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Medical Forum / Diseases and Disorders / Prostate Cancer / October 2007Another report on benefits of pomegranates
See: http://www.sciencedaily.com/releases/2007/09/070924095856.htm > See:http://www.sciencedaily.com/releases/2007/09/070924095856.htm Gosh, decrease the doubling time by fourfold! Now I'm glad I've been drinking a glass every morning. Rich so how much juice do you need to drink for it to be effective? > See: http://www.sciencedaily.com/releases/2007/09/070924095856.htm > so how much juice do you need to drink for it to be effective? That's a key question isn't it? I personally haven't been drinking the juice. I've been taking pomegranate extract pills from Puritan's Pride. A friend of mine with advanced, metastatic prostate cancer (PSA=500 before treatment) has had a gradually climbing PSA in the last year in spite of regular and second line hormone therapy. His doctor, "Snuffy" Myers, told him to stop drinking the juice and instead swallow the pills from "Life Extension". He did that and, for the first time in about a year, his PSA went down a little, from 11.2 to 10.6. It's not a big drop, but it sure beats the hell out of the steady rises he's been seeing. He says the only change in his treatment regimen is the addition of these supplement pills. I've written to ask him how many pills he takes a day and will report back when I get a reply. Alan > ... > A friend of mine with advanced, metastatic prostate cancer (PSA=500 [quoted text clipped - 9 lines] > I've written to ask him how many pills he takes a day and will > report back when I get a reply. My friend told me he's taking 5 pills a day, 3 in the morning and 2 in the evening. The pills are these ones: http://www.lef.org/newshop/items/item00956.html > My friend told me he's taking 5 pills a day, 3 in the morning and 2 > in the evening. The pills are these ones: > > http://www.lef.org/newshop/items/item00956.html There are many lower-cost sources of pomegranate extract capsules than LEF, ranging from some local health food shops to other online retailers. Check http://www.nextag.com/pomegranate-extract/search-html or the free and paid links that show up when you Google "pomegranate extract capsules". Alex >> My friend told me he's taking 5 pills a day, 3 in the morning and 2 >> in the evening. The pills are these ones: [quoted text clipped - 7 lines] > free and paid links that show up when you Google "pomegranate extract > capsules". Yes. I've been using the ones from Puritan's Pride. The formulation appears to be different from LEF's and, unfortunately, the ingredients aren't listed in the same way with the exact same terminology, so it's hard to compare them. In my friend's case, he's got galloping cancer and, whatever he's doing, seems to be working, at least in the short term. So I wouldn't recommend to him that he change anything. Buying supplements is a tough problem because the industry isn't regulated and some of the suppliers on the net are selling stuff with contaminants and/or with different ingredients or dosages than appear on the label. Someone once stated on this forum that he had seen independent reports of analyses of different supplements from different suppliers. He said that Puritan's Pride is one of the ones for whom all of their products turned out to have just what the company said they had. And since PP is not a high cost supplier, I've been buying all of my supplements from them. If anyone has more information for or against any supplement supplier, I'm all ears. However I won't just buy from the lowest cost supplier on the net. Alan > > ... > > A friend of mine with advanced, metastatic prostate cancer (PSA=500 [quoted text clipped - 14 lines] > > http://www.lef.org/newshop/items/item00956.html Does anyone know why Dr. Myers thought the supplements were better than drinking the juice. I've always had a bias in favor of something as close to the whole food as possible, so I'd be really interested to know what his thinking is. I drink 4 oz. of organic pomegranate juice - heavily diluted with seltzer water - twice a day. (Having had focal cryoablation by Dr. Onik this past May, it's (hopefully) a preventive measure.) > ... > Does anyone know why Dr. Myers thought the supplements were better [quoted text clipped - 4 lines] > cryoablation by Dr. Onik this past May, it's (hopefully) a preventive > measure.) I posted an answer to this, but it's not showing up on my screen, so I'll post it again. Forgive me if it appears twice. The LEF formula claims the equivalent of 12.3 ounces of pom juice, or 24 pomegranates, in each capsule. My friend is taking 5 caps a day. That equates to almost a half gallon of pom juice. If you're having to gag down eight ounces, imagine trying a half gallon. At any rate, that's my guess as to the answer to your question. Alan > ... > Does anyone know why Dr. Myers thought the supplements were better > than drinking the juice. I don't know but would speculate that it's in order to get a greater doseage. The