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Medical Forum / Diseases and Disorders / Prostate Cancer / July 2007

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Anybody here subscribe to The Journal of Sexual Medicine ? ? ?

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mountainguy1958 - 21 Jul 2007 00:28 GMT
Anyone here who subscribes to the Journal of Sexual Medicine, I would
appreciate your help. I've been scouring the web for the full text of
the article linked below, without success. I'm hoping that a thorough
review of literature (which this appears to be) may help with a
"managed care" insurance appeal.

Private replies to the above e-mail address are welcome, as would be a
response to the group. Your preference.

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1743-6109.2005.00117.x

The cost of $39 USD for this one article is a bit steep for me,
especially since I can't tell without reading the entire article how
useful it might be. I've checked and it's not available through any of
the libraries to which I have access.

Subscribers to The Journal of Sexual Medicine may apparently download
full texts at no cost above the annual price of their subscription.

Thanks.

Tom

------ QUOTE ------

Abstract
ORIGINAL RESEARCH—PHARMACOTHERAPY
Efficacy of Sildenafil Citrate in Men with Erectile Dysfunction
Following Radical Prostatectomy: A Systematic Review of Clinical Data

Francesco Montorsi, MD, Universita Vita Salute San Raffaele—Department
of Urology, Via Olgettina 60 Milan 20132, Italy. Tel: (+39) 02
26437286; Fax: (+39) 02 26437298; E-mail: montorsi.francesco@hsr.it

ABSTRACT

Introduction. Radical prostatectomy is a frequently used treatment
option for prostate cancer; however, prostatectomy is often associated
with significant morbidity, including erectile dysfunction (ED).

Aim. To analyze the efficacy of sildenafil citrate in treating ED
after radical prostatectomy.

Materials and Methods. MEDLINE and CANCERLIT (1998 to January 2004)
were searched for English language articles using the key words
prostatectomy, sildenafil, and phosphodiesterase inhibitors. Eleven
studies fulfilled the inclusion criteria: primary, discrete data sets
of postprostatectomy patients with ED treated with sildenafil
monotherapy.

Results. Sample sizes ranged from 13 to 198 (mean age, 61 ± 3 years).
Treatment durations were 4 weeks (or more than four doses) to 1 year,
and sildenafil dosing was in the recommended range (25–100 mg). Seven
studies reported a response rate (range, 14%−53%) for an end point
consistent with the primary analysis outcome (erection sufficient for
vaginal intercourse); the combined estimate of probability of response
was 35% (95% confidence interval [CI], 24%−48%). There was strong
evidence for a lower response rate after non–nerve-sparing (range, 0%
−15%) versus nerve-sparing surgery (range, 35%−75%; combined odds
ratio [OR] = 12.1; 95% CI, 5.5–26.6) but not after unilateral (range,
10%−80%) versus bilateral nerve-sparing surgery (range, 46%−72%;
combined OR = 2.21; 95% CI, 0.75–6.54).

Conclusions. The results of these studies demonstrate that with
sildenafil, more than one third of patients with postprostatectomy ED
achieved erection sufficient for intercourse. The odds of responding
improved 12-fold with preservation of at least one neurovascular
bundle. Early treatment failure does not necessarily imply lack of
efficacy in the future, and patients should be encouraged to continue
trying sildenafil, titrating up to 100 mg as needed. Montorsi F, and
McCullough A. Efficacy of sildenafil citrate in men with erectile
dysfunction following radical prostatectomy: a systematic review of
clinical data. J Sex Med 2005;2:658–667.

------ END QUOTE ------
callalily - 21 Jul 2007 17:42 GMT
Dear Tom,

> Anyone here who subscribes to the Journal of Sexual Medicine, I would
> appreciate your help. I've been scouring the web for the full text of
> the article linked below, without success. I'm hoping that a thorough
> review of literature (which this appears to be) may help with a
> "managed care" insurance appeal.

First of all, requesting $39 for a single article is disgusting.  I
can't stand "medical profiteering".  I suggest you subscribe to
amedeo.com, an excellent resource I just found.  They provide up-to-
date info to doctors, and they abstract hundreds of journals.

You can get a free weekly email summary of developments about a
particular topic of interest.  For example, on PC they abstract 46
journals, but they will give you info from *some* of them for free.
When I recently needed to find updated info on salvage RT, I looked
through their latest weekly summary of abstracts.  It was laborious,
but fruitful.

Secondly:  What kind of info does your insurance company want?

It reminds me of the story about when Gertrude Stein died.  She was
surrounded by friends and relatives, and somebody said:  "Gertrude,
Gertrude, what is the answer?"  And she replied, "What is the
question"?

There are 2 issues pertaining to whether Viagra and other PDE5-
inhibitors "work".

1) Will it help you get an erection after surgery?

2) Will it help restore your natural erectile function or speed or
restoration of same.

As far as Q #1, if you have a certain amt of nerve function after
surgery, Viagra may well help you function sexually.   As far as Q #2,
there really is no evidence of that, except maybe that Viagra, *in
conjunction with intracavernosal injections*, may do something.
That's what they call "combination therapy".  Also, I do have an
article from the Cleveland Clinic which says Viagra helps to increase
"smooth muscle tissue" in the penis.

There is an onging study at Hopkins re: "Effect of Viagra on return of
EF after RP".  Still in progress.  Contact: Dr. Pavlovich,
410-550-0013.

