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Medical Forum / Diseases and Disorders / Prostate Cancer / September 2007

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Lupron & Memory Loss

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alva36@gmail.com - 20 Sep 2007 00:01 GMT
Forgive me for not remembering (no pun intended) if it's been
discussed here before, but does anyone know of a remedy for the memory
loss which accompanies Lupron treatment?  Thanks.

-Gordy
Steve Jordan - 20 Sep 2007 00:46 GMT
On September 19, Gordy inquired:

> Forgive me for not remembering (no pun intended) if it's been
> discussed here before, but does anyone know of a remedy for the memory
> loss which accompanies Lupron treatment?  Thanks.

Excercise the mind. And a couple of meds listed here:

http://www.prostate-cancer.org/education/sidefx/Strum_ADS.html

Regards,

Steve J
Steve Kramer - 20 Sep 2007 01:00 GMT
> Forgive me for not remembering (no pun intended) if it's been
> discussed here before, but does anyone know of a remedy for the memory
> loss which accompanies Lupron treatment?  Thanks.

Caffeine definitely helps me.  I think walking does as well, but haven't
done enough testing to really know.
ron - 20 Sep 2007 01:29 GMT
On Sep 19, 5:01 pm, alv...@gmail.com wrote:
> Forgive me for not remembering (no pun intended) if it's been
> discussed here before, but does anyone know of a remedy for the memory
> loss which accompanies Lupron treatment?  Thanks.
>
> -Gordy

Gordy...A number of studies suggest that memory loss in men practicing
ADT is more likely due to estrogen loss rather than testosterone loss
(in men, estrogenic compounds are formed from testosterone; hence, no
testosterone, no estrogen).  Estrogen patches concurrent with, or in
place of, your Lupron could be considered.  If you are interested in
learning more see

Therapy Insight: Parenteral Estrogen Treatment for Prostate Cancer-A
New Dawn for an Old Therapy
Jeremy Ockrim; El-Nasir Lalani; Paul Abel
Nat Clin Pract Oncol.  2006;3(10):552-563
this article can be viewed at
http://www.medscape.com/viewarticle/546361_print

Testosterone loss and estradiol administration modify memory in men
J Urol. 2006 Jan;175(1):130-5
Beer TM, Bland LB, Bussiere JR, Neiss MB, Wersinger EM, Garzotto M,
Ryan CW, Janowsky JS.

and references there in

If you remain interested, discuss these articles / references with
your doc...Best wishes and good health, ron
alva36@gmail.com - 20 Sep 2007 01:48 GMT
> If you remain interested, discuss these articles / references with
> your doc...Best wishes and good health, ron

Thanks, Guys.

-Gordy
Alan Meyer - 20 Sep 2007 02:49 GMT
> Forgive me for not remembering (no pun intended) if it's been
> discussed here before, but does anyone know of a remedy for the memory
> loss which accompanies Lupron treatment?  Thanks.
>
> -Gordy

I would try some things suggested by Steves J and K.

1. Mental exercise.  If thinking is hard, think harder!  This has
been shown to make a difference even for Alzheimer's patients.

2. Physical exercise.  It keeps the blood flowing and moves
more oxygen and nutrients to the brain and everywhere else.

3. Coffee.  Of all the drugs proposed, caffeine is one that
has been used most by the most number of people and has
clearly been shown to stimulate mental activity.  Some of
the others suggested by doctors don't seem nearly as safe
to me and their effects are necessarily well documented.
It also tastes good - at least for those of us who like it.
But I wouldn't overdo it.

I would think the absolute worst possible thing to do is to
tell yourself that there are certain mental tasks you just
can't do any more.  That's a slippery slope that leads to
perdition.

   Alan
california_chief - 20 Sep 2007 07:55 GMT
> I would try some things suggested by Steves J and K.
>
> 1. Mental exercise.  If thinking is hard, think harder!  This has
> been shown to make a difference even for Alzheimer's patients.

Crossword puzzles (and other word puzzles)

> 2. Physical exercise.  It keeps the blood flowing and moves
> more oxygen and nutrients to the brain and everywhere else.

Walking (not jogging) and swimming are 2 of the best.

> 3. Coffee.

I'll drink to that.  <g>
Alan Meyer - 20 Sep 2007 20:18 GMT
> > I would try some things suggested by Steves J and K.
>
> > 1. Mental exercise.  If thinking is hard, think harder!  This has
> > been shown to make a difference even for Alzheimer's patients.
>
> Crossword puzzles (and other word puzzles)

Yes.  Computer programming also worked well for me.  I think it's
probably a good idea to exercise multiple skills - language,
logic, math, music, anything that one used to do and enjoy.

> > 2. Physical exercise.  It keeps the blood flowing and moves
> > more oxygen and nutrients to the brain and everywhere else.
>
> Walking (not jogging) and swimming are 2 of the best.

Is there a particular problem with jogging?  It is tougher on
the joints, but I think it does a good job on cardio-vascular
systems.

> > 3. Coffee.
>
> I'll drink to that.  <g>

   Alan
Steve Kramer - 21 Sep 2007 01:08 GMT
>> Walking (not jogging) and swimming are 2 of the best.
>
> Is there a particular problem with jogging?  It is tougher on
> the joints, but I think it does a good job on cardio-vascular
> systems.

It's very hard on the joints, but attaining 85% of the goal rate at our age
is easy when walking.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  <.1  <.1  <.1  .27  .37  .75            PSAD 0.19 years
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32                       PSAD .056 years
Lupron 07/03 (1 mo) 8/03 and every 4 months there after
PSA  .07 .05 .06 .09 .08 .132 .145       PSAD 1.4 years
Casodex added daily 07/06
PSA <0.04, <0.05, <0.04 (06/12/2007)
Non Illegitimi Carborundum

california_chief - 21 Sep 2007 18:32 GMT
Alan Meyer wrote and asked:

>> Walking (not jogging) and swimming are 2 of the best.

> Is there a particular problem with jogging?  It is tougher on
> the joints, but I think it does a good job on cardio-vascular
> systems.

It's tough on the feet.  It's tough on the joints.

It's does only a so-so job on the CV system.

I received a surprise when I read a chart at a gym -- square dancing beat
running, tennis, swimming, and half a dozen other activities - on a
minute-for-minute basis.  However there are a lot of pauses during a dance,
so you're not really dancing a full 3 hours when you go to one.
Steve Kramer - 20 Sep 2007 19:29 GMT
> 3. Coffee.  Of all the drugs proposed, caffeine is one that
> has been used most by the most number of people and has
[quoted text clipped - 3 lines]
> It also tastes good - at least for those of us who like it.
> But I wouldn't overdo it.

The problem with coffee is the more I drink, the more pads I need.

But, at least I remember to put them on.
california_chief - 21 Sep 2007 19:00 GMT
> The problem with coffee is the more I drink, the more pads I need.
>
> But, at least I remember to put them on.

Following my hip replacement in July, I was taking a diuretic (AMILORIDE
HCl) to reduce water retention in the legs and feet.  The first few days, I
was voiding 96 ounces daily - 32 morning and early afternoon, 32 late
afternoon and into the evening, and 32 overnight.

Eventually it dropped to 72, 60, 48, and 32 ounces, where it hovers now.
This morning I put on shoes for the 1st time in 2 months.
 
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