20:18 GMT >> I have PSA 0.6 and a small prostate with a hard lump, says my doctor >> so have to go to the urologist tomorrow. [quoted text clipped - 9 lines] > > I.P. This is extremely misleading advice from someone whose physicians recommended rapid lead infusion (look it up). Read his posts: he's always arguing with his doctors and tells you he's proud ignoring their advice. The typical example of an obnoxious patient, that did some web reading, can't place it in context but thinks he knows better than his physician. Which probably explains why he has this leaky, limp thing and many other problems, both mental and physical.
If your biopsy - if you'll have one - reveals cancer it's not at all a win/win scenario to "cure" it. Depending on your age, psa value, gleason score and some other factors state of the art advice may very well not to treat the cancer but watch its development, in your case while you take tamsulosin. Small non-aggressive, non-life threatening cancers don't need to be treated. See http://www.nccn.org/ and look for the treatment guidelines for prostate cancer. You'll see that standard practice is to apply "expectant management" (i.e.no treatment) for T1-T2a low (2-6) Gleason Score cancers where PSA < 10 ng/ml.
A couple of months ago someone like you decided not to "cure" the cancer like IP said you should. A Vietnam like month long bomb attack followed. Just ignore IP, he's a frustrated grumpy old man.
c palmer - 09 Jan 2008 23:05 GMT I.P. Freely wrote: (snip)
If the biopsy reveals cancer, you've probably caught it very early and can be cured. It's a win/win scenario unless you count little things like having a leaky, limp thing ... both unlikely. I.P.
From: safire@tele-net.com (safire) penned:
This is extremely misleading advice from someone whose physicians recommended rapid lead infusion (look it up). Read his posts: he's always arguing with his doctors and tells you he's proud ignoring their advice. The typical example of an obnoxious patient, that did some web reading, can't place it in context but thinks he knows better than his physician. Which probably explains why he has this leaky, limp thing and many other problems, both mental and physical. If your biopsy - if you'll have one - reveals cancer it's not at all a win/win scenario to "cure" it. Depending on your age, psa value, gleason score and some other factors state of the art advice may very well not to treat the cancer but watch its development, in your case while you take tamsulosin. Small non-aggressive, non-life threatening cancers don't need to be treated. See http://www.nccn.org/ and look for the treatment guidelines for prostate cancer. You'll see that standard practice is to apply "expectant management" (i.e.no treatment) for T1-T2a low (2-6) Gleason Score cancers where PSA < 10 ng/ml. A couple of months ago someone like you decided not to "cure" the cancer like IP said you should. A Vietnam like month long bomb attack followed. Just ignore IP, he's a frustrated grumpy old man.
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=> don't you find it interesting that someone is quoting scripture and verse while damning a poster for giving their opinion and then ends it with, "The typical example of an obnoxious patient, that did some web reading, can't place it in context but thinks he knows better than his physician. Which probably explains why he has this leaky, limp thing and many other problems, both mental and physical."?????
i'll stay for facts. here's the facts.
safire stated, "Small non-aggressive, non-life threatening cancers don't need to be treated. See http://www.nccn.org/ and look for the treatment guidelines for prostate cancer."
safire is quoting the guidelines for one organization. how many different non profit cancer organizations have guidelines different that what this organization states? that's a fact - look it up. see the difference.
it is a fact that safire is making a prejudical (look up the word - prejudice) statement about someone who has never met, hasn't talk to, does not know the poster's background in this field, nor his medical expertise.
now, this group is about support, not anti-support. if you are going to disagree with what another poster says, you have the right to do so, but please remember this............. are you really helping the person who has been dx'ed with pca and came to this newsgroup looking for help only to fight a group of people squabbling about who thinks they know more about prostate cancer or treatments.
but to focus back and address the facts of this post, if you go to http://www.nccn.org/ and go to their disclosure information, here's some of what they said....
they admit that some of the people have active relationships with interested parties such as pharmaceutical companies, medical device companies, insurance companies, patient advocacy groups and government agencies.
and they state further that a panel may decide to exclude a panel member from discussions in areas where s/he may have a perceived conflict of interest, but that doesn't mean that it will exclude a panel member.
while the concept may be a good one, it is one of many thoughts on what guidelines should be.
below is part of the NCCN Disclosure of Organizational Relationships for your reading pleasure......
