 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / Diseases and Disorders / Prostate Cancer / December 2007Can a benign sliver of prostate develop PCA?
I had an RP 3 1/2 years ago and have had a constant PSA reading of 0.09 ever since. My current Uro says that a benign sliver of prostate tissue was probably left and that I should have this same reading the rest of my life. Dr. Walsh's book, however, says that the reason the entire prostate is always removed is that any part of it can develop cancer in the future. Now I have to worry that the benign sliver that was left may develop cancer sometime in the future. I plan to continue PSA readings every 6 months. I can always have salvage radiation if my PSA does start rising significantly. >I had an RP 3 1/2 years ago and have had a constant PSA reading of > 0.09 ever since. My current Uro says that a [quoted text clipped - 5 lines] > future. I plan to continue PSA readings every 6 months. I can always > have salvage radiation if my PSA does start rising significantly. If a sliver was left, how can your uro say that it was benign? And was he cavalier as he informed you that he suspects he didn't finish the only job he had that morning -- cutting out the prostate? I wonder what the chances are of having cancer form from benign prostate material a second time in one's life. I suspect that with the DNA being a constant, the chances are pretty good. >> I had an RP 3 1/2 years ago and have had a constant PSA reading of >> 0.09 ever since. My current Uro says that a [quoted text clipped - 10 lines] > And was he cavalier as he informed you that he suspects he didn't finish the > only job he had that morning -- cutting out the prostate? OP refers to his "current uro". To most people that would suggest the uro talking about the sliver isn't the one that left it there. > I wonder what the chances are of having cancer form from benign prostate > material a second time in one's life. I suspect that with the DNA being a > constant, the chances are pretty good. Rhonda Joy, You are sooooo observant in correcting Steve. It's a shame the majority of your replies are so far off the mark. Ron S. -- Message posted using http://www.talkaboutsupport.com/group/alt.support.cancer.prostate/ More information at http://www.talkaboutsupport.com/faq.html > Rhonda Joy, > You are sooooo observant in correcting Steve. It's a shame the [quoted text clipped - 5 lines] > Message posted usinghttp://www.talkaboutsupport.com/group/alt.support.cancer.prostate/ > More information athttp://www.talkaboutsupport.com/faq.html To clarify, my current Uro is in Texas, but the Uro who did my RP was at UCLA. > If a sliver was left, how can your uro say that it was benign? > [quoted text clipped - 4 lines] > material a second time in one's life. I suspect that with the DNA being a > constant, the chances are pretty good. Steve...Leaving some tissue behind after RP isn't all that uncommon. Positive margins, where cancerous cells may remain behind, and negative margins, where benign tissue may have been left along the resected margin are two possibilities. These two possibilities can be distinguished by changes in PSA over time. A constant reading over time, as in jhtte's case, is highly suggestive of tissue that is benign...Best wishes and good health, ron Shinghal R, Yemoto C, McNeal JE, Brooks JD: Biochemical recurrence without PSA progression characterizes a subset of patients after radical prostatectomy. Urology 61:380-5, 2003. Department of Urology, Stanford University Medical Center, Stanford, California 94305-5118, USA. OBJECTIVES: To characterize a subset of patients with biochemical recurrence after radical prostatectomy but with little, if any, subsequent rise in serum prostate-specific antigen (PSA) and no clinical progression during long-term follow-up. METHODS: Of a series of 600 patients, 158 with biochemical recurrence after radical prostatectomy were examined. We identified a subset with measurable serum PSA levels during long-term follow-up, but with very low PSA velocity and no clinical recurrence. Serum PSA was measured with the ultrasensitive TOSOH assay with a PSA recurrence defined as a serum PSA of 0.07 ng/mL or greater. RESULTS: We identified 14 patients (8.8% of biochemical recurrences) with a detectable serum PSA level after radical prostatectomy yet without clinical or PSA progression at a mean follow-up after radical prostatectomy of 10.3 years. The mean time to PSA recurrence was 5.8 years, and the mean PSA velocity after recurrence was 0.028 ng/mL/yr. No clinical or pathologic features were found that could be used to identify this subset of patients. CONCLUSIONS: A subset of patients with biochemical recurrence after radical prostatectomy will not exhibit a progressive rise in serum PSA or clinical progression at 10 years follow-up. This suggests that serum PSA kinetics should be observed after biochemical recurrence before adjuvant hormonal therapy or radiotherapy. PMID: 12597952 > Steve...Leaving some tissue behind after RP isn't all that uncommon. I agree. But, should it happen? > A constant reading over > time, as in jhtte's case, is highly suggestive of tissue that is > benign. I agree again. And, maybe I was just thinking out loud. And, maybe I should not have been considering we are talking about a man's specific case, but I am curious as to whether a sliver of benign prostate tissue becomes a ticking timebomb if the DNA is already corrupted. > ..Best wishes and good health, ron You, too, ron. You don't mince words and your corrections are always slam dunks and yet well intentioned. I appreciate your presence here and let you know far too seldom. |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.