Medical Forum / Diseases and Disorders / Prostate Cancer / September 2007
Opinions re: CyberKnife
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Sy - 24 Aug 2007 20:01 GMT Just had a consultation with my Urologist.
PSA was 3.7 a month ago and had been increasing the last 2 years from 1.8-2.7.
DRE showed nothing . Had trans-rectal ultrasound with biopsies taken. Detected Prostate Cancer. Have Gleason of 6 and TNM of T1c.
Dr. explained various approaches, rad. prostactectomy (no way!), hormonal, radioactive seeding, radiation treatment and CyberKnife. He is a surgeon by trade but says if he were in my situation he would take the CyberKnife approach. Says it is very highly accurate and has virtually no side-effects.
Anyone have experiences with CyberKnife treatment?
Thanks in advance.
Sy
Steve Kramer - 25 Aug 2007 21:50 GMT > Just had a consultation with my Urologist. > [quoted text clipped - 9 lines] > the CyberKnife approach. Says it is very highly accurate and has > virtually no side-effects. Sy,
Welcome the club no one asked to join.
'Tis time for you to take the bull by the horns and do some.... no, a lot! ... of research. We have a great bunch of guys here who will answer any questions you put to us, but your life is in your hands and you will have to be making a huge decision soon.
Some the of criteria that goes into such a decision includes your age and physical well-being. If you are older than 70, maybe that prostatectomy is 'no way.' If you're less than 50, prostatectomy is WAY! There is a good age range for brachy and there is an age at which you probably can only consider hormones.
Personally, if my body could take it (and most can now up to 75), I would opt for the robotic laparoscopic prostatectomy, but we don't have enough of your stats to even come up with an opinion.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA <.1 <.1 <.1 .27 .37 .75 PSAD 0.19 years EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 PSAD .056 years Lupron 07/03 (1 mo) 8/03 and every 4 months there after PSA .07 .05 .06 .09 .08 .132 .145 PSAD 1.4 years Casodex added daily 07/06 PSA <0.04, <0.05, <0.04 (06/12/2007) Non Illegitimi Carborundum
Sy - 25 Aug 2007 23:42 GMT Thanks for the welcome to the "club".
I am 59 years of age and in good health otherwise. Am impressed with what I've read about the CyberKnife approach. The Urologist said that if I were to choose the CyberKnife treatments I would need to go on hormones two months beforehand. Anyone have any idea what type of hormones (brand name?) would be required?
I have read a plethora of articles. Gotta watch out for Manufacturers' web sites masquerading as some "prostate information" site.
What other "stats" would I need to supply to be a "'member' in good standing"?
Thanks,
Sy
> > Just had a consultation with my Urologist. > > [quoted text clipped - 28 lines] > opt for the robotic laparoscopic prostatectomy, but we don't have enough of > your stats to even come up with an opinion. chasjac too - 25 Aug 2007 12:34 GMT Hello, Sy:
Check the archives for information about the Cyberknife and other high-dose radiation treatments. There's one fellow who is going through it right now; I think Steve Kramer, the newsgroup historian, has provided you with a list.
The issue some here have with the Cyberknife is that it just has not yet been used a lot in the US for this type of treatment, so your doc's comments about side effects and effectiveness might be somewhat optimistic. I hope it's true, and I think it could be, based on what little I know about it. I've found a few things online about it; it seems to be in the evaluation phase at several of the medical centers that have a Cyberknife. At least check on what your insurance will cover before deciding on it as a treatment.
Do a lot of research, and read up on all of your options. The authors mentioned on this NG a lot are Scardino, Walsh, and Strum, though I always like to put in a plug for Prostate Cancer for Dummies by Lange.
Don't cast aside surgery. With your numbers and your age you should keep it in mind, as well as seeds and beam radiation. You have time to do the research you need before making a decision.
The hormone treatment you will receive before the Cyberknife treatment is a short-term androgen deprivation therapy (ADT). It's usually done with Lupron or Eligard. Depriving the prostate of testosterone will shrink it, and will also lock the tumor cells in a stage that will render them more vulnerable to the effects of the radiation. Many of the radiation therapies include something like this before the radiation is applied.
Funny thing ... one of my friends in this area is named "Si," appears to be lurching towards a diagnosis of PCa, and has asked me about the Cyberknife a few times. Coincidence? :-)
--charlie
 Signature 6/2006 PSA 5.2, DRE suspicious 7/2006 Biopsy: 2 of 10 positive, Gleason 7(3+4) 11/2006 LRP: Clear margins, N0M0 PSA < 0.01 on 1/2007, 3/2007, 6/2007 so far, so good ...
