Medical Forum / Diseases and Disorders / Prostate Cancer / November 2006
PSA result
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gabachin - 21 Nov 2006 20:06 GMT I wrote to this group six months ago after a rise in PSA from .5 to 1.8 in 20 months. I'm 47, and in good health. My stats were:
7/2002 .9 (method unknown)
10/2004 .5 (Hybritech Access)
5/27/2006 1.8 (Hybritech Access)
Since many of you were so kind to give me such helpful advice, I just wanted to let you know that my latest PSA was
11/20/2006 1.600 (Abbott Asyxm)
I've reported the results to the decimal place given by the lab. I find it interesting that Abbott's results should be good to three decimals, while the other results are reported only to one. I've also read in
http://www.diagnosis.prostate-help.org/assays.htm
that in the range PSA < 7, Hybritech and Abbott give nearly identical results. Any comments?
Six months ago, when I went to my GP, he basically told me I was being neurotic about the PSA and said not to give it a second thought. I then went to a Uro who told me the same thing. When I mentioned PSA velocity he laughed in my face and said, "oh yeah, some people even make charts." He then said that I might check it again in a year's time. Thanks to this group, I've learned a great deal about the whole issue of PSA testing and PCa in general, and I intend to keep checking my PSA every six months to get a more meaningful pattern.
Thanks again for all your advice and kind attention.
Dick Smith - 21 Nov 2006 23:08 GMT I then
> went to a Uro who told me the same thing. When I mentioned PSA velocity > he laughed in my face and said, "oh yeah, some people even make > charts." I wonder why they laugh at PSAV when it's been proven that's it's a better predictor of PCa than static PSA.
I.P. Freely - 21 Nov 2006 23:45 GMT > I then >> went to a Uro who told me the same thing. When I mentioned PSA velocity [quoted text clipped - 3 lines] > I wonder why they laugh at PSAV when it's been proven that's it's a > better predictor of PCa than static PSA. For the same reasons so many of them don't inform pts of SEs, including ignorance and/or a running meter.
I.P.
Alan Meyer - 22 Nov 2006 02:11 GMT ...
> 11/20/2006 1.600 (Abbott Asyxm) > > I've reported the results to the decimal place given by the lab. I find > it interesting that Abbott's results should be good to three decimals, > while the other results are reported only to one. ... I don't know about the differences in tests, but from what I know about PSA, the three decimals are of no real use. It may be true that you had exactly 1.600 at the moment of the blood draw, but the next day you might have had 1.523 and the previous day 1.614, and so on. PSA varies from day to day. I'm far from an expert, but my guess is that only about two decimal digits of precision (1.6 in this case) are of value in diagnosis.
> Six months ago, when I went to my GP, he basically told me I was being > neurotic about the PSA and said not to give it a second thought. I then [quoted text clipped - 6 lines] > > Thanks again for all your advice and kind attention. Your uro knows vastly more about this than I do. His advice to get yearly tests doesn't sound bad to me. Your PSA is not currently in any way alarming. The docs are right that it's possible to get neurotic about things.
On the other hand, getting tested more frequently doesn't cost much and you did have a larger rise than one would expect.
Do you have any special risk factors (smoking, obesity, exposure to carcinogens, PCa in your family?)
If I were you, knowing what I know now, I might want a test every 6 months. And making a chart may not be such a terrible idea because there's a good chance that your doctor isn't doing it. But I would also not want to obsess about it.
Alan
c palmer - 22 Nov 2006 03:27 GMT From: ptoppo@gmail.com (gabachin)
I wrote to this group six months ago after a rise in PSA from .5 to 1.8 in 20 months. I'm 47, and in good health. My stats were: 7/2002 .9 (method unknown) 10/2004 .5 (Hybritech Access) 5/27/2006 1.8 (Hybritech Access) Since many of you were so kind to give me such helpful advice, I just wanted to let you know that my latest PSA was 11/20/2006 1.600 (Abbott Asyxm) I've reported the results to the decimal place given by the lab. I find it interesting that Abbott's results should be good to three decimals, while the other results are reported only to one. I've also read in http://www.diagnosis.prostate-help.org/assays.htm that in the range PSA < 7, Hybritech and Abbott give nearly identical results. Any comments? Six months ago, when I went to my GP, he basically told me I was being neurotic about the PSA and said not to give it a second thought. I then went to a Uro who told me the same thing. When I mentioned PSA velocity he laughed in my face and said, "oh yeah, some people even make charts." He then said that I might check it again in a year's time. Thanks to this group, I've learned a great deal about the whole issue of PSA testing and PCa in general, and I intend to keep checking my PSA every six months to get a more meaningful pattern. Thanks again for all your advice and kind attention.
