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Medical Forum / Diseases and Disorders / Prostate Cancer / October 2006

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Listening For Cancer

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Alex - 20 Oct 2006 02:34 GMT
News story: researchers are using acoustic signals to detect skin cancer
cells in blood, and are looking for ways to create similar markers for other
kinds of cancer.

Alex

Doctors may be able to hear cancer's spread
Wed Oct 18, 2006

WASHINGTON (Reuters) - Doctors looking to see if cancer has spread may be
able to simply listen for it in the future, U.S researchers reported on
Tuesday.
Researchers at the University of Missouri-Columbia said they used a
technique called photoacoustic detection to pick up the characteristic
vibrations of melanoma cells in the blood.

They said their method could let oncologists spot as few as 10 cancer cells
in a blood sample, catching a tumor's spread before it can settle into
another organ.

Writing in the journal Optics Letters, the University of Missouri team said
they combined laser techniques from optics and ultrasound techniques from
acoustics, using a laser to make cells vibrate and then picking up the
characteristic sound of melanoma cells.

They said they were able to detect melanoma cells obtained from actual
patients.

The dark, microscopic granules of melanin in the melanoma cancer cells
absorb the energy bursts from the blue-laser light. As the melanoma cells
expand and contract, they generate crackling sounds that can be picked them
up with special microphones and analyzed by computer.

Other human cells do not contain pigments with the same color as melanin, so
the melanin signature is easy to tell apart from other noises, said John
Viator, a biomedical engineer who worked on the study.

"The only reason there could be melanin in the human blood is that there
would be melanoma cells," he said.

A blood screening test could reassure patients who have a growth removed --  
or tell a doctor to start chemotherapy quickly because the cancer has
already started to spread.

"It could take just 30 minutes to find out if there are any circulating
cancer cells," Viator said.

Melanoma is the deadliest form of skin cancer and spreads quickly if not
removed promptly. The American Cancer Society estimates that in 2006 there
will be 62,190 new cases of melanoma in the United States alone and 7,910
deaths.

Because of melanin, melanoma is the only type of cancer that can be detected
in this way. But the researchers said they could try using artificial
materials to act as light absorbers and as noise makers.

"We're looking for methods to attach other kinds of absorbers to cancer
cells," Viator said.
callalily - 22 Oct 2006 00:17 GMT
Alex wrote about a new technique of listening for cancer cells which I
think is really important.

Hopefully this will be the beginning of an era when the peculiar
sensory characteristics of tumors will be used to diagnose ca's with
minimally invasive tools.  This is already happening in other ways.

The technique Alex mentions is really exciting because it can pick up
ca signals in a cluster of  only 10 melanoma cells.

Along these lines, doctors have known for years that dogs can SMELL
melanoma.  This was first reported in the British Journal Lancet in
1989 and substantiated in subsequent studies.  I have seen a number of
"Miracle Dog" tv shows about  pets who were sniffing at, pawing at and
even trying to bite off their owner's peculiar skin lesions. In one
case, a man who had had two negative biopsies was so pestered by his
dog that he got a third one and it ended up being positive for
malignant melanoma.

MSNBC reported that researchers are trying to recruit dogs to diagnose
prostate cancer.  People who find the thought of a dog sniffing their
butts or their privates distressing should have no fear, say the
researchers.  "The dogs don't actually smell men's genitalia, they
sniff urine samples instead."  (From "Is there a doctor or dog in the
house?  Canine sense of smell could help diagnose disease, 11/17/04,
msnbc.msn.com/id/5183290)

Personally, I  had an up-close experience of a biopsy about a year ago
and  based on that would be very happy to be examined by a K-9 doctor
instead. I was told by the nurse that there would just be a "tissue
scrape" and the whole Procedure would take 5 minutes.  She said my
husband need not even bother to come.  Instead, I was given one
klonopin (mild tranq) "anesthesia."  (LOL)  Of course, I was wide awake
during the whole thing and I could feel this Monster cutting away at my
innards with garden shears  and poking at my viscera with knitting
needles.  The pain was indescribable.  In spite of my bloodcurdling
screams the dr ignored my pleas to stop. When I came to, I clocked the
time of the Procedure as 1/2 hour.

Based on this I would much rather have had Dr. Fido as a diagnostician.
I prefer the sniff to the knife.

Besides, dogs have been shown to produce more accurate results than
other diagnostic procedures.. "What makes a dog superior at diagnosis
is that its sense of smell is so sophisticated that it is able to smell
multiple layers of chemicals", according to a researcher, Dr. Myers
(quoted by MSNBC).   He adds, "Dogs don't detect a single chemical but
a combination of them. If they were identifying just a single chemical,
medicine might have picked up on it.  The dog may be doing something
better ."

Dogs have been shown to be 98-100 percent accurate in diagnosing
melanomas but controlled experiments have been hard to perform, say
scientists. A major obstacle has been finding willing patients.

This kind of makes me wonder.  How many of you who have undergone
painful, bloody biopsies for pca would not swap a little personal
dignity for a pain-free diagnostic procedure.  Maybe they are just not
recruiting the right patients.

Doctors say that if doggie diagnosis continues to be accurate K-9s
could  make "a significant contribution to public health."  "It's going
to be very useful for large-scale screening of populations," said Dr.
Myers.  "And it's certainly going to be effective in third-world
countries that don't have the resources to do sophisticated lab tests."

I suspect this view is kind of narrow; it might just catch on with
first-world patients who would rather be sniffed than stabbed.

I can foresee a day when dogs will replace radiologists and
pathologists, which sounds really nice except that I'm sure that
medico-corruption would soon take hold.  Drug cos. would be bombarding
K-9s with boxes of frosty paws and sending them on junkets to doggie
spas.  And instead of the pharmaceutical "salesmodels" you see in doc's
offices today there will be a bevy of beautiful bitches (the real kind)
holding briefcases full of samples.  And so it goes...

To the guy who has that restless Lab, maybe you should enroll it in
doggie "medical school."  Dogs of all breeds are being recruited and
the salary and benefits are good.

Good luck to you all.

Leah

> News story: researchers are using acoustic signals to detect skin cancer
> cells in blood, and are looking for ways to create similar markers for other
[quoted text clipped - 9 lines]
> in a blood sample, catching a tumor's spread before it can settle into
> another organ.
 
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