Steve Kramer - 26 Aug 2007 00:03 GMT > Thanks for the welcome to the "club". > [quoted text clipped - 9 lines] > What other "stats" would I need to supply to be a "'member' in good > standing"? Ha! There are no minimum qualifications.
Other Cyberknife patients that have visted here include:
rk012d1307@blueyonder.co.uk RAYMOND KING taz92652@yahoo.com taz92652
ellis@invalid.jps.net Ellis
I don't know what HT they used. I think Raymond had Zoladex. Lupron or Casodex are other possibilities, I guess, but I don't know.
At 59 and in good shape, I think you can consider the whole spectrum of treatments. Surgery seems to have a slim advantage over radiation.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA <.1 <.1 <.1 .27 .37 .75 PSAD 0.19 years EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 PSAD .056 years Lupron 07/03 (1 mo) 8/03 and every 4 months there after PSA .07 .05 .06 .09 .08 .132 .145 PSAD 1.4 years Casodex added daily 07/06 PSA <0.04, <0.05, <0.04 (06/12/2007) Non Illegitimi Carborundum
Steve Jordan - 26 Aug 2007 00:59 GMT On August 25, Sy replied to Steve K:
> I am 59 years of age and in good health otherwise. Am impressed with > what I've read about the CyberKnife approach. The Urologist said that > if I were to choose the CyberKnife treatments I would need to go on > hormones two months beforehand. Anyone have any idea what type of > hormones (brand name?) would be required? First and foremost: learn that urologists are surgeons, and very few of them are trained in the treatment (tx) of prostate cancer (PCa) beyond surgery.
The specific question about "hormones" can be answered: if the uro failed to say WHY the "hormones" are required and WHAT "hormones," he is not performing adequately.
However, I believe that the uro had in mind chemical reduction in the size of the prostate gland. Among the meds used for that purpose are the LHRH agonists such as Zoladex (goserelin acetate), Trelstar (tiriptorelin pamoate), or Lupron and its various other incarnations (leuprolide acetate).
There are also other meds such as Avodart (dutasteride) and Proscar (finasteride).
And others.
> I have read a plethora of articles. Gotta watch out for Manufacturers' > web sites masquerading as some "prostate information" site. Don't dismiss such information as being all worthless.
> What other "stats" would I need to supply to be a "'member' in good > standing"? Well, there is no Membership Committee that considers and passes upon the qualifications of newbies :-)
But it is helpful to know: Age General health, and other health issues (co-morbidities) When diagnosed PSA history for the years preceding diagnosis (dx) Clinical stage (from DRE, digital rectal examination) Frex, T2a or such Number of specimens taken at biopsy Number of specimens that contained PCa cells, and the percentage of each specimen Where the PCa specimens were located The Gleason score of each specimen The validated Gleason score from a specialist lab*
And anyone who tells a patient that a particular tx has "virtually no side effects" is blowing smoke....well you know where. What, exactly, does "virtually" mean?
Lastly: I was not txd via RP, so I can objectively ask exactly why Sy says "no way!" to RP.
Here is the encyclopedic source of PCa information: the Prostate Cancer Research Institute (PCRI) at http://prostate-cancer.org/index.html Search on "Newly Diagnosed" for a start.
Study, Learn, Take Charge!
Regards,
Steve J
"Empowerment: taking responsibility for and authority over one's own outcomes based on education and knowledge of the consequences and contingencies involved in one's own decisions. This focus provides the uplifting energy that can sustain in the face of crisis." --Donna Pogliano, co-author of _A Primer on Prostate Cancer_, subtitled "The Empowered Patient's Guide."
> Thanks, > [quoted text clipped - 31 lines] >> opt for the robotic laparoscopic prostatectomy, but we don't have enough of >> your stats to even come up with an opinion. Steve Jordan - 26 Aug 2007 01:05 GMT Here are the specialist path labs that I neglected to cite in my previous post:
Bostwick Laboratories [800] 214-6628 Dianon Laboratories [800] 328-2666 (select 5 for client services) Jon Epstein (Hopkins) [410] 955-5043 or [410] 955-2162 David Grignon (Michigan) [313] 745-2520 Jon Oppenheimer (Tennessee) [888] 868-7522 UroCor, Inc. [800] 411-1839
Regards,
Steve J Red-faced
cmdrdata - 26 Aug 2007 13:47 GMT > Just had a consultation with my Urologist. > [quoted text clipped - 11 lines] > > Anyone have experiences with CyberKnife treatment? I am one of the very few here that has cyberknife equivalent (Elekta Synergy S) and high-dose too. I enrolled in a treatment study and so far so good. The only SE is grade 1 rectal bleeding (ocasional and persistent (6 months, and still have occasional blood stripped stool). No problem with urinary or erection. PSA slowly going in a downward trend, and I did not use any hormone treatment.