~ curtis
------
NCCN Disclosure of Organizational Relationships
The development of NCCN information is based upon the independent evaluation of available scientific evidence integrated with the expert judgment of leading clinicians. The NCCN is dedicated to the provision of sound, evidenced-based, authoritative recommendations that serve the best interests of patients with cancer. A complete description (Winn, 2003) of the process for the development of the NCCN Clinical Practice Guidelines in Oncology is available for review.
Notwithstanding the above, it is critical to all who use the NCCN Clinical Practice Guidelines in Oncology, the NCCN/ACS Treatment Guidelines for Patients, The NCCN Drugs and Biologics Compendium, Task Force Reports and other information products to understand any potential sources of bias introduced into the development of NCCN information that is trusted by physicians, patients and other interested parties. NCCN Guideline Panel Members contribute their time and expertise on a pro bono basis. Volunteer contributions from our 750 Panel Members account for more than 10 thousand hours per year. However, the NCCN recognizes that as leading experts and faculty members of prestigious academic cancer centers, most Guideline Panel Members are involved in clinical research and may have other active relationships with interested parties such as pharmaceutical companies, medical device companies, insurance companies, patient advocacy groups and government agencies. It is important that these relationships be disclosed and readily available to the end user of the information to incorporate into that person's decision-making process.
The major components of such disclosure are financial support to individual panel members by entities outside the NCCN and financial support to the NCCN itself.
As to Guidelines Panel Members, the NCCN requires at the beginning of each panel meeting, a disclosure of any potential conflicts of interest, including, but not limited to, research support, service on advisory boards or speakers bureaus, consultancies, and equity holdings. A panel may decide to exclude a panel member from discussions in areas where s/he may have a perceived conflict of interest. Aggregate panel disclosures are published with each guideline.
knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc
Slobodon - 10 Jan 2008 00:12 GMT When you respond to this garbage, you become part of the problem. These people would wither on the vine were it not for their enablers....
I.P. Freely wrote: (snip)
If the biopsy reveals cancer, you've probably caught it very early and can be cured. It's a win/win scenario unless you count little things like having a leaky, limp thing ... both unlikely. I.P.
From: safire@tele-net.com (safire) penned:
This is extremely misleading advice from someone whose physicians recommended rapid lead infusion (look it up). Read his posts: he's always arguing with his doctors and tells you he's proud ignoring their advice. The typical example of an obnoxious patient, that did some web reading, can't place it in context but thinks he knows better than his physician. Which probably explains why he has this leaky, limp thing and many other problems, both mental and physical. If your biopsy - if you'll have one - reveals cancer it's not at all a win/win scenario to "cure" it. Depending on your age, psa value, gleason score and some other factors state of the art advice may very well not to treat the cancer but watch its development, in your case while you take tamsulosin. Small non-aggressive, non-life threatening cancers don't need to be treated. See http://www.nccn.org/ and look for the treatment guidelines for prostate cancer. You'll see that standard practice is to apply "expectant management" (i.e.no treatment) for T1-T2a low (2-6) Gleason Score cancers where PSA < 10 ng/ml. A couple of months ago someone like you decided not to "cure" the cancer like IP said you should. A Vietnam like month long bomb attack followed. Just ignore IP, he's a frustrated grumpy old man.
---------------------------------------------------
=> don't you find it interesting that someone is quoting scripture and verse while damning a poster for giving their opinion and then ends it with, "The typical example of an obnoxious patient, that did some web reading, can't place it in context but thinks he knows better than his physician. Which probably explains why he has this leaky, limp thing and many other problems, both mental and physical."?????
i'll stay for facts. here's the facts.
safire stated, "Small non-aggressive, non-life threatening cancers don't need to be treated. See http://www.nccn.org/ and look for the treatment guidelines for prostate cancer."
safire is quoting the guidelines for one organization. how many different non profit cancer organizations have guidelines different that what this organization states? that's a fact - look it up. see the difference.
it is a fact that safire is making a prejudical (look up the word - prejudice) statement about someone who has never met, hasn't talk to, does not know the poster's background in this field, nor his medical expertise.
now, this group is about support, not anti-support. if you are going to disagree with what another poster says, you have the right to do so, but please remember this............. are you really helping the person who has been dx'ed with pca and came to this newsgroup looking for help only to fight a group of people squabbling about who thinks they know more about prostate cancer or treatments.
but to focus back and address the facts of this post, if you go to http://www.nccn.org/ and go to their disclosure information, here's some of what they said....
they admit that some of the people have active relationships with interested parties such as pharmaceutical companies, medical device companies, insurance companies, patient advocacy groups and government agencies.
and they state further that a panel may decide to exclude a panel member from discussions in areas where s/he may have a perceived conflict of interest, but that doesn't mean that it will exclude a panel member.
while the concept may be a good one, it is one of many thoughts on what guidelines should be.
below is part of the NCCN Disclosure of Organizational Relationships for your reading pleasure......