Also, from nature.com (free). Feb '06. "Early combination therapy:
intracavernosal injections and sildenafil following RP increases
sexual activity and the return of natural erections".  Int'l Journal
of Impotence Research (2006) 18, 446-451.  Nandipati, Raina et al.

The best article on the subject of ED and penile rehab after RRP which
I have referred to here before, is a study by the Cleveland Clinic:
"Erectile Dysfunction Following RRP:  Epidemiology, Pathophysiology
and Pharmacalogical Management".  Same authors as ones cited for above
article.  Available at clevelandclinic.org website in its entirety.
The only thing that may benefit you is this:  "The investigators
concluded that early us of sildenafil (50 mg) following RP appears to
preserve smooth muscle content, and at doses of 100 mg increases the
smooth muscle content.  This article then describes 2 studies which
have found that Viagra may help in "penile rehab", but they are both
described as flawed. The second sounds more promising (use of
vardanafil), but there was no control group used in the study, so its
validity has been questioned.

["Restoring Erectile Function: Proactive Options after RP", 4/1/05,
Wayne, Hellstrom et al. Contemporary Urology."  See the discussion on
"Penile Rehab".  Sorry.  This article emphasizes that injections are
the gold standard for penile rehab.  What I had highlighted was
something about early injections may increase the responsiveness to
Viagra.]

I am losing sleep because I see that in this particular group there is
a lack of knowledge about "penile rehab" after RP, which is closely
related to the issue of "penile shrinkage".  I am going to address
this in a separate post, hopefully.

* But to all men who are or who have undergone RP, if your sexual
function is not restored by 2 mos. you should see an *ED specialist*.
If Viagra is not working for you by then, chances are it won't, at
least for a while. Your best bet, based on available research, is
starting injection therapy ASAP.  The pump is not effective in
restoring natural erectile function, or at least it's efficacy has
been questioned.

You can search this group's archives and find a number of posts by me
on sexual or penile rehab.  Search callalily and "rehab".  Also "Sex
after Surgery". This is a subject I've done a ton of research on.

By medical stds, the article you mention is a bit outdated, I think
(2004).  Of course, the person who would know more about this than
anybody, is Dr. Mulhall at MSK.

I think you are fighting an uphill battle, Tom.  It might just be
easier to order the stuff from India; it's the real thing.

I hate to give men the "dead men don't have sex" line,  but I know
that in my case, since Ted has had his recurrence, sex is at the
bottom of the priority list.  Anatole Broyard, a literary critic for
NY Times, wrote an interesting book about his experience with PC.
Excerpt:

"When I heard that the cancer might affect my sexuality, my "mind
became immediately erect".

But also:

"After my brush with death I feel that just to be alive is a permanent
orgasm".

I have a ton of stuff on ED and RP and hope to use it as the basis of
a Series of articles on penile rehab, penile shrinkage, preventative
measures for averting ED, and treatment of ED.  In any case, I just
posted a major opus on my blog on "Sexy Secrets for Finding an (ED)
doctor".  I might post it here, but it is a big long.

Too tired to proofread this.  All the best.

Leah
prostatecancerblog.net

>From WH Auden:

"As the poets have mournfully sung,
Death takes the innocent young.
The rolling in money,
The screamingly funny,
And those who are very well hung."
Alan Meyer - 21 Jul 2007 20:46 GMT
I'd be surprised if the managed care managers will read any more
than the abstract, and you'll be lucky if they read that.

I'd also be surprised if proving your point (that your treatment
for PCa caused your ED difficulties) would have any effect on
their decision.  Most people with ED have some physical cause -
whether it be diabetes, cardiac drugs, treatment for PCa, or just
aging, and a good number of those can be helped by Viagra.  But
Viagra is very expensive and the insurance companies believe that
having a better sex life, whatever the cause of the problem, is
not something they are obligated to assist.

In other words, if their denial of assistance with purchasing
Viagra is not based on the fact that you have a physical problem,
then you may be wasting your time appealing.  I expect them to
fight hard on this for fear that a very large number of their
clients might also benefit from Viagra and allowing one in the
door might force them to allow others.

But good luck to you.

If you don't get anywhere, you might try the online Indian
pharmacies, which sell the drug a lot cheaper.

   Alan
chasjac too - 22 Jul 2007 01:11 GMT
...
> The cost of $39 USD for this one article is a bit steep for me,
> especially since I can't tell without reading the entire article how
> useful it might be. I've checked and it's not available through any of
> the libraries to which I have access.
...
> Tom

Do you have access to a college library?  They can usually arrange an
interlibrary loan request.  The library that has the article will then fax
a photocopy.  Perhaps some public libraries offer this service, too.  It's
worth asking.  Be ready to supply them with the full bibliographic
reference.  

Another thing you could try is e-mailing the author and asking for a reprint
of the article.  Often, journals will provide these to authors as a
courtesy.  He may refuse, but you never know ...

--charlie

Signature

6/2006 PSA 5.2
          DRE suspicious
7/2006 Biopsy
          2 of 10 positive
          Gleason 7(3+4)
11/2006 LRP
           Clear margins
1/2007 PSA < 0.01
3/2007 PSA < 0.01
6/2007 PSA < 0.01
so far, so good

 
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