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Medical Forum / Diseases and Disorders / Prostate Cancer / May 2007

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Silver Bullet?

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kh - 10 May 2007 22:06 GMT
Saw this on Yahoo-Reuters.

++++++++++++++++++++++++++

Scientists directly target cancer cells

Thu May 10, 11:18 AM ET

SYDNEY (Reuters) - An Australian biotechnology firm said on Thursday
it had developed a means of delivering anti-cancer drugs directly to
cancer cells, which aims to avoid the debilitating toxicity associated
with chemotherapy.

The method uses nanotechnology, which involves molecules far smaller
than a human cell.

Direct targeting of chemotherapy drugs would allow dosages thousands
of times lower than that in conventional chemotherapy and be more
easily tolerated by patients, said the firm.

Writing in the May issue of U.S.-based Cancer Cell journal, the
biotech firm EnGeneIC said it had developed nano-cells containing
chemotherapy drugs.

Via antibodies on their surface, these nano-cells target and latch on
to cancer cells. Once attached, the nano-cell is engulfed and the drug
is released directly inside the cancer cell.

The firm said the bacterially derived nano-cell, called EnGeneIC
delivery vehicles, had proven safe in primate trials and resulted in
significant cancer regression.

It hoped to carry out human trials later in 2007 if it gained approval
from Australian, U.S., European and Japanese regulatory authorities.

"For the first time there is a real possibility that this technology
could lead to the use of multi-drug combinations and eventual custom-
made therapies in cancer patients," research scientist Jennifer
MacDiarmid said in a statement.

"In terms of tumor therapy, most late-stage cancer patients carry
tumor cells that exhibit various forms of drug resistance. Our
technology may provide the first in-vivo (inside an organism) solution
to this serious hurdle."

++++++++++++++++++++++++++

I have no idea if they are looking at Prostate Cancer or even how
promising this technology is.   It might even be so early that they
are just hyping their technology to get funding.

It seems, though, that Prostate Cancer, which is slow growing and a
unique tissue, would be a good candidate.

By unique tissue, I mean, you wouldn't want a targeted treatment to
wipe out all your lung tissue, skin tissue, or brain cells.    You'd
want it to target cancerous lung tissue or cancerous brain cells and
spare normal lung tissue or normal brain cells.

If you had a nano technology that killed all prostate cells, cancerous
and non-cancerous, that would be fine for most of us.  This seems like
a simpler problem.

I can't say that I like not having a functioning prostate.   It was
the source of many enjoyable hours.

I would prefer a silver bullet to my current struggle with mets and
sky rocketing PSA less than 3 years after radiation.

Considering that Prostascint and Provenge are both "targeted", maybe
they will develop a silver bullet.

-kh  We can hope.
Alex - 12 May 2007 19:54 GMT
> I can't say that I like not having a functioning prostate.   It was
> the source of many enjoyable hours.

Or, for some of it, many enjoyable minutes. (g)
Alex - 13 May 2007 01:01 GMT
>> I can't say that I like not having a functioning prostate.   It was
>> the source of many enjoyable hours.
>>
> Or, for some of it, many enjoyable minutes. (g)
Like Steve, I seem to be challenged in my typing today.
I meant to say, "Or, for some of us, many enjoyable minutes. (g)"
kh - 13 May 2007 02:47 GMT
On May 12, 8:01 pm, "Alex" <tuchasoffentisch@_NO_SPAM_gmail.com>
wrote:
> >> the source of many enjoyable hours.
>
> > Or, for some of it, many enjoyable minutes. (g)
>
> Like Steve, I seem to be challenged in my typing today.
> I meant to say, "Or, for some of us, many enjoyable minutes. (g)"

Over the years, many minutes add up to many hours AND bring smiles to
both you and your partner.

But back to "Silver Bullets", check this out, I did a google-scholar
search for "provenge":

"RESULTS
Nineteen patients could be evaluated for response to treatment. The
median time to progression was 118 days. Treatment was tolerated
reasonably well; most adverse effects were secondary to APC8015 and
were NCI Common Toxicity Criteria Grade 1-2. Four of the 21 patients
reported Grade 3-4 adverse events. Two patients exhibited a transient
25-50% decrease in prostate-specific antigen (PSA). For a third
patient, PSA dropped from 221 ng/ml at baseline to undetectable levels
by week 24 and has remained so for more than 4 years. In addition,
this patient's metastatic retroperitoneal and pelvic adenopathy has
resolved."