~ curtis
------
NCCN Disclosure of Organizational Relationships
The development of NCCN information is based upon the independent evaluation of available scientific evidence integrated with the expert judgment of leading clinicians. The NCCN is dedicated to the provision of sound, evidenced-based, authoritative recommendations that serve the best interests of patients with cancer. A complete description (Winn, 2003) of the process for the development of the NCCN Clinical Practice Guidelines in OncologyT is available for review.
Notwithstanding the above, it is critical to all who use the NCCN Clinical Practice Guidelines in OncologyT, the NCCN/ACS Treatment Guidelines for Patients, The NCCN Drugs and Biologics CompendiumT, Task Force Reports and other information products to understand any potential sources of bias introduced into the development of NCCN information that is trusted by physicians, patients and other interested parties. NCCN Guideline Panel Members contribute their time and expertise on a pro bono basis. Volunteer contributions from our 750 Panel Members account for more than 10 thousand hours per year. However, the NCCN recognizes that as leading experts and faculty members of prestigious academic cancer centers, most Guideline Panel Members are involved in clinical research and may have other active relationships with interested parties such as pharmaceutical companies, medical device companies, insurance companies, patient advocacy groups and government agencies. It is important that these relationships be disclosed and readily available to the end user of the information to incorporate into that person's decision-making process.
The major components of such disclosure are financial support to individual panel members by entities outside the NCCN and financial support to the NCCN itself.
As to Guidelines Panel Members, the NCCN requires at the beginning of each panel meeting, a disclosure of any potential conflicts of interest, including, but not limited to, research support, service on advisory boards or speakers bureaus, consultancies, and equity holdings. A panel may decide to exclude a panel member from discussions in areas where s/he may have a perceived conflict of interest. Aggregate panel disclosures are published with each guideline.
knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc
safire - 10 Jan 2008 12:35 GMT > I.P. Freely wrote: > (snip) [quoted text clipped - 34 lines] > physician. Which probably explains why he has this leaky, limp thing and > many other problems, both mental and physical."????? Read again: "can't place it in context".
YouPee admitted twice the past weeks that he ignored his doctor's advice. That's his business. But suggesting to Fred that, if cancer is found, he should have it cured is misleading advice because YouPee doesn't know Fred's conditions, as he hasn't been tested yet. Just as misleading as his statement that side effects of active treatment are "unlikely". YouPee and his foot soldiers just won't accept that watchful waiting or expectant management is, depending on the circumstances of the patient, a prudent course of action, as is confirmed by all responsible organizations.
> i'll stay for facts. here's the facts. > [quoted text clipped - 3 lines] > > safire is quoting the guidelines for one organization. Actually those of the NHS.
how many
> different non profit cancer organizations have guidelines different that > what this organization states? Give me one of those "many" representative organizations that claim all cancers should always be "cured" as YouPee asserts.
that's a fact - look it up. see the
> difference. Show me.
> it is a fact that safire is making a prejudical (look up the word - > prejudice) statement about someone who has never met, hasn't talk to, > does not know the poster's background in this field, nor his medical > expertise. No I didn't, I gave the general guidelines. Read it again. Read "depending...". Your "fact" is a lie. YouPee gave individual "advice".
> below is part of the NCCN Disclosure of Organizational Relationships for > your reading pleasure...... What the hell are you implying? That NCCN is promoting watchful waiting because some people have a financial interest in that alternative? Is that why the typical urologist shares YouPee's prejudicial attitude? Don't you think that's a bit silly? If not, please explain how NCCN members are conflicted in this case.
> ~ curtis > [quoted text clipped - 46 lines] > invariably fatal. Prostate cancer is only sometimes so." > http://community.webtv.net/PALMER_ENT/doc Alan Meyer - 09 Jan 2008 19:41 GMT > PSA every 6 months since -- undetectable. PRAISE GOD! Excellent news Wes.
> ... Father (55 at diagnosis in 1991 -- still living) ... That's one I particularly liked to see.
A strong family tendency towards PCa. Diagnosed at a later age than his sons. Treated almost 17 years ago. -- AND STILL ALIVE --
Alan
Steve Kramer - 09 Jan 2008 23:30 GMT > Hi everyone. Been awhile since I posted here. Almost exactly two years, Wes!!