El Woody - 27 Aug 2007 12:48 GMT > Just had a consultation with my Urologist. > [quoted text clipped - 15 lines] > > Sy Listen, read and consider all of this information. These guys have been the most helpful resource to me over the past several months.
Steve Kramer - 28 Aug 2007 18:58 GMT > Listen, read and consider all of this information. These guys have > been the most helpful resource to me over the past several months. Buenos dias, Sr. Woody.
When last you checked in, as I recall, you had yet to select a treatment or treatment date. Have you yet? Or are you waiting to see if the Phillies can make up those five games first.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA <.1 <.1 <.1 .27 .37 .75 PSAD 0.19 years EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 PSAD .056 years Lupron 07/03 (1 mo) 8/03 and every 4 months there after PSA .07 .05 .06 .09 .08 .132 .145 PSAD 1.4 years Casodex added daily 07/06 PSA <0.04, <0.05, <0.04 (06/12/2007) Non Illegitimi Carborundum
california_chief - 27 Aug 2007 19:55 GMT Sy wrote and asked:
> Anyone have experiences with CyberKnife treatment? I had an appointment - stressed "seeds" when making it - with a urologist.
The only thing he talked about was the CyberKnife. Handed the wife and me a small pile of literature and URL's.
Turned out the URL's were directly to CyberKnife and its press released, thumping its own chest about the marvels of the machine.
The press release that stunned the wife and me stated CyberKnife was developed for brain tumors, and later approved by the FDA for breast cancer. It has only been recently approved for treatment of PCa.
AND, the local CyberKnife this urologist wanted to send me to had been installed only the week before. I was possibly the first victim....er, patient.
This was all in June 2005. I have no idea how many men have been treated with CyberKnife in 2 or 3 years, but there just isn't enough data to prove it's more or less effective than older methods.
OH! The literature states it's "non-invasive" but somehow they have to plant "marker seed" in the prostate.
Alan Meyer - 28 Aug 2007 22:49 GMT Like you, my reaction to surgery was "no way". I had once had a botched knee surgery that left me in pain for years and my emotional reaction to another surgery was - never again would I let someone put me to sleep and then cut me open, unless there was no other choice. I opted for a combination therapy in a clinical trial including ADT, high dose rate brachytherapy, and external beam radiation.
So far, 3-1/2 years later, I'm satisfied with my treatment. That might change if my PSA goes up. However I've learned a lot more since then and I no longer have the same visceral reaction against surgery that I had at the beginning. Unfortunately, there are butchers in every field, radiation oncology as well as surgery. So you could have a bad experience with any treatment modality. There is also a certain element of luck in any treatment. That too can lead to unfortunate results.
In my (in this case informed I think) opinion, the experience, skill and commitment of the practitioner is every bit as important as the specific treatment modality. I think I'd rather have a very good surgeon than a mediocre radiation oncologist, and vice versa for a good radiation oncologist and a mediocre surgeon.
You've got some time. Your PSA and Gleason ratings are still in the "low risk" category and may not become dangerous for as long as several years (but heed Steve Jordan's advice about a second opinion on the Gleason score.) This doesn't mean you shouldn't get treatment because, at your age, it's very likely that the cancer WILL become dangerous before you die of something else and the chances of successful treatment are generally higher with early treatment than late treatment. However you do have time to research and think out the options.
I think you have two areas of research to pursue. One is to look at treatment modalities - various types of surgery vs. various types of radiation (of which Cyberknife is one) or possibly even other alternatives like HIFU or cryosurgery. The other area of research is to find the best practitioners available to you.
I would look for a doctor that specializes in treating prostate cancer (not a urologist whose specialty is female incontinence, or a radiation oncologist whose specialty is brain cancer.) I would want a guy who answers questions patiently, plausibly and honestly, not one who gives glib answers like "None of my patients develop incontinence", "My cure rate is 99%" or "Don't worry about impotence, it won't happen".
Talk to doctors and nurses in your area if you can and find out who they would send their fathers or husbands to. Make appointments for consultations with the best people you can find. Prepare a ton of written questions and bring your notebook with you when you go to see them.
Best of luck.
Alan
Beverley - 03 Sep 2007 04:44 GMT I can't say a thing about cyberknife for PC but I had it done for something entirely different. I had neurosurgery this spring and they used cyberknife. You are welcome to email me about what I had done as it would be off topic for this group.
I do know that cyberknife for PC is new. Real cutting edge technology (LOL) there's no cyber or knife in cyberknife. It's about the same as looking for the ham in hamburger.
I'll stand behind brachytherapy 100%. I know it works. Bev
> Just had a consultation with my Urologist. > [quoted text clipped - 15 lines] > > Sy
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