pills are claimed to each have the equivalent 24 pomegranates or 12.3 ounces of juice. My friend was told to take 5 of them each day. That would be the equivalent of almost a half gallon of juice. He had been drinking the juice when Dr. Myers told him to switch to the pills. Alan > - (Having had focal > cryoablation by Dr. Onik this past May, it's (hopefully) a preventive > measure.) Gary -- my apologies for steering this thread in another direction, but could you pass along your experience with focal cryo, any subsequent PSA readings, side effects, etc.? It's an option one of my PCa docs is quite enthusiastic about, while another member of the same team is a bit less so. Alex > See:http://www.sciencedaily.com/releases/2007/09/070924095856.htm Group: Navindra Seeram, lead author of this study cited in this thread, was one of the investigators in the original UCLA study headed by Alan Pantuck and published last year. The original study reported both mean and median responses and the mean (average) grabbed a lot attention as the PSADT went from 15 to 54 months, a nearly four-fold lengthening of time. The median was much less dramatic, something like 11 to 28 months. That is certainly worth the expense and the risk is as close to zero as imaginable. Mean (average) is affected by those with long low slope and median is not, or much less so. What truly collected my attention on the original study was that 83% of the 46 evaluable patients had a response. Number of patients was 46, a very small number, this group had no control arm and it does not appear that any other controls were involved such as other diet changes. Was wondering if anyone has seen other "credible" information on this topic. The health supplements industry has made billions in creating "news" regarding some "new" wonder supplement. Remember shark cartilage, chromium picolinate etc.? Sy > > See:http://www.sciencedaily.com/releases/2007/09/070924095856.htm > [quoted text clipped - 14 lines] > appear that any other controls were involved such as other diet > changes. > Was wondering if anyone has seen other "credible" information on this > topic. The health supplements industry has made billions in creating > "news" regarding some "new" wonder supplement. Remember shark > cartilage, chromium picolinate etc.? You are correct to question such things. This forum has a long history of questioning things and discounting things like shark cartilage, urine, and other wonder treatments. Right now, there is some positive information coming out of a few minor studies and, if it don't kill us, some of us try to see what happens. I wouldn't say anyone is recommending pomegranates yet, just discussing them. Personally, I'm going to get the supplements and start taking them when my PSA starts rising again.  SignaturePSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA <.1 <.1 <.1 .27 .37 .75 PSAD 0.19 years EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 PSAD .056 years Lupron 07/03 (1 mo) 8/03 and every 4 months there after PSA .07 .05 .06 .09 .08 .132 .145 PSAD 1.4 years Casodex added daily 07/06 PSA <0.04, <0.05, <0.04, <0.04 10/11/07 Non Illegitimi Carborundum Here is the URL and an excerpt from the PubMed abstract from early (2005) research on pomegranate fruit extract (PFE). http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1253570 In this study, employing human prostate cancer cells, we evaluated the antiproliferative and proapoptotic properties of PFE. PFE (10-100 ?g/ ml; 48 h) treatment of highly aggressive human prostate cancer PC3 cells resulted in a dose-dependent inhibition of cell growth/cell viability and induction of apoptosis. Immunoblot analysis revealed that PFE treatment of PC3 cells resulted in (i) induction of Bax and Bak (proapoptotic); (ii) down-regulation of Bcl-XL and Bcl-2 (antiapoptotic); (iii) induction of WAF1/p21 and KIP1/p27; (iv) a decrease in cyclins D1, D2, and E; and (v) a decrease in cyclin- dependent kinase (cdk) 2, cdk4, and cdk6 expression. These data establish the involvement of the cyclin kinase inhibitor-cyclin-cdk network during the antiproliferative effects of PFE. Oral administration of PFE (0.1% and 0.2%, wt/vol) to athymic nude mice implanted with androgen-sensitive CWR22R?1 cells resulted in a significant inhibition in tumor growth concomitant with a significant decrease in serum prostate-specific antigen levels. We suggest that pomegranate juice may have cancer-chemopreventive as well as cancer- chemotherapeutic effects against prostate cancer in humans. >See: http://www.sciencedaily.com/releases/2007/09/070924095856.htm The volume of current traffic regarding pomegranate juice and extract caused me to do a search on "Pomegranate Juice". Here's a link to an article that may be of interest to anyone using, or considering using, the juice or extract. Just fyi. No recommendations pro or con. http://altmedicine.about.com/od/druginteractions/a/pom_interaction.htm Burney dot Huff at Mindspring dot com |
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