> PSA every 6 months since -- undetectable. PRAISE GOD! Considering your age at the time, that is probably most correct response.
> If there is anyone that can still deny hereditary background to this > disease, try this one on for size..... Father (55 at diagnosis in 1991 > -- still living), Paternal Uncle (80 at diagnosis -- now 86 an still > living well), Paternal Uncle (68 at diagnosis -- no longer living), > Brother (41 at diagnosis -- pondering alternatives). About a year ago, I was at a seminar where they discussed predictors of PCa. Science has narrowed down the probabilities to heredity only if the relative gets it before his 50s. My grandfather probably died of it. My father got it at 42 and I got it at 46. Your father and definitely you were probable predictors for you brother and son; moreso than your uncles -- not that it matters now, huh?
> I think I'll start his PSA tests this year (only kidding -- > but it doesn't seem as humorus as it once was). My son is 29. He begins next year. Brings tears to these old eyes.
PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA <.1 <.1 <.1 .27 .37 .75 PSAD 0.19 years EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 PSAD .056 years Lupron 07/03 (1 mo) 8/03 and every 4 months there after PSA .07 .05 .06 .09 .08 .132 .145 PSAD 1.4 years Casodex added daily 07/06 PSA <0.04, <0.05, <0.04, <0.04 10/11/07 Non Illegitimi Carborundum
I.P. Freely - 10 Jan 2008 00:16 GMT > My son is 29. He begins [PSA checks] next year. But won't he have the advantage of genetic testing for a PC gene, especially one for aggressive PC?
I.P.
Steve Kramer - 10 Jan 2008 11:42 GMT >> My son is 29. He begins [PSA checks] next year. > > But won't he have the advantage of genetic testing for a PC gene, > especially one for aggressive PC? As a matter of fact, I think so. There is a group of scientists working on the PCa problem right here at the University of Cincinnati. We have made some quiet inquiries and we believe we, within the next five years, will have my whole surviving family (brothers, step brother, son, and grandsons) worked up on DNA. They seem rather interested in it.
My father always wore his Marine fatigue cap while working. He wore it most of his life. I am trying to get up the balls to talk to his second wife (who I haven't talked to since he died) and get the DNA out of it. I am 99% sure she would not have thrown it away, but only 50% sure she didn't wash it.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA <.1 <.1 <.1 .27 .37 .75 PSAD 0.19 years EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 PSAD .056 years Lupron 07/03 (1 mo) 8/03 and every 4 months there after PSA .07 .05 .06 .09 .08 .132 .145 PSAD 1.4 years Casodex added daily 07/06 PSA <0.04, <0.05, <0.04, <0.04 10/11/07 Non Illegitimi Carborundum
callalily - 10 Jan 2008 03:07 GMT Dear Wes,
This is hot off the press. Maybe the BRCA gene has something to do with it. Have you ever had genetic testing?
Some months ago, spouse asked me for suggestions on what to write on his Dad's Father's Day card. I suggested . . . "Thanks for the gift that keeps on giving" or "Dad, you're great -- there is nothing you ever had that you did not share with me". Husb pitched in with some similar ideas, but we ended up instead with the boring, "Dad: you're Superman", Batman & Capt. America all rolled into one. Imagine! Superman has PC. Well, he's of age.
[T's father is a nice guy, but missing some parental screws -- had PC 10 yrs ago, but never bothered to tell his son to get tested. We had no idea . . .]
L. -------------------------------------------------------------------------------------------------------------
Men Unaware Of Their Cancer Risk When Female Relatives Test Positive For BRCA Mutation
(January 2, 2008) -- Men whose mothers, sisters or daughters test positive for a cancer-causing gene mutation also have an increased risk of developing the disease but are unaware of that risk. Like their female relatives, fathers, sons or brothers can also harbor a mutation in the BRCA 1 or 2 genes.
Male carriers of these mutations, more commonly called the "breast cancer genes," face a 14 percent lifetime risk of developing prostate cancer as well as a 6 percent lifetime risk of developing breast cancer. _full story_(http://www.sciencedaily.com/releases/ 2007/12/071214094042.htm)
Califchief - 11 Jan 2008 06:00 GMT Steve K wrote:
>> My son is 29. He begins [PSA checks] next year. And I.P answered:
> But won't he have the advantage of genetic testing for a PC gene, > especially one for aggressive PC? As soon as I was diagnosed with ankylosing spondylitis and the doc stated I was carrying the HLA-B27 genetic marker, my 4 sons (the youngest 8 years old) ran out and got tested.
___ Blue Wave/QWK v2.12
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