The FDA drug label is available at:
http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=goserelin%20acetate

It mentions loss of bone mineral density, arthralgia (joint pain)
and joint disorders.  But it doesn't give any numbers for the
pain.

I had pain and stiffness in all my fingers and most of my toes
after some months on Lupron.  There's no way to know if it was
caused by the Lupron, but the Lupron drug label indicated that it
was very common.

Others on this group have also reported this problem.

Not all doctors seem to be aware of this.  I wonder if they all
really read the labels on the drugs they prescribe.  I wonder
if some doctors just don't like to hear about nasty effects of
treatments they prescribe.

For my pain, I found the best anti-dote was very, very frequent
exercise.  I kept a rubber ball and some steel hand squeezer
exercisers and literally did a thousand or more squeezes each day.
I'd wake up in the night with pain and squeeze the ball to make it
go away.  Cold water or hot water also helped.  So did stretching.

Exercise will also help keep up your bone mineral density.

For me the pain lasted well after I stopped taking Lupron, but
after I started exercising heavily it gradually got better.  Today
I still have a bit of minor pain but not much and it goes away
with exercise.

   Alan

Exacerbation of any pre-existing osteoarthritis is a well-known ADT SE.
Some people here compared their joint pain on ADT to that of breaking
bones.

I.P.

Go Sox ...... my experience is as follows this short background. I have
been on Zoladex for almost 3 years with 4 month period in the middle of
casodex. My Gleason's was 8 and my post RP undetectable. However
....... my PSA began rising after about 18 months (my lymph nodes were
positive), so have been declared HRPC. To your question - I experience
quite a bit of joint pain and it seems to take spells from barely
noticeable to bothersome. I also have "pins and needles" along with
some numbness in my legs. I should say that I had a treatment session
of taxotere, so my aches and pains could be part of the taxotere. I'm
currently only taking zoladex with a PSA of 0.3, .... fingers crossed.

Rich

On October 17, WhiteSoxFan inquired:

(snip)

As with any other LHRH agonist (e.g. Lupron & Trelstar), the SE (side
effect) arthralgia (joint pain) is not widespread, but is possible. I
know from personal experience.

See: http://www.rxlist.com/

Zoladex tends to prevent the production of the androgen testosterone (T)
by the testes. Casodex (bicalutamide) tends to prevent the receptor
binding of T produced elsewhere (not all testosterone is expressed by
the testes).

I do not believe that Casodex has any effect upon the SEs of ADT
(androgen deprivation therapy).

Broncos here. Glad to see that the Bears whipped the Cardinals last
night, though they were not pretty doing it.

Regards,

Steve J