I limit fluids after 6 P.M., and keep a plastic urinal on the night
table.

Others will mention the various medical approaches, but if they don't
work, here's what I've done for many years to mitigate the effect of
getting up in the middle of the night:

1. Don't turn on any lights. Light, even through closed eyelids,
triggers brain activity and chemicals that wakes us up. We keep those
little fluorescent discs plugged into sockets to light the way just
enough to avoid stepping on the dog.

2. Sit to pee in the middle of the night. Standing requires that I
actually wake up, pay attention, and engage my brain in all sorts of
activities such as seeing, aiming, balancing, focusing my eyes, etc.

3. If there's any chilly floor between bed and loo, put a rug on it to
avoid the shock.

4. Heed the whole list of sleep protocols, aka sleep hygiene, including:
A. Cool room. The first thing we do when moving into a new home is
install a wall AC in our bedroom to keep it chilly (humans sleep best
with temps in the 60s; I prefer 60 degrees with a fan in my face; YMMV).
B. Dark room. We usually add heavy drapes/curtains, but our current home
 offered a better remedy: we sleep underground. NO outside light gets
in, night or day. Curtains and closed doors should keep your husband's
nighttime path dark, too. The view from our upstairs bedroom is great,
but we prefer the darkness downstairs.
C. Quiet room. Heavy drapes, shut up noisy neighborhood dogs, electronic
noise masker ($20 at Walmart), earplugs, etc. Sleeping underground as we
do, we'd never know it if the garbage truck broadsided a propane truck
out front.
D. CPAP if he (or you) have apnea.
E. Drink and eat nothing for at least three hours prior to bedtime.
F. Take the phone out of the bedroom. No phone call is worth my sleep.
G. Make sure the bed is really comfortable. We LOVE a good, quality
egg-crate pad on top of our mattress. And we built a giant bed decades
ago so we can choose between closeness and wide separation for better
sleep.

Sleep interruptions do mess with our sleep patterns and thus physical
and mental restoration, but getting back to sleep quickly at least FEELS
much better. On a good night, my two trips to the bathroom cost me less
than five minutes of sleep, combined.

I.P.

   This is a case for your urologist. Many meds to try that may fix this.

I'll let someone else answer about pit stops, but I was wondering how
Henry's PSA is.  I recall it was 66+.  Did the Lupron knock it down some?

Ask the doc about Flomax, Hytrin (both by Rx) or maybe one of the other new
meds such as Detrol. I'm sure there is something out there that might help.
Even if they can just knock it down to a couple of night trips to the
bathroom that would help. He should not have to be getting up that many
times a night.

My husband is still on meds 4 1/2 years after Tx for PC. He takes alfuzosin
(Uroxatral) which has worked very well for him. He's used Hytrin and Flomax.
Recently the doc switched him to Uroxatral and it has been wonderful. Now he
gets up, usually only once, and that is about 2 hours after he has gone to
bed, the rest of the time he sleeps like a baby. Sometimes on Hytrin he'd
dribble his way to the bathroom at night yet he never had a problem during
the day.

All of these meds are apt to lower his blood pressure.
Bev (P&E)