======== your psa rise could be as simple as a minor prostate infection.
if you are in doubt, get a free psa test. that will help give you more information about your present situation.
also, you can ask the uro to put you a two week treatment of levaquin or the something similar. then take the psa test over again and see what the results are.
knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc
Alan Meyer - 22 Nov 2006 04:11 GMT > ... > also, you can ask the uro to put you a two week treatment of levaquin or > the something similar. then take the psa test over again and see what > the results are. > ... We always say this, but I still say (and will repeat from time to time) that taking antibiotics as a "just in case" treatment is not good medicine. It's a little more trouble but a lot more accurate and less invasive to get a urine culture instead to find out if there actually is a bacterial infection. If not, why contribute to developing more antibiotic resistant bacteria in your body and in society?
Alan
c palmer - 22 Nov 2006 08:00 GMT From: ameyer2@yahoo.com (Alan Meyer) We always say this, but I still say (and will repeat from time to time) that taking antibiotics as a "just in case" treatment is not good medicine. It's a little more trouble but a lot more accurate and less invasive to get a urine culture instead to find out if there actually is a bacterial infection. If not, why contribute to developing more antibiotic resistant bacteria in your body and in society? Alan
======> you're right, that is usually the first two things that they will do for testing purposes. it never hurts to see if there is some bad bugs in the urine. you need all the information you can in order to treat what the problem is.
knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc
Steve Kramer - 23 Nov 2006 01:24 GMT I don't think you can derive much benefit from tests done by alternating assays.
>I wrote to this group six months ago after a rise in PSA from .5 to > 1.8 in 20 months. I'm 47, and in good health. My stats were: [quoted text clipped - 29 lines] > > Thanks again for all your advice and kind attention. gabachin - 23 Nov 2006 16:05 GMT Steve Kramer ha escrito:
> I don't think you can derive much benefit from tests done by alternating > assays. I'm currently in Aguascalientes, Mexico and all the labs I researched here use the Abbott Asxym Microparticle Enzyme Immunoassay. The two methods seem to correlate very well, at least for PSA<4. A 2005 study by the State of New York gave the following results:
Specimen 1 Specimen 2 Specimen 3 Specimen 4 Specimen 5
Beckman Access 15.2 8 4 2 1 Abott Asxym 14.6 7.8 3.9 2 1
Steve Kramer - 25 Nov 2006 02:06 GMT > Steve Kramer ha escrito: > [quoted text clipped - 13 lines] > Abott Asxym 14.6 7.8 3.9 > 2 1 Okay. If you are satisfied with the compatibility of the assays, then you need to concern yourself with a rise in PSA that may be the beginning of an indication that you have a problem with your prostate. Notice, I did not say cancer. PSA can rise from several ailments, the minority of which is cancer.
However, the next time you have a PSA, if that one also is elevated past the first, then you may wish to get a biopsy.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05, 2/06, 6/06 PSA .07 .05 .06 .09 .08 .132 .145 Casodex added daily 07/06 PSA <0.04 Non Illegitimi Carborundum
gabachin - 28 Nov 2006 15:27 GMT I would have preferred that the test used the same assay as those I got in the States, but at least from what I've researched, there does seem to be very good agreement between the two assays, in the range 1-4.
I am concerned about the PSA being too high, and will track it, every three months. My trigger for biopsy is 2.3, what seems to be the lower limit for my age (47) suggested by the most agressive uros, and also is the PSA that will be reached if the PSAV gets > .75/year.
Incidently, I have no other risk factors for PCa.
Steve Kramer ha escrito:
> Okay. If you are satisfied with the compatibility of the assays, then you > need to concern yourself with a rise in PSA that may be the beginning of an [quoted text clipped - 4 lines] > However, the next time you have a PSA, if that one also is elevated past the > first, then you may wish to get a biopsy. Steve Kramer - 28 Nov 2006 17:39 GMT >I would have preferred that the test used the same assay as those I got > in the States, but at least from what I've researched, there does seem [quoted text clipped - 6 lines] > > Incidently, I have no other risk factors for PCa. Sounds like you've thought this through. Good luck.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05, 2/06, 6/06 PSA .07 .05 .06 .09 .08 .132 .145 Casodex added daily 07/06 PSA <0.04 Non Illegitimi Carborundum
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