It's from http://www3.interscience.wiley.com/cgi-bin/abstract/107598759/ABSTRACT?CRETRY=1&
SRETRY=0


One lucky guy's PSA dropped from 221 to undetectable!!!

-kh that'd bring a smile to me.
kh - 14 May 2007 01:05 GMT
I was looking up Provenge again and found a link to this:

++++++++++++++++++

Cell Genesys, Inc. (Cell Genesys), incorporated in 1988, is a
biotechnology company focused on the development and commercialization
of biological therapies for patients with cancer. Its clinical stage
cancer programs involve cell- or viral-based products that have been
genetically modified to impart disease-fighting characteristics that
are not found in conventional chemotherapeutic agents. The Company's
lead program is GVAX cell-based immunotherapy for cancer. As of
December 31, 2006, it was conducting two Phase lll clinical trials in
prostate cancer and Phase ll trials in each of pancreatic cancer and
leukemia. Cell Genesys initiated its Phase lll clinical trials for
GVAX immunotherapy for prostate cancer in July 2004 and June 2005,
each under a special protocol assessment (SPA) with the United States
Food and Drug Administration (FDA). In its oncolytic virus therapies
program, which the Company (as of December 31, 2006) was developing in
part through a global alliance with Novartis AG (Novartis), it
initiated a Phase 1 clinical trial of CG0070 in recurrent bladder
cancer in April 2005. It expanded the CG0070 Phase 1 trial to evaluate
escalating multiple-dose regimens during the year ended December 31,
2006. The Company also has other preclinical oncolytic virus therapy
programs, including CG5757, which it is evaluating as potential
therapies for multiple types of cancer.

GVAX Cancer Immunotherapy Program

The Company's GVAX immunotherapies are cancer treatments designed to
stimulate the patient's immune system to effectively fight cancer.
GVAX cancer immunotherapies are comprised of tumor cells that are
genetically modified to secrete an immune-stimulating cytokine known
as granulocyte-macrophage colony-stimulating factor (GM-CSF), and are
then irradiated for safety.

As of December 31, 2006, more than 600 patients had received Cell
Genesys' GVAX cancer immunotherapies in multiple Phase 1 and ll
clinical trials to date, and the immunotherapies have been shown to
have a favorable side effect profile that avoids many of the
toxicities associated with conventional cancer therapies. GVAX cancer
immunotherapies can be administered in an outpatient setting as an
injection into the skin, a site where immune cells, including in
particular dendritic cells, can be optimally accessed and activated.
As of December 31, 2006, the Company's GVAX cancer immunotherapies was
being tested as non patient-specific, or allogeneic, products.

The Company's GVAX immunotherapy for prostate cancer is a non patient-
specific product comprised of two genetically-modified prostate cancer
cell lines. It has completed five Phase 1 and Phase ll clinical trials
of its GVAX immunotherapy for prostate cancer in approximately 200
patients with various stages of recurrent prostate cancer, and the
immunotherapy has had a favorable safety profile in each trial. These
clinical trials include two Phase ll clinical trials in hormone-
refractory prostate cancer patients with radiologic evidence of
metastatic (spreading) disease (metastatic HRPC), which is the target
population for its Phase lll trials.

Cell Genesys' GVAX immunotherapy for pancreatic cancer is a non
patient-specific product. As of December 31, 2006, a Phase ll clinical
trial of GVAX immunotherapy for pancreatic cancer was being conducted
by the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins in
60 patients with resectable pancreatic cancer who received the
immunotherapy after surgical resection of their tumor and standard
adjuvant radiation and chemotherapy. Its GVAX cancer immunotherapy for
leukemia is a non patient-specific GVAX cancer immunotherapy product.

++++++++++++++++++++++

http://www.investor.reuters.wallst.com/stocks/company-profile.asp?rpc=66&ticker=
CEGE.O


So, best I can tell, there are several silver bullets being loaded.
Probably not all treatments will work for everyone but each new
treatment is another chance for each us.

The trick is to, er, like a girlfriend told me 35 years ago, "Hang on,
for the ride of your life."

-kh How am I going to explain these teethmarks?
 
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