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Medical Forum / Diseases and Disorders / Prostate Cancer / January 2008

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Nonfat Milk A Carcinogen?

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Eddie - 04 Jan 2008 21:38 GMT
http://news.yahoo.com/s/nm/20080102/hl_nm/nonfat_cancer_dc_1
Leonard Evens - 05 Jan 2008 18:55 GMT
> http://news.yahoo.com/s/nm/20080102/hl_nm/nonfat_cancer_dc_1

Apparently the studies found no link between prostate cancer and calcium
intake, as some previous studies had found.  But one of the studies
found a difference depending on how the calcium was taken.  In one case
the comparison was skim milk vs. whole milk and the other it was skim
milk vs. total calcium from other sources, I think.

One general comment.  If a study is done with one purpose and then the
group is further subdivided into separate groups looking for possible
differences, it is possible to find spurious relations.  Many
statisticians reject outright any such subsequent subgroup analysis
unless the study was carefully designed with the subgroups in mind.

I don't know to what extent this objections applies here.  I would say
that it is premature to change one's dietary habits on the basis of
these results.  We would have to await confirmation with more studies.

The basic problem is that unless you have a biological mechanism in
mind, studies which show a statistical association can be misleading
unless the results are so strong that there is little doubt.  For
example, years before a biological mechanism for how smoking causes lung
cancer was established, the fact that the lung cancer rates among
smokers was so much higher than that for nonsmokers clearly established
the risk.   On the other hand a modest association allows for other
plausible conclusions.

Perhaps I should add that I've been using nonfat milk products for
years.  I suppose that is it possible it increased my risk of prostate
cancer, but personally I doubt it.
I.P. Freely - 05 Jan 2008 19:32 GMT
> Perhaps I should add that I've been using nonfat milk products for
> years.  I suppose that is it possible it increased my risk of prostate
> cancer, but personally I doubt it.

Plus, the link between too much sat fat and cardiovascular disease is
stronger than the one between calcium and PC, and we know we need
calcium for bone strength, at least through our mid-20s.

I.P.
Alan Meyer - 06 Jan 2008 02:33 GMT
> ...
> One general comment.  If a study is done with one purpose and then the
[quoted text clipped - 3 lines]
> unless the study was carefully designed with the subgroups in mind.
> ...

I am not surprised that some types of research scientists have limited
knowledge of statistics.  However when a research study is specifically
concerned with statistical correlations, and when it's published in a
peer reviewed journal that has (or should have) access to professional
statisticians among its reviewers, you'd think this kind of problem
would
be more carefully exposed in the publication.

On the other hand, maybe it was.  All we have to go on here are
abstracts and summaries.

   Alan
 
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