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Medical Forum / Diseases and Disorders / Prostate Cancer / July 2007Fosamax and ADT
Greetings to all my fellow club members. As an infrequent correspondent , I am again making my annual report. I have been on Zoladex since about Oct 2001 after Cryosurgery on Dec 22, 2000. Preops Gleason 6 (3&3)and T1C.PSA was 9. After 2mos follow up,PSA was .2 , then 6mos follow up PSA was 7.1 . The Cryosurgery never naidered.At that time I had 11 needle sticks in the prostate all of which were negative. A CT scan and Bone scan were conducted, all negative.Casaodex and Zoladex then followed as treatment plan.. Casodex was dropped after a year and one half. Zoladex and PSA measurement continues every 3mos.PSA has dropped to undetectable levels as measured by the Bayer chemiluminescent method. However in Dec 2006 PSA was 0.1, March 2007 again 0.1. However at last visit reverted back to undetectable. I was on Fosamax until March 2005. A DEXA indicated normal and Fosamax was dropped. However March 2007 another DEXA, back on Fosamax.But I may have to have Dental work in the future. So, do I suffer toothaches or weak bones ? . I wonder what my options are! Resp'y Rod in Arlington On July 28, Rod wrote, in pertinent part: > I was on Fosamax until March 2005. A DEXA indicated normal and Fosamax > was dropped. If Ed continued on ADT, that was probably ill-advised. > However March 2007 another DEXA, back on Fosamax.But I may have to > have Dental work in the future. > So, do I suffer toothaches or weak bones ? . I wonder what my options are! Options might not be limited to the above. The incidence of osteonecrosis for patients on bisphosphonates who undergo "deep" dental procedures is small. But if it occurs, it is incurable (though treatable). And as I understand it, ONJ (osteonecrosis of the jaw) occurs *only* when the jawbone is damaged during a dental procedure, typically an extraction. And even then it is rare. So the choice does not narrow down to osteonecrosis OR "weak" bones. Here, from the website of the FDA, is detailed information: http://www.fda.gov/ohrms/dockets/ac/05/briefing/2005-4095B2_02_12-Novartis-Zomet a-App-11.pdf. or http://tinyurl.com/2hhjfx Regards, Steve J
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